SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6ek6'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H7X_A_URFA1033_1
(DIHYDROPYRIMIDINE
DEHYDROGENASE)		 6ek6 LYSINE-SPECIFIC
DEMETHYLASE
5B,LYSINE-SPECIFIC
DEMETHYLASE 5B
(Homo
sapiens) 		4 / 6 ASN A 509
ILE A 500
SER A 505
ASN A 601
 90V  A 804 ( 4.6A)
DMS  A 805 (-4.9A)
None
90V  A 804 (-3.8A)
 1.05A 1h7xA-6ek6A:
undetectable		 1h7xA-6ek6A:
6.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H7X_B_URFB1033_1
(DIHYDROPYRIMIDINE
DEHYDROGENASE)		 6ek6 LYSINE-SPECIFIC
DEMETHYLASE
5B,LYSINE-SPECIFIC
DEMETHYLASE 5B
(Homo
sapiens) 		4 / 6 ASN A 509
ILE A 500
SER A 505
ASN A 601
 90V  A 804 ( 4.6A)
DMS  A 805 (-4.9A)
None
90V  A 804 (-3.8A)
 1.05A 1h7xB-6ek6A:
undetectable		 1h7xB-6ek6A:
6.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H7X_C_URFC1033_1
(DIHYDROPYRIMIDINE
DEHYDROGENASE)		 6ek6 LYSINE-SPECIFIC
DEMETHYLASE
5B,LYSINE-SPECIFIC
DEMETHYLASE 5B
(Homo
sapiens) 		4 / 6 ASN A 509
ILE A 500
SER A 505
ASN A 601
 90V  A 804 ( 4.6A)
DMS  A 805 (-4.9A)
None
90V  A 804 (-3.8A)
 1.06A 1h7xC-6ek6A:
undetectable		 1h7xC-6ek6A:
6.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H7X_D_URFD1033_1
(DIHYDROPYRIMIDINE
DEHYDROGENASE)		 6ek6 LYSINE-SPECIFIC
DEMETHYLASE
5B,LYSINE-SPECIFIC
DEMETHYLASE 5B
(Homo
sapiens) 		4 / 6 ASN A 509
ILE A 500
SER A 505
ASN A 601
 90V  A 804 ( 4.6A)
DMS  A 805 (-4.9A)
None
90V  A 804 (-3.8A)
 1.06A 1h7xD-6ek6A:
undetectable		 1h7xD-6ek6A:
6.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HK2_A_T44A3003_1
(SERUM ALBUMIN)		 6ek6 LYSINE-SPECIFIC
DEMETHYLASE
5B,LYSINE-SPECIFIC
DEMETHYLASE 5B
(Homo
sapiens) 		4 / 6 ILE A 475
LYS A 635
ALA A 637
MET A 655
 None
 1.10A 1hk2A-6ek6A:
undetectable		 1hk2A-6ek6A:
7.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JR1_B_MOAB1333_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE 2)		 6ek6 LYSINE-SPECIFIC
DEMETHYLASE
5B,LYSINE-SPECIFIC
DEMETHYLASE 5B
(Homo
sapiens) 		4 / 8 GLY A 589
THR A 518
GLY A 593
GLN A 592
 None
 0.75A 1jr1B-6ek6A:
undetectable		 1jr1B-6ek6A:
10.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MAA_C_DMEC997_1
(ACETYLCHOLINESTERASE)		 6ek6 LYSINE-SPECIFIC
DEMETHYLASE
5B,LYSINE-SPECIFIC
DEMETHYLASE 5B
(Homo
sapiens) 		5 / 12 GLY A 576
PHE A 578
PHE A 438
TYR A 454
HIS A 512
 None
 1.32A 1maaC-6ek6A:
undetectable		 1maaC-6ek6A:
9.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MXD_A_ACRA734_1
(ALPHA AMYLASE)		 6ek6 LYSINE-SPECIFIC
DEMETHYLASE
5B,LYSINE-SPECIFIC
DEMETHYLASE 5B
(Homo
sapiens) 		4 / 6 ASN A 460
TRP A  70
HIS A 512
TYR A 510
 None
 1.50A 1mxdA-6ek6A:
undetectable		 1mxdA-6ek6A:
10.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MXD_A_ACRA734_1
(ALPHA AMYLASE)		 6ek6 LYSINE-SPECIFIC
DEMETHYLASE
5B,LYSINE-SPECIFIC
DEMETHYLASE 5B
(Homo
sapiens) 		4 / 6 ASN A 460
TRP A  70
TYR A 510
GLY A 437
 None
 1.39A 1mxdA-6ek6A:
undetectable		 1mxdA-6ek6A:
10.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RUA_H_BEZH601_0
(IMMUNOGLOBULIN
IGG2A, HEAVY CHAIN
IMMUNOGLOBULIN
IGG2A, LIGHT CHAIN)		 6ek6 LYSINE-SPECIFIC
DEMETHYLASE
5B,LYSINE-SPECIFIC
DEMETHYLASE 5B
(Homo
sapiens) 		5 / 10 ALA A 597
TRP A 519
LEU A 511
GLY A 576
PHE A 578
 90V  A 804 ( 4.5A)
None
None
None
None
 1.39A 1ruaH-6ek6A:
undetectable
1ruaL-6ek6A:
undetectable		 1ruaH-6ek6A:
undetectable
1ruaL-6ek6A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XP0_A_VDNA201_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 6ek6 LYSINE-SPECIFIC
DEMETHYLASE
5B,LYSINE-SPECIFIC
DEMETHYLASE 5B
(Homo
sapiens) 		5 / 10 LEU A 472
ALA A 473
ILE A 475
VAL A 647
ALA A 648
 None
 1.15A 1xp0A-6ek6A:
undetectable		 1xp0A-6ek6A:
11.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXF_B_DZPB2001_1
(SERUM ALBUMIN)		 6ek6 LYSINE-SPECIFIC
DEMETHYLASE
5B,LYSINE-SPECIFIC
DEMETHYLASE 5B
(Homo
sapiens) 		5 / 12 ILE A 500
LEU A 561
VAL A 522
GLU A 531
LEU A 530
 DMS  A 805 (-4.9A)
None
None
DMS  A 805 ( 4.6A)
None
 1.30A 2bxfB-6ek6A:
undetectable		 2bxfB-6ek6A:
7.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DPZ_A_TYLA2001_1
(PHOSPHOLIPASE A2
VRV-PL-VIIIA)		 6ek6 LYSINE-SPECIFIC
DEMETHYLASE
5B,LYSINE-SPECIFIC
DEMETHYLASE 5B
(Homo
sapiens) 		4 / 6 LEU A 472
ALA A 477
HIS A 503
ASP A 502
 None
 1.35A 2dpzA-6ek6A:
undetectable		 2dpzA-6ek6A:
18.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZM9_A_ACAA502_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 6ek6 LYSINE-SPECIFIC
DEMETHYLASE
5B,LYSINE-SPECIFIC
DEMETHYLASE 5B
(Homo
sapiens) 		4 / 8 ALA A 585
TRP A 498
GLY A  60
ILE A  61
 None
 0.65A 2zm9A-6ek6A:
undetectable		 2zm9A-6ek6A:
12.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CR5_X_PNTX94_0
(PROTEIN S100-B)		 6ek6 LYSINE-SPECIFIC
DEMETHYLASE
5B,LYSINE-SPECIFIC
DEMETHYLASE 5B
(Homo
sapiens) 		3 / 3 PHE A  35
CYH A  62
PHE A 582
 None
 1.02A 3cr5X-6ek6A:
undetectable		 3cr5X-6ek6A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3F8W_B_ADNB301_1
(PURINE-NUCLEOSIDE
PHOSPHORYLASE)		 6ek6 LYSINE-SPECIFIC
DEMETHYLASE
5B,LYSINE-SPECIFIC
DEMETHYLASE 5B
(Homo
sapiens) 		5 / 12 GLY A 426
TYR A 377
VAL A 489
GLY A 490
MET A 491
 None
 1.31A 3f8wB-6ek6A:
undetectable		 3f8wB-6ek6A:
15.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SOA_A_DB8A445_1
(CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE II
SUBUNIT ALPHA WITH A
BETA 7 LINKER)		 6ek6 LYSINE-SPECIFIC
DEMETHYLASE
5B,LYSINE-SPECIFIC
DEMETHYLASE 5B
(Homo
sapiens) 		4 / 6 LEU A  90
VAL A 421
PHE A 389
PHE A 394
 None
 0.97A 3soaA-6ek6A:
undetectable		 3soaA-6ek6A:
10.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UNI_A_SALA1344_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 6ek6 LYSINE-SPECIFIC
DEMETHYLASE
5B,LYSINE-SPECIFIC
DEMETHYLASE 5B
(Homo
sapiens) 		4 / 7 THR A 650
VAL A 651
LEU A 748
ALA A 752
 None
 0.89A 3uniA-6ek6A:
undetectable		 3uniA-6ek6A:
4.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R87_E_SPME202_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 6ek6 LYSINE-SPECIFIC
DEMETHYLASE
5B,LYSINE-SPECIFIC
DEMETHYLASE 5B
(Homo
sapiens) 		4 / 5 GLU A 452
GLU A 453
TYR A 454
GLU A 451
 None
 1.49A 4r87E-6ek6A:
undetectable		 4r87E-6ek6A:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_C_377C401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 6ek6 LYSINE-SPECIFIC
DEMETHYLASE
5B,LYSINE-SPECIFIC
DEMETHYLASE 5B
(Homo
sapiens) 		4 / 6 TYR A 454
TYR A 510
LEU A 461
PHE A 578
 None
 1.18A 4twdB-6ek6A:
2.8
4twdC-6ek6A:
2.8		 4twdB-6ek6A:
11.19
4twdC-6ek6A:
11.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_E_377E401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 6ek6 LYSINE-SPECIFIC
DEMETHYLASE
5B,LYSINE-SPECIFIC
DEMETHYLASE 5B
(Homo
sapiens) 		4 / 6 TYR A 454
TYR A 510
LEU A 461
PHE A 578
 None
 1.12A 4twdD-6ek6A:
undetectable
4twdE-6ek6A:
2.8		 4twdD-6ek6A:
11.19
4twdE-6ek6A:
11.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_F_377F401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 6ek6 LYSINE-SPECIFIC
DEMETHYLASE
5B,LYSINE-SPECIFIC
DEMETHYLASE 5B
(Homo
sapiens) 		4 / 7 TYR A 510
LEU A 461
PHE A 578
TYR A 454
 None
 1.18A 4twdF-6ek6A:
undetectable
4twdJ-6ek6A:
undetectable		 4twdF-6ek6A:
11.19
4twdJ-6ek6A:
11.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_G_377G401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 6ek6 LYSINE-SPECIFIC
DEMETHYLASE
5B,LYSINE-SPECIFIC
DEMETHYLASE 5B
(Homo
sapiens) 		4 / 6 TYR A 454
TYR A 510
LEU A 461
PHE A 578
 None
 1.18A 4twdF-6ek6A:
undetectable
4twdG-6ek6A:
1.1		 4twdF-6ek6A:
11.19
4twdG-6ek6A:
11.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_J_377J401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 6ek6 LYSINE-SPECIFIC
DEMETHYLASE
5B,LYSINE-SPECIFIC
DEMETHYLASE 5B
(Homo
sapiens) 		4 / 6 TYR A 454
TYR A 510
LEU A 461
PHE A 578
 None
 1.20A 4twdI-6ek6A:
undetectable
4twdJ-6ek6A:
undetectable		 4twdI-6ek6A:
11.19
4twdJ-6ek6A:
11.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B8I_C_FK5C201_2
(CALCINEURIN SUBUNIT
B, VARIANT
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE)		 6ek6 LYSINE-SPECIFIC
DEMETHYLASE
5B,LYSINE-SPECIFIC
DEMETHYLASE 5B
(Homo
sapiens) 		4 / 4 LEU A 561
MET A 534
VAL A 533
ASN A 532
 None
 1.27A 5b8iB-6ek6A:
undetectable		 5b8iB-6ek6A:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HES_A_032A401_2
(MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE MLT)		 6ek6 LYSINE-SPECIFIC
DEMETHYLASE
5B,LYSINE-SPECIFIC
DEMETHYLASE 5B
(Homo
sapiens) 		4 / 6 PHE A  46
SER A 470
VAL A 471
ASP A 606
 None
 1.29A 5hesA-6ek6A:
undetectable		 5hesA-6ek6A:
13.22