SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6ek7'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DTJ_B_THRB402_0
(ASPARTOKINASE)		 6ek7 YAXA
(Yersinia
enterocolitica) 		5 / 9 ILE A  51
ILE A 397
ASP A  49
ALA A 401
THR A  46
 MPD  A 505 ( 4.5A)
None
None
None
None
 1.37A 2dtjA-6ek7A:
undetectable
2dtjB-6ek7A:
undetectable		 2dtjA-6ek7A:
undetectable
2dtjB-6ek7A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJ8_C_SPMC500_1
(DIAMINE
ACETYLTRANSFERASE 1)		 6ek7 YAXA
(Yersinia
enterocolitica) 		4 / 6 ASP A 328
LEU A  63
LEU A 204
HIS A  99
 None
 1.18A 3bj8C-6ek7A:
undetectable
3bj8D-6ek7A:
undetectable		 3bj8C-6ek7A:
20.50
3bj8D-6ek7A:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DDY_A_RBFA187_1
(LUMAZINE PROTEIN)		 6ek7 YAXA
(Yersinia
enterocolitica) 		5 / 12 SER A 126
ASN A 129
ILE A 132
ASN A 123
ILE A 124
 None
None
None
MPD  A 506 (-3.0A)
MPD  A 506 ( 4.9A)
 1.12A 3ddyA-6ek7A:
undetectable		 3ddyA-6ek7A:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJ1_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 6ek7 YAXA
(Yersinia
enterocolitica) 		5 / 12 ILE A 135
LEU A 368
PHE A 373
LEU A 176
ILE A 131
 MPD  A 503 ( 4.4A)
None
None
MPD  A 502 ( 4.3A)
None
 1.01A 4ej1A-6ek7A:
undetectable		 4ej1A-6ek7A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I13_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 6ek7 YAXA
(Yersinia
enterocolitica) 		5 / 12 ILE A 135
LEU A 368
PHE A 373
LEU A 176
ILE A 131
 MPD  A 503 ( 4.4A)
None
None
MPD  A 502 ( 4.3A)
None
 1.00A 4i13A-6ek7A:
undetectable		 4i13A-6ek7A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X5I_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 6ek7 YAXA
(Yersinia
enterocolitica) 		5 / 12 ILE A 135
LEU A 368
PHE A 373
LEU A 176
ILE A 131
 MPD  A 503 ( 4.4A)
None
None
MPD  A 502 ( 4.3A)
None
 0.90A 4x5iA-6ek7A:
undetectable		 4x5iA-6ek7A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZO1_X_T3X500_1
(THYROID HORMONE
RECEPTOR BETA)		 6ek7 YAXA
(Yersinia
enterocolitica) 		5 / 12 ILE A  96
ALA A 100
ALA A 336
LEU A 204
PHE A  93
 None
 1.20A 4zo1X-6ek7A:
undetectable		 4zo1X-6ek7A:
16.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NWV_A_ACAA18_2
(SCRFP-TAG,GP41)		 6ek7 YAXA
(Yersinia
enterocolitica) 		4 / 7 GLN A 112
LEU A 115
ASP A 118
ALA A 121
 None
 0.91A 5nwvA-6ek7A:
undetectable		 5nwvA-6ek7A:
13.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_I_EY4I500_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 6ek7 YAXA
(Yersinia
enterocolitica) 		4 / 5 GLN A 353
VAL A 350
PRO A 383
THR A 189
 None
 1.22A 6cduI-6ek7A:
5.1
6cduJ-6ek7A:
6.1		 6cduI-6ek7A:
undetectable
6cduJ-6ek7A:
undetectable