SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6eks'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4G_A_ZMRA466_1
(NEURAMINIDASE)		 6eks SIALIDASE
(Vibrio
cholerae) 		6 / 12 ARG A 250
ASP A 276
GLU A 645
ARG A 661
ARG A 738
TYR A 766
 G39  A 908 (-2.8A)
G39  A 908 (-3.3A)
G39  A 908 (-4.0A)
G39  A 908 (-2.8A)
G39  A 908 (-3.0A)
G39  A 908 (-4.6A)
 0.39A 1a4gA-6eksA:
13.8		 1a4gA-6eksA:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4G_B_ZMRB466_1
(NEURAMINIDASE)		 6eks SIALIDASE
(Vibrio
cholerae) 		5 / 12 ARG A 250
GLU A 645
ARG A 661
ARG A 738
TYR A 766
 G39  A 908 (-2.8A)
G39  A 908 (-4.0A)
G39  A 908 (-2.8A)
G39  A 908 (-3.0A)
G39  A 908 (-4.6A)
 0.34A 1a4gB-6eksA:
13.6		 1a4gB-6eksA:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JOM_A_FFOA161_0
(DIHYDROFOLATE
REDUCTASE)		 6eks SIALIDASE
(Vibrio
cholerae) 		5 / 11 ALA A 101
ILE A 148
LEU A 146
ARG A 144
TYR A 232
 None
 1.15A 1jomA-6eksA:
undetectable		 1jomA-6eksA:
11.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L7F_A_BCZA801_0
(NEURAMINIDASE)		 6eks SIALIDASE
(Vibrio
cholerae) 		5 / 12 ASP A 276
TRP A 337
GLU A 645
ARG A 661
TYR A 766
 G39  A 908 (-3.3A)
None
G39  A 908 (-4.0A)
G39  A 908 (-2.8A)
G39  A 908 (-4.6A)
 0.60A 1l7fA-6eksA:
20.8		 1l7fA-6eksA:
17.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L7G_A_BCZA801_0
(NEURAMINIDASE)		 6eks SIALIDASE
(Vibrio
cholerae) 		5 / 12 ASP A 276
TRP A 337
GLU A 645
ARG A 661
TYR A 766
 G39  A 908 (-3.3A)
None
G39  A 908 (-4.0A)
G39  A 908 (-2.8A)
G39  A 908 (-4.6A)
 0.58A 1l7gA-6eksA:
20.7		 1l7gA-6eksA:
17.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NNC_A_ZMRA479_1
(NEURAMINIDASE N9)		 6eks SIALIDASE
(Vibrio
cholerae) 		5 / 12 ARG A 250
GLU A 645
ARG A 661
ARG A 738
TYR A 766
 G39  A 908 (-2.8A)
G39  A 908 (-4.0A)
G39  A 908 (-2.8A)
G39  A 908 (-3.0A)
G39  A 908 (-4.6A)
 0.39A 1nncA-6eksA:
20.5		 1nncA-6eksA:
17.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZF_A_FOLA605_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 6eks SIALIDASE
(Vibrio
cholerae) 		5 / 12 ALA A 101
ILE A 148
LEU A 146
ARG A 144
TYR A 232
 None
 1.12A 1qzfA-6eksA:
undetectable		 1qzfA-6eksA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZF_B_FOLB609_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 6eks SIALIDASE
(Vibrio
cholerae) 		5 / 12 ALA A 101
ILE A 148
LEU A 146
ARG A 144
TYR A 232
 None
 1.12A 1qzfB-6eksA:
undetectable		 1qzfB-6eksA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZF_C_FOLC613_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 6eks SIALIDASE
(Vibrio
cholerae) 		5 / 12 ALA A 101
ILE A 148
LEU A 146
ARG A 144
TYR A 232
 None
 1.12A 1qzfC-6eksA:
undetectable		 1qzfC-6eksA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZF_D_FOLD617_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 6eks SIALIDASE
(Vibrio
cholerae) 		5 / 12 ALA A 101
ILE A 148
LEU A 146
ARG A 144
TYR A 232
 None
 1.12A 1qzfD-6eksA:
undetectable		 1qzfD-6eksA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZF_E_FOLE621_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 6eks SIALIDASE
(Vibrio
cholerae) 		5 / 12 ALA A 101
ILE A 148
LEU A 146
ARG A 144
TYR A 232
 None
 1.13A 1qzfE-6eksA:
undetectable		 1qzfE-6eksA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S9Q_A_CHDA459_0
(ESTROGEN-RELATED
RECEPTOR GAMMA)		 6eks SIALIDASE
(Vibrio
cholerae) 		4 / 6 ASP A 602
LEU A 601
VAL A 600
ILE A 599
 GOL  A 905 ( 4.8A)
None
None
None
 0.63A 1s9qA-6eksA:
undetectable		 1s9qA-6eksA:
16.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W5U_B_DVAB8_0
(GRAMICIDIN D)		 6eks SIALIDASE
(Vibrio
cholerae) 		3 / 3 VAL A  94
VAL A  82
TRP A 103
 None
 0.95A 1w5uA-6eksA:
undetectable
1w5uB-6eksA:
undetectable		 1w5uA-6eksA:
1.96
1w5uB-6eksA:
1.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_D_SAMD301_1
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 6eks SIALIDASE
(Vibrio
cholerae) 		3 / 3 LYS A  51
ASP A 249
ASP A 242
 None
 1.00A 2br4D-6eksA:
undetectable		 2br4D-6eksA:
15.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_A_ZMRA1477_1
(NEURAMINIDASE)		 6eks SIALIDASE
(Vibrio
cholerae) 		6 / 12 ARG A 250
ASP A 276
GLU A 645
ARG A 661
ARG A 738
TYR A 766
 G39  A 908 (-2.8A)
G39  A 908 (-3.3A)
G39  A 908 (-4.0A)
G39  A 908 (-2.8A)
G39  A 908 (-3.0A)
G39  A 908 (-4.6A)
 0.44A 2cmlA-6eksA:
20.9		 2cmlA-6eksA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_B_ZMRB2477_1
(NEURAMINIDASE)		 6eks SIALIDASE
(Vibrio
cholerae) 		6 / 12 ARG A 250
ASP A 276
GLU A 645
ARG A 661
ARG A 738
TYR A 766
 G39  A 908 (-2.8A)
G39  A 908 (-3.3A)
G39  A 908 (-4.0A)
G39  A 908 (-2.8A)
G39  A 908 (-3.0A)
G39  A 908 (-4.6A)
 0.45A 2cmlB-6eksA:
10.1		 2cmlB-6eksA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_C_ZMRC3477_1
(NEURAMINIDASE)		 6eks SIALIDASE
(Vibrio
cholerae) 		6 / 12 ARG A 250
ASP A 276
GLU A 645
ARG A 661
ARG A 738
TYR A 766
 G39  A 908 (-2.8A)
G39  A 908 (-3.3A)
G39  A 908 (-4.0A)
G39  A 908 (-2.8A)
G39  A 908 (-3.0A)
G39  A 908 (-4.6A)
 0.43A 2cmlC-6eksA:
10.0		 2cmlC-6eksA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_D_ZMRD4477_1
(NEURAMINIDASE)		 6eks SIALIDASE
(Vibrio
cholerae) 		6 / 12 ARG A 250
ASP A 276
GLU A 645
ARG A 661
ARG A 738
TYR A 766
 G39  A 908 (-2.8A)
G39  A 908 (-3.3A)
G39  A 908 (-4.0A)
G39  A 908 (-2.8A)
G39  A 908 (-3.0A)
G39  A 908 (-4.6A)
 0.45A 2cmlD-6eksA:
11.6		 2cmlD-6eksA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F0Z_A_ZMRA381_1
(SIALIDASE 2)		 6eks SIALIDASE
(Vibrio
cholerae) 		6 / 12 ARG A 250
GLU A 269
GLU A 645
ARG A 661
ARG A 738
TYR A 766
 G39  A 908 (-2.8A)
G39  A 908 ( 4.7A)
G39  A 908 (-4.0A)
G39  A 908 (-2.8A)
G39  A 908 (-3.0A)
G39  A 908 (-4.6A)
 0.29A 2f0zA-6eksA:
40.4		 2f0zA-6eksA:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F10_A_BCZA382_0
(SIALIDASE 2)		 6eks SIALIDASE
(Vibrio
cholerae) 		8 / 12 ARG A 250
ILE A 251
GLU A 269
ARG A 271
GLU A 645
ARG A 661
ARG A 738
TYR A 766
 G39  A 908 (-2.8A)
G39  A 908 (-4.7A)
G39  A 908 ( 4.7A)
G39  A 908 (-4.2A)
G39  A 908 (-4.0A)
G39  A 908 (-2.8A)
G39  A 908 (-3.0A)
G39  A 908 (-4.6A)
 0.43A 2f10A-6eksA:
39.4		 2f10A-6eksA:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GVC_B_MMZB501_1
(MONOOXYGENASE)		 6eks SIALIDASE
(Vibrio
cholerae) 		3 / 3 ASN A 571
TYR A 766
SER A 644
 G39  A 908 (-4.5A)
G39  A 908 (-4.6A)
G39  A 908 ( 3.8A)
 0.78A 2gvcB-6eksA:
undetectable		 2gvcB-6eksA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GVC_E_MMZE501_1
(MONOOXYGENASE)		 6eks SIALIDASE
(Vibrio
cholerae) 		3 / 3 ASN A 571
TYR A 766
SER A 644
 G39  A 908 (-4.5A)
G39  A 908 (-4.6A)
G39  A 908 ( 3.8A)
 0.78A 2gvcE-6eksA:
undetectable		 2gvcE-6eksA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HTQ_A_ZMRA472_1
(NEURAMINIDASE)		 6eks SIALIDASE
(Vibrio
cholerae) 		5 / 12 ARG A 250
GLU A 645
ARG A 661
ARG A 738
TYR A 766
 G39  A 908 (-2.8A)
G39  A 908 (-4.0A)
G39  A 908 (-2.8A)
G39  A 908 (-3.0A)
G39  A 908 (-4.6A)
 0.55A 2htqA-6eksA:
21.3		 2htqA-6eksA:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IGT_C_SAMC1003_1
(SAM DEPENDENT
METHYLTRANSFERASE)		 6eks SIALIDASE
(Vibrio
cholerae) 		4 / 4 ASP A 315
ASP A 276
ASP A 285
GLY A 274
 CA  A 904 (-2.1A)
G39  A 908 (-3.3A)
None
None
 1.32A 2igtC-6eksA:
undetectable		 2igtC-6eksA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OXT_B_SAMB300_1
(NUCLEOSIDE-2'-O-METH
YLTRANSFERASE)		 6eks SIALIDASE
(Vibrio
cholerae) 		4 / 5 SER A 253
GLY A 575
ASP A 373
ASP A 318
 None
CA  A 903 ( 3.9A)
None
G39  A 908 ( 4.2A)
 1.13A 2oxtB-6eksA:
undetectable		 2oxtB-6eksA:
15.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q58_A_ZOLA1_1
(FARNESYL
PYROPHOSPHATE
SYNTHASE)		 6eks SIALIDASE
(Vibrio
cholerae) 		5 / 10 GLN A 800
LYS A 799
THR A 796
GLN A 716
ASP A 718
 None
 1.46A 2q58A-6eksA:
undetectable		 2q58A-6eksA:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0G_A_LEUA1887_0
(AMINOACYL-TRNA
SYNTHETASE)		 6eks SIALIDASE
(Vibrio
cholerae) 		4 / 8 ASP A 405
SER A 474
TYR A 431
HIS A 478
 None
 1.39A 2v0gA-6eksA:
undetectable		 2v0gA-6eksA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y00_B_Y00B601_2
(BETA-1 ADRENERGIC
RECEPTOR)		 6eks SIALIDASE
(Vibrio
cholerae) 		3 / 3 VAL A 128
ASN A 136
TRP A 219
 None
 1.06A 2y00B-6eksA:
undetectable		 2y00B-6eksA:
16.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7K_D_SALD1300_1
(LYSR-TYPE REGULATORY
PROTEIN)		 6eks SIALIDASE
(Vibrio
cholerae) 		5 / 12 ILE A 322
GLY A 577
TYR A 596
LEU A 580
ILE A 595
 None
 1.22A 2y7kD-6eksA:
undetectable		 2y7kD-6eksA:
14.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_A_ZMRA1776_1
(NEURAMINIDASE A)		 6eks SIALIDASE
(Vibrio
cholerae) 		6 / 12 ARG A 250
ILE A 251
ASP A 318
ARG A 661
ARG A 738
TYR A 766
 G39  A 908 (-2.8A)
G39  A 908 (-4.7A)
G39  A 908 ( 4.2A)
G39  A 908 (-2.8A)
G39  A 908 (-3.0A)
G39  A 908 (-4.6A)
 0.84A 2ya7A-6eksA:
43.2		 2ya7A-6eksA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_B_ZMRB1776_1
(NEURAMINIDASE A)		 6eks SIALIDASE
(Vibrio
cholerae) 		6 / 12 ARG A 250
ILE A 251
ASP A 318
ARG A 661
ARG A 738
TYR A 766
 G39  A 908 (-2.8A)
G39  A 908 (-4.7A)
G39  A 908 ( 4.2A)
G39  A 908 (-2.8A)
G39  A 908 (-3.0A)
G39  A 908 (-4.6A)
 0.86A 2ya7B-6eksA:
43.0		 2ya7B-6eksA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_C_ZMRC1776_1
(NEURAMINIDASE A)		 6eks SIALIDASE
(Vibrio
cholerae) 		6 / 12 ARG A 250
ILE A 251
ASP A 318
ARG A 661
ARG A 738
TYR A 766
 G39  A 908 (-2.8A)
G39  A 908 (-4.7A)
G39  A 908 ( 4.2A)
G39  A 908 (-2.8A)
G39  A 908 (-3.0A)
G39  A 908 (-4.6A)
 0.83A 2ya7C-6eksA:
41.2		 2ya7C-6eksA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_C_ZMRC1776_1
(NEURAMINIDASE A)		 6eks SIALIDASE
(Vibrio
cholerae) 		6 / 12 ARG A 250
ILE A 251
ASP A 318
LEU A 606
ARG A 738
TYR A 766
 G39  A 908 (-2.8A)
G39  A 908 (-4.7A)
G39  A 908 ( 4.2A)
None
G39  A 908 (-3.0A)
G39  A 908 (-4.6A)
 1.27A 2ya7C-6eksA:
41.2		 2ya7C-6eksA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_D_ZMRD1776_1
(NEURAMINIDASE A)		 6eks SIALIDASE
(Vibrio
cholerae) 		6 / 12 ARG A 250
ILE A 251
ASP A 318
ARG A 661
ARG A 738
TYR A 766
 G39  A 908 (-2.8A)
G39  A 908 (-4.7A)
G39  A 908 ( 4.2A)
G39  A 908 (-2.8A)
G39  A 908 (-3.0A)
G39  A 908 (-4.6A)
 0.83A 2ya7D-6eksA:
43.0		 2ya7D-6eksA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B7E_A_ZMRA1001_1
(NEURAMINIDASE)		 6eks SIALIDASE
(Vibrio
cholerae) 		6 / 12 ARG A 250
ASP A 276
GLU A 645
ARG A 661
ARG A 738
TYR A 766
 G39  A 908 (-2.8A)
G39  A 908 (-3.3A)
G39  A 908 (-4.0A)
G39  A 908 (-2.8A)
G39  A 908 (-3.0A)
G39  A 908 (-4.6A)
 0.47A 3b7eA-6eksA:
20.8		 3b7eA-6eksA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B7E_B_ZMRB1002_1
(NEURAMINIDASE)		 6eks SIALIDASE
(Vibrio
cholerae) 		6 / 12 ARG A 250
ASP A 276
GLU A 645
ARG A 661
ARG A 738
TYR A 766
 G39  A 908 (-2.8A)
G39  A 908 (-3.3A)
G39  A 908 (-4.0A)
G39  A 908 (-2.8A)
G39  A 908 (-3.0A)
G39  A 908 (-4.6A)
 0.48A 3b7eB-6eksA:
20.7		 3b7eB-6eksA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CKZ_A_ZMRA469_1
(NEURAMINIDASE)		 6eks SIALIDASE
(Vibrio
cholerae) 		5 / 12 ARG A 250
GLU A 645
ARG A 661
ARG A 738
TYR A 766
 G39  A 908 (-2.8A)
G39  A 908 (-4.0A)
G39  A 908 (-2.8A)
G39  A 908 (-3.0A)
G39  A 908 (-4.6A)
 0.32A 3ckzA-6eksA:
21.0		 3ckzA-6eksA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLD_B_GW6B2_2
(GLUCOCORTICOID
RECEPTOR)		 6eks SIALIDASE
(Vibrio
cholerae) 		4 / 8 LEU A 435
LEU A 482
GLN A 457
ILE A 437
 None
 0.90A 3cldB-6eksA:
undetectable		 3cldB-6eksA:
17.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G4L_C_ROFC903_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 6eks SIALIDASE
(Vibrio
cholerae) 		3 / 3 SER A 382
GLN A 518
PHE A 535
 None
 0.83A 3g4lC-6eksA:
undetectable		 3g4lC-6eksA:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWX_A_EPAA1_2
(PROTEIN (PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
(PPAR-DELTA)))		 6eks SIALIDASE
(Vibrio
cholerae) 		5 / 12 THR A 481
THR A 480
THR A 479
LEU A 447
ILE A 422
 None
 1.35A 3gwxA-6eksA:
undetectable		 3gwxA-6eksA:
16.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCR_A_CHDA424_0
(FERROCHELATASE,
MITOCHONDRIAL)		 6eks SIALIDASE
(Vibrio
cholerae) 		4 / 8 LEU A 601
ARG A 347
GLY A 278
PRO A 277
 None
None
CA  A 904 ( 4.6A)
G39  A 908 ( 4.4A)
 1.04A 3hcrA-6eksA:
undetectable		 3hcrA-6eksA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K37_A_BCZA468_0
(NEURAMINIDASE)		 6eks SIALIDASE
(Vibrio
cholerae) 		5 / 12 ARG A 250
TRP A 337
GLU A 645
ARG A 661
TYR A 766
 G39  A 908 (-2.8A)
None
G39  A 908 (-4.0A)
G39  A 908 (-2.8A)
G39  A 908 (-4.6A)
 0.58A 3k37A-6eksA:
13.8		 3k37A-6eksA:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K37_B_BCZB468_0
(NEURAMINIDASE)		 6eks SIALIDASE
(Vibrio
cholerae) 		6 / 12 ARG A 250
ASP A 276
TRP A 337
GLU A 645
ARG A 661
ARG A 738
 G39  A 908 (-2.8A)
G39  A 908 (-3.3A)
None
G39  A 908 (-4.0A)
G39  A 908 (-2.8A)
G39  A 908 (-3.0A)
 0.69A 3k37B-6eksA:
13.7		 3k37B-6eksA:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K39_B_BCZB1001_0
(NEURAMINIDASE)		 6eks SIALIDASE
(Vibrio
cholerae) 		5 / 12 ARG A 250
ASP A 276
GLU A 645
ARG A 661
TYR A 766
 G39  A 908 (-2.8A)
G39  A 908 (-3.3A)
G39  A 908 (-4.0A)
G39  A 908 (-2.8A)
G39  A 908 (-4.6A)
 0.43A 3k39B-6eksA:
6.3		 3k39B-6eksA:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K39_O_BCZO1001_0
(NEURAMINIDASE)		 6eks SIALIDASE
(Vibrio
cholerae) 		5 / 12 ARG A 738
GLU A 782
GLU A 269
ARG A 661
TYR A 766
 G39  A 908 (-3.0A)
None
G39  A 908 ( 4.7A)
G39  A 908 (-2.8A)
G39  A 908 (-4.6A)
 1.40A 3k39O-6eksA:
13.8		 3k39O-6eksA:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K8M_B_ACRB820_1
(ALPHA-AMYLASE, SUSG)		 6eks SIALIDASE
(Vibrio
cholerae) 		4 / 7 GLU A 495
TRP A 492
LEU A 471
TRP A 406
 None
 1.18A 3k8mB-6eksA:
undetectable		 3k8mB-6eksA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_O_TFPO201_1
(PROTEIN S100-A4)		 6eks SIALIDASE
(Vibrio
cholerae) 		4 / 8 GLY A 513
PHE A 532
GLY A 505
PHE A 504
 None
 0.89A 3ko0O-6eksA:
undetectable
3ko0Q-6eksA:
undetectable		 3ko0O-6eksA:
9.31
3ko0Q-6eksA:
9.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P2K_A_SAMA6735_1
(16S RRNA METHYLASE)		 6eks SIALIDASE
(Vibrio
cholerae) 		3 / 3 ASP A 318
GLU A 782
SER A 569
 G39  A 908 ( 4.2A)
None
None
 0.67A 3p2kA-6eksA:
undetectable		 3p2kA-6eksA:
14.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P2K_C_SAMC6735_1
(16S RRNA METHYLASE)		 6eks SIALIDASE
(Vibrio
cholerae) 		4 / 5 ASN A 354
ASP A 318
GLU A 782
SER A 569
 None
G39  A 908 ( 4.2A)
None
None
 1.30A 3p2kC-6eksA:
undetectable		 3p2kC-6eksA:
14.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3POC_B_ACRB665_1
(ALPHA-GLUCOSIDASE)		 6eks SIALIDASE
(Vibrio
cholerae) 		4 / 6 ASP A 234
TYR A  55
ASP A  54
LYS A 236
 None
 0.87A 3pocB-6eksA:
undetectable		 3pocB-6eksA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SAN_A_ZMRA901_1
(NEURAMINIDASE)		 6eks SIALIDASE
(Vibrio
cholerae) 		5 / 12 ARG A 250
GLU A 645
ARG A 661
ARG A 738
TYR A 766
 G39  A 908 (-2.8A)
G39  A 908 (-4.0A)
G39  A 908 (-2.8A)
G39  A 908 (-3.0A)
G39  A 908 (-4.6A)
 0.34A 3sanA-6eksA:
21.5		 3sanA-6eksA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SAN_B_ZMRB901_1
(NEURAMINIDASE)		 6eks SIALIDASE
(Vibrio
cholerae) 		5 / 12 ARG A 250
GLU A 645
ARG A 661
ARG A 738
TYR A 766
 G39  A 908 (-2.8A)
G39  A 908 (-4.0A)
G39  A 908 (-2.8A)
G39  A 908 (-3.0A)
G39  A 908 (-4.6A)
 0.34A 3sanB-6eksA:
21.6		 3sanB-6eksA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TI5_A_ZMRA1002_1
(NEURAMINIDASE)		 6eks SIALIDASE
(Vibrio
cholerae) 		6 / 12 ARG A 250
ASP A 276
GLU A 645
ARG A 661
ARG A 738
TYR A 766
 G39  A 908 (-2.8A)
G39  A 908 (-3.3A)
G39  A 908 (-4.0A)
G39  A 908 (-2.8A)
G39  A 908 (-3.0A)
G39  A 908 (-4.6A)
 0.43A 3ti5A-6eksA:
20.9		 3ti5A-6eksA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TI5_B_ZMRB1002_1
(NEURAMINIDASE)		 6eks SIALIDASE
(Vibrio
cholerae) 		6 / 12 ARG A 250
ASP A 276
GLU A 645
ARG A 661
ARG A 738
TYR A 766
 G39  A 908 (-2.8A)
G39  A 908 (-3.3A)
G39  A 908 (-4.0A)
G39  A 908 (-2.8A)
G39  A 908 (-3.0A)
G39  A 908 (-4.6A)
 0.45A 3ti5B-6eksA:
20.9		 3ti5B-6eksA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TIC_A_ZMRA1002_1
(NEURAMINIDASE)		 6eks SIALIDASE
(Vibrio
cholerae) 		7 / 12 ARG A 250
ASP A 276
TRP A 337
GLU A 645
ARG A 661
ARG A 738
TYR A 766
 G39  A 908 (-2.8A)
G39  A 908 (-3.3A)
None
G39  A 908 (-4.0A)
G39  A 908 (-2.8A)
G39  A 908 (-3.0A)
G39  A 908 (-4.6A)
 0.65A 3ticA-6eksA:
21.0		 3ticA-6eksA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TIC_B_ZMRB1002_1
(NEURAMINIDASE)		 6eks SIALIDASE
(Vibrio
cholerae) 		6 / 12 ARG A 250
ASP A 276
GLU A 645
ARG A 661
ARG A 738
TYR A 766
 G39  A 908 (-2.8A)
G39  A 908 (-3.3A)
G39  A 908 (-4.0A)
G39  A 908 (-2.8A)
G39  A 908 (-3.0A)
G39  A 908 (-4.6A)
 0.47A 3ticB-6eksA:
21.0		 3ticB-6eksA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TIC_C_ZMRC1002_1
(NEURAMINIDASE)		 6eks SIALIDASE
(Vibrio
cholerae) 		6 / 12 ARG A 250
ASP A 276
GLU A 645
ARG A 661
ARG A 738
TYR A 766
 G39  A 908 (-2.8A)
G39  A 908 (-3.3A)
G39  A 908 (-4.0A)
G39  A 908 (-2.8A)
G39  A 908 (-3.0A)
G39  A 908 (-4.6A)
 0.45A 3ticC-6eksA:
20.9		 3ticC-6eksA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TIC_D_ZMRD1002_1
(NEURAMINIDASE)		 6eks SIALIDASE
(Vibrio
cholerae) 		6 / 12 ARG A 250
ASP A 276
GLU A 645
ARG A 661
ARG A 738
TYR A 766
 G39  A 908 (-2.8A)
G39  A 908 (-3.3A)
G39  A 908 (-4.0A)
G39  A 908 (-2.8A)
G39  A 908 (-3.0A)
G39  A 908 (-4.6A)
 0.45A 3ticD-6eksA:
20.9		 3ticD-6eksA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B7N_A_ZMRA601_1
(NEURAMINIDASE)		 6eks SIALIDASE
(Vibrio
cholerae) 		6 / 12 ARG A 250
ASP A 276
GLU A 645
ARG A 661
ARG A 738
TYR A 766
 G39  A 908 (-2.8A)
G39  A 908 (-3.3A)
G39  A 908 (-4.0A)
G39  A 908 (-2.8A)
G39  A 908 (-3.0A)
G39  A 908 (-4.6A)
 0.46A 4b7nA-6eksA:
12.4		 4b7nA-6eksA:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B7N_A_ZMRA601_1
(NEURAMINIDASE)		 6eks SIALIDASE
(Vibrio
cholerae) 		5 / 12 ARG A 738
GLU A 782
GLU A 269
ARG A 661
TYR A 766
 G39  A 908 (-3.0A)
None
G39  A 908 ( 4.7A)
G39  A 908 (-2.8A)
G39  A 908 (-4.6A)
 1.43A 4b7nA-6eksA:
12.4		 4b7nA-6eksA:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B7Q_A_ZMRA601_1
(NEURAMINIDASE)		 6eks SIALIDASE
(Vibrio
cholerae) 		6 / 12 ARG A 250
ASP A 276
GLU A 645
ARG A 661
ARG A 738
TYR A 766
 G39  A 908 (-2.8A)
G39  A 908 (-3.3A)
G39  A 908 (-4.0A)
G39  A 908 (-2.8A)
G39  A 908 (-3.0A)
G39  A 908 (-4.6A)
 0.57A 4b7qA-6eksA:
21.0		 4b7qA-6eksA:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B7Q_B_ZMRB601_1
(NEURAMINIDASE)		 6eks SIALIDASE
(Vibrio
cholerae) 		6 / 12 ARG A 250
ASP A 276
GLU A 645
ARG A 661
ARG A 738
TYR A 766
 G39  A 908 (-2.8A)
G39  A 908 (-3.3A)
G39  A 908 (-4.0A)
G39  A 908 (-2.8A)
G39  A 908 (-3.0A)
G39  A 908 (-4.6A)
 0.51A 4b7qB-6eksA:
11.6		 4b7qB-6eksA:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B7Q_C_ZMRC601_1
(NEURAMINIDASE)		 6eks SIALIDASE
(Vibrio
cholerae) 		6 / 12 ARG A 250
ASP A 276
GLU A 645
ARG A 661
ARG A 738
TYR A 766
 G39  A 908 (-2.8A)
G39  A 908 (-3.3A)
G39  A 908 (-4.0A)
G39  A 908 (-2.8A)
G39  A 908 (-3.0A)
G39  A 908 (-4.6A)
 0.48A 4b7qC-6eksA:
12.5		 4b7qC-6eksA:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B7Q_D_ZMRD601_1
(NEURAMINIDASE)		 6eks SIALIDASE
(Vibrio
cholerae) 		6 / 12 ARG A 250
ASP A 276
GLU A 645
ARG A 661
ARG A 738
TYR A 766
 G39  A 908 (-2.8A)
G39  A 908 (-3.3A)
G39  A 908 (-4.0A)
G39  A 908 (-2.8A)
G39  A 908 (-3.0A)
G39  A 908 (-4.6A)
 0.50A 4b7qD-6eksA:
20.9		 4b7qD-6eksA:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPN_A_ZMRA700_1
(NEURAMINIDASE)		 6eks SIALIDASE
(Vibrio
cholerae) 		6 / 12 ARG A 250
ASP A 276
GLU A 645
ARG A 661
ARG A 738
TYR A 766
 G39  A 908 (-2.8A)
G39  A 908 (-3.3A)
G39  A 908 (-4.0A)
G39  A 908 (-2.8A)
G39  A 908 (-3.0A)
G39  A 908 (-4.6A)
 0.52A 4cpnA-6eksA:
24.9		 4cpnA-6eksA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPN_B_ZMRB700_1
(NEURAMINIDASE)		 6eks SIALIDASE
(Vibrio
cholerae) 		6 / 12 ARG A 250
ASP A 276
GLU A 645
ARG A 661
ARG A 738
TYR A 766
 G39  A 908 (-2.8A)
G39  A 908 (-3.3A)
G39  A 908 (-4.0A)
G39  A 908 (-2.8A)
G39  A 908 (-3.0A)
G39  A 908 (-4.6A)
 0.49A 4cpnB-6eksA:
25.0		 4cpnB-6eksA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_A_ZMRA1471_1
(NEURAMINIDASE)		 6eks SIALIDASE
(Vibrio
cholerae) 		5 / 12 ARG A 250
GLU A 645
ARG A 661
ARG A 738
TYR A 766
 G39  A 908 (-2.8A)
G39  A 908 (-4.0A)
G39  A 908 (-2.8A)
G39  A 908 (-3.0A)
G39  A 908 (-4.6A)
 0.34A 4cpzA-6eksA:
24.9		 4cpzA-6eksA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_A_ZMRA1471_1
(NEURAMINIDASE)		 6eks SIALIDASE
(Vibrio
cholerae) 		5 / 12 ARG A 250
LEU A 606
GLU A 645
ARG A 738
TYR A 766
 G39  A 908 (-2.8A)
None
G39  A 908 (-4.0A)
G39  A 908 (-3.0A)
G39  A 908 (-4.6A)
 1.22A 4cpzA-6eksA:
24.9		 4cpzA-6eksA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_B_ZMRB1471_1
(NEURAMINIDASE)		 6eks SIALIDASE
(Vibrio
cholerae) 		5 / 12 ARG A 250
GLU A 645
ARG A 661
ARG A 738
TYR A 766
 G39  A 908 (-2.8A)
G39  A 908 (-4.0A)
G39  A 908 (-2.8A)
G39  A 908 (-3.0A)
G39  A 908 (-4.6A)
 0.31A 4cpzB-6eksA:
6.7		 4cpzB-6eksA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_B_ZMRB1471_1
(NEURAMINIDASE)		 6eks SIALIDASE
(Vibrio
cholerae) 		5 / 12 ARG A 250
LEU A 606
GLU A 645
ARG A 738
TYR A 766
 G39  A 908 (-2.8A)
None
G39  A 908 (-4.0A)
G39  A 908 (-3.0A)
G39  A 908 (-4.6A)
 1.25A 4cpzB-6eksA:
6.7		 4cpzB-6eksA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_C_ZMRC1470_1
(NEURAMINIDASE)		 6eks SIALIDASE
(Vibrio
cholerae) 		6 / 12 ARG A 250
ASP A 276
GLU A 645
ARG A 661
ARG A 738
TYR A 766
 G39  A 908 (-2.8A)
G39  A 908 (-3.3A)
G39  A 908 (-4.0A)
G39  A 908 (-2.8A)
G39  A 908 (-3.0A)
G39  A 908 (-4.6A)
 0.49A 4cpzC-6eksA:
13.7		 4cpzC-6eksA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_C_ZMRC1470_1
(NEURAMINIDASE)		 6eks SIALIDASE
(Vibrio
cholerae) 		5 / 12 ARG A 738
GLU A 782
GLU A 269
ARG A 661
TYR A 766
 G39  A 908 (-3.0A)
None
G39  A 908 ( 4.7A)
G39  A 908 (-2.8A)
G39  A 908 (-4.6A)
 1.48A 4cpzC-6eksA:
13.7		 4cpzC-6eksA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_D_ZMRD1471_1
(NEURAMINIDASE)		 6eks SIALIDASE
(Vibrio
cholerae) 		5 / 12 ARG A 250
GLU A 645
ARG A 661
ARG A 738
TYR A 766
 G39  A 908 (-2.8A)
G39  A 908 (-4.0A)
G39  A 908 (-2.8A)
G39  A 908 (-3.0A)
G39  A 908 (-4.6A)
 0.34A 4cpzD-6eksA:
13.8		 4cpzD-6eksA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_D_ZMRD1471_1
(NEURAMINIDASE)		 6eks SIALIDASE
(Vibrio
cholerae) 		5 / 12 ARG A 250
LEU A 606
GLU A 645
ARG A 738
TYR A 766
 G39  A 908 (-2.8A)
None
G39  A 908 (-4.0A)
G39  A 908 (-3.0A)
G39  A 908 (-4.6A)
 1.24A 4cpzD-6eksA:
13.8		 4cpzD-6eksA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_E_ZMRE1471_1
(NEURAMINIDASE)		 6eks SIALIDASE
(Vibrio
cholerae) 		6 / 12 ARG A 250
ASP A 276
GLU A 645
ARG A 661
ARG A 738
TYR A 766
 G39  A 908 (-2.8A)
G39  A 908 (-3.3A)
G39  A 908 (-4.0A)
G39  A 908 (-2.8A)
G39  A 908 (-3.0A)
G39  A 908 (-4.6A)
 0.56A 4cpzE-6eksA:
13.8		 4cpzE-6eksA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_E_ZMRE1471_1
(NEURAMINIDASE)		 6eks SIALIDASE
(Vibrio
cholerae) 		5 / 12 ARG A 250
LEU A 606
GLU A 645
ARG A 738
TYR A 766
 G39  A 908 (-2.8A)
None
G39  A 908 (-4.0A)
G39  A 908 (-3.0A)
G39  A 908 (-4.6A)
 1.24A 4cpzE-6eksA:
13.8		 4cpzE-6eksA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_F_ZMRF1470_1
(NEURAMINIDASE)		 6eks SIALIDASE
(Vibrio
cholerae) 		6 / 12 ARG A 250
ASP A 276
GLU A 645
ARG A 661
ARG A 738
TYR A 766
 G39  A 908 (-2.8A)
G39  A 908 (-3.3A)
G39  A 908 (-4.0A)
G39  A 908 (-2.8A)
G39  A 908 (-3.0A)
G39  A 908 (-4.6A)
 0.55A 4cpzF-6eksA:
25.0		 4cpzF-6eksA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_G_ZMRG1471_1
(NEURAMINIDASE)		 6eks SIALIDASE
(Vibrio
cholerae) 		6 / 12 ARG A 250
ASP A 276
GLU A 645
ARG A 661
ARG A 738
TYR A 766
 G39  A 908 (-2.8A)
G39  A 908 (-3.3A)
G39  A 908 (-4.0A)
G39  A 908 (-2.8A)
G39  A 908 (-3.0A)
G39  A 908 (-4.6A)
 0.46A 4cpzG-6eksA:
13.8		 4cpzG-6eksA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_H_ZMRH1470_1
(NEURAMINIDASE)		 6eks SIALIDASE
(Vibrio
cholerae) 		6 / 12 ARG A 250
ASP A 276
GLU A 645
ARG A 661
ARG A 738
TYR A 766
 G39  A 908 (-2.8A)
G39  A 908 (-3.3A)
G39  A 908 (-4.0A)
G39  A 908 (-2.8A)
G39  A 908 (-3.0A)
G39  A 908 (-4.6A)
 0.56A 4cpzH-6eksA:
24.9		 4cpzH-6eksA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G24_A_ACAA1004_1
(PENTATRICOPEPTIDE
REPEAT-CONTAINING
PROTEIN AT2G32230,
MITOCHONDRIAL)		 6eks SIALIDASE
(Vibrio
cholerae) 		4 / 6 ALA A 568
ASN A 567
LEU A 601
VAL A 600
 None
GOL  A 905 (-3.0A)
None
None
 0.80A 4g24A-6eksA:
undetectable		 4g24A-6eksA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GH8_B_MTXB201_1
(DIHYDROFOLATE
REDUCTASE)		 6eks SIALIDASE
(Vibrio
cholerae) 		5 / 12 ILE A 599
ALA A 646
LEU A 662
ILE A 628
PRO A 629
 None
None
None
GOL  A 906 (-4.5A)
None
 1.27A 4gh8B-6eksA:
undetectable		 4gh8B-6eksA:
11.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I00_A_ZMRA509_1
(NEURAMINIDASE)		 6eks SIALIDASE
(Vibrio
cholerae) 		6 / 12 ARG A 250
ASP A 276
GLU A 645
ARG A 661
ARG A 738
TYR A 766
 G39  A 908 (-2.8A)
G39  A 908 (-3.3A)
G39  A 908 (-4.0A)
G39  A 908 (-2.8A)
G39  A 908 (-3.0A)
G39  A 908 (-4.6A)
 0.45A 4i00A-6eksA:
12.3		 4i00A-6eksA:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KR3_A_GLYA701_0
(GLYCINE--TRNA LIGASE)		 6eks SIALIDASE
(Vibrio
cholerae) 		4 / 6 ARG A 320
GLU A 645
ARG A 676
SER A 644
 None
G39  A 908 (-4.0A)
None
G39  A 908 ( 3.8A)
 1.35A 4kr3A-6eksA:
undetectable		 4kr3A-6eksA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWR_A_ZMRA513_1
(NEURAMINIDASE)		 6eks SIALIDASE
(Vibrio
cholerae) 		5 / 12 ARG A 250
GLU A 645
ARG A 661
ARG A 738
TYR A 766
 G39  A 908 (-2.8A)
G39  A 908 (-4.0A)
G39  A 908 (-2.8A)
G39  A 908 (-3.0A)
G39  A 908 (-4.6A)
 0.35A 4mwrA-6eksA:
20.7		 4mwrA-6eksA:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWV_A_BCZA513_0
(NEURAMINIDASE)		 6eks SIALIDASE
(Vibrio
cholerae) 		5 / 12 ASP A 276
TRP A 337
GLU A 645
ARG A 661
TYR A 766
 G39  A 908 (-3.3A)
None
G39  A 908 (-4.0A)
G39  A 908 (-2.8A)
G39  A 908 (-4.6A)
 0.58A 4mwvA-6eksA:
8.1		 4mwvA-6eksA:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWV_A_BCZA513_1
(NEURAMINIDASE)		 6eks SIALIDASE
(Vibrio
cholerae) 		3 / 3 ARG A 121
GLU A 775
ARG A 792
 None
 0.74A 4mwvA-6eksA:
10.4		 4mwvA-6eksA:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWX_A_ZMRA513_1
(NEURAMINIDASE)		 6eks SIALIDASE
(Vibrio
cholerae) 		5 / 12 ARG A 250
ASP A 276
GLU A 645
ARG A 738
TYR A 766
 G39  A 908 (-2.8A)
G39  A 908 (-3.3A)
G39  A 908 (-4.0A)
G39  A 908 (-3.0A)
G39  A 908 (-4.6A)
 0.47A 4mwxA-6eksA:
5.6		 4mwxA-6eksA:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MX0_A_BCZA513_1
(NEURAMINIDASE)		 6eks SIALIDASE
(Vibrio
cholerae) 		3 / 3 ARG A 250
ASP A 276
ARG A 738
 G39  A 908 (-2.8A)
G39  A 908 (-3.3A)
G39  A 908 (-3.0A)
 0.37A 4mx0A-6eksA:
6.0		 4mx0A-6eksA:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PGH_B_SAMB401_0
(CAFFEIC ACID
O-METHYLTRANSFERASE)		 6eks SIALIDASE
(Vibrio
cholerae) 		5 / 12 GLY A 295
ASP A 293
ASP A 299
ILE A 790
ASP A 242
 None
 1.37A 4pghB-6eksA:
undetectable		 4pghB-6eksA:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QI9_B_MTXB201_1
(DIHYDROFOLATE
REDUCTASE)		 6eks SIALIDASE
(Vibrio
cholerae) 		5 / 12 ALA A 101
ILE A 148
LEU A 146
ARG A 144
TYR A 232
 None
 1.14A 4qi9B-6eksA:
undetectable		 4qi9B-6eksA:
12.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URO_A_NOVA2000_1
(DNA GYRASE SUBUNIT B)		 6eks SIALIDASE
(Vibrio
cholerae) 		5 / 12 GLU A 269
PRO A 574
ASP A 647
ILE A 599
SER A 569
 G39  A 908 ( 4.7A)
CA  A 903 (-4.4A)
CA  A 903 (-2.1A)
None
None
 1.19A 4uroA-6eksA:
undetectable		 4uroA-6eksA:
15.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WA5_A_ZMRA501_1
(NEURAMINIDASE)		 6eks SIALIDASE
(Vibrio
cholerae) 		5 / 12 ARG A 250
ASP A 276
ARG A 661
ARG A 738
TYR A 766
 G39  A 908 (-2.8A)
G39  A 908 (-3.3A)
G39  A 908 (-2.8A)
G39  A 908 (-3.0A)
G39  A 908 (-4.6A)
 0.65A 4wa5A-6eksA:
3.7		 4wa5A-6eksA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WA5_A_ZMRA501_1
(NEURAMINIDASE)		 6eks SIALIDASE
(Vibrio
cholerae) 		5 / 12 ARG A 250
GLU A 645
ARG A 661
ARG A 738
TYR A 766
 G39  A 908 (-2.8A)
G39  A 908 (-4.0A)
G39  A 908 (-2.8A)
G39  A 908 (-3.0A)
G39  A 908 (-4.6A)
 0.34A 4wa5A-6eksA:
3.7		 4wa5A-6eksA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_A_P06A801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 6eks SIALIDASE
(Vibrio
cholerae) 		4 / 7 ILE A 356
GLY A 355
PHE A 535
PHE A 466
 None
 1.08A 5hieA-6eksA:
undetectable		 5hieA-6eksA:
17.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L17_A_ZMRA512_1
(NEURAMINIDASE)		 6eks SIALIDASE
(Vibrio
cholerae) 		6 / 12 ARG A 250
ASP A 276
GLU A 645
ARG A 661
ARG A 738
TYR A 766
 G39  A 908 (-2.8A)
G39  A 908 (-3.3A)
G39  A 908 (-4.0A)
G39  A 908 (-2.8A)
G39  A 908 (-3.0A)
G39  A 908 (-4.6A)
 0.44A 5l17A-6eksA:
20.6		 5l17A-6eksA:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L66_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA
TYPE-8,PROTEASOME
SUBUNIT BETA TYPE-5
PROTEASOME SUBUNIT
BETA
TYPE-6,PROTEASOME
SUBUNIT BETA
TYPE-1,PROTEASOME
SUBUNIT BETA
TYPE-6,PROTEASOME
SUBUNIT BETA
TYPE-1,PROTEASOME
SUBUNIT BETA TYPE-6)		 6eks SIALIDASE
(Vibrio
cholerae) 		5 / 10 ALA A 342
GLY A 355
ALA A 335
ASP A 318
SER A 317
 None
None
None
G39  A 908 ( 4.2A)
G39  A 908 ( 4.6A)
 1.45A 5l66K-6eksA:
undetectable
5l66L-6eksA:
undetectable		 5l66K-6eksA:
14.44
5l66L-6eksA:
14.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L66_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA
TYPE-8,PROTEASOME
SUBUNIT BETA TYPE-5
PROTEASOME SUBUNIT
BETA
TYPE-6,PROTEASOME
SUBUNIT BETA
TYPE-1,PROTEASOME
SUBUNIT BETA
TYPE-6,PROTEASOME
SUBUNIT BETA
TYPE-1,PROTEASOME
SUBUNIT BETA TYPE-6)		 6eks SIALIDASE
(Vibrio
cholerae) 		5 / 10 ALA A 342
GLY A 355
ALA A 335
ASP A 318
SER A 317
 None
None
None
G39  A 908 ( 4.2A)
G39  A 908 ( 4.6A)
 1.44A 5l66Y-6eksA:
undetectable
5l66Z-6eksA:
undetectable		 5l66Y-6eksA:
14.44
5l66Z-6eksA:
14.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF3_B_BO2B305_1
(PROTEASOME SUBUNIT
BETA TYPE-6)		 6eks SIALIDASE
(Vibrio
cholerae) 		5 / 12 ARG A 676
SER A 710
ALA A 646
THR A 659
SER A 253
 None
 1.36A 5lf3b-6eksA:
undetectable		 5lf3b-6eksA:
14.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF3_N_BO2N304_1
(PROTEASOME SUBUNIT
BETA TYPE-6)		 6eks SIALIDASE
(Vibrio
cholerae) 		5 / 12 ARG A 676
SER A 710
ALA A 646
THR A 659
SER A 253
 None
 1.36A 5lf3N-6eksA:
undetectable		 5lf3N-6eksA:
14.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M54_E_TA1E502_1
(TUBULIN BETA-2B
CHAIN)		 6eks SIALIDASE
(Vibrio
cholerae) 		5 / 12 ALA A 709
SER A 767
PHE A 725
ARG A 738
GLY A 705
 None
None
None
G39  A 908 (-3.0A)
None
 1.15A 5m54E-6eksA:
undetectable		 5m54E-6eksA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NR3_A_95EA401_0
(DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 3B)		 6eks SIALIDASE
(Vibrio
cholerae) 		4 / 7 ILE A 711
PHE A 725
TRP A 744
TRP A 753
 None
 1.50A 5nr3A-6eksA:
undetectable		 5nr3A-6eksA:
11.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TZO_A_7V7A201_1
(ENDO-1,4-BETA-XYLANA
SE A)		 6eks SIALIDASE
(Vibrio
cholerae) 		4 / 8 TRP A 553
THR A 554
TYR A 394
GLN A 423
 None
 1.40A 5tzoA-6eksA:
4.7		 5tzoA-6eksA:
15.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TZO_B_7V7B202_1
(ENDO-1,4-BETA-XYLANA
SE A)		 6eks SIALIDASE
(Vibrio
cholerae) 		4 / 8 TRP A 553
THR A 554
TYR A 394
GLN A 423
 None
 1.40A 5tzoB-6eksA:
4.5		 5tzoB-6eksA:
15.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TZO_C_7V7C202_1
(ENDO-1,4-BETA-XYLANA
SE A)		 6eks SIALIDASE
(Vibrio
cholerae) 		4 / 8 TRP A 553
THR A 554
TYR A 394
GLN A 423
 None
 1.37A 5tzoC-6eksA:
undetectable		 5tzoC-6eksA:
15.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_G_CVIG301_1
(REGULATORY PROTEIN
TETR)		 6eks SIALIDASE
(Vibrio
cholerae) 		4 / 7 GLY A 592
TRP A 620
TYR A 358
ASP A 615
 None
 1.29A 5vlmG-6eksA:
undetectable		 5vlmG-6eksA:
13.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AUU_A_ACTA804_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 6eks SIALIDASE
(Vibrio
cholerae) 		3 / 3 GLN A  73
TRP A 103
VAL A  94
 None
 0.89A 6auuA-6eksA:
undetectable		 6auuA-6eksA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DEB_B_MTXB303_1
(BIFUNCTIONAL PROTEIN
FOLD)		 6eks SIALIDASE
(Vibrio
cholerae) 		4 / 5 TYR A 770
GLN A 771
GLY A 592
ILE A 578
 None
 1.41A 6debB-6eksA:
undetectable		 6debB-6eksA:
7.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWD_C_GLYC713_0
(DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1)		 6eks SIALIDASE
(Vibrio
cholerae) 		3 / 3 GLN A 677
TYR A 673
ASN A 695
 None
 0.86A 6dwdC-6eksA:
undetectable		 6dwdC-6eksA:
20.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6EKU_A_ZMRA901_1
(SIALIDASE)		 6eks SIALIDASE
(Vibrio
cholerae) 		12 / 12 ARG A 250
ILE A 251
GLU A 269
ARG A 271
PRO A 277
ASP A 318
ASN A 344
GLU A 645
ARG A 661
ASP A 663
ARG A 738
TYR A 766
 G39  A 908 (-2.8A)
G39  A 908 (-4.7A)
G39  A 908 ( 4.7A)
G39  A 908 (-4.2A)
G39  A 908 ( 4.4A)
G39  A 908 ( 4.2A)
G39  A 908 (-3.5A)
G39  A 908 (-4.0A)
G39  A 908 (-2.8A)
G39  A 908 (-3.8A)
G39  A 908 (-3.0A)
G39  A 908 (-4.6A)
 0.30A 6ekuA-6eksA:
71.0		 6ekuA-6eksA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6EKU_A_ZMRA901_2
(SIALIDASE)		 6eks SIALIDASE
(Vibrio
cholerae) 		6 / 6 ASP A 276
GLN A 343
ASN A 571
LEU A 606
SER A 644
PHE A 664
 G39  A 908 (-3.3A)
G39  A 908 (-3.8A)
G39  A 908 (-4.5A)
None
G39  A 908 ( 3.8A)
None
 0.34A 6ekuA-6eksA:
71.0		 6ekuA-6eksA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HCX_A_ZMRA519_0
(NEURAMINIDASE)		 6eks SIALIDASE
(Vibrio
cholerae) 		5 / 12 ARG A 250
ASP A 276
ARG A 661
ARG A 738
TYR A 766
 G39  A 908 (-2.8A)
G39  A 908 (-3.3A)
G39  A 908 (-2.8A)
G39  A 908 (-3.0A)
G39  A 908 (-4.6A)
 0.42A 6hcxA-6eksA:
20.7		 6hcxA-6eksA:
7.54