SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6ekt'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DYR_A_TOPA407_1
(DIHYDROFOLATE
REDUCTASE)		 6ekt P-47 PROTEIN
(Clostridium
botulinum) 		5 / 11 ALA A 165
ILE A 139
PHE A 131
ILE A  84
ILE A 173
 None
 1.04A 1dyrA-6ektA:
undetectable		 1dyrA-6ektA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RTS_A_D16A309_1
(THYMIDYLATE SYNTHASE)		 6ekt P-47 PROTEIN
(Clostridium
botulinum) 		4 / 8 PHE A 166
ILE A 111
GLY A 132
PHE A 131
 None
 0.78A 1rtsA-6ektA:
undetectable		 1rtsA-6ektA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3A_B_TEPB2434_1
(CHITINASE)		 6ekt P-47 PROTEIN
(Clostridium
botulinum) 		3 / 3 TRP A 188
THR A 410
TYR A  31
 None
 1.24A 2a3aB-6ektA:
undetectable		 2a3aB-6ektA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3B_A_CFFA1434_1
(CHITINASE)		 6ekt P-47 PROTEIN
(Clostridium
botulinum) 		3 / 3 TRP A 188
THR A 410
TYR A  31
 None
 1.29A 2a3bA-6ektA:
undetectable		 2a3bA-6ektA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIK_C_CHDC271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)		 6ekt P-47 PROTEIN
(Clostridium
botulinum) 		4 / 7 LEU A 109
PHE A 166
LEU A 162
PHE A 158
 None
 0.96A 2eikC-6ektA:
undetectable
2eikJ-6ektA:
undetectable		 2eikC-6ektA:
19.06
2eikJ-6ektA:
11.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2LH6_A_NIOA155_1
(LEGHEMOGLOBIN A
(NICOTINATE MET))		 6ekt P-47 PROTEIN
(Clostridium
botulinum) 		4 / 5 PHE A 247
PHE A 430
PHE A 403
VAL A 252
 None
 1.17A 2lh6A-6ektA:
undetectable		 2lh6A-6ektA:
16.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YGQ_A_PCFA1275_0
(WNT INHIBITORY
FACTOR 1)		 6ekt P-47 PROTEIN
(Clostridium
botulinum) 		5 / 12 ILE A 111
ILE A 139
PRO A  87
ILE A  46
PHE A 131
 None
 1.05A 2ygqA-6ektA:
undetectable		 2ygqA-6ektA:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3R_A_9PLA501_1
(CYTOCHROME P450 2A6)		 6ekt P-47 PROTEIN
(Clostridium
botulinum) 		5 / 11 PHE A  68
ASN A 106
ILE A  88
LEU A 109
PHE A 166
 None
 1.16A 3t3rA-6ektA:
undetectable		 3t3rA-6ektA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WG7_C_CHDC305_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 6ekt P-47 PROTEIN
(Clostridium
botulinum) 		4 / 6 LEU A 109
PHE A 166
LEU A 162
PHE A 158
 None
 0.95A 3wg7C-6ektA:
undetectable
3wg7J-6ektA:
undetectable		 3wg7C-6ektA:
19.06
3wg7J-6ektA:
11.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AFG_C_QMRC1214_1
(CAPITELLA TELETA
ACHBP)		 6ekt P-47 PROTEIN
(Clostridium
botulinum) 		4 / 8 TRP A 413
VAL A 238
ILE A 407
ILE A 411
 None
 0.99A 4afgD-6ektA:
undetectable
4afgE-6ektA:
undetectable		 4afgD-6ektA:
22.04
4afgE-6ektA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYK_B_IMNB300_1
(LACTOYLGLUTATHIONE
LYASE)		 6ekt P-47 PROTEIN
(Clostridium
botulinum) 		5 / 12 PHE A 344
PHE A 355
LEU A 399
PHE A 403
GLY A  21
 None
 1.13A 4kykA-6ektA:
undetectable
4kykB-6ektA:
undetectable		 4kykA-6ektA:
18.54
4kykB-6ektA:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LHM_A_AZZA510_1
(THYMIDINE
PHOSPHORYLASE)		 6ekt P-47 PROTEIN
(Clostridium
botulinum) 		5 / 11 LEU A 399
VAL A 424
ILE A 432
PHE A 247
LEU A 240
 None
 1.43A 4lhmA-6ektA:
undetectable		 4lhmA-6ektA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PFJ_A_ADNA502_2
(ADENOSYLHOMOCYSTEINA
SE)		 6ekt P-47 PROTEIN
(Clostridium
botulinum) 		4 / 7 THR A  24
THR A 216
ASN A 250
SER A 213
 None
 1.02A 4pfjA-6ektA:
undetectable		 4pfjA-6ektA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1B_P_CHDP306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 6ekt P-47 PROTEIN
(Clostridium
botulinum) 		4 / 7 LEU A 109
PHE A 166
LEU A 162
PHE A 158
 None
 0.92A 5b1bP-6ektA:
undetectable
5b1bW-6ektA:
undetectable		 5b1bP-6ektA:
19.06
5b1bW-6ektA:
11.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HHJ_A_GLYA404_0
(RETRON-TYPE REVERSE
TRANSCRIPTASE)		 6ekt P-47 PROTEIN
(Clostridium
botulinum) 		4 / 4 TYR A  45
ASN A  49
ILE A  51
GLN A 172
 None
 1.28A 5hhjA-6ektA:
0.0		 5hhjA-6ektA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X19_C_CHDC304_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 6ekt P-47 PROTEIN
(Clostridium
botulinum) 		4 / 5 LEU A 109
PHE A 166
LEU A 162
PHE A 158
 None
 0.96A 5x19C-6ektA:
undetectable
5x19J-6ektA:
undetectable		 5x19C-6ektA:
19.06
5x19J-6ektA:
11.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X5Q_C_D16C402_1
(THYMIDYLATE SYNTHASE)		 6ekt P-47 PROTEIN
(Clostridium
botulinum) 		4 / 7 PHE A 166
ILE A 111
GLY A 132
PHE A 131
 None
 0.72A 5x5qC-6ektA:
undetectable		 5x5qC-6ektA:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X5Q_D_D16D402_1
(THYMIDYLATE SYNTHASE)		 6ekt P-47 PROTEIN
(Clostridium
botulinum) 		4 / 8 PHE A 166
ILE A 111
GLY A 132
PHE A 131
 None
 0.69A 5x5qD-6ektA:
undetectable		 5x5qD-6ektA:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X5Q_F_D16F402_1
(THYMIDYLATE SYNTHASE)		 6ekt P-47 PROTEIN
(Clostridium
botulinum) 		4 / 8 PHE A 166
ILE A 111
GLY A 132
PHE A 131
 None
 0.71A 5x5qF-6ektA:
undetectable		 5x5qF-6ektA:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCQ_C_CHDC306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 6ekt P-47 PROTEIN
(Clostridium
botulinum) 		4 / 7 LEU A 109
PHE A 166
LEU A 162
PHE A 158
 None
 0.97A 5zcqC-6ektA:
undetectable
5zcqJ-6ektA:
undetectable		 5zcqC-6ektA:
19.06
5zcqJ-6ektA:
11.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6R2E_A_FFOA403_0
(THYMIDYLATE SYNTHASE)		 6ekt P-47 PROTEIN
(Clostridium
botulinum) 		5 / 12 LEU A 320
GLY A 396
PHE A 397
ASN A 342
MET A 260
 None
 1.25A 6r2eA-6ektA:
undetectable		 6r2eA-6ektA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6R2E_G_FFOG403_0
(THYMIDYLATE SYNTHASE)		 6ekt P-47 PROTEIN
(Clostridium
botulinum) 		5 / 11 LEU A 320
GLY A 396
PHE A 397
ASN A 342
MET A 260
 None
 1.29A 6r2eG-6ektA:
undetectable		 6r2eG-6ektA:
21.30