SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6ekv'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7C_A_HLTA4007_1
(SERUM ALBUMIN)		 6ekv TOXIN COMPLEX
COMPONENT ORF-X2
(Clostridium
botulinum) 		4 / 8 LEU A 736
ASN A 485
ASP A 169
LEU A 170
 None
 0.96A 1e7cA-6ekvA:
2.9		 1e7cA-6ekvA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERR_B_RALB600_2
(ESTROGEN RECEPTOR)		 6ekv TOXIN COMPLEX
COMPONENT ORF-X2
(Clostridium
botulinum) 		4 / 6 LEU A 125
ASP A 122
MET A 142
LEU A  48
 None
 1.06A 1errB-6ekvA:
undetectable		 1errB-6ekvA:
15.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HVY_A_D16A414_1
(THYMIDYLATE SYNTHASE)		 6ekv TOXIN COMPLEX
COMPONENT ORF-X2
(Clostridium
botulinum) 		5 / 12 PHE A 146
ILE A 153
ASN A 158
PHE A 118
TYR A  10
 None
 1.24A 1hvyA-6ekvA:
undetectable		 1hvyA-6ekvA:
16.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HVY_C_D16C416_1
(THYMIDYLATE SYNTHASE)		 6ekv TOXIN COMPLEX
COMPONENT ORF-X2
(Clostridium
botulinum) 		5 / 11 PHE A 146
ILE A 153
ASN A 158
PHE A 118
TYR A  10
 None
 1.26A 1hvyC-6ekvA:
undetectable		 1hvyC-6ekvA:
16.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JU6_A_LYAA317_1
(THYMIDYLATE SYNTHASE)		 6ekv TOXIN COMPLEX
COMPONENT ORF-X2
(Clostridium
botulinum) 		5 / 11 PHE A 146
ILE A 153
ASN A 158
PHE A 118
TYR A  10
 None
 1.26A 1ju6A-6ekvA:
undetectable		 1ju6A-6ekvA:
16.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SG9_A_SAMA301_1
(HEMK PROTEIN)		 6ekv TOXIN COMPLEX
COMPONENT ORF-X2
(Clostridium
botulinum) 		4 / 4 THR A 177
GLY A 713
ASP A 274
ALA A 348
 None
 1.07A 1sg9A-6ekvA:
undetectable		 1sg9A-6ekvA:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B60_B_RITB100_2
(GAG-POL POLYPROTEIN)		 6ekv TOXIN COMPLEX
COMPONENT ORF-X2
(Clostridium
botulinum) 		5 / 11 ALA A 675
ILE A 524
GLY A 668
ILE A 690
ILE A 701
 None
 0.93A 2b60B-6ekvA:
undetectable		 2b60B-6ekvA:
8.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GVC_B_MMZB501_1
(MONOOXYGENASE)		 6ekv TOXIN COMPLEX
COMPONENT ORF-X2
(Clostridium
botulinum) 		3 / 3 ASN A  45
TYR A  76
SER A  85
 None
 0.90A 2gvcB-6ekvA:
undetectable		 2gvcB-6ekvA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GVC_E_MMZE501_1
(MONOOXYGENASE)		 6ekv TOXIN COMPLEX
COMPONENT ORF-X2
(Clostridium
botulinum) 		3 / 3 ASN A  45
TYR A  76
SER A  85
 None
 0.85A 2gvcE-6ekvA:
undetectable		 2gvcE-6ekvA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HW2_A_RFPA1200_1
(RIFAMPIN ADP-RIBOSYL
TRANSFERASE)		 6ekv TOXIN COMPLEX
COMPONENT ORF-X2
(Clostridium
botulinum) 		5 / 12 PHE A   7
GLY A  63
GLY A 174
LEU A 173
LEU A 172
 None
 1.05A 2hw2A-6ekvA:
undetectable		 2hw2A-6ekvA:
12.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JFA_A_RALA600_2
(ESTROGEN RECEPTOR)		 6ekv TOXIN COMPLEX
COMPONENT ORF-X2
(Clostridium
botulinum) 		4 / 5 LEU A 125
ASP A 122
MET A 142
LEU A  48
 None
 0.98A 2jfaA-6ekvA:
undetectable		 2jfaA-6ekvA:
14.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OKC_B_SAMB500_0
(TYPE I RESTRICTION
ENZYME STYSJI M
PROTEIN)		 6ekv TOXIN COMPLEX
COMPONENT ORF-X2
(Clostridium
botulinum) 		5 / 12 ILE A 690
ALA A 675
GLY A 668
SER A 706
ASN A 688
 None
 1.14A 2okcB-6ekvA:
2.4		 2okcB-6ekvA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DL9_B_V2HB602_0
(CYTOCHROME P450 2R1)		 6ekv TOXIN COMPLEX
COMPONENT ORF-X2
(Clostridium
botulinum) 		5 / 12 MET A 186
THR A 185
ALA A 340
THR A 177
ILE A 712
 None
 1.17A 3dl9B-6ekvA:
undetectable		 3dl9B-6ekvA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EBZ_B_017B201_1
(PROTEASE)		 6ekv TOXIN COMPLEX
COMPONENT ORF-X2
(Clostridium
botulinum) 		5 / 11 ALA A 675
ILE A 524
GLY A 668
ILE A 690
ILE A 701
 None
 0.95A 3ebzA-6ekvA:
undetectable		 3ebzA-6ekvA:
9.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LD6_A_KKKA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 6ekv TOXIN COMPLEX
COMPONENT ORF-X2
(Clostridium
botulinum) 		5 / 12 PHE A 508
GLY A 565
ALA A 660
ILE A 666
ILE A 487
 None
 1.29A 3ld6A-6ekvA:
undetectable		 3ld6A-6ekvA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDW_A_RITA100_2
(PROTEASE)		 6ekv TOXIN COMPLEX
COMPONENT ORF-X2
(Clostridium
botulinum) 		5 / 9 ALA A 627
ASP A 630
ILE A 634
ILE A 666
ILE A 690
 None
 1.11A 3ndwB-6ekvA:
undetectable		 3ndwB-6ekvA:
9.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NU4_B_478B401_1
(PROTEASE)		 6ekv TOXIN COMPLEX
COMPONENT ORF-X2
(Clostridium
botulinum) 		5 / 9 ALA A 675
ILE A 524
GLY A 668
ILE A 690
ILE A 701
 None
 0.84A 3nu4A-6ekvA:
undetectable		 3nu4A-6ekvA:
9.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RR3_C_FLRC700_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 6ekv TOXIN COMPLEX
COMPONENT ORF-X2
(Clostridium
botulinum) 		5 / 12 VAL A 602
TRP A 496
VAL A 555
GLY A 557
SER A 561
 None
None
None
SO4  A 803 ( 4.9A)
SO4  A 803 (-3.0A)
 1.11A 3rr3C-6ekvA:
0.3		 3rr3C-6ekvA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RR3_D_FLRD700_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 6ekv TOXIN COMPLEX
COMPONENT ORF-X2
(Clostridium
botulinum) 		5 / 12 VAL A 602
TRP A 496
VAL A 555
GLY A 557
SER A 561
 None
None
None
SO4  A 803 ( 4.9A)
SO4  A 803 (-3.0A)
 1.11A 3rr3D-6ekvA:
undetectable		 3rr3D-6ekvA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S43_A_478A401_1
(PROTEASE)		 6ekv TOXIN COMPLEX
COMPONENT ORF-X2
(Clostridium
botulinum) 		5 / 9 ALA A 675
ILE A 524
GLY A 668
ILE A 690
ILE A 701
 None
 0.90A 3s43A-6ekvA:
undetectable		 3s43A-6ekvA:
9.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S45_B_478B201_1
(PROTEASE)		 6ekv TOXIN COMPLEX
COMPONENT ORF-X2
(Clostridium
botulinum) 		5 / 9 ALA A 675
ILE A 524
GLY A 668
ILE A 690
ILE A 701
 None
 0.95A 3s45A-6ekvA:
undetectable		 3s45A-6ekvA:
9.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A83_A_DXCA1160_0
(MAJOR POLLEN
ALLERGEN BET V 1-A)		 6ekv TOXIN COMPLEX
COMPONENT ORF-X2
(Clostridium
botulinum) 		5 / 12 PHE A 414
PRO A 358
LEU A 344
ILE A 342
TYR A 265
 None
 1.43A 4a83A-6ekvA:
1.4		 4a83A-6ekvA:
12.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7U_D_YTZD802_1
(SEPIAPTERIN
REDUCTASE)		 6ekv TOXIN COMPLEX
COMPONENT ORF-X2
(Clostridium
botulinum) 		4 / 8 LEU A  97
PHE A 118
TYR A 119
PRO A  66
 None
 1.19A 4j7uD-6ekvA:
undetectable		 4j7uD-6ekvA:
15.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LUH_A_ACTA610_0
(SERUM ALBUMIN)		 6ekv TOXIN COMPLEX
COMPONENT ORF-X2
(Clostridium
botulinum) 		3 / 3 VAL A 181
SER A 182
THR A 185
 None
 0.44A 4luhA-6ekvA:
2.9		 4luhA-6ekvA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M51_A_BEZA501_0
(AMIDOHYDROLASE
FAMILY PROTEIN)		 6ekv TOXIN COMPLEX
COMPONENT ORF-X2
(Clostridium
botulinum) 		4 / 6 ILE A 659
ILE A 666
PHE A 458
LEU A 478
 None
 0.99A 4m51A-6ekvA:
undetectable		 4m51A-6ekvA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q1Y_A_017A106_2
(ASPARTYL PROTEASE)		 6ekv TOXIN COMPLEX
COMPONENT ORF-X2
(Clostridium
botulinum) 		5 / 12 ALA A 675
ILE A 524
GLY A 668
ILE A 690
ILE A 701
 None
 0.94A 4q1yB-6ekvA:
undetectable		 4q1yB-6ekvA:
9.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UW0_A_SAMA1506_0
(WBDD)		 6ekv TOXIN COMPLEX
COMPONENT ORF-X2
(Clostridium
botulinum) 		5 / 12 TYR A 363
PHE A 335
ILE A 332
VAL A 261
ILE A 259
 None
 1.12A 4uw0A-6ekvA:
undetectable		 4uw0A-6ekvA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DWK_C_ACTC207_0
(DIACYLGLYCEROL
KINASE)		 6ekv TOXIN COMPLEX
COMPONENT ORF-X2
(Clostridium
botulinum) 		4 / 5 GLU A 278
ALA A 348
GLU A 346
ASN A 279
 None
 1.03A 5dwkC-6ekvA:
undetectable		 5dwkC-6ekvA:
11.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W7P_A_SAMA501_0
(OXAC)		 6ekv TOXIN COMPLEX
COMPONENT ORF-X2
(Clostridium
botulinum) 		5 / 12 ALA A 578
GLY A 579
SER A 576
PHE A 560
LEU A 564
 None
 1.21A 5w7pA-6ekvA:
undetectable		 5w7pA-6ekvA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YW0_A_ACTA412_0
(UNCHARACTERIZED
PROTEIN KDOO)		 6ekv TOXIN COMPLEX
COMPONENT ORF-X2
(Clostridium
botulinum) 		3 / 3 LYS A 287
ASN A 285
SER A 268
 None
 1.25A 5yw0A-6ekvA:
undetectable		 5yw0A-6ekvA:
17.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NJ9_K_SAMK500_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-79
SPECIFIC)		 6ekv TOXIN COMPLEX
COMPONENT ORF-X2
(Clostridium
botulinum) 		3 / 3 THR A  47
GLU A 315
ASN A  45
 None
 0.86A 6nj9K-6ekvA:
undetectable		 6nj9K-6ekvA:
19.82