SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6elc'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_C_DCFC1353_2
(ADENOSINE DEAMINASE)		 6elc VARIANT SURFACE
GLYCOPROTEIN
(Trypanosoma
brucei) 		4 / 5 LEU A  63
LEU A 146
LEU A 384
GLY A 377
 None
 0.96A 1a4lC-6elcA:
undetectable		 1a4lC-6elcA:
13.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2D55_C_DVAC8_0
(ACTINOMYCIN D)		 6elc VARIANT SURFACE
GLYCOPROTEIN
(Trypanosoma
brucei) 		3 / 3 PRO A 172
THR A  48
PRO A  50
 None
 0.75A 2d55C-6elcA:
undetectable		 2d55C-6elcA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_A_ASDA1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 6elc VARIANT SURFACE
GLYCOPROTEIN
(Trypanosoma
brucei) 		4 / 7 TYR A 194
PHE A 266
ALA A  40
LEU A  36
 None
 1.00A 2vcvA-6elcA:
undetectable		 2vcvA-6elcA:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DFR_A_MTXA164_1
(DIHYDROFOLATE
REDUCTASE)		 6elc VARIANT SURFACE
GLYCOPROTEIN
(Trypanosoma
brucei) 		5 / 12 LEU A 290
ALA A 350
LEU A 281
LEU A 179
ALA A 289
 None
 1.05A 3dfrA-6elcA:
undetectable		 3dfrA-6elcA:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP2_B_PNNB5002_0
(TRANSCRIPTIONAL
REGULATOR TCAR)		 6elc VARIANT SURFACE
GLYCOPROTEIN
(Trypanosoma
brucei) 		4 / 5 ASN A 120
ALA A 123
ALA A 124
ARG A 128
 None
 1.36A 3kp2B-6elcA:
undetectable		 3kp2B-6elcA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BBO_C_ACTC1113_0
(BLR5658 PROTEIN)		 6elc VARIANT SURFACE
GLYCOPROTEIN
(Trypanosoma
brucei) 		4 / 4 ASN A 236
ALA A 257
GLY A 256
THR A 261
 None
 1.25A 4bboC-6elcA:
undetectable		 4bboC-6elcA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N09_A_ADNA401_2
(ADENOSINE KINASE)		 6elc VARIANT SURFACE
GLYCOPROTEIN
(Trypanosoma
brucei) 		4 / 4 LEU A 131
SER A 379
LEU A 146
LEU A 138
 None
 1.05A 4n09A-6elcA:
undetectable		 4n09A-6elcA:
11.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_E_CHDE104_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 6elc VARIANT SURFACE
GLYCOPROTEIN
(Trypanosoma
brucei) 		5 / 11 ALA A 289
LEU A 286
LEU A 281
LEU A  45
LEU A 179
 None
 0.98A 4wg0C-6elcA:
undetectable
4wg0D-6elcA:
undetectable
4wg0E-6elcA:
undetectable		 4wg0C-6elcA:
undetectable
4wg0D-6elcA:
undetectable
4wg0E-6elcA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_G_CHDG103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 6elc VARIANT SURFACE
GLYCOPROTEIN
(Trypanosoma
brucei) 		5 / 11 ALA A 289
LEU A 286
LEU A 281
LEU A  45
LEU A 179
 None
 0.98A 4wg0E-6elcA:
undetectable
4wg0F-6elcA:
undetectable
4wg0G-6elcA:
undetectable		 4wg0E-6elcA:
undetectable
4wg0F-6elcA:
undetectable
4wg0G-6elcA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I1N_G_DVAG9_0
(D-VILLIN HEADPIECE
SUBDOMAIN
VILLIN-1)		 6elc VARIANT SURFACE
GLYCOPROTEIN
(Trypanosoma
brucei) 		3 / 3 ALA A  59
ASN A  62
LEU A  63
 None
 0.34A 5i1nB-6elcA:
undetectable		 5i1nB-6elcA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L66_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA
TYPE-8,PROTEASOME
SUBUNIT BETA TYPE-5
PROTEASOME SUBUNIT
BETA
TYPE-6,PROTEASOME
SUBUNIT BETA
TYPE-1,PROTEASOME
SUBUNIT BETA
TYPE-6,PROTEASOME
SUBUNIT BETA
TYPE-1,PROTEASOME
SUBUNIT BETA TYPE-6)		 6elc VARIANT SURFACE
GLYCOPROTEIN
(Trypanosoma
brucei) 		5 / 10 THR A 208
SER A 211
GLY A 256
ALA A 262
SER A 196
 None
 1.37A 5l66Y-6elcA:
undetectable
5l66Z-6elcA:
undetectable		 5l66Y-6elcA:
17.39
5l66Z-6elcA:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BKL_G_EU7G101_0
(MATRIX PROTEIN 2)		 6elc VARIANT SURFACE
GLYCOPROTEIN
(Trypanosoma
brucei) 		5 / 9 ALA A 311
GLY A 313
ALA A 318
SER A 317
GLY A 316
 None
None
GLC  A 605 (-4.2A)
GLC  A 605 (-1.4A)
None
 1.17A 6bklE-6elcA:
undetectable
6bklF-6elcA:
undetectable
6bklG-6elcA:
undetectable
6bklH-6elcA:
undetectable		 6bklE-6elcA:
undetectable
6bklF-6elcA:
undetectable
6bklG-6elcA:
undetectable
6bklH-6elcA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F88_B_STRB502_1
(CYTOCHROME P450
CYP260A1)		 6elc VARIANT SURFACE
GLYCOPROTEIN
(Trypanosoma
brucei) 		4 / 6 LEU A 116
ALA A 112
LEU A 126
ASN A 378
 None
 0.97A 6f88B-6elcA:
undetectable		 6f88B-6elcA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MDQ_A_TESA604_0
(SERUM ALBUMIN)		 6elc VARIANT SURFACE
GLYCOPROTEIN
(Trypanosoma
brucei) 		4 / 8 ARG A 143
ALA A 142
LEU A 138
ALA A 134
 NAG  A 601 (-4.5A)
None
None
None
 0.66A 6mdqA-6elcA:
1.9		 6mdqA-6elcA:
17.89