SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6elq'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTI_F_CCSF47_0
(GLUTATHIONE
S-TRANSFERASE)		 6elq CARBON MONOXIDE
DEHYDROGENASE
(Carboxydothermus
hydrogenoformans) 		4 / 5 THR X 227
LEU X 225
GLY X 222
TYR X 162
 None
 1.17A 1gtiF-6elqX:
undetectable		 1gtiF-6elqX:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J96_B_TESB904_1
(3ALPHA-HYDROXYSTEROI
D DEHYDROGENASE TYPE
3)		 6elq CARBON MONOXIDE
DEHYDROGENASE
(Carboxydothermus
hydrogenoformans) 		4 / 7 VAL X  11
ILE X  12
HIS X 259
LEU X 338
 None
 0.96A 1j96B-6elqX:
undetectable		 1j96B-6elqX:
14.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQT_A_ACTA1866_0
(FPRA)		 6elq CARBON MONOXIDE
DEHYDROGENASE
(Carboxydothermus
hydrogenoformans) 		4 / 4 ARG X 213
LEU X 209
ASN X 206
VAL X 180
 None
 1.31A 1lqtA-6elqX:
2.9		 1lqtA-6elqX:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQT_B_ACTB1875_0
(FPRA)		 6elq CARBON MONOXIDE
DEHYDROGENASE
(Carboxydothermus
hydrogenoformans) 		4 / 4 ARG X 213
LEU X 209
ASN X 206
VAL X 180
 None
 1.32A 1lqtB-6elqX:
5.6		 1lqtB-6elqX:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQU_A_ACTA1423_0
(FPRA)		 6elq CARBON MONOXIDE
DEHYDROGENASE
(Carboxydothermus
hydrogenoformans) 		4 / 4 ARG X 213
LEU X 209
ASN X 206
VAL X 180
 None
 1.32A 1lquA-6elqX:
3.4		 1lquA-6elqX:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQU_B_ACTB1432_0
(FPRA)		 6elq CARBON MONOXIDE
DEHYDROGENASE
(Carboxydothermus
hydrogenoformans) 		4 / 4 ARG X 213
LEU X 209
ASN X 206
VAL X 180
 None
 1.32A 1lquB-6elqX:
3.2		 1lquB-6elqX:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NOD_A_H4BA902_1
(NITRIC OXIDE
SYNTHASE)		 6elq CARBON MONOXIDE
DEHYDROGENASE
(Carboxydothermus
hydrogenoformans) 		4 / 5 TRP X 569
MET X 573
ILE X 603
TRP X 175
 None
 1.43A 1nodA-6elqX:
0.0		 1nodA-6elqX:
11.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RU9_H_ACTH611_0
(IMMUNOGLOBULIN
IGG2A, HEAVY CHAIN
IMMUNOGLOBULIN
IGG2A, LIGHT CHAIN)		 6elq CARBON MONOXIDE
DEHYDROGENASE
(Carboxydothermus
hydrogenoformans) 		4 / 6 LEU X 172
TRP X 175
LEU X 216
PHE X 220
 None
 1.45A 1ru9H-6elqX:
undetectable
1ru9L-6elqX:
undetectable		 1ru9H-6elqX:
undetectable
1ru9L-6elqX:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TYR_A_9CRA131_1
(TRANSTHYRETIN)		 6elq CARBON MONOXIDE
DEHYDROGENASE
(Carboxydothermus
hydrogenoformans) 		4 / 6 ALA X  87
LEU X 564
SER X 565
THR X  86
 None
 1.34A 1tyrA-6elqX:
undetectable		 1tyrA-6elqX:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXG_A_IBPA2002_1
(SERUM ALBUMIN)		 6elq CARBON MONOXIDE
DEHYDROGENASE
(Carboxydothermus
hydrogenoformans) 		4 / 8 ALA X 442
ALA X 570
LEU X 534
VAL X 535
 None
 0.75A 2bxgA-6elqX:
undetectable		 2bxgA-6elqX:
8.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GJ5_A_VD3A163_1
(BETA-LACTOGLOBULIN)		 6elq CARBON MONOXIDE
DEHYDROGENASE
(Carboxydothermus
hydrogenoformans) 		5 / 12 VAL X  99
ILE X 233
LEU X 229
ILE X 232
ILE X 115
 None
 1.23A 2gj5A-6elqX:
undetectable		 2gj5A-6elqX:
16.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NOD_A_H4BA902_1
(NITRIC OXIDE
SYNTHASE)		 6elq CARBON MONOXIDE
DEHYDROGENASE
(Carboxydothermus
hydrogenoformans) 		4 / 5 TRP X 569
MET X 573
ILE X 603
TRP X 175
 None
 1.44A 2nodA-6elqX:
0.0		 2nodA-6elqX:
11.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD3_A_CHDA502_0
(FERROCHELATASE)		 6elq CARBON MONOXIDE
DEHYDROGENASE
(Carboxydothermus
hydrogenoformans) 		4 / 8 MET X 302
PRO X 263
SER X 266
VAL X 526
 None
 1.13A 2qd3A-6elqX:
3.6		 2qd3A-6elqX:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLC_A_GLYA333_0
(CHOLOYLGLYCINE
HYDROLASE)		 6elq CARBON MONOXIDE
DEHYDROGENASE
(Carboxydothermus
hydrogenoformans) 		3 / 3 ASN X 289
ASN X 255
ARG X 389
 None
 0.92A 2rlcA-6elqX:
undetectable		 2rlcA-6elqX:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VJ1_A_BEZA1303_0
(SARS CORONAVIRUS
MAIN PROTEINASE)		 6elq CARBON MONOXIDE
DEHYDROGENASE
(Carboxydothermus
hydrogenoformans) 		3 / 3 HIS X 521
MET X 487
MET X 302
 None
 1.23A 2vj1A-6elqX:
undetectable		 2vj1A-6elqX:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN5_A_FUNA1356_2
(THYROXINE-BINDING
GLOBULIN)		 6elq CARBON MONOXIDE
DEHYDROGENASE
(Carboxydothermus
hydrogenoformans) 		3 / 3 LEU X   6
ARG X  20
ILE X  12
 None
 0.60A 2xn5B-6elqX:
undetectable		 2xn5B-6elqX:
16.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YLG_A_ASCA130_0
(CYTOCHROME C')		 6elq CARBON MONOXIDE
DEHYDROGENASE
(Carboxydothermus
hydrogenoformans) 		4 / 5 ALA X 563
GLY X 475
CYH X 525
HIS X  92
 None
BF8  X 702 ( 4.1A)
BF8  X 702 (-2.0A)
None
 1.43A 2ylgA-6elqX:
undetectable		 2ylgA-6elqX:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DDY_A_RBFA187_1
(LUMAZINE PROTEIN)		 6elq CARBON MONOXIDE
DEHYDROGENASE
(Carboxydothermus
hydrogenoformans) 		5 / 12 VAL X  27
THR X  26
ILE X 319
ALA X 318
ASN X 311
 None
 0.98A 3ddyA-6elqX:
undetectable		 3ddyA-6elqX:
16.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EJ8_A_H4BA1902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 6elq CARBON MONOXIDE
DEHYDROGENASE
(Carboxydothermus
hydrogenoformans) 		4 / 7 MET X 573
ILE X 603
TRP X 175
TRP X 569
 None
 1.49A 3ej8A-6elqX:
undetectable
3ej8B-6elqX:
undetectable		 3ej8A-6elqX:
12.87
3ej8B-6elqX:
12.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EJ8_B_H4BB2902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 6elq CARBON MONOXIDE
DEHYDROGENASE
(Carboxydothermus
hydrogenoformans) 		4 / 7 TRP X 569
MET X 573
ILE X 603
TRP X 175
 None
 1.36A 3ej8A-6elqX:
undetectable
3ej8B-6elqX:
undetectable		 3ej8A-6elqX:
12.87
3ej8B-6elqX:
12.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EJ8_D_H4BD4902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 6elq CARBON MONOXIDE
DEHYDROGENASE
(Carboxydothermus
hydrogenoformans) 		4 / 7 TRP X 569
MET X 573
ILE X 603
TRP X 175
 None
 1.48A 3ej8C-6elqX:
undetectable
3ej8D-6elqX:
undetectable		 3ej8C-6elqX:
12.87
3ej8D-6elqX:
12.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FPJ_B_SAMB301_1
(PUTATIVE
UNCHARACTERIZED
PROTEIN)		 6elq CARBON MONOXIDE
DEHYDROGENASE
(Carboxydothermus
hydrogenoformans) 		4 / 7 GLY X 475
GLY X 445
GLU X 299
ALA X 478
 BF8  X 702 ( 4.1A)
BF8  X 702 (-4.2A)
None
None
 0.85A 3fpjB-6elqX:
3.9		 3fpjB-6elqX:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N61_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE)		 6elq CARBON MONOXIDE
DEHYDROGENASE
(Carboxydothermus
hydrogenoformans) 		4 / 7 GLU X 267
SER X 266
VAL X 270
VAL X 258
 None
 1.21A 3n61A-6elqX:
0.8
3n61B-6elqX:
0.9		 3n61A-6elqX:
11.06
3n61B-6elqX:
11.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NBQ_A_URFA400_1
(URIDINE
PHOSPHORYLASE 1)		 6elq CARBON MONOXIDE
DEHYDROGENASE
(Carboxydothermus
hydrogenoformans) 		5 / 9 THR X 174
GLY X 179
GLU X 176
LEU X 209
ILE X 212
 None
 1.45A 3nbqA-6elqX:
undetectable		 3nbqA-6elqX:
15.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NK7_B_SAMB770_0
(23S RRNA
METHYLTRANSFERASE)		 6elq CARBON MONOXIDE
DEHYDROGENASE
(Carboxydothermus
hydrogenoformans) 		5 / 12 LEU X 602
GLY X 604
GLY X 574
ILE X 208
LEU X 595
 None
 0.99A 3nk7B-6elqX:
4.7		 3nk7B-6elqX:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLR_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 6elq CARBON MONOXIDE
DEHYDROGENASE
(Carboxydothermus
hydrogenoformans) 		4 / 8 GLU X 267
SER X 266
VAL X 270
VAL X 258
 None
 1.16A 3nlrA-6elqX:
undetectable
3nlrB-6elqX:
1.2		 3nlrA-6elqX:
11.06
3nlrB-6elqX:
11.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NOD_A_H4BA902_1
(NITRIC OXIDE
SYNTHASE)		 6elq CARBON MONOXIDE
DEHYDROGENASE
(Carboxydothermus
hydrogenoformans) 		4 / 5 TRP X 569
MET X 573
ILE X 603
TRP X 175
 None
 1.40A 3nodA-6elqX:
0.0		 3nodA-6elqX:
11.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUE_C_SUEC1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 6elq CARBON MONOXIDE
DEHYDROGENASE
(Carboxydothermus
hydrogenoformans) 		5 / 12 HIS X 578
GLY X 580
VAL X 444
ALA X 617
ALA X 618
 None
 1.09A 3sueC-6elqX:
undetectable		 3sueC-6elqX:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UCJ_B_AZMB229_2
(CARBONIC ANHYDRASE)		 6elq CARBON MONOXIDE
DEHYDROGENASE
(Carboxydothermus
hydrogenoformans) 		5 / 10 VAL X  75
CYH X  69
GLY X  70
ALA X  71
ALA X  66
 None
SF4  X 701 (-2.2A)
None
SF4  X 701 ( 4.2A)
None
 1.17A 3ucjB-6elqX:
undetectable		 3ucjB-6elqX:
16.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UY4_A_PAUA302_0
(PANTOTHENATE
SYNTHETASE)		 6elq CARBON MONOXIDE
DEHYDROGENASE
(Carboxydothermus
hydrogenoformans) 		4 / 8 HIS X  95
VAL X  99
VAL X 102
GLN X 230
 None
 1.13A 3uy4A-6elqX:
2.3		 3uy4A-6elqX:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJW_A_SRYA2001_2
(TRANSCRIPTIONAL
REGULATOR TCAR)		 6elq CARBON MONOXIDE
DEHYDROGENASE
(Carboxydothermus
hydrogenoformans) 		4 / 6 GLU X 340
ILE X 341
HIS X 259
VAL X 356
 None
 1.11A 4ejwB-6elqX:
undetectable		 4ejwB-6elqX:
17.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F5Z_A_BEZA302_0
(HALOALKANE
DEHALOGENASE)		 6elq CARBON MONOXIDE
DEHYDROGENASE
(Carboxydothermus
hydrogenoformans) 		4 / 8 ASN X 255
ASP X 325
VAL X 394
HIS X 346
 None
 0.92A 4f5zA-6elqX:
undetectable		 4f5zA-6elqX:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IB4_A_ERMA2001_2
(CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 2B AND E.
COLI SOLUBLE
CYTOCHROME B562)		 6elq CARBON MONOXIDE
DEHYDROGENASE
(Carboxydothermus
hydrogenoformans) 		4 / 7 ASP X 454
LEU X 481
ASN X 298
LEU X 308
 None
 1.08A 4ib4A-6elqX:
2.3		 4ib4A-6elqX:
10.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KMM_A_CHDA503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 6elq CARBON MONOXIDE
DEHYDROGENASE
(Carboxydothermus
hydrogenoformans) 		4 / 7 MET X 302
PRO X 263
SER X 266
VAL X 526
 None
 1.28A 4kmmA-6elqX:
undetectable		 4kmmA-6elqX:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O1E_A_C2FA3000_0
(DIHYDROPTEROATE
SYNTHASE DHPS)		 6elq CARBON MONOXIDE
DEHYDROGENASE
(Carboxydothermus
hydrogenoformans) 		5 / 12 ILE X 334
ILE X 566
LEU X 223
ASP X 218
GLY X  88
 None
 1.16A 4o1eA-6elqX:
undetectable		 4o1eA-6elqX:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW1_H_BO2H301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 6elq CARBON MONOXIDE
DEHYDROGENASE
(Carboxydothermus
hydrogenoformans) 		5 / 12 THR X  77
CYH X  47
ALA X  73
ALA X  71
CYH X  69
 None
SF4  X 701 (-2.3A)
None
SF4  X 701 ( 4.2A)
SF4  X 701 (-2.2A)
 1.06A 4qw1H-6elqX:
undetectable
4qw1I-6elqX:
undetectable		 4qw1H-6elqX:
15.95
4qw1I-6elqX:
16.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW1_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 6elq CARBON MONOXIDE
DEHYDROGENASE
(Carboxydothermus
hydrogenoformans) 		5 / 12 THR X  77
CYH X  47
ALA X  73
ALA X  71
CYH X  69
 None
SF4  X 701 (-2.3A)
None
SF4  X 701 ( 4.2A)
SF4  X 701 (-2.2A)
 1.06A 4qw1V-6elqX:
undetectable
4qw1W-6elqX:
undetectable		 4qw1V-6elqX:
15.95
4qw1W-6elqX:
16.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RFQ_A_SAMA401_1
(HISTIDINE PROTEIN
METHYLTRANSFERASE 1
HOMOLOG)		 6elq CARBON MONOXIDE
DEHYDROGENASE
(Carboxydothermus
hydrogenoformans) 		4 / 4 THR X 227
GLY X 219
ASP X 218
SER X 529
 None
 1.24A 4rfqA-6elqX:
undetectable		 4rfqA-6elqX:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_L_CHDL103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 6elq CARBON MONOXIDE
DEHYDROGENASE
(Carboxydothermus
hydrogenoformans) 		4 / 7 LEU X 499
ARG X 500
LEU X 503
LEU X 470
 None
 0.79A 4wg0L-6elqX:
undetectable
4wg0M-6elqX:
undetectable		 4wg0L-6elqX:
undetectable
4wg0M-6elqX:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CVT_B_ACTB200_0
(N5-CARBOXYAMINOIMIDA
ZOLE RIBONUCLEOTIDE
MUTASE)		 6elq CARBON MONOXIDE
DEHYDROGENASE
(Carboxydothermus
hydrogenoformans) 		3 / 3 ASN X 255
ALA X 323
ARG X 389
 None
 0.73A 5cvtB-6elqX:
6.9		 5cvtB-6elqX:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D0X_H_BO2H301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 6elq CARBON MONOXIDE
DEHYDROGENASE
(Carboxydothermus
hydrogenoformans) 		5 / 12 THR X  77
CYH X  47
ALA X  73
ALA X  71
CYH X  69
 None
SF4  X 701 (-2.3A)
None
SF4  X 701 ( 4.2A)
SF4  X 701 (-2.2A)
 1.08A 5d0xH-6elqX:
undetectable
5d0xI-6elqX:
undetectable		 5d0xH-6elqX:
15.95
5d0xI-6elqX:
16.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGY_A_ERYA403_0
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 6elq CARBON MONOXIDE
DEHYDROGENASE
(Carboxydothermus
hydrogenoformans) 		5 / 12 GLY X 523
ASN X 298
HIS X  95
SER X 565
ILE X 566
 None
 1.16A 5igyA-6elqX:
undetectable		 5igyA-6elqX:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JLI_A_ASCA202_0
(CYTOCHROME C')		 6elq CARBON MONOXIDE
DEHYDROGENASE
(Carboxydothermus
hydrogenoformans) 		4 / 5 ALA X 563
GLY X 475
CYH X 525
HIS X  92
 None
BF8  X 702 ( 4.1A)
BF8  X 702 (-2.0A)
None
 1.42A 5jliA-6elqX:
undetectable		 5jliA-6elqX:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KM9_B_ADNB201_1
(HISTIDINE TRIAD
NUCLEOTIDE-BINDING
PROTEIN 2,
MITOCHONDRIAL)		 6elq CARBON MONOXIDE
DEHYDROGENASE
(Carboxydothermus
hydrogenoformans) 		5 / 12 ILE X 212
ILE X 208
LEU X 209
ALA X 601
VAL X 571
 None
 1.05A 5km9B-6elqX:
undetectable		 5km9B-6elqX:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SYE_B_TA1B502_1
(TUBULIN BETA CHAIN)		 6elq CARBON MONOXIDE
DEHYDROGENASE
(Carboxydothermus
hydrogenoformans) 		5 / 12 VAL X 526
ASP X 527
ASP X  98
HIS X  95
GLY X 297
 None
 1.23A 5syeB-6elqX:
2.3		 5syeB-6elqX:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_F_CVIF301_1
(REGULATORY PROTEIN
TETR)		 6elq CARBON MONOXIDE
DEHYDROGENASE
(Carboxydothermus
hydrogenoformans) 		4 / 8 TRP X 569
ARG X 171
VAL X 535
ASP X 548
 None
 1.08A 5vlmF-6elqX:
undetectable		 5vlmF-6elqX:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_E_PCFE202_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 5A,
MITOCHONDRIAL
CYTOCHROME C OXIDASE
SUBUNIT 1)		 6elq CARBON MONOXIDE
DEHYDROGENASE
(Carboxydothermus
hydrogenoformans) 		4 / 8 ILE X 148
ALA X 221
VAL X 217
ASP X 533
 None
 0.96A 6hu9a-6elqX:
undetectable
6hu9e-6elqX:
undetectable		 6hu9a-6elqX:
undetectable
6hu9e-6elqX:
undetectable