SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6em0'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DZ6_B_CAMB502_0
(CYTOCHROME P450-CAM)		 6em0 2-HYDROXYBIPHENYL-3-
MONOOXYGENASE
(Pseudomonas
nitroreducens) 		4 / 5 PHE A 559
TYR A 440
VAL A 363
ASP A 557
 None
 1.45A 1dz6B-6em0A:
undetectable		 1dz6B-6em0A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HK1_A_T44A3004_1
(SERUM ALBUMIN)		 6em0 2-HYDROXYBIPHENYL-3-
MONOOXYGENASE
(Pseudomonas
nitroreducens) 		4 / 6 GLU A  64
LEU A  63
VAL A 127
MET A 126
 None
 0.97A 1hk1A-6em0A:
undetectable		 1hk1A-6em0A:
8.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_G_BEZG513_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 6em0 2-HYDROXYBIPHENYL-3-
MONOOXYGENASE
(Pseudomonas
nitroreducens) 		4 / 5 ARG A 245
ILE A 251
PRO A  45
GLU A 207
 None
 1.41A 1oniG-6em0A:
undetectable
1oniH-6em0A:
undetectable		 1oniG-6em0A:
undetectable
1oniH-6em0A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SG9_A_SAMA301_0
(HEMK PROTEIN)		 6em0 2-HYDROXYBIPHENYL-3-
MONOOXYGENASE
(Pseudomonas
nitroreducens) 		5 / 12 PRO A  16
ILE A 295
GLY A 325
THR A 319
VAL A 368
 FAD  A 601 (-3.5A)
None
FAD  A 601 (-3.6A)
None
None
 1.11A 1sg9A-6em0A:
3.3		 1sg9A-6em0A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T03_P_TFOP822_1
(POL POLYPROTEIN
SYNTHETIC
OLIGONUCLEOTIDE
PRIMER)		 6em0 2-HYDROXYBIPHENYL-3-
MONOOXYGENASE
(Pseudomonas
nitroreducens) 		4 / 7 ASP A 222
TYR A 115
ASP A 117
HIS A  80
 None
 1.37A 1t03A-6em0A:
undetectable		 1t03A-6em0A:
10.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BJF_A_DXCA330_0
(CHOLOYLGLYCINE
HYDROLASE)		 6em0 2-HYDROXYBIPHENYL-3-
MONOOXYGENASE
(Pseudomonas
nitroreducens) 		5 / 12 PHE A 461
ASN A 327
ILE A 426
ILE A 425
LEU A 324
 None
 1.33A 2bjfA-6em0A:
undetectable		 2bjfA-6em0A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IGT_A_SAMA1001_0
(SAM DEPENDENT
METHYLTRANSFERASE)		 6em0 2-HYDROXYBIPHENYL-3-
MONOOXYGENASE
(Pseudomonas
nitroreducens) 		5 / 12 ALA A 341
ALA A 348
ALA A 337
PRO A 556
GLY A 494
 None
 0.89A 2igtA-6em0A:
3.5		 2igtA-6em0A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IGT_B_SAMB1002_0
(SAM DEPENDENT
METHYLTRANSFERASE)		 6em0 2-HYDROXYBIPHENYL-3-
MONOOXYGENASE
(Pseudomonas
nitroreducens) 		5 / 12 ALA A 341
ALA A 348
ALA A 337
PRO A 556
GLY A 494
 None
 0.91A 2igtB-6em0A:
3.6		 2igtB-6em0A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OAX_F_SNLF6001_2
(MINERALOCORTICOID
RECEPTOR)		 6em0 2-HYDROXYBIPHENYL-3-
MONOOXYGENASE
(Pseudomonas
nitroreducens) 		4 / 5 LEU A  70
LEU A 118
MET A 126
MET A  20
 None
 1.13A 2oaxF-6em0A:
undetectable		 2oaxF-6em0A:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UXO_B_TACB1211_1
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR TTGR)		 6em0 2-HYDROXYBIPHENYL-3-
MONOOXYGENASE
(Pseudomonas
nitroreducens) 		5 / 11 LEU A  86
CYH A 252
ILE A 206
VAL A 285
ILE A 283
 None
 1.18A 2uxoB-6em0A:
0.9		 2uxoB-6em0A:
18.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WA2_A_SAMA1248_0
(NON-STRUCTURAL
PROTEIN 5)		 6em0 2-HYDROXYBIPHENYL-3-
MONOOXYGENASE
(Pseudomonas
nitroreducens) 		5 / 12 GLY A 550
SER A 568
THR A 500
LEU A 499
VAL A 524
 None
 1.23A 2wa2A-6em0A:
3.8		 2wa2A-6em0A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_A_QPSA1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		 6em0 2-HYDROXYBIPHENYL-3-
MONOOXYGENASE
(Pseudomonas
nitroreducens) 		5 / 12 THR A 304
ASN A 303
VAL A 315
GLY A 312
ALA A 314
 None
None
None
FAD  A 601 (-3.3A)
None
 1.20A 2x2iA-6em0A:
undetectable		 2x2iA-6em0A:
5.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_C_QPSC1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		 6em0 2-HYDROXYBIPHENYL-3-
MONOOXYGENASE
(Pseudomonas
nitroreducens) 		5 / 12 THR A 304
ASN A 303
VAL A 315
GLY A 312
ALA A 314
 None
None
None
FAD  A 601 (-3.3A)
None
 1.24A 2x2iC-6em0A:
undetectable		 2x2iC-6em0A:
5.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_C_QPSC1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		 6em0 2-HYDROXYBIPHENYL-3-
MONOOXYGENASE
(Pseudomonas
nitroreducens) 		5 / 12 VAL A  12
ASN A 303
VAL A 315
GLY A 312
ALA A 314
 FAD  A 601 ( 4.9A)
None
None
FAD  A 601 (-3.3A)
None
 1.26A 2x2iC-6em0A:
undetectable		 2x2iC-6em0A:
5.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZTH_A_SAMA305_1
(CATECHOL
O-METHYLTRANSFERASE)		 6em0 2-HYDROXYBIPHENYL-3-
MONOOXYGENASE
(Pseudomonas
nitroreducens) 		3 / 3 SER A 329
GLU A 124
ASP A 313
 FAD  A 601 ( 3.8A)
FAD  A 601 ( 4.8A)
FAD  A 601 (-3.1A)
 0.66A 2zthA-6em0A:
undetectable		 2zthA-6em0A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BWM_A_SAMA301_1
(CATECHOL
O-METHYLTRANSFERASE)		 6em0 2-HYDROXYBIPHENYL-3-
MONOOXYGENASE
(Pseudomonas
nitroreducens) 		3 / 3 SER A 329
GLU A 124
ASP A 313
 FAD  A 601 ( 3.8A)
FAD  A 601 ( 4.8A)
FAD  A 601 (-3.1A)
 0.74A 3bwmA-6em0A:
3.8		 3bwmA-6em0A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BWY_A_SAMA301_1
(COMT PROTEIN)		 6em0 2-HYDROXYBIPHENYL-3-
MONOOXYGENASE
(Pseudomonas
nitroreducens) 		3 / 3 SER A 329
GLU A 124
ASP A 313
 FAD  A 601 ( 3.8A)
FAD  A 601 ( 4.8A)
FAD  A 601 (-3.1A)
 0.71A 3bwyA-6em0A:
3.8		 3bwyA-6em0A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FXR_A_ASCA3001_0
(LYSR TYPE REGULATOR
OF TSAMBCD)		 6em0 2-HYDROXYBIPHENYL-3-
MONOOXYGENASE
(Pseudomonas
nitroreducens) 		4 / 8 HIS A  48
ARG A 242
ALA A 240
PRO A 320
 None
FAD  A 601 ( 4.8A)
None
FAD  A 601 (-4.8A)
 1.03A 3fxrA-6em0A:
undetectable		 3fxrA-6em0A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JB3_A_SAMA1102_0
(STRUCTURAL PROTEIN
VP3)		 6em0 2-HYDROXYBIPHENYL-3-
MONOOXYGENASE
(Pseudomonas
nitroreducens) 		5 / 12 ILE A 174
GLY A 176
ALA A  17
ALA A 185
VAL A 184
 None
None
FAD  A 601 (-4.0A)
None
None
 1.10A 3jb3A-6em0A:
2.0		 3jb3A-6em0A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KM6_A_EAAA222_1
(GLUTATHIONE
S-TRANSFERASE P)		 6em0 2-HYDROXYBIPHENYL-3-
MONOOXYGENASE
(Pseudomonas
nitroreducens) 		5 / 10 VAL A 315
VAL A 363
GLN A 438
ILE A 175
GLY A 312
 None
None
None
None
FAD  A 601 (-3.3A)
 1.31A 3km6A-6em0A:
undetectable		 3km6A-6em0A:
17.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L8L_B_DVAB8_0
(GRAMICIDIN D)		 6em0 2-HYDROXYBIPHENYL-3-
MONOOXYGENASE
(Pseudomonas
nitroreducens) 		3 / 3 VAL A 238
VAL A 253
TRP A 225
 None
 0.82A 3l8lA-6em0A:
undetectable
3l8lB-6em0A:
undetectable		 3l8lA-6em0A:
undetectable
3l8lB-6em0A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OKX_B_SAMB201_0
(YAEB-LIKE PROTEIN
RPA0152)		 6em0 2-HYDROXYBIPHENYL-3-
MONOOXYGENASE
(Pseudomonas
nitroreducens) 		3 / 3 LYS A 493
ARG A 134
LYS A  68
 None
 1.46A 3okxA-6em0A:
undetectable		 3okxA-6em0A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TKD_B_CYZB267_2
(GLUTAMATE RECEPTOR 2)		 6em0 2-HYDROXYBIPHENYL-3-
MONOOXYGENASE
(Pseudomonas
nitroreducens) 		5 / 9 PRO A 125
SER A 129
LEU A  70
SER A  66
LEU A  63
 None
 1.48A 3tkdB-6em0A:
undetectable		 3tkdB-6em0A:
16.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DM8_A_REAA501_1
(RETINOIC ACID
RECEPTOR BETA)		 6em0 2-HYDROXYBIPHENYL-3-
MONOOXYGENASE
(Pseudomonas
nitroreducens) 		5 / 11 LEU A 352
LEU A 583
ILE A 582
SER A 517
LEU A  28
 None
 1.21A 4dm8A-6em0A:
undetectable		 4dm8A-6em0A:
15.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HTF_A_ACTA303_0
(S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE)		 6em0 2-HYDROXYBIPHENYL-3-
MONOOXYGENASE
(Pseudomonas
nitroreducens) 		3 / 3 TYR A 463
HIS A 472
ARG A  53
 None
 0.97A 4htfA-6em0A:
undetectable		 4htfA-6em0A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_B_STRB601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 6em0 2-HYDROXYBIPHENYL-3-
MONOOXYGENASE
(Pseudomonas
nitroreducens) 		4 / 5 ILE A  61
LEU A  24
GLU A 130
VAL A 138
 None
 1.03A 4nkxB-6em0A:
undetectable		 4nkxB-6em0A:
10.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RJD_B_TFPB203_1
(CALMODULIN)		 6em0 2-HYDROXYBIPHENYL-3-
MONOOXYGENASE
(Pseudomonas
nitroreducens) 		4 / 7 PHE A  91
LEU A 385
MET A 396
ALA A 420
 None
 1.03A 4rjdB-6em0A:
undetectable		 4rjdB-6em0A:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UCK_B_SAMB2409_0
(RNA-DIRECTED RNA
POLYMERASE L)		 6em0 2-HYDROXYBIPHENYL-3-
MONOOXYGENASE
(Pseudomonas
nitroreducens) 		5 / 12 GLY A  18
GLY A  13
LEU A  24
ALA A  26
ALA A 131
 None
FAD  A 601 (-2.8A)
None
None
None
 1.07A 4uckB-6em0A:
undetectable		 4uckB-6em0A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XNX_A_41XA707_1
(TRANSPORTER)		 6em0 2-HYDROXYBIPHENYL-3-
MONOOXYGENASE
(Pseudomonas
nitroreducens) 		5 / 11 ALA A 314
VAL A 315
GLY A 189
VAL A 184
GLY A 176
 None
 1.20A 4xnxA-6em0A:
undetectable		 4xnxA-6em0A:
10.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XT8_A_TMQA302_1
(RV2671)		 6em0 2-HYDROXYBIPHENYL-3-
MONOOXYGENASE
(Pseudomonas
nitroreducens) 		5 / 12 ILE A 175
SER A  21
GLY A  18
ALA A 177
ARG A 360
 None
 1.26A 4xt8A-6em0A:
undetectable		 4xt8A-6em0A:
16.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUD_A_SAMA303_1
(CATECHOL
O-METHYLTRANSFERASE)		 6em0 2-HYDROXYBIPHENYL-3-
MONOOXYGENASE
(Pseudomonas
nitroreducens) 		3 / 3 SER A 329
GLU A 124
ASP A 313
 FAD  A 601 ( 3.8A)
FAD  A 601 ( 4.8A)
FAD  A 601 (-3.1A)
 0.64A 4xudA-6em0A:
3.7		 4xudA-6em0A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZJL_A_ERYA1101_0
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 6em0 2-HYDROXYBIPHENYL-3-
MONOOXYGENASE
(Pseudomonas
nitroreducens) 		5 / 12 SER A 129
PHE A 140
GLU A 130
LEU A 118
THR A  54
 None
 1.47A 4zjlA-6em0A:
undetectable		 4zjlA-6em0A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HPU_C_IPHC101_0
(INSULIN, CHAIN A
INSULIN, CHAIN B)		 6em0 2-HYDROXYBIPHENYL-3-
MONOOXYGENASE
(Pseudomonas
nitroreducens) 		4 / 6 CYH A 491
LEU A 473
CYH A 525
LEU A 499
 None
 1.13A 5hpuC-6em0A:
undetectable
5hpuD-6em0A:
undetectable		 5hpuC-6em0A:
undetectable
5hpuD-6em0A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_B_TLFB601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 6em0 2-HYDROXYBIPHENYL-3-
MONOOXYGENASE
(Pseudomonas
nitroreducens) 		3 / 3 TYR A 356
TYR A 144
SER A 182
 None
 1.00A 5iktB-6em0A:
undetectable		 5iktB-6em0A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TZO_B_7V7B201_2
(ENDO-1,4-BETA-XYLANA
SE A)		 6em0 2-HYDROXYBIPHENYL-3-
MONOOXYGENASE
(Pseudomonas
nitroreducens) 		3 / 3 ARG A 439
PRO A 453
TYR A 463
 None
 1.03A 5tzoB-6em0A:
undetectable		 5tzoB-6em0A:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z6J_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 6em0 2-HYDROXYBIPHENYL-3-
MONOOXYGENASE
(Pseudomonas
nitroreducens) 		3 / 3 MET A 558
ASP A 489
ARG A 114
 None
 1.19A 5z6jA-6em0A:
undetectable		 5z6jA-6em0A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z6K_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 6em0 2-HYDROXYBIPHENYL-3-
MONOOXYGENASE
(Pseudomonas
nitroreducens) 		3 / 3 MET A 558
ASP A 489
ARG A 114
 None
 1.09A 5z6kA-6em0A:
undetectable		 5z6kA-6em0A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJZ_C_GMJC301_0
(SIGMA NON-OPIOID
INTRACELLULAR
RECEPTOR 1)		 6em0 2-HYDROXYBIPHENYL-3-
MONOOXYGENASE
(Pseudomonas
nitroreducens) 		5 / 12 ALA A  98
PHE A 227
VAL A 381
VAL A 238
TYR A 115
 None
 1.17A 6djzC-6em0A:
undetectable		 6djzC-6em0A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FBV_D_FI8D1904_1
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA')		 6em0 2-HYDROXYBIPHENYL-3-
MONOOXYGENASE
(Pseudomonas
nitroreducens) 		4 / 8 ARG A 139
VAL A 184
ARG A  46
GLN A 120
 None
None
FAD  A 601 (-3.5A)
FAD  A 601 (-3.2A)
 1.16A 6fbvD-6em0A:
undetectable		 6fbvD-6em0A:
undetectable