SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6emg'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_B_115B1_1
(HMG-COA REDUCTASE)		 6emg G0S4M2
(Chaetomium
thermophilum) 		5 / 9 CYH A  71
HIS A  30
LEU A  26
ALA A  57
LEU A  14
 None
 1.46A 1hwiA-6emgA:
undetectable		 1hwiA-6emgA:
10.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWK_A_117A2_2
(HMG-COA REDUCTASE)		 6emg G0S4M2
(Chaetomium
thermophilum) 		5 / 11 CYH A  71
HIS A  30
LEU A  26
ALA A  57
LEU A  14
 None
 1.47A 1hwkB-6emgA:
undetectable		 1hwkB-6emgA:
10.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWK_B_117B1_1
(HMG-COA REDUCTASE)		 6emg G0S4M2
(Chaetomium
thermophilum) 		5 / 11 CYH A  71
HIS A  30
LEU A  26
ALA A  57
LEU A  14
 None
 1.47A 1hwkA-6emgA:
undetectable		 1hwkA-6emgA:
10.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWK_C_117C4_2
(HMG-COA REDUCTASE)		 6emg G0S4M2
(Chaetomium
thermophilum) 		5 / 11 CYH A  71
HIS A  30
LEU A  26
ALA A  57
LEU A  14
 None
 1.47A 1hwkD-6emgA:
undetectable		 1hwkD-6emgA:
10.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWK_D_117D3_1
(HMG-COA REDUCTASE)		 6emg G0S4M2
(Chaetomium
thermophilum) 		5 / 11 CYH A  71
HIS A  30
LEU A  26
ALA A  57
LEU A  14
 None
 1.47A 1hwkC-6emgA:
undetectable		 1hwkC-6emgA:
10.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KGL_A_RTLA175_1
(CELLULAR
RETINOL-BINDING
PROTEIN TYPE I)		 6emg G0S4M2
(Chaetomium
thermophilum) 		4 / 7 LEU A  58
MET A 193
TRP A 165
GLN A 187
 None
 1.26A 1kglA-6emgA:
undetectable		 1kglA-6emgA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HC4_A_VDXA525_1
(VITAMIN D RECEPTOR)		 6emg G0S4M2
(Chaetomium
thermophilum) 		5 / 12 LEU A 232
VAL A 229
SER A 245
LEU A 120
LEU A 159
 None
 1.37A 2hc4A-6emgA:
undetectable		 2hc4A-6emgA:
15.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WSC_A_PQNA1802_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1)		 6emg G0S4M2
(Chaetomium
thermophilum) 		5 / 9 TRP A  94
PHE A 124
ARG A 117
LEU A 120
GLY A 121
 None
None
EDO  A 306 (-4.0A)
None
None
 1.16A 2wscA-6emgA:
undetectable		 2wscA-6emgA:
8.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WSE_A_PQNA1801_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1)		 6emg G0S4M2
(Chaetomium
thermophilum) 		5 / 9 TRP A  94
PHE A 124
ARG A 117
LEU A 120
GLY A 121
 None
None
EDO  A 306 (-4.0A)
None
None
 1.16A 2wseA-6emgA:
undetectable		 2wseA-6emgA:
8.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WSF_A_PQNA1802_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1)		 6emg G0S4M2
(Chaetomium
thermophilum) 		5 / 9 TRP A  94
PHE A 124
ARG A 117
LEU A 120
GLY A 121
 None
None
EDO  A 306 (-4.0A)
None
None
 1.17A 2wsfA-6emgA:
undetectable		 2wsfA-6emgA:
8.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G1U_B_ADNB438_1
(ADENOSYLHOMOCYSTEINA
SE)		 6emg G0S4M2
(Chaetomium
thermophilum) 		5 / 12 LEU A  14
THR A  23
LEU A  70
LEU A  74
HIS A  30
 None
 1.33A 3g1uB-6emgA:
undetectable		 3g1uB-6emgA:
10.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G1U_D_ADND438_1
(ADENOSYLHOMOCYSTEINA
SE)		 6emg G0S4M2
(Chaetomium
thermophilum) 		5 / 12 LEU A  14
THR A  23
LEU A  70
LEU A  74
HIS A  30
 None
 1.29A 3g1uD-6emgA:
undetectable		 3g1uD-6emgA:
10.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LW5_A_PQNA5001_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1)		 6emg G0S4M2
(Chaetomium
thermophilum) 		5 / 9 TRP A  94
PHE A 124
ARG A 117
LEU A 120
GLY A 121
 None
None
EDO  A 306 (-4.0A)
None
None
 1.23A 3lw5A-6emgA:
undetectable		 3lw5A-6emgA:
8.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_B_W9TB501_1
(HEMOLYTIC LECTIN
CEL-III)		 6emg G0S4M2
(Chaetomium
thermophilum) 		4 / 5 SER A 123
GLY A 121
TRP A  79
ASP A  76
 None
 1.43A 3w9tB-6emgA:
undetectable		 3w9tB-6emgA:
10.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_C_W9TC1003_1
(HEMOLYTIC LECTIN
CEL-III)		 6emg G0S4M2
(Chaetomium
thermophilum) 		4 / 5 SER A 123
GLY A 121
TRP A  79
ASP A  76
 None
 1.44A 3w9tC-6emgA:
undetectable		 3w9tC-6emgA:
10.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_D_W9TD501_1
(HEMOLYTIC LECTIN
CEL-III)		 6emg G0S4M2
(Chaetomium
thermophilum) 		4 / 5 SER A 123
GLY A 121
TRP A  79
ASP A  76
 None
 1.45A 3w9tD-6emgA:
undetectable		 3w9tD-6emgA:
10.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KCN_B_MTLB805_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 6emg G0S4M2
(Chaetomium
thermophilum) 		4 / 6 GLU A 206
ARG A 207
ASP A 203
ARG A 117
 None
EDO  A 308 (-3.5A)
None
EDO  A 306 (-4.0A)
 1.40A 4kcnB-6emgA:
undetectable		 4kcnB-6emgA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MDQ_A_TESA605_0
(SERUM ALBUMIN)		 6emg G0S4M2
(Chaetomium
thermophilum) 		4 / 8 LYS A 125
GLY A 209
LEU A 210
GLU A 217
 None
 0.84A 6mdqA-6emgA:
undetectable		 6mdqA-6emgA:
22.50