SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6emk'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AV2_B_DVAB8_0
(GRAMICIDIN A)		 6emk SERINE/THREONINE-PRO
TEIN KINASE TOR2
(Saccharomyces
cerevisiae) 		3 / 3 VAL A1218
VAL A1285
TRP A1284
 None
 0.88A 1av2A-6emkA:
undetectable
1av2B-6emkA:
undetectable		 1av2A-6emkA:
undetectable
1av2B-6emkA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERR_B_RALB600_2
(ESTROGEN RECEPTOR)		 6emk TARGET OF RAPAMYCIN
COMPLEX SUBUNIT LST8
(Saccharomyces
cerevisiae) 		4 / 6 LEU B 131
ASP B 193
LEU B 165
HIS B 115
 None
 1.10A 1errB-6emkB:
undetectable		 1errB-6emkB:
15.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FXV_B_PNNB1001_0
(PENICILLIN ACYLASE)		 6emk SERINE/THREONINE-PRO
TEIN KINASE TOR2
(Saccharomyces
cerevisiae) 		4 / 7 PHE A 576
SER A 615
SER A 598
ALA A 569
 None
 1.20A 1fxvA-6emkA:
undetectable
1fxvB-6emkA:
undetectable		 1fxvA-6emkA:
undetectable
1fxvB-6emkA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HRK_A_CHDA1502_0
(FERROCHELATASE)		 6emk SERINE/THREONINE-PRO
TEIN KINASE TOR2
(Saccharomyces
cerevisiae) 		4 / 8 MET A1083
ARG A1107
LEU A1149
GLY A1072
 None
 0.90A 1hrkA-6emkA:
undetectable		 1hrkA-6emkA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HRK_B_CHDB2502_0
(FERROCHELATASE)		 6emk SERINE/THREONINE-PRO
TEIN KINASE TOR2
(Saccharomyces
cerevisiae) 		4 / 8 MET A1083
ARG A1107
LEU A1149
GLY A1072
 None
 0.93A 1hrkB-6emkA:
undetectable		 1hrkB-6emkA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IE4_A_T44A128_1
(TRANSTHYRETIN)		 6emk TARGET OF RAPAMYCIN
COMPLEX SUBUNIT LST8
(Saccharomyces
cerevisiae) 		5 / 10 LEU B 214
ALA B 223
LEU B 265
ALA B 257
LEU B 279
 None
 1.18A 1ie4A-6emkB:
undetectable
1ie4C-6emkB:
undetectable		 1ie4A-6emkB:
21.74
1ie4C-6emkB:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J96_B_TESB904_1
(3ALPHA-HYDROXYSTEROI
D DEHYDROGENASE TYPE
3)		 6emk SERINE/THREONINE-PRO
TEIN KINASE TOR2
(Saccharomyces
cerevisiae) 		4 / 7 ILE A 415
HIS A 494
GLU A 497
LEU A 485
 None
 1.05A 1j96B-6emkA:
undetectable		 1j96B-6emkA:
11.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KI7_B_ID2B2_0
(THYMIDINE KINASE)		 6emk SERINE/THREONINE-PRO
TEIN KINASE TOR2
(Saccharomyces
cerevisiae) 		5 / 12 ILE A1933
ILE A1918
GLN A1926
ARG A1937
GLU A1948
 None
 1.41A 1ki7B-6emkA:
undetectable		 1ki7B-6emkA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OLT_A_SAMA501_0
(OXYGEN-INDEPENDENT
COPROPORPHYRINOGEN
III OXIDASE)		 6emk TARGET OF RAPAMYCIN
COMPLEX SUBUNIT LST8
(Saccharomyces
cerevisiae) 		5 / 12 ASP B 271
GLY B 248
ARG B 275
ASP B 247
ALA B 223
 None
 1.26A 1oltA-6emkB:
undetectable		 1oltA-6emkB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QFI_B_DVAB8_0
(ACTINOMYCIN X2)		 6emk SERINE/THREONINE-PRO
TEIN KINASE TOR2
(Saccharomyces
cerevisiae) 		3 / 3 THR A1044
THR A1042
PRO A1040
 None
 0.84A 1qfiB-6emkA:
undetectable		 1qfiB-6emkA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R55_A_097A518_1
(ADAM 33)		 6emk TARGET OF RAPAMYCIN
COMPLEX SUBUNIT LST8
(Saccharomyces
cerevisiae) 		5 / 10 ALA B 299
VAL B   6
HIS B  30
HIS B  12
ALA B  48
 None
 1.22A 1r55A-6emkB:
undetectable		 1r55A-6emkB:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S14_A_NOVA1300_1
(TOPOISOMERASE IV
SUBUNIT B)		 6emk SERINE/THREONINE-PRO
TEIN KINASE TOR2
TARGET OF RAPAMYCIN
COMPLEX 2 SUBUNIT
AVO1
(Saccharomyces
cerevisiae) 		5 / 12 ASN I 735
SER I 734
ASP I 732
ASP A2215
ILE I 680
 None
 1.48A 1s14A-6emkI:
undetectable		 1s14A-6emkI:
18.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SBR_A_VIBA502_1
(YKOF)		 6emk SERINE/THREONINE-PRO
TEIN KINASE TOR2
(Saccharomyces
cerevisiae) 		4 / 6 ALA A1841
LEU A1842
ILE A2356
SER A1837
 None
 0.94A 1sbrA-6emkA:
undetectable
1sbrB-6emkA:
undetectable		 1sbrA-6emkA:
21.02
1sbrB-6emkA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SBR_B_VIBB504_1
(YKOF)		 6emk SERINE/THREONINE-PRO
TEIN KINASE TOR2
(Saccharomyces
cerevisiae) 		4 / 6 PRO A1878
LEU A2175
ILE A2167
SER A1951
 None
 1.19A 1sbrA-6emkA:
undetectable
1sbrB-6emkA:
undetectable		 1sbrA-6emkA:
21.02
1sbrB-6emkA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SN0_C_T44C601_1
(TRANSTHYRETIN)		 6emk TARGET OF RAPAMYCIN
COMPLEX SUBUNIT LST8
(Saccharomyces
cerevisiae) 		5 / 9 LEU B 265
ALA B 257
LEU B 279
LEU B 214
ALA B 223
 None
 1.27A 1sn0A-6emkB:
undetectable
1sn0C-6emkB:
undetectable		 1sn0A-6emkB:
24.79
1sn0C-6emkB:
24.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TZ8_B_DESB128_1
(TRANSTHYRETIN)		 6emk SERINE/THREONINE-PRO
TEIN KINASE TOR2
(Saccharomyces
cerevisiae) 		5 / 11 LEU A1531
ALA A1539
LEU A 824
LEU A 827
SER A 830
 None
 1.24A 1tz8A-6emkA:
undetectable
1tz8B-6emkA:
undetectable		 1tz8A-6emkA:
20.00
1tz8B-6emkA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TZ8_B_DESB128_1
(TRANSTHYRETIN)		 6emk TARGET OF RAPAMYCIN
COMPLEX SUBUNIT LST8
(Saccharomyces
cerevisiae) 		5 / 11 LEU B 214
ALA B 223
ALA B 257
LEU B 279
SER B 262
 None
 1.23A 1tz8A-6emkB:
undetectable
1tz8B-6emkB:
undetectable		 1tz8A-6emkB:
21.74
1tz8B-6emkB:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TZ8_B_DESB128_1
(TRANSTHYRETIN)		 6emk TARGET OF RAPAMYCIN
COMPLEX SUBUNIT LST8
(Saccharomyces
cerevisiae) 		5 / 11 LEU B 265
ALA B 257
LEU B 279
SER B 262
ALA B 223
 None
 1.20A 1tz8A-6emkB:
undetectable
1tz8B-6emkB:
undetectable		 1tz8A-6emkB:
21.74
1tz8B-6emkB:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1U18_B_HSMB402_1
(NITROPHORIN 1)		 6emk SERINE/THREONINE-PRO
TEIN KINASE TOR2
(Saccharomyces
cerevisiae) 		4 / 5 ASP A2237
GLU A2234
THR A2319
LEU A2322
 None
 1.05A 1u18B-6emkA:
undetectable		 1u18B-6emkA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UW6_A_NCTA1208_1
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 6emk SERINE/THREONINE-PRO
TEIN KINASE TOR2
(Saccharomyces
cerevisiae) 		4 / 8 THR A1752
TYR A1754
TRP A1760
LEU A1712
 None
 1.46A 1uw6A-6emkA:
undetectable
1uw6B-6emkA:
undetectable		 1uw6A-6emkA:
16.04
1uw6B-6emkA:
16.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UW6_D_NCTD1208_1
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 6emk SERINE/THREONINE-PRO
TEIN KINASE TOR2
(Saccharomyces
cerevisiae) 		4 / 8 THR A1752
TYR A1754
TRP A1760
LEU A1712
 None
 1.45A 1uw6D-6emkA:
undetectable
1uw6E-6emkA:
undetectable		 1uw6D-6emkA:
16.04
1uw6E-6emkA:
16.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UW6_P_NCTP1206_1
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 6emk SERINE/THREONINE-PRO
TEIN KINASE TOR2
(Saccharomyces
cerevisiae) 		4 / 8 THR A1752
TYR A1754
TRP A1760
LEU A1712
 None
 1.45A 1uw6P-6emkA:
undetectable
1uw6Q-6emkA:
undetectable		 1uw6P-6emkA:
16.04
1uw6Q-6emkA:
16.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UW6_T_NCTT1208_1
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 6emk SERINE/THREONINE-PRO
TEIN KINASE TOR2
(Saccharomyces
cerevisiae) 		4 / 8 TRP A1760
LEU A1712
THR A1752
TYR A1754
 None
 1.43A 1uw6P-6emkA:
undetectable
1uw6T-6emkA:
undetectable		 1uw6P-6emkA:
16.04
1uw6T-6emkA:
16.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
209D_C_DVAC2_0
(N8-ACTINOMYCIN D)		 6emk SERINE/THREONINE-PRO
TEIN KINASE TOR2
(Saccharomyces
cerevisiae) 		3 / 3 THR A1042
PRO A1040
THR A1044
 None
 0.74A 209dC-6emkA:
undetectable		 209dC-6emkA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IZQ_C_DVAC8_0
(GRAMICIDIN D)		 6emk SERINE/THREONINE-PRO
TEIN KINASE TOR2
(Saccharomyces
cerevisiae) 		3 / 3 VAL A1285
TRP A1284
VAL A1218
 None
 0.82A 2izqC-6emkA:
undetectable
2izqD-6emkA:
undetectable		 2izqC-6emkA:
undetectable
2izqD-6emkA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JFA_A_RALA600_2
(ESTROGEN RECEPTOR)		 6emk TARGET OF RAPAMYCIN
COMPLEX SUBUNIT LST8
(Saccharomyces
cerevisiae) 		4 / 5 LEU B 131
ASP B 193
LEU B 165
HIS B 115
 None
 1.07A 2jfaA-6emkB:
undetectable		 2jfaA-6emkB:
15.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JJ8_A_AZZA1211_1
(DEOXYNUCLEOSIDE
KINASE)		 6emk SERINE/THREONINE-PRO
TEIN KINASE TOR2
TARGET OF RAPAMYCIN
COMPLEX SUBUNIT LST8
(Saccharomyces
cerevisiae) 		5 / 10 GLU B  39
VAL B 298
GLN A2221
VAL B 296
ARG B  37
 None
 1.45A 2jj8A-6emkB:
undetectable		 2jj8A-6emkB:
14.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NYR_B_SVRB401_2
(NAD-DEPENDENT
DEACETYLASE
SIRTUIN-5)		 6emk SERINE/THREONINE-PRO
TEIN KINASE TOR2
(Saccharomyces
cerevisiae) 		4 / 6 PHE A2155
ARG A2156
ASN A1585
LEU A 848
 None
 1.20A 2nyrA-6emkA:
undetectable		 2nyrA-6emkA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q2H_B_ACTB501_0
(SECRETION CHAPERONE,
PHAGE-DISPLAY
DERIVED PEPTIDE)		 6emk TARGET OF RAPAMYCIN
COMPLEX SUBUNIT LST8
(Saccharomyces
cerevisiae) 		3 / 3 ARG B  56
SER B  33
TYR B  58
 None
 0.88A 2q2hA-6emkB:
undetectable
2q2hB-6emkB:
undetectable		 2q2hA-6emkB:
undetectable
2q2hB-6emkB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD4_A_CHDA801_0
(FERROCHELATASE)		 6emk SERINE/THREONINE-PRO
TEIN KINASE TOR2
(Saccharomyces
cerevisiae) 		5 / 12 LEU A 740
LEU A 744
GLN A 809
SER A 747
LEU A 785
 None
 1.38A 2qd4A-6emkA:
undetectable		 2qd4A-6emkA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QO6_A_CHDA130_0
(LIVER-BASIC FATTY
ACID BINDING PROTEIN)		 6emk TARGET OF RAPAMYCIN
COMPLEX SUBUNIT LST8
(Saccharomyces
cerevisiae) 		5 / 12 TYR B 288
LEU B   5
ILE B   4
LEU B 300
VAL B 285
 None
 1.16A 2qo6A-6emkB:
undetectable		 2qo6A-6emkB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QXS_A_RALA600_2
(ESTROGEN RECEPTOR)		 6emk TARGET OF RAPAMYCIN
COMPLEX SUBUNIT LST8
(Saccharomyces
cerevisiae) 		4 / 5 LEU B 131
ASP B 193
LEU B 165
HIS B 115
 None
 1.13A 2qxsA-6emkB:
undetectable		 2qxsA-6emkB:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QXS_B_RALB600_2
(ESTROGEN RECEPTOR)		 6emk TARGET OF RAPAMYCIN
COMPLEX SUBUNIT LST8
(Saccharomyces
cerevisiae) 		4 / 5 LEU B 131
ASP B 193
LEU B 165
HIS B 115
 None
 1.12A 2qxsB-6emkB:
undetectable		 2qxsB-6emkB:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R2V_D_ACTD37_0
(GCN4 LEUCINE ZIPPER)		 6emk TARGET OF RAPAMYCIN
COMPLEX SUBUNIT LST8
(Saccharomyces
cerevisiae) 		3 / 3 LYS B   6
ARG B  37
VAL B  35
 None
 1.09A 2r2vC-6emkB:
undetectable
2r2vD-6emkB:
undetectable		 2r2vC-6emkB:
undetectable
2r2vD-6emkB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RCT_A_RTLA140_0
(RETINOL-BINDING
PROTEIN II, CELLULAR)		 6emk SERINE/THREONINE-PRO
TEIN KINASE TOR2
(Saccharomyces
cerevisiae) 		5 / 12 PHE A2316
ILE A2331
ALA A2455
LYS A2272
VAL A2345
 None
 1.31A 2rctA-6emkA:
undetectable		 2rctA-6emkA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VJ1_A_BEZA1303_0
(SARS CORONAVIRUS
MAIN PROTEINASE)		 6emk TARGET OF RAPAMYCIN
COMPLEX SUBUNIT LST8
(Saccharomyces
cerevisiae) 		3 / 3 HIS B 125
MET B 167
MET B 188
 None
 1.23A 2vj1A-6emkB:
undetectable		 2vj1A-6emkB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X91_A_LPRA1615_2
(ANGIOTENSIN
CONVERTING ENZYME)		 6emk TARGET OF RAPAMYCIN
COMPLEX SUBUNIT LST8
(Saccharomyces
cerevisiae) 		3 / 3 SER B 226
THR B 267
PHE B 258
 None
 0.73A 2x91A-6emkB:
undetectable		 2x91A-6emkB:
9.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XCT_H_CPFH1020_1
(DNA GYRASE SUBUNIT
B, DNA GYRASE
SUBUNIT A)		 6emk TARGET OF RAPAMYCIN
COMPLEX 2 SUBUNIT
AVO1
(Saccharomyces
cerevisiae) 		3 / 3 ARG I 698
GLU I 788
SER I 768
 None
 0.89A 2xctD-6emkI:
undetectable		 2xctD-6emkI:
7.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJ8_C_SPMC500_1
(DIAMINE
ACETYLTRANSFERASE 1)		 6emk SERINE/THREONINE-PRO
TEIN KINASE TOR2
(Saccharomyces
cerevisiae) 		4 / 6 LEU A1845
ASP A1840
LEU A1762
HIS A1758
 None
 1.27A 3bj8C-6emkA:
undetectable
3bj8D-6emkA:
undetectable		 3bj8C-6emkA:
17.50
3bj8D-6emkA:
17.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CD2_A_MTXA307_1
(DIHYDROFOLATE
REDUCTASE)		 6emk TARGET OF RAPAMYCIN
COMPLEX SUBUNIT LST8
(Saccharomyces
cerevisiae) 		6 / 12 ILE B 140
GLU B 121
SER B 166
LYS B 173
PRO B 126
ILE B 142
 None
 1.24A 3cd2A-6emkB:
undetectable		 3cd2A-6emkB:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FBX_A_ACTA608_0
(PUTATIVE
PHOSPHOLIPASE B-LIKE
2)		 6emk SERINE/THREONINE-PRO
TEIN KINASE TOR2
(Saccharomyces
cerevisiae) 		3 / 3 GLU A1722
VAL A1725
CYH A1726
 None
 1.08A 3fbxA-6emkA:
undetectable		 3fbxA-6emkA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FHJ_A_TRPA1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 6emk SERINE/THREONINE-PRO
TEIN KINASE TOR2
(Saccharomyces
cerevisiae) 		5 / 10 GLN A2106
ASP A2296
ILE A2295
VAL A2179
VAL A2124
 None
 1.07A 3fhjA-6emkA:
undetectable		 3fhjA-6emkA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FHJ_C_TRPC1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 6emk SERINE/THREONINE-PRO
TEIN KINASE TOR2
(Saccharomyces
cerevisiae) 		5 / 10 GLN A2106
ASP A2296
ILE A2295
VAL A2179
VAL A2124
 None
 1.10A 3fhjC-6emkA:
undetectable		 3fhjC-6emkA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FHJ_E_TRPE1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 6emk SERINE/THREONINE-PRO
TEIN KINASE TOR2
(Saccharomyces
cerevisiae) 		5 / 10 GLN A2106
ASP A2296
ILE A2295
VAL A2179
VAL A2124
 None
 1.04A 3fhjE-6emkA:
undetectable		 3fhjE-6emkA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_A_TRPA1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 6emk SERINE/THREONINE-PRO
TEIN KINASE TOR2
(Saccharomyces
cerevisiae) 		5 / 9 GLN A2106
ASP A2296
ILE A2295
VAL A2179
VAL A2124
 None
 1.07A 3fi0A-6emkA:
undetectable		 3fi0A-6emkA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_C_TRPC1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 6emk SERINE/THREONINE-PRO
TEIN KINASE TOR2
(Saccharomyces
cerevisiae) 		5 / 9 GLN A2106
ASP A2296
ILE A2295
VAL A2179
VAL A2124
 None
 1.11A 3fi0C-6emkA:
undetectable		 3fi0C-6emkA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_H_TRPH1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 6emk SERINE/THREONINE-PRO
TEIN KINASE TOR2
(Saccharomyces
cerevisiae) 		5 / 9 GLN A2106
ASP A2296
ILE A2295
VAL A2179
VAL A2124
 None
 1.10A 3fi0H-6emkA:
undetectable		 3fi0H-6emkA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_K_TRPK1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 6emk SERINE/THREONINE-PRO
TEIN KINASE TOR2
(Saccharomyces
cerevisiae) 		5 / 9 GLN A2106
ASP A2296
ILE A2295
VAL A2179
VAL A2124
 None
 1.16A 3fi0K-6emkA:
undetectable		 3fi0K-6emkA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_L_TRPL1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 6emk SERINE/THREONINE-PRO
TEIN KINASE TOR2
(Saccharomyces
cerevisiae) 		5 / 9 GLN A2106
ASP A2296
ILE A2295
VAL A2179
VAL A2124
 None
 1.04A 3fi0L-6emkA:
undetectable		 3fi0L-6emkA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_M_TRPM1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 6emk SERINE/THREONINE-PRO
TEIN KINASE TOR2
(Saccharomyces
cerevisiae) 		5 / 9 GLN A2106
ASP A2296
ILE A2295
VAL A2179
VAL A2124
 None
 1.11A 3fi0M-6emkA:
undetectable		 3fi0M-6emkA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_N_TRPN1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 6emk SERINE/THREONINE-PRO
TEIN KINASE TOR2
(Saccharomyces
cerevisiae) 		5 / 9 GLN A2106
ASP A2296
ILE A2295
VAL A2179
VAL A2124
 None
 1.11A 3fi0N-6emkA:
undetectable		 3fi0N-6emkA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_O_TRPO1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 6emk SERINE/THREONINE-PRO
TEIN KINASE TOR2
(Saccharomyces
cerevisiae) 		5 / 9 GLN A2106
ASP A2296
ILE A2295
VAL A2179
VAL A2124
 None
 1.11A 3fi0O-6emkA:
undetectable		 3fi0O-6emkA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HGG_A_CHDA211_0
(CMER)		 6emk SERINE/THREONINE-PRO
TEIN KINASE TOR2
(Saccharomyces
cerevisiae) 		4 / 7 CYH A1283
PHE A1276
PHE A1280
SER A1290
 None
 1.50A 3hggA-6emkA:
undetectable		 3hggA-6emkA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HM1_B_J3ZB1_1
(ESTROGEN RECEPTOR)		 6emk SERINE/THREONINE-PRO
TEIN KINASE TOR2
(Saccharomyces
cerevisiae) 		5 / 11 LEU A 482
LEU A 483
GLU A 510
LEU A 502
GLY A 464
 None
 1.24A 3hm1B-6emkA:
undetectable		 3hm1B-6emkA:
14.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IJD_B_C2FB314_1
(UNCHARACTERIZED
PROTEIN)		 6emk SERINE/THREONINE-PRO
TEIN KINASE TOR2
(Saccharomyces
cerevisiae) 		3 / 3 THR A 216
LYS A 250
GLU A 213
 None
 0.92A 3ijdB-6emkA:
undetectable		 3ijdB-6emkA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3J7Z_A_ERYA9000_0
(23S RRNA
50S RIBOSOMAL
PROTEIN L22
ERMCL NASCENT CHAIN)		 6emk SERINE/THREONINE-PRO
TEIN KINASE TOR2
(Saccharomyces
cerevisiae) 		3 / 3 LYS A2353
ILE A1823
PHE A1826
 None
 0.94A 3j7zS-6emkA:
undetectable
3j7za-6emkA:
undetectable		 3j7zS-6emkA:
undetectable
3j7za-6emkA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LPS_A_NOVA901_1
(TOPOISOMERASE IV
SUBUNIT B)		 6emk SERINE/THREONINE-PRO
TEIN KINASE TOR2
TARGET OF RAPAMYCIN
COMPLEX 2 SUBUNIT
AVO1
(Saccharomyces
cerevisiae) 		5 / 12 ASN I 735
SER I 734
ASP I 732
ASP A2215
ILE I 680
 None
 1.38A 3lpsA-6emkI:
undetectable		 3lpsA-6emkI:
12.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OKX_B_SAMB201_0
(YAEB-LIKE PROTEIN
RPA0152)		 6emk SERINE/THREONINE-PRO
TEIN KINASE TOR2
(Saccharomyces
cerevisiae) 		3 / 3 LYS A 595
ARG A 608
LYS A 522
 None
 0.92A 3okxA-6emkA:
undetectable		 3okxA-6emkA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OKX_B_SAMB201_0
(YAEB-LIKE PROTEIN
RPA0152)		 6emk SERINE/THREONINE-PRO
TEIN KINASE TOR2
(Saccharomyces
cerevisiae) 		3 / 3 LYS A1512
ARG A1507
LYS A1470
 None
 1.44A 3okxA-6emkA:
undetectable		 3okxA-6emkA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OKX_B_SAMB201_0
(YAEB-LIKE PROTEIN
RPA0152)		 6emk SERINE/THREONINE-PRO
TEIN KINASE TOR2
(Saccharomyces
cerevisiae) 		3 / 3 LYS A1643
ARG A1678
LYS A1656
 None
 1.30A 3okxA-6emkA:
undetectable		 3okxA-6emkA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q87_B_SAMB300_0
(N6 ADENINE SPECIFIC
DNA METHYLASE)		 6emk TARGET OF RAPAMYCIN
COMPLEX SUBUNIT LST8
(Saccharomyces
cerevisiae) 		5 / 12 THR B 179
GLY B 138
ASP B 137
LEU B 154
ASN B 178
 None
 0.93A 3q87B-6emkB:
undetectable		 3q87B-6emkB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RFM_A_CFFA330_1
(ADENOSINE RECEPTOR
A2A)		 6emk SERINE/THREONINE-PRO
TEIN KINASE TOR2
(Saccharomyces
cerevisiae) 		4 / 7 PHE A 212
LEU A 286
ASN A 266
ILE A 245
 None
 0.92A 3rfmA-6emkA:
undetectable		 3rfmA-6emkA:
10.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SI7_A_ACTA5_0
(CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR)		 6emk SERINE/THREONINE-PRO
TEIN KINASE TOR2
(Saccharomyces
cerevisiae) 		3 / 3 LYS A2257
SER A1382
GLN A1379
 None
 1.28A 3si7A-6emkA:
undetectable		 3si7A-6emkA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WRK_D_CAMD502_0
(CAMPHOR
5-MONOOXYGENASE)		 6emk SERINE/THREONINE-PRO
TEIN KINASE TOR2
(Saccharomyces
cerevisiae) 		4 / 5 PHE A2141
LEU A2273
GLY A2270
VAL A2292
 None
 0.99A 3wrkD-6emkA:
undetectable		 3wrkD-6emkA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WXO_A_NIZA804_1
(CATALASE-PEROXIDASE)		 6emk TARGET OF RAPAMYCIN
COMPLEX 2 SUBUNIT
AVO1
(Saccharomyces
cerevisiae) 		3 / 3 ASN I 785
GLU I 731
ARG I 698
 None
 1.00A 3wxoA-6emkI:
undetectable		 3wxoA-6emkI:
7.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B9Z_A_ACRA1818_1
(ALPHA-GLUCOSIDASE,
PUTATIVE, ADG31B)		 6emk SERINE/THREONINE-PRO
TEIN KINASE TOR2
(Saccharomyces
cerevisiae) 		5 / 12 ASP A2277
LEU A2275
ASP A2296
GLU A2129
HIS A2279
 None
 1.20A 4b9zA-6emkA:
undetectable		 4b9zA-6emkA:
6.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BBO_B_ACTB1114_0
(BLR5658 PROTEIN)		 6emk TARGET OF RAPAMYCIN
COMPLEX SUBUNIT LST8
(Saccharomyces
cerevisiae) 		3 / 3 TRP B 252
TRP B 254
THR B 211
 None
 1.23A 4bboB-6emkB:
undetectable		 4bboB-6emkB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DJE_A_C2FA300_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 6emk SERINE/THREONINE-PRO
TEIN KINASE TOR2
(Saccharomyces
cerevisiae) 		5 / 12 GLU A 425
PHE A 383
LEU A 478
GLY A 427
SER A 429
 None
 1.34A 4djeA-6emkA:
undetectable		 4djeA-6emkA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DV7_A_SRYA1601_1
(16S RRNA
RIBOSOMAL PROTEIN
S12)		 6emk SERINE/THREONINE-PRO
TEIN KINASE TOR2
(Saccharomyces
cerevisiae) 		3 / 3 LYS A1057
PRO A1061
LYS A1054
 None
 1.03A 4dv7L-6emkA:
undetectable		 4dv7L-6emkA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EB6_C_VLBC503_1
(TUBULIN BETA CHAIN
TUBULIN ALPHA CHAIN)		 6emk SERINE/THREONINE-PRO
TEIN KINASE TOR2
(Saccharomyces
cerevisiae) 		5 / 12 VAL A1060
ASP A1053
ILE A1102
VAL A1086
ILE A1082
 None
 1.42A 4eb6B-6emkA:
undetectable
4eb6C-6emkA:
undetectable		 4eb6B-6emkA:
12.30
4eb6C-6emkA:
11.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_C_SAMC401_1
(METHYLTRANSFERASE
NSUN4)		 6emk TARGET OF RAPAMYCIN
COMPLEX SUBUNIT LST8
(Saccharomyces
cerevisiae) 		3 / 3 ASP B 271
ARG B 251
ASP B  11
 None
 0.69A 4fp9C-6emkB:
undetectable		 4fp9C-6emkB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J4V_D_SVRD301_1
(NUCLEOCAPSID PROTEIN)		 6emk SERINE/THREONINE-PRO
TEIN KINASE TOR2
(Saccharomyces
cerevisiae) 		5 / 11 GLY A2235
ALA A2229
PHE A2185
ILE A2189
LYS A2207
 None
 1.47A 4j4vD-6emkA:
undetectable
4j4vE-6emkA:
undetectable		 4j4vD-6emkA:
15.29
4j4vE-6emkA:
15.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KR3_A_GLYA701_0
(GLYCINE--TRNA LIGASE)		 6emk SERINE/THREONINE-PRO
TEIN KINASE TOR2
(Saccharomyces
cerevisiae) 		4 / 6 ARG A2157
ARG A2256
GLU A2327
SER A2334
 None
 1.43A 4kr3A-6emkA:
undetectable		 4kr3A-6emkA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KTV_A_ADNA403_1
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 6emk SERINE/THREONINE-PRO
TEIN KINASE TOR2
(Saccharomyces
cerevisiae) 		5 / 12 HIS A 946
SER A 987
ASP A 960
ILE A 962
ILE A 991
 None
 1.34A 4ktvA-6emkA:
undetectable
4ktvB-6emkA:
undetectable		 4ktvA-6emkA:
10.91
4ktvB-6emkA:
10.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LRH_A_FOLA301_1
(FOLATE RECEPTOR
ALPHA)		 6emk SERINE/THREONINE-PRO
TEIN KINASE TOR2
TARGET OF RAPAMYCIN
COMPLEX SUBUNIT LST8
(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		3 / 3 ASP A2215
TRP B 254
SER B  33
 None
 0.71A 4lrhA-6emkA:
undetectable		 4lrhA-6emkA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MA3_L_ACTL301_0
(C2095 HEAVY CHAIN
C2095 LIGHT CHAIN)		 6emk SERINE/THREONINE-PRO
TEIN KINASE TOR2
(Saccharomyces
cerevisiae) 		3 / 3 PRO A1362
ASN A1394
HIS A1393
 None
 1.03A 4ma3H-6emkA:
undetectable
4ma3L-6emkA:
undetectable		 4ma3H-6emkA:
undetectable
4ma3L-6emkA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O8F_B_BRLB501_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 6emk SERINE/THREONINE-PRO
TEIN KINASE TOR2
(Saccharomyces
cerevisiae) 		4 / 6 GLY A2274
ILE A2161
ILE A2272
LEU A2451
 None
 0.63A 4o8fB-6emkA:
undetectable		 4o8fB-6emkA:
17.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PTJ_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 6emk SERINE/THREONINE-PRO
TEIN KINASE TOR2
TARGET OF RAPAMYCIN
COMPLEX 2 SUBUNIT
AVO1
(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		3 / 3 ASP A1971
LYS I 654
LEU I 728
 None
 1.06A 4ptjA-6emkA:
undetectable		 4ptjA-6emkA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QB9_E_PARE500_1
(ENHANCED
INTRACELLULAR
SURVIVAL PROTEIN)		 6emk SERINE/THREONINE-PRO
TEIN KINASE TOR2
(Saccharomyces
cerevisiae) 		5 / 12 LEU A1440
GLU A1418
ASP A1411
TYR A1403
GLY A1432
 None
 1.44A 4qb9E-6emkA:
undetectable		 4qb9E-6emkA:
10.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QZU_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 2)		 6emk SERINE/THREONINE-PRO
TEIN KINASE TOR2
(Saccharomyces
cerevisiae) 		5 / 12 PHE A2316
ILE A2331
ALA A2455
LYS A2272
VAL A2345
 None
 1.31A 4qzuA-6emkA:
undetectable		 4qzuA-6emkA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QZU_C_RTLC201_1
(RETINOL-BINDING
PROTEIN 2)		 6emk SERINE/THREONINE-PRO
TEIN KINASE TOR2
(Saccharomyces
cerevisiae) 		3 / 3 LYS A2127
TRP A1961
GLN A1964
 None
 1.36A 4qzuC-6emkA:
undetectable		 4qzuC-6emkA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R38_C_RBFC201_2
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 6emk SERINE/THREONINE-PRO
TEIN KINASE TOR2
(Saccharomyces
cerevisiae) 		5 / 9 ILE A2161
ASN A2341
LEU A2451
LEU A2263
ILE A2331
 None
 1.29A 4r38C-6emkA:
undetectable		 4r38C-6emkA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TVT_A_ASCA301_0
(THAUMATIN-1)		 6emk TARGET OF RAPAMYCIN
COMPLEX SUBUNIT LST8
(Saccharomyces
cerevisiae) 		3 / 3 THR B 160
ASN B 178
SER B 161
 None
 0.78A 4tvtA-6emkB:
undetectable		 4tvtA-6emkB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TXN_A_URFA302_1
(URIDINE
PHOSPHORYLASE)		 6emk SERINE/THREONINE-PRO
TEIN KINASE TOR2
(Saccharomyces
cerevisiae) 		4 / 7 GLY A1385
GLN A1391
ALA A1383
ILE A1371
 None
 0.82A 4txnA-6emkA:
undetectable		 4txnA-6emkA:
13.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TXN_B_URFB302_1
(URIDINE
PHOSPHORYLASE)		 6emk SERINE/THREONINE-PRO
TEIN KINASE TOR2
(Saccharomyces
cerevisiae) 		4 / 7 GLY A1385
GLN A1391
ALA A1383
ILE A1371
 None
 0.84A 4txnB-6emkA:
undetectable		 4txnB-6emkA:
13.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TXN_C_URFC302_1
(URIDINE
PHOSPHORYLASE)		 6emk SERINE/THREONINE-PRO
TEIN KINASE TOR2
(Saccharomyces
cerevisiae) 		4 / 7 GLY A1385
GLN A1391
ALA A1383
ILE A1371
 None
 0.84A 4txnC-6emkA:
undetectable		 4txnC-6emkA:
13.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TXN_D_URFD302_1
(URIDINE
PHOSPHORYLASE)		 6emk SERINE/THREONINE-PRO
TEIN KINASE TOR2
(Saccharomyces
cerevisiae) 		4 / 7 GLY A1385
GLN A1391
ALA A1383
ILE A1371
 None
 0.83A 4txnD-6emkA:
undetectable		 4txnD-6emkA:
13.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNV_D_QI9D602_0
(CYTOCHROME P450 2D6)		 6emk SERINE/THREONINE-PRO
TEIN KINASE TOR2
(Saccharomyces
cerevisiae) 		4 / 7 PHE A 619
LEU A 618
SER A 629
VAL A 592
 None
 1.01A 4wnvD-6emkA:
undetectable		 4wnvD-6emkA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WQ5_B_ACTB404_0
(TRNA N6-ADENOSINE
THREONYLCARBAMOYLTRA
NSFERASE)		 6emk SERINE/THREONINE-PRO
TEIN KINASE TOR2
(Saccharomyces
cerevisiae) 		3 / 3 TYR A 709
ARG A 715
LYS A 712
 None
 1.36A 4wq5B-6emkA:
undetectable		 4wq5B-6emkA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X3U_B_SVRB102_1
(CHROMOBOX PROTEIN
HOMOLOG 7)		 6emk SERINE/THREONINE-PRO
TEIN KINASE TOR2
(Saccharomyces
cerevisiae) 		3 / 3 LYS A1533
ARG A1545
VAL A1542
 None
 1.06A 4x3uA-6emkA:
undetectable
4x3uB-6emkA:
undetectable		 4x3uA-6emkA:
17.50
4x3uB-6emkA:
17.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X3U_B_SVRB102_1
(CHROMOBOX PROTEIN
HOMOLOG 7)		 6emk SERINE/THREONINE-PRO
TEIN KINASE TOR2
(Saccharomyces
cerevisiae) 		3 / 3 LYS A2430
ARG A2347
VAL A2345
 None
 1.08A 4x3uA-6emkA:
undetectable
4x3uB-6emkA:
undetectable		 4x3uA-6emkA:
17.50
4x3uB-6emkA:
17.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XE0_A_40LA1101_0
(PHOSPHATIDYLINOSITOL
4,5-BISPHOSPHATE
3-KINASE CATALYTIC
SUBUNIT DELTA
ISOFORM)		 6emk SERINE/THREONINE-PRO
TEIN KINASE TOR2
(Saccharomyces
cerevisiae) 		5 / 12 TYR A2164
ASP A2183
THR A2184
MET A2284
ILE A2295
 None
 1.45A 4xe0A-6emkA:
undetectable		 4xe0A-6emkA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XI3_B_29SB601_1
(ESTROGEN RECEPTOR)		 6emk SERINE/THREONINE-PRO
TEIN KINASE TOR2
(Saccharomyces
cerevisiae) 		5 / 12 ALA A1841
ASP A1840
ARG A1883
ILE A1870
GLY A1871
 None
 0.96A 4xi3B-6emkA:
undetectable		 4xi3B-6emkA:
14.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YHA_F_MZMF302_1
(ALPHA-CARBONIC
ANHYDRASE)		 6emk SERINE/THREONINE-PRO
TEIN KINASE TOR2
(Saccharomyces
cerevisiae) 		5 / 10 ASN A2282
HIS A2279
HIS A2464
LEU A2306
ALA A2303
 None
 1.29A 4yhaF-6emkA:
undetectable		 4yhaF-6emkA:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YHA_H_MZMH303_1
(ALPHA-CARBONIC
ANHYDRASE)		 6emk SERINE/THREONINE-PRO
TEIN KINASE TOR2
(Saccharomyces
cerevisiae) 		5 / 10 ASN A2282
HIS A2279
HIS A2464
LEU A2306
ALA A2303
 None
 1.42A 4yhaH-6emkA:
undetectable		 4yhaH-6emkA:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4H_A_IPHA904_0
(PROTEIN ARGONAUTE-2)		 6emk SERINE/THREONINE-PRO
TEIN KINASE TOR2
(Saccharomyces
cerevisiae) 		4 / 5 GLN A2162
PRO A2180
ILE A2288
ASP A2286
 None
 1.50A 4z4hA-6emkA:
undetectable		 4z4hA-6emkA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B2Q_A_ACTA1728_0
(CRISPR-ASSOCIATED
ENDONUCLEASE CAS9)		 6emk SERINE/THREONINE-PRO
TEIN KINASE TOR2
(Saccharomyces
cerevisiae) 		3 / 3 ASN A 227
SER A 230
ARG A 215
 None
 0.86A 5b2qA-6emkA:
undetectable		 5b2qA-6emkA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BPH_D_ACTD406_0
(D-ALANINE--D-ALANINE
LIGASE)		 6emk SERINE/THREONINE-PRO
TEIN KINASE TOR2
(Saccharomyces
cerevisiae) 		4 / 4 LYS A 156
ARG A 171
ASN A 193
GLY A 196
 None
 1.28A 5bphD-6emkA:
undetectable		 5bphD-6emkA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DQF_A_LCRA612_1
(SERUM ALBUMIN)		 6emk SERINE/THREONINE-PRO
TEIN KINASE TOR2
(Saccharomyces
cerevisiae) 		5 / 9 ASP A2299
LEU A2275
GLY A2274
LEU A2273
LEU A2140
 None
 1.07A 5dqfA-6emkA:
undetectable		 5dqfA-6emkA:
7.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E8Q_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 6emk SERINE/THREONINE-PRO
TEIN KINASE TOR2
(Saccharomyces
cerevisiae) 		3 / 3 ASP A 362
LEU A 271
ARG A 279
 None
 0.89A 5e8qA-6emkA:
undetectable		 5e8qA-6emkA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESL_A_1YNA701_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 6emk TARGET OF RAPAMYCIN
COMPLEX 2 SUBUNIT
AVO1
TARGET OF RAPAMYCIN
COMPLEX SUBUNIT LST8
(Saccharomyces
cerevisiae) 		5 / 12 GLY B   9
ILE I 703
GLY I 677
HIS B  30
THR B  13
 None
 1.26A 5eslA-6emkB:
undetectable		 5eslA-6emkB:
9.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I8F_A_ML1A210_1
(PHENOLIC OXIDATIVE
COUPLING PROTEIN)		 6emk SERINE/THREONINE-PRO
TEIN KINASE TOR2
(Saccharomyces
cerevisiae) 		5 / 12 LEU A 242
LEU A 280
VAL A 330
GLY A 287
LYS A 288
 None
 1.34A 5i8fA-6emkA:
undetectable		 5i8fA-6emkA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IWU_A_ERYA404_0
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 6emk SERINE/THREONINE-PRO
TEIN KINASE TOR2
(Saccharomyces
cerevisiae) 		5 / 12 HIS A 946
GLU A1208
ALA A 940
SER A 990
ILE A 991
 None
 1.35A 5iwuA-6emkA:
1.6		 5iwuA-6emkA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JCN_B_ASCB502_0
(OS09G0567300 PROTEIN)		 6emk SERINE/THREONINE-PRO
TEIN KINASE TOR2
(Saccharomyces
cerevisiae) 		4 / 6 GLU A2203
ARG A2193
PHE A2185
ARG A2317
 None
 1.33A 5jcnB-6emkA:
undetectable		 5jcnB-6emkA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JHD_J_EDTJ301_0
(TCRBETA CHAIN)		 6emk SERINE/THREONINE-PRO
TEIN KINASE TOR2
(Saccharomyces
cerevisiae) 		4 / 5 LYS A1029
GLU A1025
GLY A 986
SER A 990
 None
 1.47A 5jhdJ-6emkA:
undetectable		 5jhdJ-6emkA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JS1_A_IPHA901_0
(PROTEIN ARGONAUTE-2)		 6emk SERINE/THREONINE-PRO
TEIN KINASE TOR2
(Saccharomyces
cerevisiae) 		4 / 5 TYR A 254
LYS A 293
LEU A 256
TYR A 259
 None
 1.18A 5js1A-6emkA:
undetectable		 5js1A-6emkA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JWA_H_ACTH612_0
(NADH DEHYDROGENASE,
PUTATIVE)		 6emk SERINE/THREONINE-PRO
TEIN KINASE TOR2
(Saccharomyces
cerevisiae) 		3 / 3 ARG A1545
PRO A 858
ASN A1585
 None
 1.05A 5jwaA-6emkA:
undetectable
5jwaH-6emkA:
undetectable		 5jwaA-6emkA:
undetectable
5jwaH-6emkA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2T_A_6ZZA900_2
(CYCLIN-DEPENDENT
KINASE 6)		 6emk SERINE/THREONINE-PRO
TEIN KINASE TOR2
(Saccharomyces
cerevisiae) 		3 / 3 LYS A2257
GLN A1376
ASN A1374
 None
 0.97A 5l2tA-6emkA:
1.4		 5l2tA-6emkA:
16.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MAF_A_XINA403_2
(MATERNAL EMBRYONIC
LEUCINE ZIPPER
KINASE)		 6emk SERINE/THREONINE-PRO
TEIN KINASE TOR2
(Saccharomyces
cerevisiae) 		4 / 5 LEU A1593
CYH A1616
LEU A1615
ASP A1587
 None
 1.28A 5mafA-6emkA:
undetectable		 5mafA-6emkA:
25.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ODI_A_ACTA701_0
(HETERODISULFIDE
REDUCTASE, SUBUNIT A)		 6emk SERINE/THREONINE-PRO
TEIN KINASE TOR2
(Saccharomyces
cerevisiae) 		3 / 3 LYS A1286
LYS A1278
SER A1282
 None
 1.42A 5odiA-6emkA:
undetectable		 5odiA-6emkA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ODI_A_ACTA701_0
(HETERODISULFIDE
REDUCTASE, SUBUNIT A)		 6emk SERINE/THREONINE-PRO
TEIN KINASE TOR2
(Saccharomyces
cerevisiae) 		3 / 3 LYS A1957
LYS A2060
SER A2065
 None
 1.39A 5odiA-6emkA:
undetectable		 5odiA-6emkA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_A_CUA602_0
(THIOCYANATE
DEHYDROGENASE)		 6emk SERINE/THREONINE-PRO
TEIN KINASE TOR2
(Saccharomyces
cerevisiae) 		3 / 3 LYS A2467
HIS A2464
HIS A2279
 None
 1.27A 5oexA-6emkA:
undetectable		 5oexA-6emkA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_B_CUB602_0
(THIOCYANATE
DEHYDROGENASE)		 6emk SERINE/THREONINE-PRO
TEIN KINASE TOR2
(Saccharomyces
cerevisiae) 		3 / 3 LYS A2467
HIS A2464
HIS A2279
 None
 1.25A 5oexB-6emkA:
undetectable		 5oexB-6emkA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_C_CUC603_0
(THIOCYANATE
DEHYDROGENASE)		 6emk SERINE/THREONINE-PRO
TEIN KINASE TOR2
(Saccharomyces
cerevisiae) 		3 / 3 LYS A2467
HIS A2464
HIS A2279
 None
 1.24A 5oexC-6emkA:
undetectable		 5oexC-6emkA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_D_CUD603_0
(THIOCYANATE
DEHYDROGENASE)		 6emk SERINE/THREONINE-PRO
TEIN KINASE TOR2
(Saccharomyces
cerevisiae) 		3 / 3 LYS A2467
HIS A2464
HIS A2279
 None
 1.26A 5oexD-6emkA:
undetectable		 5oexD-6emkA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OS7_A_ACTA402_0
(CASEIN KINASE II
SUBUNIT ALPHA)		 6emk SERINE/THREONINE-PRO
TEIN KINASE TOR2
(Saccharomyces
cerevisiae) 		3 / 3 HIS A1173
SER A1174
LYS A1170
 None
 0.73A 5os7A-6emkA:
0.4		 5os7A-6emkA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OS7_A_ACTA402_0
(CASEIN KINASE II
SUBUNIT ALPHA)		 6emk SERINE/THREONINE-PRO
TEIN KINASE TOR2
(Saccharomyces
cerevisiae) 		3 / 3 HIS A1828
SER A1829
LYS A1830
 None
 1.38A 5os7A-6emkA:
0.4		 5os7A-6emkA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OSR_A_ACTA401_0
(CASEIN KINASE II
SUBUNIT ALPHA)		 6emk SERINE/THREONINE-PRO
TEIN KINASE TOR2
(Saccharomyces
cerevisiae) 		4 / 5 LYS A2245
ARG A2255
LEU A2285
ASN A2181
 None
 0.97A 5osrA-6emkA:
0.5		 5osrA-6emkA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OTR_A_ACTA401_0
(CASEIN KINASE II
SUBUNIT ALPHA)		 6emk SERINE/THREONINE-PRO
TEIN KINASE TOR2
(Saccharomyces
cerevisiae) 		4 / 5 LYS A2245
ARG A2255
LEU A2285
ASN A2181
 None
 0.84A 5otrA-6emkA:
0.0		 5otrA-6emkA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SYF_B_TA1B502_1
(TUBULIN BETA CHAIN)		 6emk TARGET OF RAPAMYCIN
COMPLEX SUBUNIT LST8
(Saccharomyces
cerevisiae) 		5 / 12 VAL B  55
ASP B  43
ALA B  69
SER B  70
ARG B  61
 None
 1.25A 5syfB-6emkB:
undetectable		 5syfB-6emkB:
12.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VIM_A_SAMA301_1
(METHYLTRANSFERASE)		 6emk SERINE/THREONINE-PRO
TEIN KINASE TOR2
(Saccharomyces
cerevisiae) 		4 / 4 SER A2352
THR A2146
ASP A2160
ASP A2348
 None
 1.46A 5vimA-6emkA:
undetectable		 5vimA-6emkA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VIM_B_SAMB301_1
(METHYLTRANSFERASE)		 6emk SERINE/THREONINE-PRO
TEIN KINASE TOR2
(Saccharomyces
cerevisiae) 		4 / 4 SER A2352
THR A2146
ASP A2160
ASP A2348
 None
 1.49A 5vimB-6emkA:
undetectable		 5vimB-6emkA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDH_A_DAHA60_1
(PUTATIVE CYTOCHROME
C)		 6emk SERINE/THREONINE-PRO
TEIN KINASE TOR2
TARGET OF RAPAMYCIN
COMPLEX SUBUNIT LST8
(Saccharomyces
cerevisiae) 		4 / 6 HIS B 291
VAL B 296
LEU B  38
GLN A2221
 None
 1.46A 5xdhA-6emkB:
undetectable
5xdhC-6emkB:
undetectable		 5xdhA-6emkB:
20.43
5xdhC-6emkB:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7P_C_CHDC401_0
(BILE SALT HYDROLASE)		 6emk SERINE/THREONINE-PRO
TEIN KINASE TOR2
(Saccharomyces
cerevisiae) 		4 / 8 LEU A 680
ILE A 691
LEU A 671
ALA A 672
 None
 0.82A 5y7pC-6emkA:
undetectable		 5y7pC-6emkA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AZ3_1_PAR11802_1
(RRNA ALPHA
RIBOSOMAL PROTEIN
UL4
RIBOSOMAL PROTEIN
UL15
RIBOSOMAL PROTEIN
EL15)		 6emk SERINE/THREONINE-PRO
TEIN KINASE TOR2
(Saccharomyces
cerevisiae) 		3 / 3 ARG A1591
LYS A1553
ARG A1545
 None
 1.41A 6az3C-6emkA:
undetectable
6az3L-6emkA:
undetectable
6az3M-6emkA:
undetectable		 6az3C-6emkA:
18.29
6az3L-6emkA:
21.84
6az3M-6emkA:
16.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6D9H_R_ADNR400_1
(CHIMERA PROTEIN OF
MUSCARINIC
ACETYLCHOLINE
RECEPTOR M4 AND
ADENOSINE RECEPTOR
A1)		 6emk SERINE/THREONINE-PRO
TEIN KINASE TOR2
(Saccharomyces
cerevisiae) 		5 / 10 PHE A 212
GLU A 213
LEU A 286
ASN A 266
ILE A 245
 None
 1.15A 6d9hR-6emkA:
undetectable		 6d9hR-6emkA:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G31_L_ZOLL401_0
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE)		 6emk SERINE/THREONINE-PRO
TEIN KINASE TOR2
TARGET OF RAPAMYCIN
COMPLEX 2 SUBUNIT
AVO1
(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		4 / 6 ASP A2040
ARG I 650
GLN A2037
LYS A2044
 None
 1.35A 6g31L-6emkA:
undetectable		 6g31L-6emkA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GBF_A_ACTA507_0
(MOLYBDOPTERIN
BIOSYNTHESIS PROTEIN
CNX1)		 6emk SERINE/THREONINE-PRO
TEIN KINASE TOR2
(Saccharomyces
cerevisiae) 		3 / 3 LYS A 835
SER A1529
SER A 830
 None
 1.14A 6gbfA-6emkA:
undetectable		 6gbfA-6emkA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GMD_B_ACTB402_0
(CASEIN KINASE II
SUBUNIT ALPHA)		 6emk SERINE/THREONINE-PRO
TEIN KINASE TOR2
(Saccharomyces
cerevisiae) 		3 / 3 HIS A1173
SER A1174
LYS A1170
 None
 0.73A 6gmdB-6emkA:
0.4		 6gmdB-6emkA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GMD_B_ACTB402_0
(CASEIN KINASE II
SUBUNIT ALPHA)		 6emk SERINE/THREONINE-PRO
TEIN KINASE TOR2
(Saccharomyces
cerevisiae) 		3 / 3 HIS A1828
SER A1829
LYS A1830
 None
 1.38A 6gmdB-6emkA:
0.4		 6gmdB-6emkA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_Q_PCFQ202_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 5A,
MITOCHONDRIAL
CYTOCHROME C OXIDASE
SUBUNIT 1)		 6emk SERINE/THREONINE-PRO
TEIN KINASE TOR2
(Saccharomyces
cerevisiae) 		4 / 6 TYR A 257
ILE A 245
ALA A 282
ASP A 265
 None
 1.12A 6hu9m-6emkA:
undetectable
6hu9q-6emkA:
0.0		 6hu9m-6emkA:
undetectable
6hu9q-6emkA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6JNH_A_ASCA202_0
(PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE)		 6emk SERINE/THREONINE-PRO
TEIN KINASE TOR2
(Saccharomyces
cerevisiae) 		3 / 3 ASN A1541
PRO A 858
GLN A1583
 None
 0.90A 6jnhA-6emkA:
undetectable		 6jnhA-6emkA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6JOG_A_ASCA202_0
(PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE)		 6emk SERINE/THREONINE-PRO
TEIN KINASE TOR2
(Saccharomyces
cerevisiae) 		3 / 3 ASN A1541
PRO A 858
GLN A1583
 None
 0.92A 6jogA-6emkA:
undetectable		 6jogA-6emkA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_A_AM2A301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 6emk SERINE/THREONINE-PRO
TEIN KINASE TOR2
TARGET OF RAPAMYCIN
COMPLEX SUBUNIT LST8
TARGET OF RAPAMYCIN
COMPLEX 2 SUBUNIT
AVO1
(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		4 / 8 ASP A2213
HIS B  52
GLU I 717
GLU I 724
 None
 1.13A 6mn4A-6emkA:
undetectable		 6mn4A-6emkA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_D_AM2D301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 6emk SERINE/THREONINE-PRO
TEIN KINASE TOR2
TARGET OF RAPAMYCIN
COMPLEX SUBUNIT LST8
TARGET OF RAPAMYCIN
COMPLEX 2 SUBUNIT
AVO1
(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		4 / 8 ASP A2213
HIS B  52
GLU I 717
GLU I 724
 None
 1.12A 6mn4D-6emkA:
undetectable		 6mn4D-6emkA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMP_C_CHDC307_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 6emk SERINE/THREONINE-PRO
TEIN KINASE TOR2
(Saccharomyces
cerevisiae) 		4 / 6 LYS A2370
PHE A2360
LEU A2275
PHE A2297
 None
 1.34A 6nmpC-6emkA:
undetectable
6nmpJ-6emkA:
undetectable		 6nmpC-6emkA:
undetectable
6nmpJ-6emkA:
undetectable