SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6ems'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QX6_A_ML1A233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 6ems TRNA
(GUANINE(9)-/ADENINE
(9)-N1)-METHYLTRANSF
ERASE
(Thermococcus
kodakarensis) 		4 / 6 PHE A 148
ILE A 119
GLY A 202
GLY A 203
 None
 0.78A 2qx6A-6emsA:
undetectable
2qx6B-6emsA:
undetectable		 2qx6A-6emsA:
15.86
2qx6B-6emsA:
15.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_C_KLNC1498_1
(CYTOCHROME P450 3A4)		 6ems TRNA
(GUANINE(9)-/ADENINE
(9)-N1)-METHYLTRANSF
ERASE
(Thermococcus
kodakarensis) 		5 / 12 SER A 126
LEU A 105
PHE A 148
ILE A 247
GLU A 138
 None
 1.28A 2v0mC-6emsA:
undetectable		 2v0mC-6emsA:
9.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_A_CHDA200_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 6ems TRNA
(GUANINE(9)-/ADENINE
(9)-N1)-METHYLTRANSF
ERASE
(Thermococcus
kodakarensis) 		4 / 5 THR A  55
VAL A  57
GLY A  68
LYS A  54
 None
 1.14A 3elzA-6emsA:
undetectable		 3elzA-6emsA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_B_TFPB202_2
(PROTEIN S100-A4)		 6ems TRNA
(GUANINE(9)-/ADENINE
(9)-N1)-METHYLTRANSF
ERASE
(Thermococcus
kodakarensis) 		4 / 6 LEU A 170
SER A 167
PHE A 169
ILE A 102
 None
 0.98A 3ko0B-6emsA:
undetectable		 3ko0B-6emsA:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LM8_D_VIBD223_1
(THIAMINE
PYROPHOSPHOKINASE)		 6ems TRNA
(GUANINE(9)-/ADENINE
(9)-N1)-METHYLTRANSF
ERASE
(Thermococcus
kodakarensis) 		4 / 8 ASP A  97
HIS A  43
TYR A 100
SER A 137
 None
 0.90A 3lm8B-6emsA:
undetectable
3lm8D-6emsA:
undetectable		 3lm8B-6emsA:
14.88
3lm8D-6emsA:
14.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DUB_A_LDPA501_1
(CYTOCHROME P450 BM3
VARIANT 9D7)		 6ems TRNA
(GUANINE(9)-/ADENINE
(9)-N1)-METHYLTRANSF
ERASE
(Thermococcus
kodakarensis) 		4 / 6 PHE A 148
ALA A 120
GLY A 154
PRO A 155
 None
 0.82A 4dubA-6emsA:
undetectable		 4dubA-6emsA:
8.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKV_B_AERB601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 6ems TRNA
(GUANINE(9)-/ADENINE
(9)-N1)-METHYLTRANSF
ERASE
(Thermococcus
kodakarensis) 		5 / 12 LEU A 130
ALA A 140
ILE A 254
LEU A 251
ALA A 198
 None
 0.79A 4nkvB-6emsA:
undetectable		 4nkvB-6emsA:
9.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PWJ_B_30ZB201_1
(TRANSTHYRETIN)		 6ems TRNA
(GUANINE(9)-/ADENINE
(9)-N1)-METHYLTRANSF
ERASE
(Thermococcus
kodakarensis) 		4 / 7 THR A 142
ALA A 140
SER A 137
THR A 160
 None
 0.98A 4pwjB-6emsA:
undetectable		 4pwjB-6emsA:
24.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_E_CHDE104_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 6ems TRNA
(GUANINE(9)-/ADENINE
(9)-N1)-METHYLTRANSF
ERASE
(Thermococcus
kodakarensis) 		5 / 11 GLU A  14
LYS A  13
LEU A  12
LEU A  61
LEU A  34
 None
 1.01A 4wg0C-6emsA:
undetectable
4wg0D-6emsA:
undetectable
4wg0E-6emsA:
undetectable		 4wg0C-6emsA:
undetectable
4wg0D-6emsA:
undetectable
4wg0E-6emsA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_G_CHDG103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 6ems TRNA
(GUANINE(9)-/ADENINE
(9)-N1)-METHYLTRANSF
ERASE
(Thermococcus
kodakarensis) 		5 / 11 GLU A  14
LYS A  13
LEU A  12
LEU A  61
LEU A  34
 None
 0.97A 4wg0E-6emsA:
undetectable
4wg0F-6emsA:
undetectable
4wg0G-6emsA:
undetectable		 4wg0E-6emsA:
undetectable
4wg0F-6emsA:
undetectable
4wg0G-6emsA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EMU_B_SAMB301_0
(TRNA
(GUANINE(9)-/ADENINE
(9)-N1)-METHYLTRANSF
ERASE)		 6ems TRNA
(GUANINE(9)-/ADENINE
(9)-N1)-METHYLTRANSF
ERASE
(Thermococcus
kodakarensis) 		5 / 12 LEU A 181
ILE A 201
GLY A 202
ILE A 234
ILE A 250
 None
 0.77A 6emuB-6emsA:
25.8		 6emuB-6emsA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EMU_B_SAMB301_0
(TRNA
(GUANINE(9)-/ADENINE
(9)-N1)-METHYLTRANSF
ERASE)		 6ems TRNA
(GUANINE(9)-/ADENINE
(9)-N1)-METHYLTRANSF
ERASE
(Thermococcus
kodakarensis) 		5 / 12 LEU A 181
PRO A 183
GLY A 202
ILE A 234
ILE A 250
 None
 0.75A 6emuB-6emsA:
25.8		 6emuB-6emsA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EMU_B_SAMB301_0
(TRNA
(GUANINE(9)-/ADENINE
(9)-N1)-METHYLTRANSF
ERASE)		 6ems TRNA
(GUANINE(9)-/ADENINE
(9)-N1)-METHYLTRANSF
ERASE
(Thermococcus
kodakarensis) 		5 / 12 LEU A 181
PRO A 183
TRP A 184
ILE A 234
ILE A 250
 None
 0.73A 6emuB-6emsA:
25.8		 6emuB-6emsA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EMU_C_SAMC301_0
(TRNA
(GUANINE(9)-/ADENINE
(9)-N1)-METHYLTRANSF
ERASE)		 6ems TRNA
(GUANINE(9)-/ADENINE
(9)-N1)-METHYLTRANSF
ERASE
(Thermococcus
kodakarensis) 		5 / 12 LEU A 181
ILE A 201
GLY A 202
ILE A 234
ILE A 250
 None
 0.77A 6emuC-6emsA:
7.9		 6emuC-6emsA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EMU_C_SAMC301_0
(TRNA
(GUANINE(9)-/ADENINE
(9)-N1)-METHYLTRANSF
ERASE)		 6ems TRNA
(GUANINE(9)-/ADENINE
(9)-N1)-METHYLTRANSF
ERASE
(Thermococcus
kodakarensis) 		5 / 12 LEU A 181
PRO A 183
GLY A 202
ILE A 234
ILE A 250
 None
 0.77A 6emuC-6emsA:
7.9		 6emuC-6emsA:
undetectable