SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6en4'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BU5_B_RBFB302_1
(PROTEIN (FLAVODOXIN))		 6en4 SPLICING FACTOR 3B
SUBUNIT 3
(Homo
sapiens) 		4 / 8 THR A 420
TRP A 720
ASP A1203
GLY A 441
 None
 0.89A 1bu5B-6en4A:
undetectable		 1bu5B-6en4A:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DZ6_B_CAMB502_0
(CYTOCHROME P450-CAM)		 6en4 SPLICING FACTOR 3B
SUBUNIT 3
(Homo
sapiens) 		4 / 5 PHE A 330
VAL A 341
VAL A 333
ASP A 331
 None
 1.19A 1dz6B-6en4A:
undetectable		 1dz6B-6en4A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FBM_B_RTLB951_0
(PROTEIN (CARTILAGE
OLIGOMERIC MATRIX
PROTEIN))		 6en4 SPLICING FACTOR 3B
SUBUNIT 3
(Homo
sapiens) 		4 / 4 THR A 677
LEU A 665
LEU A 592
GLN A 553
 None
 0.94A 1fbmA-6en4A:
undetectable		 1fbmA-6en4A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FK9_A_EFZA999_1
(HIV-1 RT, A-CHAIN)		 6en4 SPLICING FACTOR 3B
SUBUNIT 3
(Homo
sapiens) 		5 / 10 LEU A 669
VAL A 614
VAL A 588
GLY A 608
LEU A 675
 None
 1.38A 1fk9A-6en4A:
undetectable		 1fk9A-6en4A:
9.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HPK_A_ACAA80_1
(PLASMINOGEN)		 6en4 SPLICING FACTOR 3B
SUBUNIT 3
(Homo
sapiens) 		4 / 6 PRO A1136
ASP A1157
ASN A   5
ASP A1159
 None
 1.44A 1hpkA-6en4A:
undetectable		 1hpkA-6en4A:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I7Q_A_BEZA1501_0
(ANTHRANILATE
SYNTHASE)		 6en4 SPLICING FACTOR 3B
SUBUNIT 3
(Homo
sapiens) 		5 / 11 GLY A  24
THR A  25
LEU A  40
ARG A  42
GLY A  20
 None
 1.23A 1i7qA-6en4A:
undetectable		 1i7qA-6en4A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I9G_A_SAMA301_0
(HYPOTHETICAL PROTEIN
RV2118C)		 6en4 SPLICING FACTOR 3B
SUBUNIT 1
(Homo
sapiens) 		5 / 12 GLY C 991
SER C 992
ALA C 996
LEU C 997
LEU C1024
 None
 0.94A 1i9gA-6en4C:
undetectable		 1i9gA-6en4C:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JKH_A_EFZA999_1
(HIV-1 RT, A-CHAIN
HIV-1 RT, B-CHAIN)		 6en4 SPLICING FACTOR 3B
SUBUNIT 3
(Homo
sapiens) 		5 / 11 LEU A 669
VAL A 614
VAL A 588
GLY A 608
LEU A 675
 None
 1.34A 1jkhA-6en4A:
undetectable
1jkhB-6en4A:
undetectable		 1jkhA-6en4A:
9.89
1jkhB-6en4A:
12.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LHU_A_ESTA301_1
(SEX HORMONE-BINDING
GLOBULIN)		 6en4 SPLICING FACTOR 3B
SUBUNIT 1
SPLICING FACTOR 3B
SUBUNIT 3
SPLICING FACTOR 3B
SUBUNIT 5
(Homo
sapiens) 		5 / 12 GLY A 428
PHE A 353
ASN B  58
LEU C1304
LEU A1084
 None
 1.30A 1lhuA-6en4A:
1.0		 1lhuA-6en4A:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LWF_A_NVPA999_1
(HIV-1 REVERSE
TRANSCRIPTASE)		 6en4 SPLICING FACTOR 3B
SUBUNIT 3
(Homo
sapiens) 		5 / 9 LEU A 669
VAL A 614
VAL A 588
GLY A 608
LEU A 675
 None
 1.48A 1lwfA-6en4A:
undetectable		 1lwfA-6en4A:
10.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SDU_B_MK1B902_1
(PROTEASE RETROPEPSIN)		 6en4 SPLICING FACTOR 3B
SUBUNIT 3
(Homo
sapiens) 		5 / 11 LEU A 906
ILE A 990
GLY A 964
VAL A 959
ILE A 952
 None
 1.03A 1sduA-6en4A:
undetectable		 1sduA-6en4A:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VRT_A_NVPA999_1
(HIV-1 REVERSE
TRANSCRIPTASE)		 6en4 SPLICING FACTOR 3B
SUBUNIT 3
(Homo
sapiens) 		5 / 9 LEU A 669
VAL A 614
VAL A 588
GLY A 608
LEU A 675
 None
 1.44A 1vrtA-6en4A:
undetectable		 1vrtA-6en4A:
9.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WSV_A_THHA3001_0
(AMINOMETHYLTRANSFERA
SE)		 6en4 SPLICING FACTOR 3B
SUBUNIT 3
(Homo
sapiens) 		5 / 12 THR A 761
LEU A 762
ILE A 757
PHE A 478
LEU A 485
 None
 1.27A 1wsvA-6en4A:
undetectable		 1wsvA-6en4A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WSV_B_THHB4001_0
(AMINOMETHYLTRANSFERA
SE)		 6en4 SPLICING FACTOR 3B
SUBUNIT 3
(Homo
sapiens) 		5 / 12 THR A 761
LEU A 762
ILE A 757
PHE A 478
LEU A 485
 None
 1.27A 1wsvB-6en4A:
undetectable		 1wsvB-6en4A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_C_CTXC3_2
(CES1 PROTEIN)		 6en4 SPLICING FACTOR 3B
SUBUNIT 3
(Homo
sapiens) 		4 / 4 LEU A 401
PRO A  45
ILE A  30
LEU A  41
 None
 1.10A 1ya4C-6en4A:
undetectable		 1ya4C-6en4A:
10.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAT_A_FK5A108_1
(FK506 BINDING
PROTEIN)		 6en4 SPLICING FACTOR 3B
SUBUNIT 1
(Homo
sapiens) 		5 / 11 PHE C 724
VAL C 687
ILE C 690
LEU C 707
ILE C 704
 None
 1.30A 1yatA-6en4C:
undetectable		 1yatA-6en4C:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOI_C_FRDC305_2
(POL POLYPROTEIN
PEPTIDE INHIBITOR)		 6en4 SPLICING FACTOR 3B
SUBUNIT 3
(Homo
sapiens) 		4 / 5 LEU A 249
PRO A 239
VAL A 238
ILE A 236
 None
 0.96A 2aoiB-6en4A:
undetectable		 2aoiB-6en4A:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVO_B_MK1B902_1
(POL POLYPROTEIN)		 6en4 SPLICING FACTOR 3B
SUBUNIT 3
(Homo
sapiens) 		5 / 9 LEU A   6
ILE A 412
ILE A1092
VAL A1112
ILE A1110
 None
 0.92A 2avoA-6en4A:
undetectable		 2avoA-6en4A:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXG_A_IBPA2002_1
(SERUM ALBUMIN)		 6en4 SPLICING FACTOR 3B
SUBUNIT 1
(Homo
sapiens) 		4 / 8 ALA C 716
GLU C 722
LEU C 686
VAL C 687
 None
 0.85A 2bxgA-6en4C:
2.8		 2bxgA-6en4C:
9.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BYO_A_LNLA1216_1
(LIPOPROTEIN LPPX)		 6en4 SPLICING FACTOR 3B
SUBUNIT 3
(Homo
sapiens) 		4 / 5 LEU A 679
ILE A 616
LEU A 605
SER A 618
 None
 0.96A 2byoA-6en4A:
undetectable		 2byoA-6en4A:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HYY_C_STIC600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 6en4 SPLICING FACTOR 3B
SUBUNIT 3
(Homo
sapiens) 		4 / 6 LEU A1084
LYS A 787
VAL A 925
ILE A 800
 None
 1.00A 2hyyC-6en4A:
undetectable		 2hyyC-6en4A:
15.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2KCE_A_D16A566_1
(THYMIDYLATE SYNTHASE)		 6en4 SPLICING FACTOR 3B
SUBUNIT 3
(Homo
sapiens) 		5 / 12 SER A 717
GLU A 418
LEU A 423
GLY A 441
ALA A1198
 None
 1.22A 2kceA-6en4A:
undetectable		 2kceA-6en4A:
15.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OAX_C_SNLC3001_1
(MINERALOCORTICOID
RECEPTOR)		 6en4 SPLICING FACTOR 3B
SUBUNIT 1
(Homo
sapiens) 		5 / 12 LEU C1101
ALA C1131
LEU C1172
LEU C1154
THR C1112
 None
 1.48A 2oaxC-6en4C:
undetectable		 2oaxC-6en4C:
17.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V7B_B_BEZB1529_0
(BENZOATE-COENZYME A
LIGASE)		 6en4 SPLICING FACTOR 3B
SUBUNIT 3
(Homo
sapiens) 		5 / 9 ALA A 953
ALA A 950
GLY A 992
ILE A 990
LYS A 787
 None
 1.34A 2v7bB-6en4A:
undetectable		 2v7bB-6en4A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WQ5_A_MIYA1120_1
(PHOSPHOLIPASE A2,
ACIDIC)		 6en4 SPLICING FACTOR 3B
SUBUNIT 3
(Homo
sapiens) 		4 / 7 ALA A 134
GLY A 118
ARG A  63
PHE A 107
 None
 0.87A 2wq5A-6en4A:
undetectable		 2wq5A-6en4A:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_A_HSMA1161_1
(ALLERGEN ARG R 1)		 6en4 SPLICING FACTOR 3B
SUBUNIT 3
(Homo
sapiens) 		4 / 5 VAL A 959
TYR A 970
VAL A 925
SER A 890
 None
 0.87A 2x45A-6en4A:
undetectable		 2x45A-6en4A:
17.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_B_HSMB1161_1
(ALLERGEN ARG R 1)		 6en4 SPLICING FACTOR 3B
SUBUNIT 3
(Homo
sapiens) 		4 / 4 VAL A 959
TYR A 970
VAL A 925
SER A 890
 None
 0.92A 2x45B-6en4A:
undetectable		 2x45B-6en4A:
17.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_C_HSMC1161_1
(ALLERGEN ARG R 1)		 6en4 SPLICING FACTOR 3B
SUBUNIT 3
(Homo
sapiens) 		4 / 5 VAL A 959
TYR A 970
VAL A 925
SER A 890
 None
 0.84A 2x45C-6en4A:
undetectable		 2x45C-6en4A:
17.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YOE_C_FL7C1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 6en4 SPLICING FACTOR 3B
SUBUNIT 1
(Homo
sapiens) 		4 / 8 GLY C1089
ILE C1158
VAL C1114
TYR C1157
 None
 0.88A 2yoeB-6en4C:
2.7
2yoeC-6en4C:
2.7		 2yoeB-6en4C:
14.77
2yoeC-6en4C:
14.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_B_PM6B301_1
(THIOPURINE
S-METHYLTRANSFERASE)		 6en4 SPLICING FACTOR 3B
SUBUNIT 3
(Homo
sapiens) 		4 / 8 GLY A 247
VAL A 238
LEU A 315
PRO A 245
 None
 1.07A 3bgdB-6en4A:
undetectable		 3bgdB-6en4A:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DZY_A_9CRA463_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 6en4 SPLICING FACTOR 3B
SUBUNIT 1
(Homo
sapiens) 		5 / 12 ALA C 672
GLN C 669
LEU C 712
ALA C 711
LEU C 644
 None
 1.03A 3dzyA-6en4C:
undetectable		 3dzyA-6en4C:
10.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_A_CHDA152_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 6en4 SPLICING FACTOR 3B
SUBUNIT 3
(Homo
sapiens) 		3 / 3 VAL A 931
LYS A 936
HIS A 941
 None
 0.93A 3elzA-6en4A:
undetectable		 3elzA-6en4A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HLW_B_CE3B302_2
(CTX-M-9
EXTENDED-SPECTRUM
BETA-LACTAMASE)		 6en4 SPLICING FACTOR 3B
SUBUNIT 1
SPLICING FACTOR 3B
SUBUNIT 3
(Homo
sapiens) 		3 / 3 CYH C 677
PRO C 718
ASP A 147
 None
 0.73A 3hlwB-6en4C:
undetectable		 3hlwB-6en4C:
14.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8Y_A_DIFA701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 6en4 SPLICING FACTOR 3B
SUBUNIT 3
(Homo
sapiens) 		5 / 11 ILE A1053
GLY A1046
ALA A1045
SER A1037
LEU A1039
 None
 0.97A 3n8yA-6en4A:
undetectable		 3n8yA-6en4A:
10.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8Y_B_SALB900_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 6en4 SPLICING FACTOR 3B
SUBUNIT 1
(Homo
sapiens) 		4 / 5 VAL C1128
LEU C1129
ILE C1158
ALA C1117
 None
 0.95A 3n8yB-6en4C:
1.2		 3n8yB-6en4C:
10.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8Z_B_FLPB1701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 6en4 SPLICING FACTOR 3B
SUBUNIT 3
(Homo
sapiens) 		5 / 12 ILE A1053
GLY A1046
ALA A1045
SER A1037
LEU A1039
 None
 1.06A 3n8zB-6en4A:
undetectable		 3n8zB-6en4A:
10.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NT1_A_NPSA5_1
(PROSTAGLANDIN-ENDOPE
ROXIDE SYNTHASE 2)		 6en4 SPLICING FACTOR 3B
SUBUNIT 1
(Homo
sapiens) 		5 / 12 LEU C1098
VAL C1143
GLY C1146
SER C1150
LEU C1151
 None
 1.00A 3nt1A-6en4C:
undetectable		 3nt1A-6en4C:
10.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NT1_B_NPSB4_1
(PROSTAGLANDIN-ENDOPE
ROXIDE SYNTHASE 2)		 6en4 SPLICING FACTOR 3B
SUBUNIT 1
(Homo
sapiens) 		5 / 12 LEU C1098
VAL C1143
GLY C1146
SER C1150
LEU C1151
 None
 0.99A 3nt1B-6en4C:
undetectable		 3nt1B-6en4C:
10.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O1C_A_ADNA127_1
(HISTIDINE TRIAD
NUCLEOTIDE-BINDING
PROTEIN 1)		 6en4 SPLICING FACTOR 3B
SUBUNIT 3
(Homo
sapiens) 		5 / 10 ILE A  78
ILE A  18
ILE A  62
SER A  82
LEU A 121
 None
 0.96A 3o1cA-6en4A:
undetectable		 3o1cA-6en4A:
17.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OGP_B_017B200_1
(FIV PROTEASE)		 6en4 SPLICING FACTOR 3B
SUBUNIT 1
(Homo
sapiens) 		5 / 10 ILE C1036
GLY C 991
ILE C 993
VAL C1001
LEU C1038
 None
 1.04A 3ogpA-6en4C:
undetectable		 3ogpA-6en4C:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUD_B_SUEB1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 6en4 SPLICING FACTOR 3B
SUBUNIT 1
(Homo
sapiens) 		5 / 12 GLN C 794
GLY C 751
ILE C 673
ALA C 713
ALA C 708
 None
 1.08A 3sudB-6en4C:
undetectable		 3sudB-6en4C:
16.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUF_C_SUEC1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 6en4 SPLICING FACTOR 3B
SUBUNIT 3
SPLICING FACTOR 3B
SUBUNIT 5
(Homo
sapiens) 		5 / 11 PHE A 353
ASP B  48
GLY A 354
SER A 405
ALA A  11
 None
 1.14A 3sufC-6en4A:
undetectable		 3sufC-6en4A:
17.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TMZ_A_06XA504_1
(CYTOCHROME P450 2B4)		 6en4 SPLICING FACTOR 3B
SUBUNIT 3
(Homo
sapiens) 		5 / 9 LEU A 408
LEU A1104
ILE A1108
ILE A 412
VAL A 425
 None
 1.04A 3tmzA-6en4A:
undetectable		 3tmzA-6en4A:
11.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W68_B_VIVB301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 6en4 SPLICING FACTOR 3B
SUBUNIT 1
(Homo
sapiens) 		5 / 12 TYR C 864
VAL C 868
ILE C 849
LEU C 840
VAL C 792
 None
 1.08A 3w68B-6en4C:
undetectable		 3w68B-6en4C:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WFA_B_EDTB802_0
(ALPHA-GLUCOSIDASE)		 6en4 SPLICING FACTOR 3B
SUBUNIT 3
(Homo
sapiens) 		4 / 6 ARG A 390
ASN A 394
TYR A 329
LYS A 328
 None
 1.31A 3wfaA-6en4A:
undetectable
3wfaB-6en4A:
undetectable		 3wfaA-6en4A:
undetectable
3wfaB-6en4A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A79_A_P1BA601_1
(AMINE OXIDASE
[FLAVIN-CONTAINING]
B)		 6en4 SPLICING FACTOR 3B
SUBUNIT 3
(Homo
sapiens) 		5 / 12 LEU A1091
CYH A 410
ILE A1108
ILE A1110
TYR A1101
 None
 1.25A 4a79A-6en4A:
undetectable		 4a79A-6en4A:
11.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A79_B_P1BB601_1
(AMINE OXIDASE
[FLAVIN-CONTAINING]
B)		 6en4 SPLICING FACTOR 3B
SUBUNIT 3
(Homo
sapiens) 		5 / 12 LEU A1091
CYH A 410
ILE A1108
ILE A1110
TYR A1101
 None
 1.26A 4a79B-6en4A:
undetectable		 4a79B-6en4A:
11.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ABZ_A_T1CA1209_1
(TETRACYCLINE
REPRESSOR CLASS D)		 6en4 SPLICING FACTOR 3B
SUBUNIT 3
SPLICING FACTOR 3B
SUBUNIT 5
(Homo
sapiens) 		5 / 12 ARG A 429
PRO A 406
THR A1103
LEU B  50
SER A  15
 None
 1.42A 4abzA-6en4A:
undetectable		 4abzA-6en4A:
16.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ABZ_A_T1CA1209_1
(TETRACYCLINE
REPRESSOR CLASS D)		 6en4 SPLICING FACTOR 3B
SUBUNIT 3
SPLICING FACTOR 3B
SUBUNIT 5
(Homo
sapiens) 		5 / 12 HIS A 356
ARG A 429
THR A1103
LEU B  50
SER A  15
 None
 1.31A 4abzA-6en4A:
undetectable		 4abzA-6en4A:
16.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_D_ZMRD1471_1
(NEURAMINIDASE)		 6en4 SPLICING FACTOR 3B
SUBUNIT 3
SPLICING FACTOR 3B
SUBUNIT 5
(Homo
sapiens) 		5 / 12 ARG A 283
GLU B  59
LEU B  50
GLU B  57
ARG A 429
 None
 1.48A 4cpzD-6en4A:
10.5		 4cpzD-6en4A:
10.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GRK_A_KTRA713_1
(LACTOTRANSFERRIN)		 6en4 SPLICING FACTOR 3B
SUBUNIT 3
(Homo
sapiens) 		4 / 5 THR A 538
GLY A 523
VAL A 519
PRO A 521
 None
 1.01A 4grkA-6en4A:
undetectable		 4grkA-6en4A:
12.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JQ4_B_IMNB401_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 6en4 SPLICING FACTOR 3B
SUBUNIT 3
(Homo
sapiens) 		5 / 10 TYR A 723
VAL A 704
ILE A 754
TYR A1201
LEU A 734
 None
 1.38A 4jq4B-6en4A:
undetectable		 4jq4B-6en4A:
12.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N49_A_SAMA601_0
(CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1)		 6en4 SPLICING FACTOR 3B
SUBUNIT 3
(Homo
sapiens) 		5 / 12 GLY A 232
PHE A 234
ASN A 254
ILE A 325
LEU A 327
 None
 0.90A 4n49A-6en4A:
undetectable		 4n49A-6en4A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O8F_B_BRLB501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 6en4 SPLICING FACTOR 3B
SUBUNIT 3
(Homo
sapiens) 		5 / 12 SER A1098
LEU A1039
VAL A1055
MET A1075
LEU A1091
 None
 1.43A 4o8fB-6en4A:
undetectable		 4o8fB-6en4A:
15.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLT_A_GCSA303_1
(CHITOSANASE)		 6en4 SPLICING FACTOR 3B
SUBUNIT 1
(Homo
sapiens) 		4 / 6 ILE C 556
ASP C 557
GLY C 593
VAL C 634
 None
 0.92A 4oltA-6en4C:
undetectable		 4oltA-6en4C:
15.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLT_B_GCSB303_1
(CHITOSANASE)		 6en4 SPLICING FACTOR 3B
SUBUNIT 1
(Homo
sapiens) 		4 / 6 ILE C 556
ASP C 557
GLY C 593
VAL C 634
 None
 0.97A 4oltB-6en4C:
undetectable		 4oltB-6en4C:
15.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OR0_A_NPSA603_1
(SERUM ALBUMIN)		 6en4 SPLICING FACTOR 3B
SUBUNIT 3
(Homo
sapiens) 		5 / 11 LEU A 734
ARG A 718
TRP A 720
LEU A 442
LEU A 713
 None
 1.36A 4or0A-6en4A:
undetectable		 4or0A-6en4A:
10.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PGH_A_SAMA401_0
(CAFFEIC ACID
O-METHYLTRANSFERASE)		 6en4 SPLICING FACTOR 3B
SUBUNIT 1
(Homo
sapiens) 		5 / 11 GLY C 913
GLY C 915
THR C 958
MET C 869
ILE C 896
 None
 1.17A 4pghA-6en4C:
undetectable		 4pghA-6en4C:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PGH_D_SAMD401_0
(CAFFEIC ACID
O-METHYLTRANSFERASE)		 6en4 SPLICING FACTOR 3B
SUBUNIT 1
(Homo
sapiens) 		5 / 12 GLY C 913
GLY C 915
THR C 958
MET C 869
ILE C 896
 None
 1.14A 4pghD-6en4C:
undetectable		 4pghD-6en4C:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PH9_A_IBPA601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 6en4 SPLICING FACTOR 3B
SUBUNIT 3
(Homo
sapiens) 		5 / 10 VAL A  80
LEU A  90
GLY A  35
SER A  33
LEU A  38
 None
 1.12A 4ph9A-6en4A:
undetectable		 4ph9A-6en4A:
9.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PH9_B_IBPB601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 6en4 SPLICING FACTOR 3B
SUBUNIT 3
(Homo
sapiens) 		5 / 10 VAL A  80
LEU A  90
GLY A  35
SER A  33
LEU A  38
 None
 1.10A 4ph9B-6en4A:
undetectable		 4ph9B-6en4A:
9.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PM5_A_CE3A301_2
(BETA-LACTAMASE
CTX-M-14)		 6en4 SPLICING FACTOR 3B
SUBUNIT 1
SPLICING FACTOR 3B
SUBUNIT 3
(Homo
sapiens) 		3 / 3 CYH C 677
PRO C 718
ASP A 147
 None
 0.72A 4pm5A-6en4C:
undetectable		 4pm5A-6en4C:
14.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PO0_A_NPSA601_1
(SERUM ALBUMIN)		 6en4 SPLICING FACTOR 3B
SUBUNIT 1
(Homo
sapiens) 		5 / 12 VAL C1230
LEU C1148
VAL C1215
LEU C1177
ARG C1185
 None
 1.39A 4po0A-6en4C:
undetectable		 4po0A-6en4C:
9.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QB9_D_PARD500_1
(ENHANCED
INTRACELLULAR
SURVIVAL PROTEIN)		 6en4 SPLICING FACTOR 3B
SUBUNIT 3
(Homo
sapiens) 		4 / 8 PHE A 741
SER A 507
SER A 743
ASP A 471
 None
 1.40A 4qb9D-6en4A:
undetectable		 4qb9D-6en4A:
11.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QYQ_A_3CJA607_1
(LACTOPEROXIDASE)		 6en4 SPLICING FACTOR 3B
SUBUNIT 1
(Homo
sapiens) 		3 / 3 GLN C 737
HIS C 738
ARG C 702
 None
 1.03A 4qyqA-6en4C:
undetectable		 4qyqA-6en4C:
10.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QYQ_B_3CJB607_1
(LACTOPEROXIDASE)		 6en4 SPLICING FACTOR 3B
SUBUNIT 1
(Homo
sapiens) 		3 / 3 GLN C 737
HIS C 738
ARG C 702
 None
 0.98A 4qyqB-6en4C:
undetectable		 4qyqB-6en4C:
10.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R21_B_STRB601_1
(CYTOCHROME P450
FAMILY 17
POLYPEPTIDE 2)		 6en4 SPLICING FACTOR 3B
SUBUNIT 1
(Homo
sapiens) 		5 / 9 ALA C 745
ILE C 690
VAL C 687
ALA C 710
VAL C 727
 None
 1.08A 4r21B-6en4C:
undetectable		 4r21B-6en4C:
11.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRW_A_LURA705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 6en4 SPLICING FACTOR 3B
SUBUNIT 1
(Homo
sapiens) 		5 / 12 LEU C1098
VAL C1143
GLY C1146
SER C1150
LEU C1151
 None
 1.02A 4rrwA-6en4C:
1.0		 4rrwA-6en4C:
10.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRW_B_LURB705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 6en4 SPLICING FACTOR 3B
SUBUNIT 1
(Homo
sapiens) 		5 / 12 LEU C1098
VAL C1143
GLY C1146
SER C1150
LEU C1151
 None
 1.02A 4rrwB-6en4C:
undetectable		 4rrwB-6en4C:
10.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRW_C_LURC705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 6en4 SPLICING FACTOR 3B
SUBUNIT 1
(Homo
sapiens) 		5 / 12 LEU C1098
VAL C1143
GLY C1146
SER C1150
LEU C1151
 None
 1.00A 4rrwC-6en4C:
undetectable		 4rrwC-6en4C:
10.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRX_A_LURA706_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 6en4 SPLICING FACTOR 3B
SUBUNIT 1
(Homo
sapiens) 		5 / 12 LEU C1098
VAL C1143
GLY C1146
SER C1150
LEU C1151
 None
 0.98A 4rrxA-6en4C:
undetectable		 4rrxA-6en4C:
10.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRX_B_LURB706_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 6en4 SPLICING FACTOR 3B
SUBUNIT 1
(Homo
sapiens) 		5 / 12 LEU C1098
VAL C1143
GLY C1146
SER C1150
LEU C1151
 None
 0.97A 4rrxB-6en4C:
undetectable		 4rrxB-6en4C:
10.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRZ_A_LURA705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 6en4 SPLICING FACTOR 3B
SUBUNIT 1
(Homo
sapiens) 		5 / 12 LEU C1098
VAL C1143
GLY C1146
SER C1150
LEU C1151
 None
 1.02A 4rrzA-6en4C:
1.0		 4rrzA-6en4C:
10.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRZ_B_LURB705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 6en4 SPLICING FACTOR 3B
SUBUNIT 1
(Homo
sapiens) 		5 / 12 LEU C1098
VAL C1143
GLY C1146
SER C1150
LEU C1151
 None
 1.02A 4rrzB-6en4C:
undetectable		 4rrzB-6en4C:
10.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRZ_C_LURC705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 6en4 SPLICING FACTOR 3B
SUBUNIT 1
(Homo
sapiens) 		5 / 12 LEU C1098
VAL C1143
GLY C1146
SER C1150
LEU C1151
 None
 1.00A 4rrzC-6en4C:
undetectable		 4rrzC-6en4C:
10.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UBS_A_DIFA503_1
(PENTALENIC ACID
SYNTHASE)		 6en4 SPLICING FACTOR 3B
SUBUNIT 3
(Homo
sapiens) 		4 / 7 LEU A 633
ALA A 606
LEU A 609
ILE A 616
 None
 0.70A 4ubsA-6en4A:
undetectable		 4ubsA-6en4A:
13.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UHX_A_LZUA3008_1
(ALDEHYDE OXIDASE)		 6en4 SPLICING FACTOR 3B
SUBUNIT 3
(Homo
sapiens) 		4 / 8 HIS A 730
ASP A1203
ARG A 676
PRO A 733
 None
 1.18A 4uhxA-6en4A:
undetectable		 4uhxA-6en4A:
5.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UHX_A_RTZA3009_1
(ALDEHYDE OXIDASE)		 6en4 SPLICING FACTOR 3B
SUBUNIT 3
(Homo
sapiens) 		4 / 8 HIS A 730
ASP A1203
ARG A 676
PRO A 733
 None
 1.18A 4uhxA-6en4A:
undetectable		 4uhxA-6en4A:
5.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V20_A_ACTA1444_0
(CELLOBIOHYDROLASE)		 6en4 SPLICING FACTOR 3B
SUBUNIT 3
(Homo
sapiens) 		4 / 5 GLY A  13
THR A  12
HIS A 356
GLY A 354
 None
 0.98A 4v20A-6en4A:
undetectable		 4v20A-6en4A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5O_A_IPHA906_0
(PROTEIN ARGONAUTE-2)		 6en4 SPLICING FACTOR 3B
SUBUNIT 3
(Homo
sapiens) 		4 / 5 PHE A  68
PRO A 125
VAL A 123
PHE A 182
 None
 1.20A 4w5oA-6en4A:
undetectable		 4w5oA-6en4A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_B_CHDB102_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 6en4 SPLICING FACTOR 3B
SUBUNIT 1
(Homo
sapiens) 		5 / 11 LEU C1020
ARG C1019
LEU C1016
LEU C1038
TYR C 979
 None
 0.95A 4wg0B-6en4C:
undetectable
4wg0C-6en4C:
undetectable
4wg0D-6en4C:
undetectable		 4wg0B-6en4C:
undetectable
4wg0C-6en4C:
undetectable
4wg0D-6en4C:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_D_CHDD102_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 6en4 SPLICING FACTOR 3B
SUBUNIT 1
(Homo
sapiens) 		5 / 11 LEU C1020
ARG C1019
LEU C1016
LEU C1038
TYR C 979
 None
 0.97A 4wg0D-6en4C:
undetectable
4wg0E-6en4C:
undetectable
4wg0F-6en4C:
undetectable		 4wg0D-6en4C:
undetectable
4wg0E-6en4C:
undetectable
4wg0F-6en4C:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_E_CHDE104_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 6en4 SPLICING FACTOR 3B
SUBUNIT 1
(Homo
sapiens) 		5 / 11 TYR C 979
LEU C1038
LEU C1020
ARG C1019
LEU C1016
 None
 0.99A 4wg0C-6en4C:
undetectable
4wg0D-6en4C:
undetectable
4wg0E-6en4C:
undetectable		 4wg0C-6en4C:
undetectable
4wg0D-6en4C:
undetectable
4wg0E-6en4C:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_G_CHDG103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 6en4 SPLICING FACTOR 3B
SUBUNIT 1
(Homo
sapiens) 		5 / 11 TYR C 979
LEU C1038
LEU C1020
ARG C1019
LEU C1016
 None
 0.99A 4wg0E-6en4C:
undetectable
4wg0F-6en4C:
undetectable
4wg0G-6en4C:
undetectable		 4wg0E-6en4C:
undetectable
4wg0F-6en4C:
undetectable
4wg0G-6en4C:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4C_A_IPHA905_0
(PROTEIN ARGONAUTE-2)		 6en4 SPLICING FACTOR 3B
SUBUNIT 3
(Homo
sapiens) 		4 / 5 PHE A  68
PRO A 125
VAL A 123
PHE A 182
 None
 1.20A 4z4cA-6en4A:
undetectable		 4z4cA-6en4A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4D_A_IPHA904_0
(PROTEIN ARGONAUTE-2)		 6en4 SPLICING FACTOR 3B
SUBUNIT 3
(Homo
sapiens) 		4 / 5 PHE A  68
PRO A 125
VAL A 123
PHE A 182
 None
 1.22A 4z4dA-6en4A:
undetectable		 4z4dA-6en4A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4E_A_IPHA906_0
(PROTEIN ARGONAUTE-2)		 6en4 SPLICING FACTOR 3B
SUBUNIT 3
(Homo
sapiens) 		4 / 5 PHE A  68
PRO A 125
VAL A 123
PHE A 182
 None
 1.20A 4z4eA-6en4A:
undetectable		 4z4eA-6en4A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4I_A_IPHA903_0
(PROTEIN ARGONAUTE-2)		 6en4 SPLICING FACTOR 3B
SUBUNIT 3
(Homo
sapiens) 		3 / 3 VAL A 288
ALA A 303
PHE A 234
 None
 0.80A 4z4iA-6en4A:
undetectable		 4z4iA-6en4A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A7M_A_ACTA1923_0
(BETA-XYLOSIDASE)		 6en4 SPLICING FACTOR 3B
SUBUNIT 3
SPLICING FACTOR 3B
SUBUNIT 1
(Homo
sapiens;
Homo
sapiens) 		3 / 3 ASP C1301
ARG A 918
TYR C1298
 None
 0.90A 5a7mA-6en4C:
2.1		 5a7mA-6en4C:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A7M_B_ACTB1924_0
(BETA-XYLOSIDASE)		 6en4 SPLICING FACTOR 3B
SUBUNIT 3
SPLICING FACTOR 3B
SUBUNIT 1
(Homo
sapiens;
Homo
sapiens) 		3 / 3 ASP C1301
ARG A 918
TYR C1298
 None
 0.89A 5a7mB-6en4C:
undetectable		 5a7mB-6en4C:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ALC_L_TIQL1210_2
(ANTI-TICAGRELOR FAB
72, LIGHT CHAIN)		 6en4 SPLICING FACTOR 3B
SUBUNIT 3
(Homo
sapiens) 		4 / 8 SER A 639
GLY A 668
SER A 696
GLY A 672
 None
 0.84A 5alcL-6en4A:
undetectable		 5alcL-6en4A:
17.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CU6_A_ACTA403_0
(CASEIN KINASE II
SUBUNIT ALPHA)		 6en4 SPLICING FACTOR 3B
SUBUNIT 3
(Homo
sapiens) 		4 / 6 TYR A 926
ILE A 800
VAL A 909
ALA A 888
 None
 0.85A 5cu6A-6en4A:
undetectable		 5cu6A-6en4A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_3_BEZ3801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
BEZ-LEU-LEU)		 6en4 SPLICING FACTOR 3B
SUBUNIT 3
(Homo
sapiens) 		4 / 4 LEU A 563
ILE A 556
GLY A 561
ILE A 544
 None
 0.89A 5dzk3-6en4A:
undetectable
5dzkm-6en4A:
undetectable		 5dzk3-6en4A:
undetectable
5dzkm-6en4A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_Y_BEZY801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 6en4 SPLICING FACTOR 3B
SUBUNIT 3
(Homo
sapiens) 		4 / 5 ILE A 556
GLY A 561
ILE A 544
LEU A 563
 None
 0.93A 5dzkd-6en4A:
undetectable
5dzkk-6en4A:
undetectable
5dzky-6en4A:
undetectable		 5dzkd-6en4A:
undetectable
5dzkk-6en4A:
undetectable
5dzky-6en4A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EB5_A_010A609_0
(HNL ISOENZYME 5)		 6en4 SPLICING FACTOR 3B
SUBUNIT 3
(Homo
sapiens) 		5 / 11 ALA A1025
ALA A1071
VAL A1056
LEU A1058
VAL A1044
 None
 1.09A 5eb5A-6en4A:
undetectable		 5eb5A-6en4A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EML_A_SAMA701_0
(PROTEIN ARGININE
N-METHYLTRANSFERASE
5)		 6en4 SPLICING FACTOR 3B
SUBUNIT 1
(Homo
sapiens) 		5 / 12 PRO C1022
LEU C1024
GLY C 983
LEU C1020
CYH C1035
 None
 1.46A 5emlA-6en4C:
undetectable		 5emlA-6en4C:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FLC_C_RAPC999_1
(SERINE/THREONINE-PRO
TEIN KINASE MTOR
FKBP)		 6en4 SPLICING FACTOR 3B
SUBUNIT 1
(Homo
sapiens) 		4 / 8 PHE C 914
GLY C 913
THR C 935
TYR C 928
 None
 0.91A 5flcB-6en4C:
undetectable		 5flcB-6en4C:
5.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FLC_G_RAPG999_1
(SERINE/THREONINE-PRO
TEIN KINASE MTOR
FKBP)		 6en4 SPLICING FACTOR 3B
SUBUNIT 1
(Homo
sapiens) 		4 / 8 PHE C 914
GLY C 913
THR C 935
TYR C 928
 None
 0.90A 5flcF-6en4C:
undetectable		 5flcF-6en4C:
5.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JS1_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 6en4 SPLICING FACTOR 3B
SUBUNIT 3
(Homo
sapiens) 		3 / 3 VAL A 288
ALA A 303
PHE A 234
 None
 0.78A 5js1A-6en4A:
undetectable		 5js1A-6en4A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JVZ_A_FLPA601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 6en4 SPLICING FACTOR 3B
SUBUNIT 1
(Homo
sapiens) 		5 / 12 LEU C1098
VAL C1143
GLY C1146
SER C1150
LEU C1151
 None
 1.06A 5jvzA-6en4C:
undetectable		 5jvzA-6en4C:
10.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KBW_B_RBFB201_1
(RIBOFLAVIN
TRANSPORTER RIBU)		 6en4 SPLICING FACTOR 3B
SUBUNIT 3
SPLICING FACTOR 3B
SUBUNIT 5
(Homo
sapiens) 		5 / 12 GLU B  59
GLY A 858
ASN A 859
ASN A 885
TYR A 807
 None
 1.33A 5kbwB-6en4B:
undetectable		 5kbwB-6en4B:
18.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KQX_A_ROCA101_2
(PROTEASE E35D-SQV)		 6en4 SPLICING FACTOR 3B
SUBUNIT 3
(Homo
sapiens) 		5 / 9 LEU A   6
VAL A1100
ILE A 412
ILE A1092
ILE A1110
 None
 1.08A 5kqxB-6en4A:
undetectable		 5kqxB-6en4A:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M66_D_ADND502_2
(ADENOSYLHOMOCYSTEINA
SE)		 6en4 SPLICING FACTOR 3B
SUBUNIT 1
(Homo
sapiens) 		3 / 3 THR C 627
THR C 612
LEU C 600
 None
 0.49A 5m66D-6en4C:
undetectable		 5m66D-6en4C:
10.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O4Y_A_CCSA14_0
(PHE-MAA-ASN-PRO-HIS-
LEU-SER-TRP-SER-TRP-
9KK-9KK-ARG-CCS-GLY-
NH2)		 6en4 SPLICING FACTOR 3B
SUBUNIT 3
(Homo
sapiens) 		4 / 6 PHE A  59
LEU A1137
ARG A1140
GLY A1139
 None
 0.98A 5o4yA-6en4A:
undetectable		 5o4yA-6en4A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O4Y_F_CCSF14_0
(PHE-MAA-ASN-PRO-HIS-
LEU-SER-TRP-SER-TRP-
9KK-9KK-ARG-CCS-GLY-
NH2)		 6en4 SPLICING FACTOR 3B
SUBUNIT 3
(Homo
sapiens) 		4 / 6 PHE A  59
LEU A1137
ARG A1140
GLY A1139
 None
 1.08A 5o4yF-6en4A:
undetectable		 5o4yF-6en4A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SYE_B_TA1B502_1
(TUBULIN BETA CHAIN)		 6en4 SPLICING FACTOR 3B
SUBUNIT 3
(Homo
sapiens) 		5 / 12 GLU A 178
VAL A 175
LEU A 158
ASP A 214
GLY A 127
 None
 1.25A 5syeB-6en4A:
undetectable		 5syeB-6en4A:
11.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TUD_A_ERMA2001_2
(5-HYDROXYTRYPTAMINE
RECEPTOR 2B,SOLUBLE
CYTOCHROME B562
CHIMERA)		 6en4 SPLICING FACTOR 3B
SUBUNIT 1
(Homo
sapiens) 		4 / 7 THR C1122
LEU C1066
GLN C1032
GLU C1033
 None
 1.10A 5tudA-6en4C:
undetectable		 5tudA-6en4C:
11.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCY_A_DB8A401_2
(MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE)		 6en4 SPLICING FACTOR 3B
SUBUNIT 3
(Homo
sapiens) 		4 / 4 VAL A1083
LEU A1099
ASN A1052
ASP A1048
 None
 1.16A 5vcyA-6en4A:
undetectable		 5vcyA-6en4A:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X23_A_LSNA502_1
(CYTOCHROME P450 2C9)		 6en4 SPLICING FACTOR 3B
SUBUNIT 1
(Homo
sapiens) 		5 / 12 ASN C 878
GLY C 880
ALA C 881
LEU C 888
LEU C 892
 None
 0.98A 5x23A-6en4C:
undetectable		 5x23A-6en4C:
9.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7P_B_ACRB1471_1
(GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE)		 6en4 SPLICING FACTOR 3B
SUBUNIT 1
SPLICING FACTOR 3B
SUBUNIT 3
(Homo
sapiens) 		5 / 12 ARG A1031
GLY C1242
GLU C1205
TYR C1200
ASN A1154
 None
 1.30A 5x7pB-6en4A:
undetectable		 5x7pB-6en4A:
4.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XXI_A_LSNA501_1
(CYTOCHROME P450 2C9)		 6en4 SPLICING FACTOR 3B
SUBUNIT 1
(Homo
sapiens) 		5 / 12 ASN C 878
GLY C 880
ALA C 881
LEU C 888
LEU C 892
 None
 0.97A 5xxiA-6en4C:
undetectable		 5xxiA-6en4C:
9.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y2T_B_8LXB501_0
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 6en4 SPLICING FACTOR 3B
SUBUNIT 3
(Homo
sapiens) 		5 / 12 PHE A  99
GLN A 104
ILE A 154
TYR A 142
ILE A  78
 None
 0.83A 5y2tB-6en4A:
undetectable		 5y2tB-6en4A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YK2_A_ERYA501_0
(PROBABLE CONSERVED
ATP-BINDING PROTEIN
ABC TRANSPORTER)		 6en4 SPLICING FACTOR 3B
SUBUNIT 3
SPLICING FACTOR 3B
SUBUNIT 5
(Homo
sapiens;
Homo
sapiens) 		5 / 11 GLU B  59
ASP A 803
ALA A 806
ALA A 854
ARG A 429
 None
 1.14A 5yk2A-6en4B:
undetectable		 5yk2A-6en4B:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z6F_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 6en4 SPLICING FACTOR 3B
SUBUNIT 1
(Homo
sapiens) 		5 / 12 ALA C 636
LEU C 648
PHE C 647
THR C 628
ARG C 614
 None
 1.29A 5z6fA-6en4C:
undetectable		 5z6fA-6en4C:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z6J_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 6en4 SPLICING FACTOR 3B
SUBUNIT 3
(Homo
sapiens) 		3 / 3 MET A 285
ASP A 279
ARG A 429
 None
 1.00A 5z6jA-6en4A:
undetectable		 5z6jA-6en4A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z6K_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 6en4 SPLICING FACTOR 3B
SUBUNIT 3
(Homo
sapiens) 		3 / 3 MET A 285
ASP A 279
ARG A 429
 None
 1.12A 5z6kA-6en4A:
undetectable		 5z6kA-6en4A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZW2_A_ACTA511_0
(L-PROLYL-[PEPTIDYL-C
ARRIER PROTEIN]
DEHYDROGENASE)		 6en4 SPLICING FACTOR 3B
SUBUNIT 1
(Homo
sapiens) 		3 / 3 ARG C1238
ILE C1272
SER C1271
 None
 0.72A 5zw2A-6en4C:
undetectable		 5zw2A-6en4C:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZW4_A_SAMA302_0
(PUTATIVE
O-METHYLTRANSFERASE
YRRM)		 6en4 SPLICING FACTOR 3B
SUBUNIT 3
(Homo
sapiens) 		5 / 12 GLU A 947
ALA A 921
ALA A 910
ALA A 887
PHE A 889
 None
 1.04A 5zw4A-6en4A:
undetectable		 5zw4A-6en4A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A4I_A_TRPA403_0
(TRYPTOPHAN
2,3-DIOXYGENASE)		 6en4 SPLICING FACTOR 3B
SUBUNIT 3
(Homo
sapiens) 		4 / 8 GLU A 576
THR A 538
PRO A 539
ILE A 544
 None
 0.64A 6a4iA-6en4A:
undetectable		 6a4iA-6en4A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A4I_A_TRPA403_0
(TRYPTOPHAN
2,3-DIOXYGENASE)		 6en4 SPLICING FACTOR 3B
SUBUNIT 3
SPLICING FACTOR 3B
SUBUNIT 5
(Homo
sapiens;
Homo
sapiens) 		4 / 8 THR A 784
PRO A 785
ILE B  55
PRO A 406
 None
 0.97A 6a4iA-6en4A:
undetectable		 6a4iA-6en4A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A4I_D_TRPD403_0
(TRYPTOPHAN
2,3-DIOXYGENASE)		 6en4 SPLICING FACTOR 3B
SUBUNIT 3
(Homo
sapiens) 		5 / 9 GLU A 576
THR A 538
PRO A 539
ILE A 544
ARG A 580
 None
 0.77A 6a4iD-6en4A:
0.1		 6a4iD-6en4A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B54_A_OAQA302_0
(SULFOTRANSFERASE)		 6en4 SPLICING FACTOR 3B
SUBUNIT 3
(Homo
sapiens) 		5 / 12 ILE A 256
LEU A 249
PHE A 287
THR A 314
LEU A 315
 None
 1.19A 6b54A-6en4A:
undetectable		 6b54A-6en4A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSI_A_EFZA601_1
(REVERSE
TRANSCRIPTASE P66
SUBUNIT)		 6en4 SPLICING FACTOR 3B
SUBUNIT 3
(Homo
sapiens) 		5 / 10 LEU A 669
VAL A 614
VAL A 588
GLY A 608
LEU A 675
 None
 1.41A 6bsiA-6en4A:
undetectable		 6bsiA-6en4A:
16.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSJ_A_EFZA601_1
(REVERSE
TRANSCRIPTASE P66
SUBUNIT)		 6en4 SPLICING FACTOR 3B
SUBUNIT 3
(Homo
sapiens) 		5 / 10 LEU A 669
VAL A 614
VAL A 588
GLY A 608
LEU A 675
 None
 1.46A 6bsjA-6en4A:
undetectable		 6bsjA-6en4A:
16.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C2M_A_SUEA1202_0
(NS3 PROTEASE)		 6en4 SPLICING FACTOR 3B
SUBUNIT 3
(Homo
sapiens) 		5 / 12 GLN A  28
HIS A  19
GLY A  20
VAL A  32
ALA A 291
 None
 1.07A 6c2mA-6en4A:
undetectable		 6c2mA-6en4A:
26.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EKZ_A_SNPA413_0
(AROMATIC
PEROXYGENASE)		 6en4 SPLICING FACTOR 3B
SUBUNIT 1
(Homo
sapiens) 		4 / 7 ASP C 953
SER C 992
GLY C 991
VAL C1031
 None
 0.95A 6ekzA-6en4C:
undetectable		 6ekzA-6en4C:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6J_A_ACTA404_0
(L-LYSINE
3-HYDROXYLASE)		 6en4 SPLICING FACTOR 3B
SUBUNIT 1
(Homo
sapiens) 		4 / 6 ILE C 596
LEU C 581
VAL C 553
ARG C 549
 None
 1.16A 6f6jA-6en4C:
undetectable		 6f6jA-6en4C:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA810_0
(GEPHYRIN)		 6en4 SPLICING FACTOR 3B
SUBUNIT 3
(Homo
sapiens) 		3 / 3 LEU A 438
LEU A 404
ARG A 436
 None
 0.63A 6fgdA-6en4A:
undetectable		 6fgdA-6en4A:
undetectable