SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6en9'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DRF_A_FOLA187_0
(DIHYDROFOLATE
REDUCTASE)		 6en9 HYDROGENASE-2 SMALL
CHAIN
(Escherichia
coli) 		5 / 12 LEU S 177
ARG S 189
PHE S 185
ILE S 151
PRO S 152
 None
 1.10A 1drfA-6en9S:
undetectable		 1drfA-6en9S:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FM6_U_9CRU502_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 6en9 HYDROGENASE-2 SMALL
CHAIN
(Escherichia
coli) 		5 / 12 ALA S 127
ALA S 129
VAL S  80
ILE S 117
CYH S  25
 None
None
None
None
SF4  S 303 (-2.2A)
 1.00A 1fm6U-6en9S:
undetectable		 1fm6U-6en9S:
16.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MXD_A_ACRA732_1
(ALPHA AMYLASE)		 6en9 HYDROGENASE-2 SMALL
CHAIN
(Escherichia
coli) 		5 / 9 GLY S 218
PRO S 254
GLY S 252
GLY S 211
ASP S 212
 None
 1.18A 1mxdA-6en9S:
undetectable		 1mxdA-6en9S:
9.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MXD_A_ACRA732_1
(ALPHA AMYLASE)		 6en9 HYDROGENASE-2 SMALL
CHAIN
(Escherichia
coli) 		5 / 9 GLY S 257
PRO S 152
GLY S 153
GLY S 125
GLY S 124
 F3S  S 302 (-4.4A)
None
None
None
None
 1.05A 1mxdA-6en9S:
undetectable		 1mxdA-6en9S:
9.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MXG_A_ACRA442_1
(ALPHA AMYLASE)		 6en9 HYDROGENASE-2 SMALL
CHAIN
(Escherichia
coli) 		5 / 11 GLY S 257
PRO S 152
GLY S 153
GLY S 125
GLY S 124
 F3S  S 302 (-4.4A)
None
None
None
None
 1.08A 1mxgA-6en9S:
undetectable		 1mxgA-6en9S:
9.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_H_BEZH515_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 6en9 HYDROGENASE-2 SMALL
CHAIN
(Escherichia
coli) 		4 / 6 PHE S 185
ALA S 163
ILE S 149
PRO S 175
 None
 1.17A 1oniH-6en9S:
undetectable
1oniI-6en9S:
undetectable		 1oniH-6en9S:
undetectable
1oniI-6en9S:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO7_A_CHDA501_0
(FERROCHELATASE,
MITOCHONDRIAL)		 6en9 HYDROGENASE-2 SMALL
CHAIN
(Escherichia
coli) 		5 / 12 LEU S 162
ILE S 169
LEU S  53
VAL S  52
VAL S  14
 None
 1.22A 2po7A-6en9S:
undetectable		 2po7A-6en9S:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VUF_B_FUAB2002_1
(SERUM ALBUMIN)		 6en9 HYDROGENASE-2 SMALL
CHAIN
(Escherichia
coli) 		4 / 9 ILE S 191
ALA S 250
VAL S 249
CYH S 226
 None
None
SF4  S 301 ( 4.9A)
SF4  S 301 (-2.3A)
 1.03A 2vufB-6en9S:
undetectable		 2vufB-6en9S:
9.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BA0_A_HAEA477_1
(MACROPHAGE
METALLOELASTASE)		 6en9 HYDROGENASE-2 SMALL
CHAIN
(Escherichia
coli) 		3 / 3 HIS S 194
GLU S 193
HIS S 192
 None
None
SF4  S 301 (-3.1A)
 0.83A 3ba0A-6en9S:
undetectable		 3ba0A-6en9S:
14.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_C_CHDC151_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 6en9 HYDROGENASE-2 SMALL
CHAIN
(Escherichia
coli) 		5 / 10 ILE S 104
ILE S  84
VAL S 137
GLY S 124
VAL S 148
 None
 1.04A 3elzC-6en9S:
undetectable		 3elzC-6en9S:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NMU_F_SAMF228_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE
NOP5/NOP56 RELATED
PROTEIN)		 6en9 HYDROGENASE-2 SMALL
CHAIN
(Escherichia
coli) 		5 / 12 GLU S  70
TYR S  72
GLY S 110
ALA S 112
GLN S  75
 None
 1.10A 3nmuA-6en9S:
undetectable
3nmuF-6en9S:
undetectable		 3nmuA-6en9S:
undetectable
3nmuF-6en9S:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L4C_B_CAMB502_0
(CAMPHOR
5-MONOOXYGENASE)		 6en9 HYDROGENASE-2 SMALL
CHAIN
(Escherichia
coli) 		4 / 8 PHE S 161
LEU S  47
VAL S  14
ILE S 115
 None
 0.94A 4l4cB-6en9S:
undetectable		 4l4cB-6en9S:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMB_A_SREA603_1
(TRANSPORTER)		 6en9 HYDROGENASE-2 SMALL
CHAIN
(Escherichia
coli) 		5 / 9 VAL S 126
ALA S 127
GLY S 153
SER S 121
GLY S 124
 None
 1.34A 4mmbA-6en9S:
undetectable		 4mmbA-6en9S:
10.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MME_A_29QA603_1
(TRANSPORTER)		 6en9 HYDROGENASE-2 SMALL
CHAIN
(Escherichia
coli) 		5 / 9 VAL S 126
ALA S 127
GLY S 153
SER S 121
GLY S 124
 None
 1.41A 4mmeA-6en9S:
undetectable		 4mmeA-6en9S:
10.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MME_A_29QA603_1
(TRANSPORTER)		 6en9 HYDROGENASE-2 SMALL
CHAIN
(Escherichia
coli) 		5 / 9 VAL S 126
ALA S 128
GLY S 153
SER S 121
GLY S 124
 None
 1.39A 4mmeA-6en9S:
undetectable		 4mmeA-6en9S:
10.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMF_B_29QB603_1
(TRANSPORTER)		 6en9 HYDROGENASE-2 SMALL
CHAIN
(Escherichia
coli) 		5 / 9 VAL S 126
ALA S 127
GLY S 153
SER S 121
GLY S 124
 None
 1.37A 4mmfB-6en9S:
undetectable		 4mmfB-6en9S:
9.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMF_B_29QB603_1
(TRANSPORTER)		 6en9 HYDROGENASE-2 SMALL
CHAIN
(Escherichia
coli) 		5 / 9 VAL S 126
ALA S 128
GLY S 153
SER S 121
GLY S 124
 None
 1.39A 4mmfB-6en9S:
undetectable		 4mmfB-6en9S:
9.65