SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6eno'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BRP_A_RTLA183_0
(RETINOL BINDING
PROTEIN)
6eno DEHYDRATASE FAMILY
PROTEIN

(Carboxydothermus
hydrogenoformans)
5 / 12 PHE A 131
GLY A  92
PHE A  74
LEU A 239
GLN A 238
None
1.21A 1brpA-6enoA:
undetectable
1brpA-6enoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_C_BEZC505_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)
6eno DEHYDRATASE FAMILY
PROTEIN

(Carboxydothermus
hydrogenoformans)
4 / 6 ILE A 207
PRO A 245
GLU A  80
PHE A 248
None
1.49A 1oniA-6enoA:
undetectable
1oniC-6enoA:
undetectable
1oniA-6enoA:
undetectable
1oniC-6enoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S9A_B_BEZB307_0
(CHLOROCATECHOL
1,2-DIOXYGENASE)
6eno DEHYDRATASE FAMILY
PROTEIN

(Carboxydothermus
hydrogenoformans)
5 / 12 LEU A 217
ILE A 309
GLY A 310
HIS A 292
GLN A 284
None
1.22A 1s9aB-6enoA:
undetectable
1s9aB-6enoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXM_A_IMNA2002_1
(SERUM ALBUMIN)
6eno DEHYDRATASE FAMILY
PROTEIN

(Carboxydothermus
hydrogenoformans)
5 / 11 LEU A 239
ILE A  52
LEU A  21
ARG A  56
GLY A  54
None
GOL  A 503 ( 4.4A)
None
None
None
1.35A 2bxmA-6enoA:
undetectable
2bxmA-6enoA:
10.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G70_A_SAMA2001_1
(PHENYLETHANOLAMINE
N-METHYLTRANSFERASE)
6eno DEHYDRATASE FAMILY
PROTEIN

(Carboxydothermus
hydrogenoformans)
4 / 7 GLY A 348
THR A 347
ASP A 352
ASN A 339
None
0.87A 2g70A-6enoA:
undetectable
2g70A-6enoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G70_B_SAMB2002_1
(PHENYLETHANOLAMINE
N-METHYLTRANSFERASE)
6eno DEHYDRATASE FAMILY
PROTEIN

(Carboxydothermus
hydrogenoformans)
4 / 7 GLY A 348
THR A 347
ASP A 352
ASN A 339
None
0.88A 2g70B-6enoA:
undetectable
2g70B-6enoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PKK_A_2FAA501_1
(ADENOSINE KINASE)
6eno DEHYDRATASE FAMILY
PROTEIN

(Carboxydothermus
hydrogenoformans)
5 / 12 ASP A  51
GLY A  54
ASN A   3
GLY A   0
ASP A   2
None
None
CIT  A 502 (-3.8A)
CIT  A 502 (-3.1A)
None
1.03A 2pkkA-6enoA:
3.0
2pkkA-6enoA:
12.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD4_A_CHDA803_0
(FERROCHELATASE)
6eno DEHYDRATASE FAMILY
PROTEIN

(Carboxydothermus
hydrogenoformans)
4 / 5 LEU A 108
PRO A 109
LEU A 112
ILE A 116
None
0.87A 2qd4A-6enoA:
3.3
2qd4A-6enoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NXU_B_RITB600_2
(CYTOCHROME P450 3A4)
6eno DEHYDRATASE FAMILY
PROTEIN

(Carboxydothermus
hydrogenoformans)
5 / 9 ARG A 334
ILE A 207
LEU A 200
GLU A 319
GLY A 326
None
None
None
GOL  A 504 (-2.4A)
None
1.33A 3nxuB-6enoA:
undetectable
3nxuB-6enoA:
8.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PS9_A_SAMA670_1
(TRNA
5-METHYLAMINOMETHYL-
2-THIOURIDINE
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
MNMC)
6eno DEHYDRATASE FAMILY
PROTEIN

(Carboxydothermus
hydrogenoformans)
4 / 6 TYR A 376
GLY A 281
THR A 282
GLU A 306
BJ8  A 501 (-4.8A)
None
BJ8  A 501 (-3.9A)
None
0.80A 3ps9A-6enoA:
undetectable
3ps9A-6enoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UBO_A_ADNA353_1
(ADENOSINE KINASE)
6eno DEHYDRATASE FAMILY
PROTEIN

(Carboxydothermus
hydrogenoformans)
5 / 12 ILE A  55
ASP A  51
GLY A  54
GLY A   0
ASP A   2
None
None
None
CIT  A 502 (-3.1A)
None
0.98A 3uboA-6enoA:
undetectable
3uboA-6enoA:
15.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UBO_B_ADNB353_1
(ADENOSINE KINASE)
6eno DEHYDRATASE FAMILY
PROTEIN

(Carboxydothermus
hydrogenoformans)
5 / 12 ILE A  55
ASP A  51
GLY A  54
ASN A   3
ASP A   2
None
None
None
CIT  A 502 (-3.8A)
None
1.07A 3uboB-6enoA:
undetectable
3uboB-6enoA:
15.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CEV_B_GAIB408_0
(PROTEIN (ARGINASE))
6eno DEHYDRATASE FAMILY
PROTEIN

(Carboxydothermus
hydrogenoformans)
4 / 5 ARG A  38
HIS A 229
GLU A 296
ASP A 232
None
1.28A 4cevB-6enoA:
2.9
4cevC-6enoA:
2.8
4cevB-6enoA:
undetectable
4cevC-6enoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CEV_F_GAIF412_0
(PROTEIN (ARGINASE))
6eno DEHYDRATASE FAMILY
PROTEIN

(Carboxydothermus
hydrogenoformans)
4 / 5 ASP A 232
ARG A  38
HIS A 229
GLU A 296
None
1.26A 4cevD-6enoA:
undetectable
4cevF-6enoA:
undetectable
4cevD-6enoA:
undetectable
4cevF-6enoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E3A_A_ADNA500_1
(SUGAR KINASE PROTEIN)
6eno DEHYDRATASE FAMILY
PROTEIN

(Carboxydothermus
hydrogenoformans)
5 / 12 ILE A  55
ASP A  51
GLY A  54
ASN A   3
ASP A   2
None
None
None
CIT  A 502 (-3.8A)
None
1.06A 4e3aA-6enoA:
undetectable
4e3aA-6enoA:
14.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E3A_B_ADNB500_1
(SUGAR KINASE PROTEIN)
6eno DEHYDRATASE FAMILY
PROTEIN

(Carboxydothermus
hydrogenoformans)
6 / 12 ILE A  55
ASP A  51
GLY A  54
ASN A   3
GLY A   0
ASP A   2
None
None
None
CIT  A 502 (-3.8A)
CIT  A 502 (-3.1A)
None
1.10A 4e3aB-6enoA:
undetectable
4e3aB-6enoA:
14.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EIL_A_FOLA703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)
6eno DEHYDRATASE FAMILY
PROTEIN

(Carboxydothermus
hydrogenoformans)
5 / 11 VAL A  70
ALA A  72
PHE A 242
VAL A 133
THR A  73
None
None
GOL  A 503 (-4.0A)
None
None
1.45A 4eilA-6enoA:
undetectable
4eilA-6enoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EIL_B_FOLB703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)
6eno DEHYDRATASE FAMILY
PROTEIN

(Carboxydothermus
hydrogenoformans)
5 / 10 VAL A  70
ALA A  72
PHE A 242
VAL A 133
THR A  73
None
None
GOL  A 503 (-4.0A)
None
None
1.45A 4eilB-6enoA:
undetectable
4eilB-6enoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EIL_C_FOLC703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)
6eno DEHYDRATASE FAMILY
PROTEIN

(Carboxydothermus
hydrogenoformans)
5 / 11 VAL A  70
ALA A  72
PHE A 242
VAL A 133
THR A  73
None
None
GOL  A 503 (-4.0A)
None
None
1.45A 4eilC-6enoA:
undetectable
4eilC-6enoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EIL_D_FOLD703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)
6eno DEHYDRATASE FAMILY
PROTEIN

(Carboxydothermus
hydrogenoformans)
5 / 10 VAL A  70
ALA A  72
PHE A 242
VAL A 133
THR A  73
None
None
GOL  A 503 (-4.0A)
None
None
1.45A 4eilD-6enoA:
undetectable
4eilD-6enoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJW_A_SRYA2001_2
(TRANSCRIPTIONAL
REGULATOR TCAR)
6eno DEHYDRATASE FAMILY
PROTEIN

(Carboxydothermus
hydrogenoformans)
4 / 6 GLU A  80
ILE A  83
ASN A  84
GLU A  66
None
0.86A 4ejwB-6enoA:
undetectable
4ejwB-6enoA:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJW_A_SRYA2001_2
(TRANSCRIPTIONAL
REGULATOR TCAR)
6eno DEHYDRATASE FAMILY
PROTEIN

(Carboxydothermus
hydrogenoformans)
4 / 6 GLU A  80
ILE A  83
ASN A  84
VAL A 133
None
1.03A 4ejwB-6enoA:
undetectable
4ejwB-6enoA:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F4D_B_CHDB504_0
(FERROCHELATASE,
MITOCHONDRIAL)
6eno DEHYDRATASE FAMILY
PROTEIN

(Carboxydothermus
hydrogenoformans)
4 / 4 LEU A 108
PRO A 109
LEU A 112
ILE A 116
None
0.99A 4f4dB-6enoA:
2.4
4f4dB-6enoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JKU_B_ADNB500_1
(PROBABLE SUGAR
KINASE PROTEIN)
6eno DEHYDRATASE FAMILY
PROTEIN

(Carboxydothermus
hydrogenoformans)
5 / 12 ILE A  55
ASP A  51
GLY A  54
ASN A   3
ASP A   2
None
None
None
CIT  A 502 (-3.8A)
None
1.09A 4jkuB-6enoA:
undetectable
4jkuB-6enoA:
14.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K8P_A_ADNA401_1
(SUGAR KINASE)
6eno DEHYDRATASE FAMILY
PROTEIN

(Carboxydothermus
hydrogenoformans)
5 / 12 ILE A  55
ASP A  51
GLY A  54
ASN A   3
ASP A   2
None
None
None
CIT  A 502 (-3.8A)
None
1.07A 4k8pA-6enoA:
undetectable
4k8pA-6enoA:
14.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K8P_B_ADNB401_1
(SUGAR KINASE)
6eno DEHYDRATASE FAMILY
PROTEIN

(Carboxydothermus
hydrogenoformans)
5 / 12 ILE A  55
ASP A  51
GLY A  54
ASN A   3
ASP A   2
None
None
None
CIT  A 502 (-3.8A)
None
1.08A 4k8pB-6enoA:
undetectable
4k8pB-6enoA:
14.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K8T_A_ADNA401_1
(SUGAR KINASE)
6eno DEHYDRATASE FAMILY
PROTEIN

(Carboxydothermus
hydrogenoformans)
5 / 12 ILE A  55
ASP A  51
GLY A  54
ASN A   3
ASP A   2
None
None
None
CIT  A 502 (-3.8A)
None
1.06A 4k8tA-6enoA:
undetectable
4k8tA-6enoA:
14.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K8T_B_ADNB401_1
(SUGAR KINASE)
6eno DEHYDRATASE FAMILY
PROTEIN

(Carboxydothermus
hydrogenoformans)
5 / 12 ILE A  55
ASP A  51
GLY A  54
ASN A   3
ASP A   2
None
None
None
CIT  A 502 (-3.8A)
None
1.08A 4k8tB-6enoA:
undetectable
4k8tB-6enoA:
14.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K93_A_ADNA401_1
(SUGAR KINASE)
6eno DEHYDRATASE FAMILY
PROTEIN

(Carboxydothermus
hydrogenoformans)
5 / 12 ILE A  55
ASP A  51
GLY A  54
ASN A   3
ASP A   2
None
None
None
CIT  A 502 (-3.8A)
None
1.07A 4k93A-6enoA:
undetectable
4k93A-6enoA:
14.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K93_B_ADNB402_1
(SUGAR KINASE)
6eno DEHYDRATASE FAMILY
PROTEIN

(Carboxydothermus
hydrogenoformans)
5 / 12 ILE A  55
ASP A  51
GLY A  54
ASN A   3
ASP A   2
None
None
None
CIT  A 502 (-3.8A)
None
1.07A 4k93B-6enoA:
undetectable
4k93B-6enoA:
14.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K9C_A_ADNA401_1
(SUGAR KINASE)
6eno DEHYDRATASE FAMILY
PROTEIN

(Carboxydothermus
hydrogenoformans)
5 / 12 ILE A  55
ASP A  51
GLY A  54
ASN A   3
ASP A   2
None
None
None
CIT  A 502 (-3.8A)
None
1.06A 4k9cA-6enoA:
undetectable
4k9cA-6enoA:
14.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K9C_B_ADNB401_1
(SUGAR KINASE)
6eno DEHYDRATASE FAMILY
PROTEIN

(Carboxydothermus
hydrogenoformans)
5 / 12 ILE A  55
ASP A  51
GLY A  54
ASN A   3
ASP A   2
None
None
None
CIT  A 502 (-3.8A)
None
1.07A 4k9cB-6enoA:
undetectable
4k9cB-6enoA:
14.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K9I_A_ADNA401_1
(SUGAR KINASE)
6eno DEHYDRATASE FAMILY
PROTEIN

(Carboxydothermus
hydrogenoformans)
5 / 12 ILE A  55
ASP A  51
GLY A  54
ASN A   3
ASP A   2
None
None
None
CIT  A 502 (-3.8A)
None
1.06A 4k9iA-6enoA:
undetectable
4k9iA-6enoA:
14.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K9I_B_ADNB401_1
(SUGAR KINASE)
6eno DEHYDRATASE FAMILY
PROTEIN

(Carboxydothermus
hydrogenoformans)
5 / 12 ILE A  55
ASP A  51
GLY A  54
ASN A   3
ASP A   2
None
None
None
CIT  A 502 (-3.8A)
None
1.07A 4k9iB-6enoA:
undetectable
4k9iB-6enoA:
14.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KAD_A_ADNA401_1
(PROBABLE SUGAR
KINASE PROTEIN)
6eno DEHYDRATASE FAMILY
PROTEIN

(Carboxydothermus
hydrogenoformans)
5 / 12 ILE A  55
ASP A  51
GLY A  54
ASN A   3
ASP A   2
None
None
None
CIT  A 502 (-3.8A)
None
1.08A 4kadA-6enoA:
undetectable
4kadA-6enoA:
14.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KAD_B_ADNB401_1
(PROBABLE SUGAR
KINASE PROTEIN)
6eno DEHYDRATASE FAMILY
PROTEIN

(Carboxydothermus
hydrogenoformans)
5 / 12 ILE A  55
ASP A  51
GLY A  54
ASN A   3
ASP A   2
None
None
None
CIT  A 502 (-3.8A)
None
1.08A 4kadB-6enoA:
undetectable
4kadB-6enoA:
14.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_D_FOLD703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)
6eno DEHYDRATASE FAMILY
PROTEIN

(Carboxydothermus
hydrogenoformans)
5 / 12 VAL A  70
ALA A  72
PHE A 242
VAL A 133
THR A  73
None
None
GOL  A 503 (-4.0A)
None
None
1.46A 4kyaD-6enoA:
undetectable
4kyaD-6enoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_F_FOLF703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)
6eno DEHYDRATASE FAMILY
PROTEIN

(Carboxydothermus
hydrogenoformans)
5 / 12 VAL A  70
ALA A  72
PHE A 242
VAL A 133
THR A  73
None
None
GOL  A 503 (-4.0A)
None
None
1.47A 4kyaF-6enoA:
undetectable
4kyaF-6enoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LBX_A_ADNA401_1
(PROBABLE SUGAR
KINASE PROTEIN)
6eno DEHYDRATASE FAMILY
PROTEIN

(Carboxydothermus
hydrogenoformans)
5 / 12 ILE A  55
ASP A  51
GLY A  54
ASN A   3
ASP A   2
None
None
None
CIT  A 502 (-3.8A)
None
1.07A 4lbxA-6enoA:
undetectable
4lbxA-6enoA:
14.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LBX_B_ADNB401_1
(PROBABLE SUGAR
KINASE PROTEIN)
6eno DEHYDRATASE FAMILY
PROTEIN

(Carboxydothermus
hydrogenoformans)
5 / 12 ILE A  55
ASP A  51
GLY A  54
ASN A   3
ASP A   2
None
None
None
CIT  A 502 (-3.8A)
None
1.08A 4lbxB-6enoA:
undetectable
4lbxB-6enoA:
14.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LC4_A_ADNA401_1
(PROBABLE SUGAR
KINASE PROTEIN)
6eno DEHYDRATASE FAMILY
PROTEIN

(Carboxydothermus
hydrogenoformans)
5 / 12 ILE A  55
ASP A  51
GLY A  54
ASN A   3
ASP A   2
None
None
None
CIT  A 502 (-3.8A)
None
1.07A 4lc4A-6enoA:
undetectable
4lc4A-6enoA:
14.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LC4_B_ADNB401_1
(PROBABLE SUGAR
KINASE PROTEIN)
6eno DEHYDRATASE FAMILY
PROTEIN

(Carboxydothermus
hydrogenoformans)
5 / 12 ILE A  55
ASP A  51
GLY A  54
ASN A   3
ASP A   2
None
None
None
CIT  A 502 (-3.8A)
None
1.08A 4lc4B-6enoA:
undetectable
4lc4B-6enoA:
14.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QD3_A_5AEA201_1
(PEPTIDYL-TRNA
HYDROLASE)
6eno DEHYDRATASE FAMILY
PROTEIN

(Carboxydothermus
hydrogenoformans)
5 / 9 HIS A  17
GLY A  54
HIS A  53
VAL A  12
LEU A  14
None
None
GOL  A 503 (-3.9A)
None
None
1.18A 4qd3A-6enoA:
undetectable
4qd3A-6enoA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RZV_A_032A801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)
6eno DEHYDRATASE FAMILY
PROTEIN

(Carboxydothermus
hydrogenoformans)
4 / 5 ILE A 157
VAL A 137
PHE A 241
CYH A 128
None
None
None
GOL  A 503 (-3.0A)
1.38A 4rzvA-6enoA:
undetectable
4rzvA-6enoA:
13.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4S0V_A_SUVA2001_2
(HUMAN OREXIN
RECEPTOR TYPE 2
FUSION PROTEIN TO P.
ABYSII GLYCOGEN
SYNTHASE)
6eno DEHYDRATASE FAMILY
PROTEIN

(Carboxydothermus
hydrogenoformans)
4 / 5 ILE A 309
PRO A 285
TYR A  28
VAL A  49
None
1.23A 4s0vA-6enoA:
3.8
4s0vA-6enoA:
10.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_F_377F401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)
6eno DEHYDRATASE FAMILY
PROTEIN

(Carboxydothermus
hydrogenoformans)
4 / 7 GLU A  81
GLU A  80
TYR A 313
LEU A 214
None
1.19A 4twdF-6enoA:
undetectable
4twdJ-6enoA:
undetectable
4twdF-6enoA:
11.40
4twdJ-6enoA:
11.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UBS_A_DIFA502_1
(PENTALENIC ACID
SYNTHASE)
6eno DEHYDRATASE FAMILY
PROTEIN

(Carboxydothermus
hydrogenoformans)
5 / 9 ARG A 221
VAL A 302
LEU A 214
THR A 307
ILE A 309
None
1.31A 4ubsA-6enoA:
undetectable
4ubsA-6enoA:
9.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V20_A_ACTA1444_0
(CELLOBIOHYDROLASE)
6eno DEHYDRATASE FAMILY
PROTEIN

(Carboxydothermus
hydrogenoformans)
4 / 5 GLY A 281
THR A 282
HIS A 367
GLY A 377
None
BJ8  A 501 (-3.9A)
None
None
0.99A 4v20A-6enoA:
undetectable
4v20A-6enoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_L_CHDL103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)
6eno DEHYDRATASE FAMILY
PROTEIN

(Carboxydothermus
hydrogenoformans)
4 / 7 ASN A   3
LEU A   6
LEU A  10
GLU A  59
CIT  A 502 (-3.8A)
None
None
None
0.73A 4wg0L-6enoA:
undetectable
4wg0M-6enoA:
undetectable
4wg0L-6enoA:
undetectable
4wg0M-6enoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YHA_B_MZMB303_1
(ALPHA-CARBONIC
ANHYDRASE)
6eno DEHYDRATASE FAMILY
PROTEIN

(Carboxydothermus
hydrogenoformans)
5 / 10 ASP A   2
HIS A  17
HIS A  53
VAL A  57
LEU A  10
None
None
GOL  A 503 (-3.9A)
None
None
1.44A 4yhaB-6enoA:
undetectable
4yhaB-6enoA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZJO_D_ERYD1101_0
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)
6eno DEHYDRATASE FAMILY
PROTEIN

(Carboxydothermus
hydrogenoformans)
5 / 11 TYR A 376
ALA A 240
GLU A 311
THR A 282
GLY A 281
BJ8  A 501 (-4.8A)
None
None
BJ8  A 501 (-3.9A)
None
1.43A 4zjoD-6enoA:
undetectable
4zjoD-6enoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_B_ADNB501_2
(ADENOSYLHOMOCYSTEINA
SE)
6eno DEHYDRATASE FAMILY
PROTEIN

(Carboxydothermus
hydrogenoformans)
4 / 5 GLU A 140
THR A 141
GLU A 179
LEU A 336
None
1.20A 5hm8B-6enoA:
undetectable
5hm8B-6enoA:
11.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_C_ADNC501_2
(ADENOSYLHOMOCYSTEINA
SE)
6eno DEHYDRATASE FAMILY
PROTEIN

(Carboxydothermus
hydrogenoformans)
4 / 5 GLU A 140
THR A 141
GLU A 179
LEU A 336
None
1.20A 5hm8C-6enoA:
undetectable
5hm8C-6enoA:
11.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_E_ADNE501_2
(ADENOSYLHOMOCYSTEINA
SE)
6eno DEHYDRATASE FAMILY
PROTEIN

(Carboxydothermus
hydrogenoformans)
4 / 5 GLU A 140
THR A 141
GLU A 179
LEU A 336
None
1.20A 5hm8E-6enoA:
undetectable
5hm8E-6enoA:
11.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_F_ADNF501_2
(ADENOSYLHOMOCYSTEINA
SE)
6eno DEHYDRATASE FAMILY
PROTEIN

(Carboxydothermus
hydrogenoformans)
4 / 5 GLU A 140
THR A 141
GLU A 179
LEU A 336
None
1.20A 5hm8F-6enoA:
undetectable
5hm8F-6enoA:
11.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_H_ADNH501_2
(ADENOSYLHOMOCYSTEINA
SE)
6eno DEHYDRATASE FAMILY
PROTEIN

(Carboxydothermus
hydrogenoformans)
4 / 5 GLU A 140
THR A 141
GLU A 179
LEU A 336
None
1.20A 5hm8H-6enoA:
undetectable
5hm8H-6enoA:
11.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JCN_B_ASCB502_0
(OS09G0567300 PROTEIN)
6eno DEHYDRATASE FAMILY
PROTEIN

(Carboxydothermus
hydrogenoformans)
4 / 6 GLU A 305
GLY A 304
ARG A 221
PHE A 314
None
1.40A 5jcnB-6enoA:
2.4
5jcnB-6enoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NN8_A_ACRA1015_1
(LYSOSOMAL
ALPHA-GLUCOSIDASE)
6eno DEHYDRATASE FAMILY
PROTEIN

(Carboxydothermus
hydrogenoformans)
5 / 12 ASP A  46
LEU A 217
ILE A 228
ASP A 232
ARG A  38
None
1.42A 5nn8A-6enoA:
undetectable
5nn8A-6enoA:
6.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NN8_A_ACRA1015_1
(LYSOSOMAL
ALPHA-GLUCOSIDASE)
6eno DEHYDRATASE FAMILY
PROTEIN

(Carboxydothermus
hydrogenoformans)
5 / 12 ASP A  46
LEU A 259
ILE A 228
ASP A 232
ARG A  38
None
1.31A 5nn8A-6enoA:
undetectable
5nn8A-6enoA:
6.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SYJ_A_NIZA809_1
(CATALASE-PEROXIDASE)
6eno DEHYDRATASE FAMILY
PROTEIN

(Carboxydothermus
hydrogenoformans)
4 / 8 VAL A 133
GLY A  92
LEU A  93
THR A  73
None
None
GOL  A 503 ( 4.4A)
None
1.07A 5syjA-6enoA:
undetectable
5syjA-6enoA:
10.00