SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6enz'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DMA_B_NCAB700_0
(EXOTOXIN A)		 6enz ACIDIC AMINO ACID
DECARBOXYLASE GADL1
(Mus
musculus) 		4 / 6 HIS A 303
GLY A 301
ALA A 269
GLU A 270
 None
 0.99A 1dmaB-6enzA:
undetectable		 1dmaB-6enzA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N13_B_AG2B7011_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN)		 6enz ACIDIC AMINO ACID
DECARBOXYLASE GADL1
(Mus
musculus) 		4 / 5 GLU A 137
LEU A 141
ASP A 154
LEU A 334
 None
 1.02A 1n13B-6enzA:
undetectable
1n13C-6enzA:
undetectable		 1n13B-6enzA:
21.62
1n13C-6enzA:
27.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QCA_A_FUAA221_1
(TYPE III
CHLORAMPHENICOL
ACETYLTRANSFERASE)		 6enz ACIDIC AMINO ACID
DECARBOXYLASE GADL1
(Mus
musculus) 		4 / 7 THR A 419
PHE A 394
PHE A 262
LEU A 316
 None
 0.98A 1qcaA-6enzA:
undetectable		 1qcaA-6enzA:
16.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QHY_A_CLMA888_0
(CHLORAMPHENICOL
PHOSPHOTRANSFERASE)		 6enz ACIDIC AMINO ACID
DECARBOXYLASE GADL1
(Mus
musculus) 		4 / 6 PRO A 230
ALA A 269
GLU A 273
GLU A 270
 None
 1.47A 1qhyA-6enzA:
undetectable		 1qhyA-6enzA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M7R_A_VDXA425_1
(VITAMIN D3 RECEPTOR)		 6enz ACIDIC AMINO ACID
DECARBOXYLASE GADL1
(Mus
musculus) 		5 / 12 LEU A 102
SER A 323
SER A 162
SER A 202
GLN A 101
 PLP  A 601 (-3.6A)
PLP  A 601 ( 4.8A)
PLP  A 601 (-2.5A)
PLP  A 601 ( 3.9A)
None
 1.24A 3m7rA-6enzA:
undetectable		 3m7rA-6enzA:
15.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A7T_A_5FWA1000_1
(SUPEROXIDE DISMUTASE
[CU-ZN])		 6enz ACIDIC AMINO ACID
DECARBOXYLASE GADL1
(Mus
musculus) 		4 / 6 GLU A 146
LYS A 142
LYS A 151
GLU A 152
 None
 1.34A 4a7tA-6enzA:
undetectable		 4a7tA-6enzA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A7U_A_ALEA1001_1
(SUPEROXIDE DISMUTASE
[CU-ZN])		 6enz ACIDIC AMINO ACID
DECARBOXYLASE GADL1
(Mus
musculus) 		4 / 6 GLU A 146
LYS A 142
LYS A 151
GLU A 152
 None
 1.22A 4a7uA-6enzA:
undetectable		 4a7uA-6enzA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AC9_C_DXCC1477_0
(MJ0495-LIKE PROTEIN)		 6enz ACIDIC AMINO ACID
DECARBOXYLASE GADL1
(Mus
musculus) 		4 / 6 THR A  93
GLY A 105
ARG A 475
ILE A 479
 None
 1.02A 4ac9C-6enzA:
3.3		 4ac9C-6enzA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACA_C_DXCC1477_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 6enz ACIDIC AMINO ACID
DECARBOXYLASE GADL1
(Mus
musculus) 		4 / 6 THR A  93
GLY A 105
ARG A 475
ILE A 479
 None
 1.03A 4acaC-6enzA:
undetectable		 4acaC-6enzA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I13_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 6enz ACIDIC AMINO ACID
DECARBOXYLASE GADL1
(Mus
musculus) 		3 / 3 ASP A 107
ARG A 392
THR A 377
 None
 0.81A 4i13A-6enzA:
undetectable		 4i13A-6enzA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KF9_A_ACTA407_0
(GLUTATHIONE
S-TRANSFERASE
PROTEIN)		 6enz ACIDIC AMINO ACID
DECARBOXYLASE GADL1
(Mus
musculus) 		3 / 3 GLU A 198
ARG A 468
HIS A 467
 None
 0.73A 4kf9A-6enzA:
undetectable		 4kf9A-6enzA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KRH_B_SAMB900_1
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
2)		 6enz ACIDIC AMINO ACID
DECARBOXYLASE GADL1
(Mus
musculus) 		4 / 4 ILE A 124
SER A 123
ASP A 357
ASP A 349
 None
 1.42A 4krhB-6enzA:
3.1		 4krhB-6enzA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P3R_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 6enz ACIDIC AMINO ACID
DECARBOXYLASE GADL1
(Mus
musculus) 		3 / 3 ASP A 107
ARG A 392
THR A 377
 None
 0.79A 4p3rA-6enzA:
undetectable		 4p3rA-6enzA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QD3_A_5AEA201_1
(PEPTIDYL-TRNA
HYDROLASE)		 6enz ACIDIC AMINO ACID
DECARBOXYLASE GADL1
(Mus
musculus) 		5 / 9 LEU A 316
GLY A 287
VAL A 291
SER A 292
VAL A 390
 None
 1.10A 4qd3A-6enzA:
undetectable		 4qd3A-6enzA:
14.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WOZ_F_MN9F401_0
(N-ACETYLNEURAMINATE
LYASE)		 6enz ACIDIC AMINO ACID
DECARBOXYLASE GADL1
(Mus
musculus) 		4 / 5 LEU A 492
ASP A 493
TYR A 399
LEU A 400
 None
 1.24A 4wozF-6enzA:
undetectable
4wozH-6enzA:
undetectable		 4wozF-6enzA:
undetectable
4wozH-6enzA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1K_D_LOCD502_1
(TUBULIN ALPHA CHAIN
TUBULIN BETA CHAIN)		 6enz ACIDIC AMINO ACID
DECARBOXYLASE GADL1
(Mus
musculus) 		4 / 4 ASN A 165
SER A 323
ALA A 309
VAL A 308
 PLP  A 601 ( 4.5A)
PLP  A 601 ( 4.8A)
None
None
 0.97A 4x1kC-6enzA:
undetectable		 4x1kC-6enzA:
10.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XT8_A_TMQA302_1
(RV2671)		 6enz ACIDIC AMINO ACID
DECARBOXYLASE GADL1
(Mus
musculus) 		5 / 12 ILE A 479
SER A 480
GLY A 105
ALA A 104
PHE A  99
 None
 1.13A 4xt8A-6enzA:
undetectable		 4xt8A-6enzA:
15.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YV5_A_SVRA205_2
(BASIC PHOSPHOLIPASE
A2 HOMOLOG 2)		 6enz ACIDIC AMINO ACID
DECARBOXYLASE GADL1
(Mus
musculus) 		4 / 6 PHE A 372
LEU A 120
ASN A 121
PRO A 122
 None
 1.26A 4yv5B-6enzA:
undetectable		 4yv5B-6enzA:
17.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GWZ_D_010D6_0
(N-[(5-METHYLISOXAZOL
-3-YL)CARBONYL]ALANY
L-L-VALYL-N~1~-((1R,
2Z)-4-(BENZYLOXY)-4-
OXO-1-{[(3R)-2-OXOPY
RROLIDIN-3-YL]METHYL
}BUT-2-ENYL)-L-LEUCI
NAMIDE
PEDV MAIN PROTEASE)		 6enz ACIDIC AMINO ACID
DECARBOXYLASE GADL1
(Mus
musculus) 		3 / 3 MET A 203
HIS A 280
GLY A 161
 None
None
PLP  A 601 (-3.7A)
 0.73A 5gwzB-6enzA:
undetectable		 5gwzB-6enzA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IY5_P_CHDP307_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 6enz ACIDIC AMINO ACID
DECARBOXYLASE GADL1
(Mus
musculus) 		4 / 5 LEU A 491
PHE A 490
LEU A 462
PHE A 474
 None
 1.23A 5iy5P-6enzA:
undetectable
5iy5W-6enzA:
undetectable		 5iy5P-6enzA:
undetectable
5iy5W-6enzA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JHD_E_EDTE301_0
(BETA-2-MICROGLOBULIN
TCRBETA CHAIN)		 6enz ACIDIC AMINO ACID
DECARBOXYLASE GADL1
(Mus
musculus) 		4 / 8 TYR A 125
SER A 366
ARG A 368
PRO A 369
 None
 1.12A 5jhdE-6enzA:
undetectable
5jhdG-6enzA:
undetectable		 5jhdE-6enzA:
undetectable
5jhdG-6enzA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L8D_B_ACTB601_0
(NICKEL-BINDING
PERIPLASMIC PROTEIN)		 6enz ACIDIC AMINO ACID
DECARBOXYLASE GADL1
(Mus
musculus) 		3 / 3 THR A  46
PRO A  96
ASP A 487
 None
 0.64A 5l8dB-6enzA:
undetectable		 5l8dB-6enzA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MWU_B_ACTB601_0
(NICKEL-BINDING
PERIPLASMIC PROTEIN)		 6enz ACIDIC AMINO ACID
DECARBOXYLASE GADL1
(Mus
musculus) 		3 / 3 THR A  46
PRO A  96
ASP A 487
 None
 0.64A 5mwuB-6enzA:
undetectable		 5mwuB-6enzA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NM5_B_LOCB502_1
(TUBULIN ALPHA-1B
CHAIN
TUBULIN BETA-2B
CHAIN)		 6enz ACIDIC AMINO ACID
DECARBOXYLASE GADL1
(Mus
musculus) 		4 / 4 ASN A 165
SER A 323
ALA A 309
VAL A 308
 PLP  A 601 ( 4.5A)
PLP  A 601 ( 4.8A)
None
None
 1.09A 5nm5A-6enzA:
3.2		 5nm5A-6enzA:
10.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TUI_B_CTCB405_0
(TETRACYCLINE
DESTRUCTASE TET(50))		 6enz ACIDIC AMINO ACID
DECARBOXYLASE GADL1
(Mus
musculus) 		5 / 12 VAL A 446
LEU A 413
PRO A 427
GLY A 409
ILE A 404
 None
 1.25A 5tuiB-6enzA:
undetectable		 5tuiB-6enzA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXC_A_ZITA307_1
(PREDICTED
AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		 6enz ACIDIC AMINO ACID
DECARBOXYLASE GADL1
(Mus
musculus) 		4 / 5 PRO A 122
GLU A 118
ARG A 114
THR A 117
 None
 1.48A 5uxcA-6enzA:
undetectable		 5uxcA-6enzA:
11.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X6Y_A_SAMA902_0
(MRNA CAPPING ENZYME
P5)		 6enz ACIDIC AMINO ACID
DECARBOXYLASE GADL1
(Mus
musculus) 		5 / 12 LEU A 290
GLY A 255
ALA A 289
GLU A 198
THR A 253
 None
None
None
None
PLP  A 601 ( 4.1A)
 1.24A 5x6yA-6enzA:
undetectable		 5x6yA-6enzA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X6Y_C_SAMC902_0
(MRNA CAPPING ENZYME
P5)		 6enz ACIDIC AMINO ACID
DECARBOXYLASE GADL1
(Mus
musculus) 		5 / 12 LEU A 290
GLY A 255
ALA A 289
GLU A 198
THR A 253
 None
None
None
None
PLP  A 601 ( 4.1A)
 1.29A 5x6yC-6enzA:
undetectable		 5x6yC-6enzA:
undetectable