SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6eot'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J3J_A_CP6A609_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 6eot DIPEPTIDYL PEPTIDASE
8
(Homo
sapiens) 		5 / 10 ILE A 393
ALA A 381
PHE A 453
ILE A 464
ILE A 404
 None
 1.19A 1j3jA-6eotA:
undetectable		 1j3jA-6eotA:
13.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JLF_A_NVPA999_1
(HIV-1 RT A-CHAIN
HIV-1 RT B-CHAIN)		 6eot DIPEPTIDYL PEPTIDASE
8
(Homo
sapiens) 		4 / 8 LEU A 880
VAL A 665
GLY A 750
TRP A 754
 None
 1.06A 1jlfA-6eotA:
undetectable
1jlfB-6eotA:
undetectable		 1jlfA-6eotA:
9.61
1jlfB-6eotA:
11.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MXD_A_ACRA732_1
(ALPHA AMYLASE)		 6eot DIPEPTIDYL PEPTIDASE
8
(Homo
sapiens) 		5 / 9 PRO A 799
GLU A 793
GLY A 797
GLY A 790
ASP A 788
 None
 1.17A 1mxdA-6eotA:
undetectable		 1mxdA-6eotA:
11.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S3Z_B_RIOB501_0
(AMINOGLYCOSIDE
6'-N-ACETYLTRANSFERA
SE)		 6eot DIPEPTIDYL PEPTIDASE
8
(Homo
sapiens) 		4 / 8 GLU A 863
VAL A 869
ARG A 158
GLU A 153
 None
 1.17A 1s3zA-6eotA:
undetectable
1s3zB-6eotA:
1.8		 1s3zA-6eotA:
undetectable
1s3zB-6eotA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X70_A_715A801_1
(DIPEPTIDYL PEPTIDASE
IV)		 6eot DIPEPTIDYL PEPTIDASE
8
(Homo
sapiens) 		10 / 12 ARG A 160
GLU A 275
GLU A 276
TYR A 669
VAL A 781
TYR A 787
TYR A 791
ASN A 835
VAL A 836
HIS A 865
 None
 0.63A 1x70A-6eotA:
undetectable		 1x70A-6eotA:
7.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X70_B_715B801_1
(DIPEPTIDYL PEPTIDASE
IV)		 6eot DIPEPTIDYL PEPTIDASE
8
(Homo
sapiens) 		10 / 12 ARG A 160
GLU A 275
GLU A 276
SER A 755
VAL A 781
TYR A 787
TYR A 791
ASN A 835
VAL A 836
HIS A 865
 None
 0.62A 1x70B-6eotA:
undetectable		 1x70B-6eotA:
7.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Y7I_A_SALA501_1
(SALICYLIC
ACID-BINDING PROTEIN
2)		 6eot DIPEPTIDYL PEPTIDASE
8
(Homo
sapiens) 		5 / 9 GLY A 758
ALA A 777
SER A 761
LEU A 762
LEU A 825
 None
 1.35A 1y7iA-6eotA:
10.7		 1y7iA-6eotA:
11.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA3_B_STRB2001_1
(MINERALOCORTICOID
RECEPTOR)		 6eot DIPEPTIDYL PEPTIDASE
8
(Homo
sapiens) 		5 / 12 LEU A 406
MET A 345
LEU A 364
LEU A 302
THR A 384
 None
 1.40A 1ya3B-6eotA:
undetectable		 1ya3B-6eotA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZEA_A_DHIA6_0
(MONOCLONAL
ANTI-CHOLERA TOXIN
IGG1 KAPPA ANTIBODY,
H CHAIN
MONOCLONAL
ANTI-CHOLERA TOXIN
IGG1 KAPPA ANTIBODY,
L CHAIN
SHORT SYNTHETIC
D-AMINO ACID PEPTIDE
D2)		 6eot DIPEPTIDYL PEPTIDASE
8
(Homo
sapiens) 		3 / 3 TRP A 237
ARG A 215
PHE A 230
 None
 0.86A 1zeaH-6eotA:
undetectable
1zeaL-6eotA:
undetectable		 1zeaH-6eotA:
undetectable
1zeaL-6eotA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BL9_A_CP6A1240_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 6eot DIPEPTIDYL PEPTIDASE
8
(Homo
sapiens) 		5 / 12 ILE A 393
ALA A 381
PHE A 453
ILE A 464
ILE A 404
 None
 1.17A 2bl9A-6eotA:
undetectable		 2bl9A-6eotA:
14.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BLA_A_CP6A302_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 6eot DIPEPTIDYL PEPTIDASE
8
(Homo
sapiens) 		5 / 11 ILE A 393
ALA A 381
PHE A 453
ILE A 464
ILE A 404
 None
 1.20A 2blaA-6eotA:
undetectable		 2blaA-6eotA:
15.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_F_SAMF301_1
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 6eot DIPEPTIDYL PEPTIDASE
8
(Homo
sapiens) 		3 / 3 LYS A 685
ASP A 703
CYH A 708
 None
 1.44A 2br4F-6eotA:
undetectable		 2br4F-6eotA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IGT_A_SAMA1001_1
(SAM DEPENDENT
METHYLTRANSFERASE)		 6eot DIPEPTIDYL PEPTIDASE
8
(Homo
sapiens) 		3 / 3 ASP A 170
ASP A  82
ASP A 217
 None
 0.66A 2igtA-6eotA:
undetectable		 2igtA-6eotA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OAX_A_SNLA1001_1
(MINERALOCORTICOID
RECEPTOR)		 6eot DIPEPTIDYL PEPTIDASE
8
(Homo
sapiens) 		5 / 12 LEU A 406
MET A 345
LEU A 364
LEU A 302
THR A 384
 None
 1.39A 2oaxA-6eotA:
undetectable		 2oaxA-6eotA:
15.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OAX_B_SNLB2001_1
(MINERALOCORTICOID
RECEPTOR)		 6eot DIPEPTIDYL PEPTIDASE
8
(Homo
sapiens) 		5 / 12 LEU A 406
MET A 345
LEU A 364
LEU A 302
THR A 384
 None
 1.35A 2oaxB-6eotA:
undetectable		 2oaxB-6eotA:
15.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OAX_C_SNLC3001_1
(MINERALOCORTICOID
RECEPTOR)		 6eot DIPEPTIDYL PEPTIDASE
8
(Homo
sapiens) 		5 / 12 LEU A 406
MET A 345
LEU A 364
LEU A 302
THR A 384
 None
 1.38A 2oaxC-6eotA:
undetectable		 2oaxC-6eotA:
15.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PGF_A_ADNA501_1
(ADENOSINE DEAMINASE)		 6eot DIPEPTIDYL PEPTIDASE
8
(Homo
sapiens) 		5 / 12 ASP A 278
ASP A 451
GLY A 523
GLU A 520
HIS A 709
 None
 1.42A 2pgfA-6eotA:
undetectable		 2pgfA-6eotA:
13.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RCT_A_RTLA140_1
(RETINOL-BINDING
PROTEIN II, CELLULAR)		 6eot DIPEPTIDYL PEPTIDASE
8
(Homo
sapiens) 		3 / 3 GLN A 181
THR A 209
TRP A 237
 None
 1.09A 2rctA-6eotA:
undetectable		 2rctA-6eotA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RGU_A_356A901_1
(DIPEPTIDYL PEPTIDASE
4)		 6eot DIPEPTIDYL PEPTIDASE
8
(Homo
sapiens) 		10 / 12 GLU A 275
GLU A 276
TYR A 669
SER A 755
TYR A 756
VAL A 781
TYR A 787
TYR A 791
VAL A 836
HIS A 865
 None
 0.56A 2rguA-6eotA:
30.1		 2rguA-6eotA:
8.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RGU_A_356A901_1
(DIPEPTIDYL PEPTIDASE
4)		 6eot DIPEPTIDYL PEPTIDASE
8
(Homo
sapiens) 		6 / 12 GLU A 275
TYR A 669
SER A 755
VAL A 781
TYR A 787
VAL A 836
 None
 1.19A 2rguA-6eotA:
30.1		 2rguA-6eotA:
8.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RGU_A_356A901_1
(DIPEPTIDYL PEPTIDASE
4)		 6eot DIPEPTIDYL PEPTIDASE
8
(Homo
sapiens) 		5 / 12 SER A 755
TYR A 759
TYR A 787
VAL A 836
HIS A 865
 None
 1.09A 2rguA-6eotA:
30.1		 2rguA-6eotA:
8.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RGU_B_356B902_1
(DIPEPTIDYL PEPTIDASE
4)		 6eot DIPEPTIDYL PEPTIDASE
8
(Homo
sapiens) 		10 / 11 GLU A 275
GLU A 276
TYR A 669
SER A 755
TYR A 756
VAL A 781
TYR A 787
TYR A 791
VAL A 836
HIS A 865
 None
 0.54A 2rguB-6eotA:
4.8		 2rguB-6eotA:
8.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RGU_B_356B902_1
(DIPEPTIDYL PEPTIDASE
4)		 6eot DIPEPTIDYL PEPTIDASE
8
(Homo
sapiens) 		6 / 11 GLU A 275
TYR A 669
SER A 755
VAL A 781
TYR A 787
VAL A 836
 None
 1.18A 2rguB-6eotA:
4.8		 2rguB-6eotA:
8.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RGU_B_356B902_1
(DIPEPTIDYL PEPTIDASE
4)		 6eot DIPEPTIDYL PEPTIDASE
8
(Homo
sapiens) 		5 / 11 SER A 755
TYR A 759
TYR A 787
VAL A 836
HIS A 865
 None
 1.12A 2rguB-6eotA:
4.8		 2rguB-6eotA:
8.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_C_HSMC1162_1
(ALLERGEN ARG R 1)		 6eot DIPEPTIDYL PEPTIDASE
8
(Homo
sapiens) 		3 / 3 GLU A 376
HIS A 798
GLU A 793
 None
 0.88A 2x45C-6eotA:
undetectable		 2x45C-6eotA:
17.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJM_A_BJMA1_1
(DIPEPTIDYL PEPTIDASE
4)		 6eot DIPEPTIDYL PEPTIDASE
8
(Homo
sapiens) 		12 / 12 ARG A 160
GLU A 275
GLU A 276
TYR A 669
SER A 755
TYR A 756
VAL A 781
TYR A 787
TYR A 791
ASN A 835
VAL A 836
HIS A 865
 None
 0.69A 3bjmA-6eotA:
29.3		 3bjmA-6eotA:
7.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJM_A_BJMA1_1
(DIPEPTIDYL PEPTIDASE
4)		 6eot DIPEPTIDYL PEPTIDASE
8
(Homo
sapiens) 		6 / 12 GLU A 275
TYR A 669
SER A 755
VAL A 781
TYR A 787
VAL A 836
 None
 1.11A 3bjmA-6eotA:
29.3		 3bjmA-6eotA:
7.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJM_A_BJMA1_1
(DIPEPTIDYL PEPTIDASE
4)		 6eot DIPEPTIDYL PEPTIDASE
8
(Homo
sapiens) 		6 / 12 SER A 755
TYR A 759
TYR A 787
ASN A 835
VAL A 836
HIS A 865
 None
 1.17A 3bjmA-6eotA:
29.3		 3bjmA-6eotA:
7.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJM_B_BJMB2_1
(DIPEPTIDYL PEPTIDASE
4)		 6eot DIPEPTIDYL PEPTIDASE
8
(Homo
sapiens) 		11 / 12 ARG A 160
GLU A 275
GLU A 276
TYR A 669
SER A 755
VAL A 781
TYR A 787
TYR A 791
ASN A 835
VAL A 836
HIS A 865
 None
 0.72A 3bjmB-6eotA:
28.7		 3bjmB-6eotA:
7.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJM_B_BJMB2_1
(DIPEPTIDYL PEPTIDASE
4)		 6eot DIPEPTIDYL PEPTIDASE
8
(Homo
sapiens) 		6 / 12 GLU A 275
TYR A 669
SER A 755
VAL A 781
TYR A 787
VAL A 836
 None
 1.11A 3bjmB-6eotA:
28.7		 3bjmB-6eotA:
7.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DCJ_A_THHA401_0
(PROBABLE
5'-PHOSPHORIBOSYLGLY
CINAMIDE
FORMYLTRANSFERASE
PURN)		 6eot DIPEPTIDYL PEPTIDASE
8
(Homo
sapiens) 		5 / 12 MET A 763
ILE A 751
LEU A 734
ASN A 704
PRO A 672
 None
 1.24A 3dcjA-6eotA:
3.6
3dcjB-6eotA:
2.8		 3dcjA-6eotA:
undetectable
3dcjB-6eotA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G0B_A_T22A800_1
(DIPEPTIDYL PEPTIDASE
4)		 6eot DIPEPTIDYL PEPTIDASE
8
(Homo
sapiens) 		12 / 12 ARG A 160
GLU A 275
GLU A 276
TYR A 669
SER A 755
TYR A 756
VAL A 781
TYR A 787
TYR A 791
ASN A 835
VAL A 836
HIS A 865
 None
 0.85A 3g0bA-6eotA:
30.8		 3g0bA-6eotA:
7.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G0B_A_T22A800_1
(DIPEPTIDYL PEPTIDASE
4)		 6eot DIPEPTIDYL PEPTIDASE
8
(Homo
sapiens) 		6 / 12 GLU A 275
TYR A 669
SER A 755
VAL A 781
TYR A 787
VAL A 836
 None
 1.34A 3g0bA-6eotA:
30.8		 3g0bA-6eotA:
7.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G0B_A_T22A800_1
(DIPEPTIDYL PEPTIDASE
4)		 6eot DIPEPTIDYL PEPTIDASE
8
(Homo
sapiens) 		6 / 12 SER A 755
TYR A 759
TYR A 787
ASN A 835
VAL A 836
HIS A 865
 None
 1.13A 3g0bA-6eotA:
30.8		 3g0bA-6eotA:
7.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G0B_B_T22B800_1
(DIPEPTIDYL PEPTIDASE
4)		 6eot DIPEPTIDYL PEPTIDASE
8
(Homo
sapiens) 		12 / 12 ARG A 160
GLU A 275
GLU A 276
TYR A 669
SER A 755
TYR A 756
VAL A 781
TYR A 787
TYR A 791
ASN A 835
VAL A 836
HIS A 865
 None
 0.85A 3g0bB-6eotA:
28.0		 3g0bB-6eotA:
7.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G0B_B_T22B800_1
(DIPEPTIDYL PEPTIDASE
4)		 6eot DIPEPTIDYL PEPTIDASE
8
(Homo
sapiens) 		6 / 12 GLU A 275
TYR A 669
SER A 755
VAL A 781
TYR A 787
VAL A 836
 None
 1.33A 3g0bB-6eotA:
28.0		 3g0bB-6eotA:
7.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G0B_B_T22B800_1
(DIPEPTIDYL PEPTIDASE
4)		 6eot DIPEPTIDYL PEPTIDASE
8
(Homo
sapiens) 		6 / 12 SER A 755
TYR A 759
TYR A 787
ASN A 835
VAL A 836
HIS A 865
 None
 1.15A 3g0bB-6eotA:
28.0		 3g0bB-6eotA:
7.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G0B_C_T22C800_1
(DIPEPTIDYL PEPTIDASE
4)		 6eot DIPEPTIDYL PEPTIDASE
8
(Homo
sapiens) 		10 / 12 ARG A 160
GLU A 275
GLU A 276
TYR A 669
SER A 755
TYR A 756
TYR A 787
ASN A 835
VAL A 836
HIS A 865
 None
 0.94A 3g0bC-6eotA:
29.5		 3g0bC-6eotA:
7.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G0B_C_T22C800_1
(DIPEPTIDYL PEPTIDASE
4)		 6eot DIPEPTIDYL PEPTIDASE
8
(Homo
sapiens) 		11 / 12 ARG A 160
GLU A 275
GLU A 276
TYR A 669
TYR A 756
VAL A 781
TYR A 787
TYR A 791
ASN A 835
VAL A 836
HIS A 865
 None
 0.80A 3g0bC-6eotA:
29.5		 3g0bC-6eotA:
7.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G0B_C_T22C800_1
(DIPEPTIDYL PEPTIDASE
4)		 6eot DIPEPTIDYL PEPTIDASE
8
(Homo
sapiens) 		5 / 12 GLU A 275
TYR A 669
SER A 755
TYR A 787
VAL A 836
 None
 1.37A 3g0bC-6eotA:
29.5		 3g0bC-6eotA:
7.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G0B_C_T22C800_1
(DIPEPTIDYL PEPTIDASE
4)		 6eot DIPEPTIDYL PEPTIDASE
8
(Homo
sapiens) 		5 / 12 GLU A 275
TYR A 669
VAL A 781
TYR A 787
VAL A 836
 None
 1.17A 3g0bC-6eotA:
29.5		 3g0bC-6eotA:
7.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G0B_C_T22C800_1
(DIPEPTIDYL PEPTIDASE
4)		 6eot DIPEPTIDYL PEPTIDASE
8
(Homo
sapiens) 		6 / 12 SER A 755
TYR A 759
TYR A 787
ASN A 835
VAL A 836
HIS A 865
 None
 1.16A 3g0bC-6eotA:
29.5		 3g0bC-6eotA:
7.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G0B_D_T22D800_1
(DIPEPTIDYL PEPTIDASE
4)		 6eot DIPEPTIDYL PEPTIDASE
8
(Homo
sapiens) 		12 / 12 ARG A 160
GLU A 275
GLU A 276
TYR A 669
SER A 755
TYR A 756
VAL A 781
TYR A 787
TYR A 791
ASN A 835
VAL A 836
HIS A 865
 None
 0.86A 3g0bD-6eotA:
30.2		 3g0bD-6eotA:
7.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G0B_D_T22D800_1
(DIPEPTIDYL PEPTIDASE
4)		 6eot DIPEPTIDYL PEPTIDASE
8
(Homo
sapiens) 		6 / 12 GLU A 275
TYR A 669
SER A 755
VAL A 781
TYR A 787
VAL A 836
 None
 1.32A 3g0bD-6eotA:
30.2		 3g0bD-6eotA:
7.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G0B_D_T22D800_1
(DIPEPTIDYL PEPTIDASE
4)		 6eot DIPEPTIDYL PEPTIDASE
8
(Homo
sapiens) 		6 / 12 SER A 755
TYR A 759
TYR A 787
ASN A 835
VAL A 836
HIS A 865
 None
 1.15A 3g0bD-6eotA:
30.2		 3g0bD-6eotA:
7.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GF2_A_SALA147_1
(146AA LONG
HYPOTHETICAL
TRANSCRIPTIONAL
REGULATOR)		 6eot DIPEPTIDYL PEPTIDASE
8
(Homo
sapiens) 		4 / 4 TYR A 651
LEU A 689
ARG A 688
TYR A 630
 None
 1.43A 3gf2A-6eotA:
0.0		 3gf2A-6eotA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JQA_A_DX4A270_0
(PTERIDINE REDUCTASE
1)		 6eot DIPEPTIDYL PEPTIDASE
8
(Homo
sapiens) 		4 / 6 SER A 586
PHE A 584
ASP A 568
TYR A 600
 None
 1.48A 3jqaA-6eotA:
4.1		 3jqaA-6eotA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K13_A_THHA642_1
(5-METHYLTETRAHYDROFO
LATE-HOMOCYSTEINE
METHYLTRANSFERASE)		 6eot DIPEPTIDYL PEPTIDASE
8
(Homo
sapiens) 		3 / 3 ASN A 835
ASP A 788
ARG A 380
 None
 0.87A 3k13A-6eotA:
undetectable		 3k13A-6eotA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L8L_B_DVAB8_0
(GRAMICIDIN D)		 6eot DIPEPTIDYL PEPTIDASE
8
(Homo
sapiens) 		3 / 3 VAL A 781
VAL A 811
TRP A 784
 None
 0.89A 3l8lA-6eotA:
undetectable
3l8lB-6eotA:
undetectable		 3l8lA-6eotA:
undetectable
3l8lB-6eotA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LM8_C_VIBC223_1
(THIAMINE
PYROPHOSPHOKINASE)		 6eot DIPEPTIDYL PEPTIDASE
8
(Homo
sapiens) 		4 / 8 TYR A 600
LEU A 602
LEU A 566
SER A 586
 None
 1.02A 3lm8A-6eotA:
undetectable
3lm8C-6eotA:
undetectable		 3lm8A-6eotA:
13.96
3lm8C-6eotA:
13.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NK2_X_LDPX433_1
(6-HYDROXY-L-NICOTINE
OXIDASE)		 6eot DIPEPTIDYL PEPTIDASE
8
(Homo
sapiens) 		4 / 7 TYR A 759
ASN A 704
LEU A 676
LEU A 760
 None
 1.24A 3nk2X-6eotA:
undetectable		 3nk2X-6eotA:
10.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OWX_B_XRAB233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 6eot DIPEPTIDYL PEPTIDASE
8
(Homo
sapiens) 		5 / 11 PHE A 343
GLY A 282
GLY A 267
ASN A 306
ILE A 236
 None
 1.40A 3owxA-6eotA:
2.9
3owxB-6eotA:
2.8		 3owxA-6eotA:
18.09
3owxB-6eotA:
18.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QGT_A_CP6A609_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 6eot DIPEPTIDYL PEPTIDASE
8
(Homo
sapiens) 		5 / 10 ILE A 393
ALA A 381
PHE A 453
ILE A 464
ILE A 404
 None
 1.15A 3qgtA-6eotA:
undetectable		 3qgtA-6eotA:
8.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QGT_B_CP6B609_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 6eot DIPEPTIDYL PEPTIDASE
8
(Homo
sapiens) 		5 / 10 ILE A 393
ALA A 381
PHE A 453
ILE A 464
ILE A 404
 None
 1.15A 3qgtB-6eotA:
undetectable		 3qgtB-6eotA:
8.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S8P_A_SAMA500_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV420H1)		 6eot DIPEPTIDYL PEPTIDASE
8
(Homo
sapiens) 		3 / 3 HIS A 232
SER A 239
GLU A 246
 None
 0.83A 3s8pA-6eotA:
undetectable		 3s8pA-6eotA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TQ8_A_TOPA2001_1
(DIHYDROFOLATE
REDUCTASE)		 6eot DIPEPTIDYL PEPTIDASE
8
(Homo
sapiens) 		5 / 9 ILE A 393
ALA A 381
PHE A 453
ILE A 464
ILE A 404
 None
 1.16A 3tq8A-6eotA:
undetectable		 3tq8A-6eotA:
15.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9H_A_NCAA1163_0
(TANKYRASE-2)		 6eot DIPEPTIDYL PEPTIDASE
8
(Homo
sapiens) 		4 / 8 HIS A 752
GLY A 753
ALA A 775
SER A 761
 None
 0.86A 3u9hA-6eotA:
undetectable		 3u9hA-6eotA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9H_B_NCAB1164_0
(TANKYRASE-2)		 6eot DIPEPTIDYL PEPTIDASE
8
(Homo
sapiens) 		4 / 8 HIS A 752
GLY A 753
ALA A 775
SER A 761
 None
 0.86A 3u9hB-6eotA:
undetectable		 3u9hB-6eotA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VHU_A_SNLA1001_1
(MINERALOCORTICOID
RECEPTOR)		 6eot DIPEPTIDYL PEPTIDASE
8
(Homo
sapiens) 		5 / 12 LEU A 406
MET A 345
LEU A 364
LEU A 302
THR A 384
 None
 1.40A 3vhuA-6eotA:
undetectable		 3vhuA-6eotA:
13.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W2T_A_LF7A801_1
(DIPEPTIDYL PEPTIDASE
4)		 6eot DIPEPTIDYL PEPTIDASE
8
(Homo
sapiens) 		12 / 12 ARG A 160
GLU A 275
GLU A 276
TYR A 669
SER A 755
TYR A 756
VAL A 781
TYR A 787
TYR A 791
ASN A 835
VAL A 836
HIS A 865
 None
 0.69A 3w2tA-6eotA:
30.3		 3w2tA-6eotA:
8.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W2T_A_LF7A801_1
(DIPEPTIDYL PEPTIDASE
4)		 6eot DIPEPTIDYL PEPTIDASE
8
(Homo
sapiens) 		6 / 12 GLU A 275
TYR A 669
SER A 755
VAL A 781
TYR A 787
VAL A 836
 None
 1.09A 3w2tA-6eotA:
30.3		 3w2tA-6eotA:
8.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W2T_A_LF7A801_1
(DIPEPTIDYL PEPTIDASE
4)		 6eot DIPEPTIDYL PEPTIDASE
8
(Homo
sapiens) 		6 / 12 SER A 755
TYR A 759
TYR A 787
ASN A 835
VAL A 836
HIS A 865
 None
 1.18A 3w2tA-6eotA:
30.3		 3w2tA-6eotA:
8.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W2T_B_LF7B801_1
(DIPEPTIDYL PEPTIDASE
4)		 6eot DIPEPTIDYL PEPTIDASE
8
(Homo
sapiens) 		12 / 12 ARG A 160
GLU A 275
GLU A 276
TYR A 669
SER A 755
TYR A 756
VAL A 781
TYR A 787
TYR A 791
ASN A 835
VAL A 836
HIS A 865
 None
 0.69A 3w2tB-6eotA:
30.2		 3w2tB-6eotA:
8.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W2T_B_LF7B801_1
(DIPEPTIDYL PEPTIDASE
4)		 6eot DIPEPTIDYL PEPTIDASE
8
(Homo
sapiens) 		6 / 12 GLU A 275
TYR A 669
SER A 755
VAL A 781
TYR A 787
VAL A 836
 None
 1.10A 3w2tB-6eotA:
30.2		 3w2tB-6eotA:
8.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W2T_B_LF7B801_1
(DIPEPTIDYL PEPTIDASE
4)		 6eot DIPEPTIDYL PEPTIDASE
8
(Homo
sapiens) 		6 / 12 SER A 755
TYR A 759
TYR A 787
ASN A 835
VAL A 836
HIS A 865
 None
 1.19A 3w2tB-6eotA:
30.2		 3w2tB-6eotA:
8.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BJC_A_RPBA2162_1
(TANKYRASE-2)		 6eot DIPEPTIDYL PEPTIDASE
8
(Homo
sapiens) 		4 / 8 HIS A 752
GLY A 753
ALA A 775
SER A 761
 None
 0.86A 4bjcA-6eotA:
undetectable		 4bjcA-6eotA:
15.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F5Z_A_BEZA302_0
(HALOALKANE
DEHALOGENASE)		 6eot DIPEPTIDYL PEPTIDASE
8
(Homo
sapiens) 		4 / 8 ASN A 835
ASP A 833
VAL A 781
HIS A 829
 None
 1.21A 4f5zA-6eotA:
11.9		 4f5zA-6eotA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FFW_A_715A801_1
(DIPEPTIDYL PEPTIDASE
4)		 6eot DIPEPTIDYL PEPTIDASE
8
(Homo
sapiens) 		10 / 12 ARG A 160
GLU A 275
GLU A 276
TYR A 669
SER A 755
VAL A 781
TYR A 787
ASN A 835
VAL A 836
HIS A 865
 None
 0.71A 4ffwA-6eotA:
30.9		 4ffwA-6eotA:
8.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FFW_A_715A801_1
(DIPEPTIDYL PEPTIDASE
4)		 6eot DIPEPTIDYL PEPTIDASE
8
(Homo
sapiens) 		5 / 12 GLU A 275
TYR A 669
SER A 755
VAL A 781
TYR A 787
 None
 1.16A 4ffwA-6eotA:
30.9		 4ffwA-6eotA:
8.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FFW_B_715B801_1
(DIPEPTIDYL PEPTIDASE
4)		 6eot DIPEPTIDYL PEPTIDASE
8
(Homo
sapiens) 		10 / 12 ARG A 160
GLU A 275
GLU A 276
TYR A 669
SER A 755
VAL A 781
TYR A 787
TYR A 791
VAL A 836
HIS A 865
 None
 0.56A 4ffwB-6eotA:
29.3		 4ffwB-6eotA:
8.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FFW_B_715B801_1
(DIPEPTIDYL PEPTIDASE
4)		 6eot DIPEPTIDYL PEPTIDASE
8
(Homo
sapiens) 		5 / 12 GLU A 275
TYR A 669
SER A 755
VAL A 781
TYR A 787
 None
 1.11A 4ffwB-6eotA:
29.3		 4ffwB-6eotA:
8.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGK_A_0TXA302_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 6eot DIPEPTIDYL PEPTIDASE
8
(Homo
sapiens) 		4 / 7 GLY A 183
GLY A 185
TYR A 187
GLU A 152
 None
 1.09A 4fgkB-6eotA:
2.8		 4fgkB-6eotA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HYF_A_NCAA1201_0
(TANKYRASE-2)		 6eot DIPEPTIDYL PEPTIDASE
8
(Homo
sapiens) 		4 / 7 HIS A 752
GLY A 753
ALA A 775
SER A 761
 None
 0.87A 4hyfA-6eotA:
undetectable		 4hyfA-6eotA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HYF_B_NCAB1201_0
(TANKYRASE-2)		 6eot DIPEPTIDYL PEPTIDASE
8
(Homo
sapiens) 		4 / 8 HIS A 752
GLY A 753
ALA A 775
SER A 761
 None
 0.86A 4hyfB-6eotA:
undetectable		 4hyfB-6eotA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HYF_C_NCAC1201_0
(TANKYRASE-2)		 6eot DIPEPTIDYL PEPTIDASE
8
(Homo
sapiens) 		4 / 8 HIS A 752
GLY A 753
ALA A 775
SER A 761
 None
 0.84A 4hyfC-6eotA:
undetectable		 4hyfC-6eotA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMD_A_29EA603_1
(TRANSPORTER)		 6eot DIPEPTIDYL PEPTIDASE
8
(Homo
sapiens) 		5 / 10 TYR A 759
TYR A 669
GLY A 723
SER A 755
GLY A 758
 None
 1.29A 4mmdA-6eotA:
undetectable		 4mmdA-6eotA:
8.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_I_HCYI900_2
(GLUCOCORTICOID
RECEPTOR)		 6eot DIPEPTIDYL PEPTIDASE
8
(Homo
sapiens) 		3 / 3 MET A 722
MET A 813
TYR A 787
 None
 1.34A 4p6xI-6eotA:
undetectable		 4p6xI-6eotA:
15.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PTJ_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 6eot DIPEPTIDYL PEPTIDASE
8
(Homo
sapiens) 		5 / 12 ILE A 393
ALA A 381
PHE A 453
ILE A 464
ILE A 404
 None
 1.12A 4ptjA-6eotA:
undetectable		 4ptjA-6eotA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RYA_A_MTLA501_1
(ABC TRANSPORTER
SUBSTRATE BINDING
PROTEIN (SORBITOL))		 6eot DIPEPTIDYL PEPTIDASE
8
(Homo
sapiens) 		3 / 3 GLU A 363
TYR A 303
GLU A 305
 None
 0.83A 4ryaA-6eotA:
undetectable		 4ryaA-6eotA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_B_CHDB102_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 6eot DIPEPTIDYL PEPTIDASE
8
(Homo
sapiens) 		5 / 11 LEU A  65
LEU A  64
LEU A 881
ALA A 693
LEU A 695
 None
 1.18A 4wg0B-6eotA:
undetectable
4wg0C-6eotA:
undetectable
4wg0D-6eotA:
undetectable		 4wg0B-6eotA:
undetectable
4wg0C-6eotA:
undetectable
4wg0D-6eotA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_D_CHDD102_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 6eot DIPEPTIDYL PEPTIDASE
8
(Homo
sapiens) 		5 / 11 LEU A  65
LEU A  64
LEU A 881
ALA A 693
LEU A 695
 None
 1.16A 4wg0D-6eotA:
undetectable
4wg0E-6eotA:
undetectable
4wg0F-6eotA:
undetectable		 4wg0D-6eotA:
undetectable
4wg0E-6eotA:
undetectable
4wg0F-6eotA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_F_CHDF103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 6eot DIPEPTIDYL PEPTIDASE
8
(Homo
sapiens) 		5 / 11 LEU A  65
LEU A  64
LEU A 881
ALA A 693
LEU A 695
 None
 1.18A 4wg0F-6eotA:
undetectable
4wg0G-6eotA:
undetectable
4wg0H-6eotA:
undetectable		 4wg0F-6eotA:
undetectable
4wg0G-6eotA:
undetectable
4wg0H-6eotA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_H_CHDH103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 6eot DIPEPTIDYL PEPTIDASE
8
(Homo
sapiens) 		5 / 11 LEU A  65
LEU A  64
LEU A 881
ALA A 693
LEU A 695
 None
 1.18A 4wg0H-6eotA:
undetectable
4wg0I-6eotA:
undetectable
4wg0J-6eotA:
undetectable		 4wg0H-6eotA:
undetectable
4wg0I-6eotA:
undetectable
4wg0J-6eotA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_J_CHDJ103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 6eot DIPEPTIDYL PEPTIDASE
8
(Homo
sapiens) 		5 / 11 LEU A  65
LEU A  64
LEU A 881
ALA A 693
LEU A 695
 None
 1.17A 4wg0J-6eotA:
undetectable
4wg0K-6eotA:
undetectable
4wg0L-6eotA:
undetectable		 4wg0J-6eotA:
undetectable
4wg0K-6eotA:
undetectable
4wg0L-6eotA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_K_CHDK103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 6eot DIPEPTIDYL PEPTIDASE
8
(Homo
sapiens) 		5 / 11 ALA A 693
LEU A 695
LEU A 881
LEU A  65
LEU A  64
 None
 1.14A 4wg0I-6eotA:
undetectable
4wg0J-6eotA:
undetectable
4wg0K-6eotA:
undetectable		 4wg0I-6eotA:
undetectable
4wg0J-6eotA:
undetectable
4wg0K-6eotA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_M_CHDM103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 6eot DIPEPTIDYL PEPTIDASE
8
(Homo
sapiens) 		5 / 11 ALA A 693
LEU A 695
LEU A 881
LEU A  65
LEU A  64
 None
 1.15A 4wg0K-6eotA:
undetectable
4wg0L-6eotA:
undetectable
4wg0M-6eotA:
undetectable		 4wg0K-6eotA:
undetectable
4wg0L-6eotA:
undetectable
4wg0M-6eotA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZB_C_ACTC401_0
(PROTON-GATED ION
CHANNEL)		 6eot DIPEPTIDYL PEPTIDASE
8
(Homo
sapiens) 		4 / 7 ILE A 393
PHE A 468
ILE A 447
GLU A 441
 None
 0.92A 4zzbC-6eotA:
undetectable
4zzbD-6eotA:
undetectable		 4zzbC-6eotA:
undetectable
4zzbD-6eotA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZC_A_ACTA401_0
(PROTON-GATED ION
CHANNEL)		 6eot DIPEPTIDYL PEPTIDASE
8
(Homo
sapiens) 		4 / 6 ILE A 393
PHE A 468
ILE A 447
GLU A 441
 None
 0.90A 4zzcA-6eotA:
undetectable
4zzcB-6eotA:
undetectable		 4zzcA-6eotA:
undetectable
4zzcB-6eotA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZC_B_ACTB401_0
(PROTON-GATED ION
CHANNEL)		 6eot DIPEPTIDYL PEPTIDASE
8
(Homo
sapiens) 		4 / 6 ILE A 393
PHE A 468
ILE A 447
GLU A 441
 None
 0.94A 4zzcB-6eotA:
undetectable
4zzcC-6eotA:
undetectable		 4zzcB-6eotA:
undetectable
4zzcC-6eotA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HWA_A_GCSA301_1
(CHITOSANASE)		 6eot DIPEPTIDYL PEPTIDASE
8
(Homo
sapiens) 		4 / 8 ASP A 745
ARG A 748
GLY A 750
LEU A 884
 None
 0.98A 5hwaA-6eotA:
undetectable		 5hwaA-6eotA:
15.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IAO_C_URFC301_1
(BIFUNCTIONAL PROTEIN
PYRR)		 6eot DIPEPTIDYL PEPTIDASE
8
(Homo
sapiens) 		3 / 3 ARG A  98
HIS A  95
ARG A  88
 None
 1.06A 5iaoC-6eotA:
undetectable		 5iaoC-6eotA:
15.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IAO_F_URFF301_1
(BIFUNCTIONAL PROTEIN
PYRR)		 6eot DIPEPTIDYL PEPTIDASE
8
(Homo
sapiens) 		3 / 3 ARG A  98
HIS A  95
ARG A  88
 None
 1.05A 5iaoF-6eotA:
undetectable		 5iaoF-6eotA:
15.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MM4_B_TA1B501_1
(TUBULIN BETA CHAIN)		 6eot DIPEPTIDYL PEPTIDASE
8
(Homo
sapiens) 		5 / 10 GLU A 726
LEU A 884
ALA A 764
PHE A 772
THR A 664
 None
 1.19A 5mm4B-6eotA:
2.7		 5mm4B-6eotA:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OG9_A_TESA504_1
(-)		 6eot DIPEPTIDYL PEPTIDASE
8
(Homo
sapiens) 		4 / 8 ILE A 301
VAL A 359
ILE A 350
THR A 243
 None
 0.75A 5og9A-6eotA:
undetectable		 5og9A-6eotA:
10.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YW0_A_ACTA409_0
(UNCHARACTERIZED
PROTEIN KDOO)		 6eot DIPEPTIDYL PEPTIDASE
8
(Homo
sapiens) 		3 / 3 ASP A 788
PHE A 277
ARG A 794
 None
 1.13A 5yw0A-6eotA:
undetectable		 5yw0A-6eotA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B1E_B_LF7B801_1
(DIPEPTIDYL PEPTIDASE
4)		 6eot DIPEPTIDYL PEPTIDASE
8
(Homo
sapiens) 		12 / 12 ARG A 160
GLU A 275
GLU A 276
TYR A 669
SER A 755
TYR A 756
VAL A 781
TYR A 787
TYR A 791
ASN A 835
VAL A 836
HIS A 865
 None
 0.69A 6b1eB-6eotA:
29.3		 6b1eB-6eotA:
7.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B1E_B_LF7B801_1
(DIPEPTIDYL PEPTIDASE
4)		 6eot DIPEPTIDYL PEPTIDASE
8
(Homo
sapiens) 		6 / 12 GLU A 275
TYR A 669
SER A 755
VAL A 781
TYR A 787
VAL A 836
 None
 1.11A 6b1eB-6eotA:
29.3		 6b1eB-6eotA:
7.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B1E_B_LF7B801_1
(DIPEPTIDYL PEPTIDASE
4)		 6eot DIPEPTIDYL PEPTIDASE
8
(Homo
sapiens) 		6 / 12 SER A 755
TYR A 759
TYR A 787
ASN A 835
VAL A 836
HIS A 865
 None
 1.18A 6b1eB-6eotA:
29.3		 6b1eB-6eotA:
7.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNE_A_ACRA602_1
(-)		 6eot DIPEPTIDYL PEPTIDASE
8
(Homo
sapiens) 		5 / 12 GLY A 758
GLY A 757
VAL A 674
PRO A 672
GLY A 670
 None
 1.10A 6gneA-6eotA:
4.4		 6gneA-6eotA:
10.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNE_B_ACRB602_1
(-)		 6eot DIPEPTIDYL PEPTIDASE
8
(Homo
sapiens) 		5 / 12 GLY A 758
GLY A 757
VAL A 674
PRO A 672
GLY A 670
 None
 1.10A 6gneB-6eotA:
5.8		 6gneB-6eotA:
10.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GQI_A_ACTA604_0
(CYCLOHEXANONE
MONOOXYGENASE FROM
THERMOCRISPUM
MUNICIPALE)		 6eot DIPEPTIDYL PEPTIDASE
8
(Homo
sapiens) 		4 / 6 TRP A 754
ILE A 867
GLY A 830
TYR A 860
 None
 1.10A 6gqiA-6eotA:
undetectable		 6gqiA-6eotA:
undetectable