SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6epc'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YVL_B_SAMB602_1
(HYPOTHETICAL PROTEIN)		 6epc PROTEASOME (PROSOME,
MACROPAIN) 26S
SUBUNIT, NON-ATPASE,
12
(Rattus
norvegicus) 		3 / 3 GLU P 346
ASP P 339
TYR P 273
 None
 0.79A 2yvlB-6epcP:
undetectable		 2yvlB-6epcP:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABK_W_CHDW1059_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 6epc PROTEASOME (PROSOME,
MACROPAIN) 26S
SUBUNIT, NON-ATPASE,
12
(Rattus
norvegicus) 		4 / 5 ILE P 363
ARG P 377
MET P 375
THR P 374
 None
 1.19A 3abkN-6epcP:
0.7
3abkW-6epcP:
undetectable		 3abkN-6epcP:
undetectable
3abkW-6epcP:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IV6_C_SAMC301_1
(PUTATIVE
ZN-DEPENDENT ALCOHOL
DEHYDROGENASE)		 6epc PROTEASOME (PROSOME,
MACROPAIN) 26S
SUBUNIT, NON-ATPASE,
12
(Rattus
norvegicus) 		3 / 3 SER P  21
ASP P  25
ASP P  59
 None
 0.81A 3iv6C-6epcP:
undetectable		 3iv6C-6epcP:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AFG_C_QMRC1214_1
(CAPITELLA TELETA
ACHBP)		 6epc PROTEASOME (PROSOME,
MACROPAIN) 26S
SUBUNIT, NON-ATPASE,
12
(Rattus
norvegicus) 		4 / 8 TYR P 247
CYH P 244
ILE P 275
ILE P 290
 None
 0.99A 4afgD-6epcP:
undetectable
4afgE-6epcP:
undetectable		 4afgD-6epcP:
17.49
4afgE-6epcP:
17.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IMS_B_ACTB713_0
(ACETOLACTATE
SYNTHASE CATALYTIC
SUBUNIT,
MITOCHONDRIAL)		 6epc PROTEASOME (PROSOME,
MACROPAIN) 26S
SUBUNIT, NON-ATPASE,
12
(Rattus
norvegicus) 		3 / 3 GLY P  38
GLN P  41
LYS P  78
 None
 1.00A 5imsB-6epcP:
undetectable		 5imsB-6epcP:
undetectable