SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6epe'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IKE_A_HSMA190_1
(NITROPHORIN 4)		 6epe PROTEASOME (PROSOME,
MACROPAIN) 26S
SUBUNIT, NON-ATPASE,
7 (PREDICTED)
(Rattus
norvegicus) 		3 / 3 ASP U 178
LEU U 175
LEU U 176
 None
 0.74A 1ikeA-6epeU:
undetectable		 1ikeA-6epeU:
16.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_F_SVRF509_2
(PHOSPHOLIPASE A2)		 6epe PROTEASOME (PROSOME,
MACROPAIN) 26S
SUBUNIT, NON-ATPASE,
7 (PREDICTED)
(Rattus
norvegicus) 		4 / 8 LYS U  84
ASN U  77
PRO U  57
PHE U  69
 None
 1.20A 3bjwD-6epeU:
undetectable		 3bjwD-6epeU:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ILT_H_TRUH800_1
(GLUTAMATE RECEPTOR 2)		 6epe PROTEASOME SUBUNIT
BETA TYPE-1
(Rattus
norvegicus) 		3 / 3 ILE 6 115
SER 6 161
SER 6 150
 None
 0.46A 3iltH-6epe6:
undetectable		 3iltH-6epe6:
17.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ILU_E_HFZE800_1
(GLUTAMATE RECEPTOR 2)		 6epe PROTEASOME SUBUNIT
BETA TYPE-1
(Rattus
norvegicus) 		5 / 11 ILE 6 115
GLY 6 113
SER 6 105
LEU 6 119
SER 6 120
 None
 1.15A 3iluB-6epe6:
undetectable
3iluE-6epe6:
undetectable		 3iluB-6epe6:
17.02
3iluE-6epe6:
17.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DJF_A_C2FA300_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 6epe PROTEASOME SUBUNIT
BETA TYPE-1
(Rattus
norvegicus) 		5 / 12 GLU 6 138
PHE 6  84
ILE 6  49
ASP 6  46
GLY 6  44
 None
 1.41A 4djfA-6epe6:
undetectable		 4djfA-6epe6:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UCI_A_SAMA2409_0
(RNA-DIRECTED RNA
POLYMERASE L)		 6epe PROTEASOME SUBUNIT
BETA TYPE-1
(Rattus
norvegicus) 		5 / 12 GLY 6 113
GLU 6 143
GLY 6 144
GLY 6 146
ALA 6 116
 None
 1.00A 4uciA-6epe6:
undetectable		 4uciA-6epe6:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UCI_B_SAMB2409_0
(RNA-DIRECTED RNA
POLYMERASE L)		 6epe PROTEASOME SUBUNIT
BETA TYPE-1
(Rattus
norvegicus) 		5 / 12 GLY 6 113
GLU 6 143
GLY 6 144
GLY 6 146
ALA 6 116
 None
 0.99A 4uciB-6epe6:
undetectable		 4uciB-6epe6:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WQ5_B_ACTB404_0
(TRNA N6-ADENOSINE
THREONYLCARBAMOYLTRA
NSFERASE)		 6epe PROTEASOME (PROSOME,
MACROPAIN) 26S
SUBUNIT, NON-ATPASE,
7 (PREDICTED)
(Rattus
norvegicus) 		3 / 3 TYR U  79
ARG U  90
LYS U  83
 None
 1.31A 4wq5B-6epeU:
undetectable		 4wq5B-6epeU:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGI_A_ZITA402_2
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		 6epe PROTEASOME (PROSOME,
MACROPAIN) 26S
SUBUNIT, NON-ATPASE,
7 (PREDICTED)
(Rattus
norvegicus) 		4 / 6 PRO U 134
HIS U  96
GLU U  60
ALA U  55
 None
 1.00A 5igiA-6epeU:
undetectable		 5igiA-6epeU:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IH0_A_ERYA404_0
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 6epe PROTEASOME SUBUNIT
BETA TYPE-1
(Rattus
norvegicus) 		5 / 12 HIS 6 190
GLY 6 181
SER 6 208
ILE 6 207
PHE 6 206
 None
 1.23A 5ih0A-6epe6:
undetectable		 5ih0A-6epe6:
undetectable