SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6epi'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VPT_A_SAMA400_0
(VP39)		 6epi ZETA_1 TOXIN
(Neisseria
gonorrhoeae) 		5 / 12 GLN B 266
GLY B 112
GLY B 182
VAL B 161
ALA B 165
 None
SO4  B 502 (-3.3A)
None
None
None
 0.94A 1vptA-6epiB:
undetectable		 1vptA-6epiB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J5M_A_ACTA1321_0
(CHLOROPEROXIDASE)		 6epi ZETA_1 TOXIN
(Neisseria
gonorrhoeae) 		4 / 6 LEU B 195
ILE B 212
VAL B 230
ALA B 160
 None
 0.92A 2j5mA-6epiB:
undetectable		 2j5mA-6epiB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZM9_A_ACAA502_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 6epi ZETA_1 TOXIN
(Neisseria
gonorrhoeae) 		4 / 8 MET B 188
ALA B 189
GLY B 186
ILE B 185
 None
None
SO4  B 503 ( 4.4A)
None
 0.77A 2zm9A-6epiB:
undetectable		 2zm9A-6epiB:
11.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LM8_A_VIBA223_1
(THIAMINE
PYROPHOSPHOKINASE)		 6epi ZETA_1 TOXIN
(Neisseria
gonorrhoeae) 		4 / 7 LEU B 234
SER B 221
ASN B 216
THR B 118
 None
 0.97A 3lm8A-6epiB:
undetectable
3lm8C-6epiB:
4.4		 3lm8A-6epiB:
18.22
3lm8C-6epiB:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9T_A_BEZA264_0
(ECHA1_1)		 6epi ZETA_1 TOXIN
(Neisseria
gonorrhoeae) 		5 / 8 ALA B 247
ILE B 250
LEU B 273
ALA B 344
ALA B 345
 None
 1.05A 3r9tA-6epiB:
undetectable		 3r9tA-6epiB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9T_B_BEZB264_0
(ECHA1_1)		 6epi ZETA_1 TOXIN
(Neisseria
gonorrhoeae) 		4 / 7 ILE B 250
LEU B 273
ALA B 344
ALA B 345
 None
 0.89A 3r9tB-6epiB:
undetectable		 3r9tB-6epiB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUE_A_SUEA1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 6epi ZETA_1 TOXIN
(Neisseria
gonorrhoeae) 		5 / 12 GLY B 134
ASP B  56
ILE B   8
SER B  86
ALA B  82
 BNW  B 501 (-3.5A)
BNW  B 501 (-3.2A)
None
BNW  B 501 ( 3.8A)
None
 1.05A 3sueA-6epiB:
undetectable		 3sueA-6epiB:
16.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_H_ACTH502_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 6epi ZETA_1 TOXIN
(Neisseria
gonorrhoeae) 		3 / 3 SER B 336
GLY B 337
GLN B 349
 None
 0.51A 3v4tH-6epiB:
2.3		 3v4tH-6epiB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AX8_A_SAMA1474_0
(WBDD)		 6epi ZETA_1 TOXIN
(Neisseria
gonorrhoeae) 		5 / 12 GLY B 374
ILE B 339
ILE B 373
VAL B 313
ILE B 311
 None
 0.85A 4ax8A-6epiB:
2.1		 4ax8A-6epiB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWZ_A_SAMA301_1
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 6epi EPSILON_1 ANTITOXIN
ZETA_1 TOXIN
(Neisseria
gonorrhoeae;
Neisseria
gonorrhoeae) 		3 / 3 SER A   9
ASP B 225
ASP B 228
 None
 0.90A 4mwzA-6epiA:
undetectable		 4mwzA-6epiA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E72_A_SAMA400_0
(N2,
N2-DIMETHYLGUANOSINE
TRNA
METHYLTRANSFERASE)		 6epi ZETA_1 TOXIN
(Neisseria
gonorrhoeae) 		5 / 12 PHE B 348
GLY B 374
ILE B 339
ARG B 286
ALA B 326
 None
 0.88A 5e72A-6epiB:
undetectable		 5e72A-6epiB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKQ_A_JMSA602_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 6epi ZETA_1 TOXIN
(Neisseria
gonorrhoeae) 		3 / 3 VAL B 161
SER B 117
MET B 123
 None
 0.83A 5ikqA-6epiB:
undetectable		 5ikqA-6epiB:
9.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C2M_B_SUEB1202_1
(NS3 PROTEASE)		 6epi ZETA_1 TOXIN
(Neisseria
gonorrhoeae) 		5 / 9 ASP B 225
LEU B 199
ALA B 160
VAL B 161
SER B 162
 None
 1.36A 6c2mB-6epiB:
undetectable		 6c2mB-6epiB:
21.18