SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6eqc'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1H8S_A_AICA1000_1
(MUTANT AL2 6E7P9G)		 6eqc SCFV OF 9C12
ANTIBODY
(Mus
musculus) 		6 / 12 TYR D  43
LEU D 103
PHE D 105
VAL D 167
ALA D 226
TRP D 237
 None
 0.67A 1h8sA-6eqcD:
28.9		 1h8sA-6eqcD:
68.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JGL_L_ESTL911_1
(IG GAMMA-1-CHAIN
IG KAPPA-CHAIN)		 6eqc SCFV OF 9C12
ANTIBODY
(Mus
musculus) 		5 / 10 ALA D  41
TYR D  43
LEU D  53
TYR D  56
HIS D  96
 None
 0.60A 1jglH-6eqcD:
14.8
1jglL-6eqcD:
20.0		 1jglH-6eqcD:
16.20
1jglL-6eqcD:
49.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JGL_L_ESTL911_1
(IG GAMMA-1-CHAIN
IG KAPPA-CHAIN)		 6eqc SCFV OF 9C12
ANTIBODY
(Mus
musculus) 		5 / 10 GLY D 229
ALA D  41
TYR D  43
LEU D  53
TYR D  56
 None
 1.00A 1jglH-6eqcD:
14.8
1jglL-6eqcD:
20.0		 1jglH-6eqcD:
16.20
1jglL-6eqcD:
49.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CBR_A_A80A201_1
(PROTEIN (CRABP-I))		 6eqc SCFV OF 9C12
ANTIBODY
(Mus
musculus) 		5 / 12 VAL D 197
LEU D 212
VAL D 148
THR D 241
VAL D 243
 None
 1.07A 2cbrA-6eqcD:
undetectable		 2cbrA-6eqcD:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q8H_A_TF4A438_1
([PYRUVATE
DEHYDROGENASE
[LIPOAMIDE]] KINASE
ISOZYME 1)		 6eqc SCFV OF 9C12
ANTIBODY
(Mus
musculus) 		4 / 6 LEU D  80
TYR D  93
ILE D  82
ARG D  68
 None
 0.96A 2q8hA-6eqcD:
undetectable		 2q8hA-6eqcD:
14.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEE_B_30BB500_2
(GENOME POLYPROTEIN)		 6eqc SCFV OF 9C12
ANTIBODY
(Mus
musculus) 		3 / 3 PHE D  78
TYR D  99
LEU D  54
 None
 0.78A 3keeB-6eqcD:
undetectable		 3keeB-6eqcD:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QN9_B_DXCB610_0
(N-ACYL-PHOSPHATIDYLE
THANOLAMINE-HYDROLYZ
ING PHOSPHOLIPASE D)		 6eqc SCFV OF 9C12
ANTIBODY
(Mus
musculus) 		3 / 3 GLY D  48
PRO D  47
ALA D  91
 None
 0.28A 4qn9B-6eqcD:
undetectable		 4qn9B-6eqcD:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWP_B_GCSB305_1
(CHITOSANASE)		 6eqc SCFV OF 9C12
ANTIBODY
(Mus
musculus) 		3 / 3 GLY D  48
PRO D  47
GLN D 169
 None
 0.57A 4qwpB-6eqcD:
undetectable		 4qwpB-6eqcD:
15.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z2E_H_TR6H101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
SYMMETRIZED E-SITE
DNA)		 6eqc SCFV OF 9C12
ANTIBODY
(Mus
musculus) 		3 / 5 GLY D 172
GLY D 174
GLU D 176
 None
 0.00A 4z2eA-6eqcD:
undetectable
4z2eD-6eqcD:
undetectable		 4z2eA-6eqcD:
9.21
4z2eD-6eqcD:
14.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NZ0_A_ZLDA301_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR ETHR)		 6eqc SCFV OF 9C12
ANTIBODY
(Mus
musculus) 		5 / 12 GLY D 229
TRP D 237
TYR D 236
VAL D 132
LEU D 103
 None
 1.41A 5nz0A-6eqcD:
undetectable		 5nz0A-6eqcD:
undetectable