SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6eqi'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIA_B_SAMB1293_1
(GLYCINE
N-METHYLTRANSFERASE)		 6eqi NB696
SERINE/THREONINE-PRO
TEIN KINASE PINK1,
PUTATIVE
(Lama
glama;
Pediculus
humanus) 		4 / 5 ARG B  97
ASP C 338
SER C 337
ASN C 383
 None
GOL  C 602 (-4.2A)
GOL  C 602 (-2.9A)
None
 1.50A 1kiaB-6eqiB:
undetectable		 1kiaB-6eqiB:
17.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIA_C_SAMC2293_1
(GLYCINE
N-METHYLTRANSFERASE)		 6eqi NB696
SERINE/THREONINE-PRO
TEIN KINASE PINK1,
PUTATIVE
(Lama
glama;
Pediculus
humanus) 		4 / 6 ARG B  97
ASP C 338
SER C 337
ASN C 383
 None
GOL  C 602 (-4.2A)
GOL  C 602 (-2.9A)
None
 1.50A 1kiaC-6eqiB:
undetectable		 1kiaC-6eqiB:
17.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWH_A_BAXA1723_2
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 6eqi SERINE/THREONINE-PRO
TEIN KINASE PINK1,
PUTATIVE
(Pediculus
humanus) 		4 / 6 ILE C 165
VAL C 173
ILE C 246
ILE C 330
 None
 0.60A 1uwhA-6eqiC:
20.8		 1uwhA-6eqiC:
23.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWH_A_BAXA1723_2
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 6eqi SERINE/THREONINE-PRO
TEIN KINASE PINK1,
PUTATIVE
(Pediculus
humanus) 		4 / 6 ILE C 165
VAL C 173
VAL C 216
ILE C 246
 None
 0.71A 1uwhA-6eqiC:
20.8		 1uwhA-6eqiC:
23.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWJ_A_BAXA1723_2
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 6eqi SERINE/THREONINE-PRO
TEIN KINASE PINK1,
PUTATIVE
(Pediculus
humanus) 		4 / 7 ILE C 165
LYS C 193
ILE C 246
ILE C 330
 None
 0.64A 1uwjA-6eqiC:
8.2		 1uwjA-6eqiC:
24.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ACL_G_REAG501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 6eqi SERINE/THREONINE-PRO
TEIN KINASE PINK1,
PUTATIVE
(Pediculus
humanus) 		5 / 12 ALA C 479
LEU C 548
ILE C 549
ARG C 555
ALA C 476
 None
 0.90A 2aclG-6eqiC:
undetectable		 2aclG-6eqiC:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F10_A_BCZA382_0
(SIALIDASE 2)		 6eqi SERINE/THREONINE-PRO
TEIN KINASE PINK1,
PUTATIVE
(Pediculus
humanus) 		5 / 12 ARG C 274
ILE C 275
ASN C 263
TYR C 174
LEU C 161
 None
 1.15A 2f10A-6eqiC:
undetectable		 2f10A-6eqiC:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FUM_D_MIXD3539_1
(PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNB)		 6eqi SERINE/THREONINE-PRO
TEIN KINASE PINK1,
PUTATIVE
(Pediculus
humanus) 		7 / 12 GLY C 168
VAL C 173
ALA C 191
MET C 290
LYS C 336
ASN C 339
ASP C 357
 None
 1.00A 2fumD-6eqiC:
20.3		 2fumD-6eqiC:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FUM_D_MIXD3539_1
(PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNB)		 6eqi SERINE/THREONINE-PRO
TEIN KINASE PINK1,
PUTATIVE
(Pediculus
humanus) 		7 / 12 GLY C 168
VAL C 173
ALA C 191
MET C 290
THR C 296
ASN C 339
ASP C 357
 None
 0.88A 2fumD-6eqiC:
20.3		 2fumD-6eqiC:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U7S_A_017A201_2
(POL POLYPROTEIN)		 6eqi SERINE/THREONINE-PRO
TEIN KINASE PINK1,
PUTATIVE
(Pediculus
humanus) 		5 / 9 ALA C 475
ASP C 473
GLY C 564
ILE C 568
LEU C 483
 None
 1.22A 3u7sB-6eqiC:
undetectable		 3u7sB-6eqiC:
12.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZD_A_LEVA1201_2
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 6eqi SERINE/THREONINE-PRO
TEIN KINASE PINK1,
PUTATIVE
(Pediculus
humanus) 		4 / 5 LYS C 193
VAL C 247
LEU C 341
ASP C 357
 None
 0.95A 3wzdA-6eqiC:
19.3		 3wzdA-6eqiC:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AN2_A_EUIA1382_1
(DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1)		 6eqi SERINE/THREONINE-PRO
TEIN KINASE PINK1,
PUTATIVE
(Pediculus
humanus) 		6 / 12 LYS C 193
MET C 290
ASP C 334
ASN C 339
ASP C 357
VAL C 216
 None
 1.21A 4an2A-6eqiC:
19.8		 4an2A-6eqiC:
24.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I22_A_IREA9001_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 6eqi SERINE/THREONINE-PRO
TEIN KINASE PINK1,
PUTATIVE
(Pediculus
humanus) 		8 / 12 VAL C 173
ALA C 191
LYS C 193
LEU C 288
MET C 290
LEU C 341
THR C 356
ASP C 357
 None
 0.90A 4i22A-6eqiC:
20.1		 4i22A-6eqiC:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OU1_A_BEZA302_0
(RETRO-ALDOLASE,
DESIGN RA114)		 6eqi SERINE/THREONINE-PRO
TEIN KINASE PINK1,
PUTATIVE
(Pediculus
humanus) 		4 / 8 ILE C 340
ILE C 355
ASN C 245
ALA C 321
 None
 0.84A 4ou1A-6eqiC:
undetectable		 4ou1A-6eqiC:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N3H_A_NCAA401_0
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA)		 6eqi SERINE/THREONINE-PRO
TEIN KINASE PINK1,
PUTATIVE
(Pediculus
humanus) 		6 / 10 VAL C 173
ALA C 191
VAL C 247
MET C 290
LEU C 341
THR C 356
 None
 0.77A 5n3hA-6eqiC:
21.5		 5n3hA-6eqiC:
25.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YU9_A_1E8A1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 6eqi SERINE/THREONINE-PRO
TEIN KINASE PINK1,
PUTATIVE
(Pediculus
humanus) 		6 / 12 VAL C 173
ALA C 191
LEU C 288
LEU C 341
THR C 356
ASP C 357
 None
 0.62A 5yu9A-6eqiC:
20.1		 5yu9A-6eqiC:
12.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YU9_B_1E8B1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 6eqi SERINE/THREONINE-PRO
TEIN KINASE PINK1,
PUTATIVE
(Pediculus
humanus) 		6 / 12 VAL C 173
ALA C 191
LEU C 288
LEU C 341
THR C 356
ASP C 357
 None
 0.60A 5yu9B-6eqiC:
20.4		 5yu9B-6eqiC:
12.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YU9_C_1E8C1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 6eqi SERINE/THREONINE-PRO
TEIN KINASE PINK1,
PUTATIVE
(Pediculus
humanus) 		5 / 12 VAL C 173
ALA C 191
LEU C 288
THR C 356
ASP C 357
 None
 0.57A 5yu9C-6eqiC:
19.6		 5yu9C-6eqiC:
12.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YU9_C_1E8C1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 6eqi SERINE/THREONINE-PRO
TEIN KINASE PINK1,
PUTATIVE
(Pediculus
humanus) 		6 / 12 VAL C 173
ALA C 191
LYS C 193
MET C 290
THR C 356
ASP C 357
 None
 1.22A 5yu9C-6eqiC:
19.6		 5yu9C-6eqiC:
12.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YU9_D_1E8D1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 6eqi SERINE/THREONINE-PRO
TEIN KINASE PINK1,
PUTATIVE
(Pediculus
humanus) 		6 / 12 VAL C 173
ALA C 191
LYS C 193
MET C 290
THR C 356
ASP C 357
 None
 1.18A 5yu9D-6eqiC:
20.5		 5yu9D-6eqiC:
12.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YU9_D_1E8D1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 6eqi SERINE/THREONINE-PRO
TEIN KINASE PINK1,
PUTATIVE
(Pediculus
humanus) 		6 / 12 VAL C 173
ALA C 191
MET C 290
LEU C 341
THR C 356
ASP C 357
 None
 0.89A 5yu9D-6eqiC:
20.5		 5yu9D-6eqiC:
12.56