SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6eqn'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BX4_A_ADNA355_1
(PROTEIN (ADENOSINE
KINASE))		 6eqn TRYPTOPHAN SYNTHASE
BETA CHAIN 2
(Sulfobacillus) 		6 / 12 GLY B 140
ARG B 169
THR B 132
ALA B 146
ALA B 115
ILE B 112
 None
 1.43A 1bx4A-6eqnB:
2.4		 1bx4A-6eqnB:
14.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BX4_A_ADNA355_1
(PROTEIN (ADENOSINE
KINASE))		 6eqn TRYPTOPHAN SYNTHASE
BETA CHAIN 2
(Sulfobacillus) 		5 / 12 GLY B 263
ALA B 268
HIS B 110
ALA B 269
ILE B 233
 PLP  B 501 (-3.5A)
None
PLP  B 501 (-3.9A)
None
None
 0.95A 1bx4A-6eqnB:
2.4		 1bx4A-6eqnB:
14.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BX4_A_ADNA355_1
(PROTEIN (ADENOSINE
KINASE))		 6eqn TRYPTOPHAN SYNTHASE
BETA CHAIN 2
(Sulfobacillus) 		6 / 12 THR B 132
GLY B 140
ARG B 169
ALA B 146
ALA B 115
ILE B 112
 None
 1.39A 1bx4A-6eqnB:
2.4		 1bx4A-6eqnB:
14.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_T_TRPT81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 6eqn TRYPTOPHAN SYNTHASE
BETA CHAIN 2
(Sulfobacillus) 		4 / 7 GLY B 137
ALA B 144
THR B 132
THR B 134
 None
 0.90A 1c9sT-6eqnB:
undetectable
1c9sU-6eqnB:
undetectable		 1c9sT-6eqnB:
undetectable
1c9sU-6eqnB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HK3_A_T44A3003_1
(SERUM ALBUMIN)		 6eqn TRYPTOPHAN SYNTHASE
BETA CHAIN 2
(Sulfobacillus) 		3 / 4 LYS B 123
ALA B 122
MET B 152
 None
 1.00A 1hk3A-6eqnB:
undetectable		 1hk3A-6eqnB:
10.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KYV_D_RBFD504_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 6eqn TRYPTOPHAN SYNTHASE
BETA CHAIN 2
(Sulfobacillus) 		5 / 12 HIS B 118
TRP B 139
GLY B 140
SER B 141
ILE B 112
 None
 1.24A 1kyvC-6eqnB:
undetectable
1kyvD-6eqnB:
undetectable		 1kyvC-6eqnB:
18.44
1kyvD-6eqnB:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KYV_E_RBFE505_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 6eqn TRYPTOPHAN SYNTHASE
BETA CHAIN 2
(Sulfobacillus) 		5 / 12 HIS B 118
TRP B 139
GLY B 140
SER B 141
ILE B 112
 None
 1.21A 1kyvD-6eqnB:
undetectable
1kyvE-6eqnB:
undetectable		 1kyvD-6eqnB:
18.44
1kyvE-6eqnB:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AOC_C_ERYC3402_0
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 6eqn TRYPTOPHAN SYNTHASE
BETA CHAIN 2
(Sulfobacillus) 		5 / 12 SER B 412
MET B 158
ILE B 156
LEU B 416
GLU B 383
 PLP  B 501 (-2.5A)
None
None
None
PLP  B 501 (-3.9A)
 1.19A 3aocC-6eqnB:
undetectable		 3aocC-6eqnB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C6G_B_VD3B700_1
(CYTOCHROME P450 2R1)		 6eqn TRYPTOPHAN SYNTHASE
BETA CHAIN 2
(Sulfobacillus) 		5 / 12 ALA B 239
ALA B 268
THR B 107
VAL B  75
THR B 105
 None
 1.13A 3c6gB-6eqnB:
undetectable		 3c6gB-6eqnB:
10.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZH_B_D2VB602_1
(CYTOCHROME P450 2R1)		 6eqn TRYPTOPHAN SYNTHASE
BETA CHAIN 2
(Sulfobacillus) 		5 / 12 ALA B 239
ALA B 268
THR B 107
VAL B  75
THR B 105
 None
 1.13A 3czhB-6eqnB:
undetectable		 3czhB-6eqnB:
10.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GVU_A_STIA1001_2
(TYROSINE-PROTEIN
KINASE ABL2)		 6eqn TRYPTOPHAN SYNTHASE
BETA CHAIN 2
(Sulfobacillus) 		4 / 5 VAL B 328
ILE B 323
TYR B 306
MET B 317
 None
 1.39A 3gvuA-6eqnB:
undetectable		 3gvuA-6eqnB:
14.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWU_A_SREA801_1
(TRANSPORTER)		 6eqn TRYPTOPHAN SYNTHASE
BETA CHAIN 2
(Sulfobacillus) 		5 / 12 LEU B 371
LEU B 375
ALA B  84
LEU B 391
THR B 384
 None
None
None
None
PLP  B 501 ( 4.6A)
 1.14A 3gwuA-6eqnB:
undetectable		 3gwuA-6eqnB:
9.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q70_A_RITA2001_2
(CANDIDAPEPSIN-2)		 6eqn TRYPTOPHAN SYNTHASE
BETA CHAIN 2
(Sulfobacillus) 		4 / 6 THR B 322
SER B 227
ILE B 209
ASP B 326
 None
 1.09A 3q70A-6eqnB:
undetectable		 3q70A-6eqnB:
11.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UCB_A_017A201_2
(PROTEASE)		 6eqn TRYPTOPHAN SYNTHASE
BETA CHAIN 2
(Sulfobacillus) 		5 / 12 GLY B 259
ALA B 290
ILE B 350
VAL B 342
VAL B 355
 None
 0.90A 3ucbB-6eqnB:
undetectable		 3ucbB-6eqnB:
28.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UCB_A_017A201_2
(PROTEASE)		 6eqn TRYPTOPHAN SYNTHASE
BETA CHAIN 2
(Sulfobacillus) 		5 / 12 GLY B 259
ILE B 350
VAL B 342
GLY B 264
VAL B 355
 None
None
None
PLP  B 501 (-3.6A)
None
 1.03A 3ucbB-6eqnB:
undetectable		 3ucbB-6eqnB:
28.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BLV_A_SAMA1281_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE J)		 6eqn TRYPTOPHAN SYNTHASE
BETA CHAIN 2
(Sulfobacillus) 		5 / 12 TYR B 422
GLY B 377
LEU B 417
GLY B 108
PRO B 382
 None
 1.11A 4blvA-6eqnB:
2.2		 4blvA-6eqnB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YIA_B_IMNB401_1
(THYROXINE-BINDING
GLOBULIN)		 6eqn TRYPTOPHAN SYNTHASE
BETA CHAIN 2
(Sulfobacillus) 		5 / 10 SER B 365
LEU B  91
LEU B  87
SER B 385
LEU B 388
 None
 1.07A 4yiaA-6eqnB:
undetectable		 4yiaA-6eqnB:
11.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_A_ACRA608_0
(ALPHA-AMYLASE)		 6eqn TRYPTOPHAN SYNTHASE
BETA CHAIN 2
(Sulfobacillus) 		4 / 6 PHE B 411
GLY B 413
THR B 384
TYR B 422
 None
PLP  B 501 (-2.9A)
PLP  B 501 ( 4.6A)
None
 1.03A 6ag0A-6eqnB:
undetectable		 6ag0A-6eqnB:
12.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_C_ACRC606_0
(ALPHA-AMYLASE)		 6eqn TRYPTOPHAN SYNTHASE
BETA CHAIN 2
(Sulfobacillus) 		4 / 6 PHE B 411
GLY B 413
THR B 384
TYR B 422
 None
PLP  B 501 (-2.9A)
PLP  B 501 ( 4.6A)
None
 0.98A 6ag0C-6eqnB:
undetectable		 6ag0C-6eqnB:
12.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BOC_A_EU7A102_0
(MATRIX PROTEIN 2)		 6eqn TRYPTOPHAN SYNTHASE
BETA CHAIN 2
(Sulfobacillus) 		4 / 6 SER B 109
ALA B 115
SER B 114
SER B 142
 PLP  B 501 ( 4.5A)
None
None
None
 0.89A 6bocA-6eqnB:
undetectable
6bocB-6eqnB:
undetectable
6bocC-6eqnB:
undetectable
6bocD-6eqnB:
undetectable		 6bocA-6eqnB:
undetectable
6bocB-6eqnB:
undetectable
6bocC-6eqnB:
undetectable
6bocD-6eqnB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BOC_A_EU7A102_0
(MATRIX PROTEIN 2)		 6eqn TRYPTOPHAN SYNTHASE
BETA CHAIN 2
(Sulfobacillus) 		4 / 6 SER B 142
SER B 109
ALA B 115
SER B 114
 None
PLP  B 501 ( 4.5A)
None
None
 0.89A 6bocA-6eqnB:
undetectable
6bocB-6eqnB:
undetectable
6bocC-6eqnB:
undetectable
6bocD-6eqnB:
undetectable		 6bocA-6eqnB:
undetectable
6bocB-6eqnB:
undetectable
6bocC-6eqnB:
undetectable
6bocD-6eqnB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NCS_A_ACTA303_0
(N-ACETYLNEURAMINIC
ACID (SIALIC ACID)
SYNTHETASE)		 6eqn TRYPTOPHAN SYNTHASE
BETA CHAIN 2
(Sulfobacillus) 		3 / 3 ILE B 238
THR B 237
PRO B  15
 None
 0.45A 6ncsA-6eqnB:
undetectable		 6ncsA-6eqnB:
undetectable