SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6er3'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QAB_F_RTLF2_0
(PROTEIN (RETINOL
BINDING PROTEIN))		 6er3 BNR/ASP-BOX REPEAT
PROTEIN
([Ruminococcus]
gnavus) 		5 / 12 ALA A 120
GLY A  40
TYR A 181
LEU A  10
GLN A 179
 None
 1.23A 1qabF-6er3A:
undetectable		 1qabF-6er3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YVP_A_ACTA2001_0
(60-KDA SS-A/RO
RIBONUCLEOPROTEIN)		 6er3 BNR/ASP-BOX REPEAT
PROTEIN
([Ruminococcus]
gnavus) 		4 / 5 SER A  45
SER A 113
THR A 115
ASN A 132
 None
 1.40A 1yvpA-6er3A:
undetectable		 1yvpA-6er3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_E_SC2E1289_1
(FICOLIN-2)		 6er3 BNR/ASP-BOX REPEAT
PROTEIN
([Ruminococcus]
gnavus) 		4 / 6 ASP A 121
ASP A 140
THR A 138
ASP A 187
 None
 1.23A 2j2pE-6er3A:
undetectable
2j2pF-6er3A:
undetectable		 2j2pE-6er3A:
16.13
2j2pF-6er3A:
16.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QO6_A_CHDA130_0
(LIVER-BASIC FATTY
ACID BINDING PROTEIN)		 6er3 BNR/ASP-BOX REPEAT
PROTEIN
([Ruminococcus]
gnavus) 		5 / 12 LEU A 129
ALA A 131
VAL A 103
PHE A  72
HIS A  73
 None
 1.32A 2qo6A-6er3A:
undetectable		 2qo6A-6er3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W1B_A_DXCA2034_0
(ACRIFLAVIN
RESISTANCE PROTEIN B)		 6er3 BNR/ASP-BOX REPEAT
PROTEIN
([Ruminococcus]
gnavus) 		3 / 3 PHE A 144
SER A 148
LEU A  37
 None
 0.77A 2w1bA-6er3A:
undetectable		 2w1bA-6er3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IA4_B_MTXB164_1
(DIHYDROFOLATE
REDUCTASE)		 6er3 BNR/ASP-BOX REPEAT
PROTEIN
([Ruminococcus]
gnavus) 		5 / 12 ALA A 143
SER A 148
ILE A 150
ARG A  70
TYR A 127
 None
 1.28A 3ia4B-6er3A:
undetectable		 3ia4B-6er3A:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TNE_B_RITB401_2
(SECRETED ASPARTIC
PROTEASE)		 6er3 BNR/ASP-BOX REPEAT
PROTEIN
([Ruminococcus]
gnavus) 		4 / 7 TYR A  46
VAL A 103
ILE A  76
THR A  49
 None
 1.06A 3tneB-6er3A:
undetectable		 3tneB-6er3A:
15.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A9K_B_TYLB2198_1
(CREB-BINDING PROTEIN)		 6er3 BNR/ASP-BOX REPEAT
PROTEIN
([Ruminococcus]
gnavus) 		4 / 5 VAL A  82
LEU A 129
ILE A 136
ASN A 132
 None
 0.99A 4a9kB-6er3A:
undetectable		 4a9kB-6er3A:
17.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AE1_A_NCAA1536_0
(DIPHTHERIA TOXIN)		 6er3 BNR/ASP-BOX REPEAT
PROTEIN
([Ruminococcus]
gnavus) 		4 / 6 GLY A 160
TYR A  75
TYR A 169
GLU A  85
 None
SIA  A 201 ( 4.4A)
None
SIA  A 201 (-3.1A)
 1.00A 4ae1A-6er3A:
undetectable		 4ae1A-6er3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QI9_C_MTXC201_1
(DIHYDROFOLATE
REDUCTASE)		 6er3 BNR/ASP-BOX REPEAT
PROTEIN
([Ruminococcus]
gnavus) 		5 / 11 ALA A 143
SER A 148
ILE A 150
ARG A  70
TYR A 127
 None
 1.20A 4qi9C-6er3A:
undetectable		 4qi9C-6er3A:
17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESK_A_1YNA701_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 6er3 BNR/ASP-BOX REPEAT
PROTEIN
([Ruminococcus]
gnavus) 		5 / 12 GLY A 160
LEU A  86
PHE A 144
PHE A 146
THR A  41
 None
 1.14A 5eskA-6er3A:
undetectable		 5eskA-6er3A:
10.35