SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6ero'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ESW_A_ACRA652_1
(AMYLOMALTASE)		 6ero DIMETHYLADENOSINE
TRANSFERASE 2,
MITOCHONDRIAL,DIMETH
YLADENOSINE
TRANSFERASE 2,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 6 TYR A  14
GLY A  45
GLY A 133
SER A  65
 None
 0.90A 1eswA-6eroA:
undetectable		 1eswA-6eroA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LH6_A_NIOA155_1
(LEGHEMOGLOBIN A
(NICOTINATE MET))		 6ero DIMETHYLADENOSINE
TRANSFERASE 2,
MITOCHONDRIAL,DIMETH
YLADENOSINE
TRANSFERASE 2,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 7 PHE A  91
PHE A  92
PHE A 135
VAL A 131
 None
 0.93A 1lh6A-6eroA:
undetectable		 1lh6A-6eroA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WOP_A_FFOA2888_0
(AMINOMETHYLTRANSFERA
SE)		 6ero DIMETHYLADENOSINE
TRANSFERASE 2,
MITOCHONDRIAL,DIMETH
YLADENOSINE
TRANSFERASE 2,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 10 LEU A 268
LEU A 290
ILE A 267
GLU A 308
LEU A 240
 None
 1.14A 1wopA-6eroA:
undetectable		 1wopA-6eroA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YDO_A_ADNA400_1
(ADENOSINE RECEPTOR
A2A)		 6ero DIMETHYLADENOSINE
TRANSFERASE 2,
MITOCHONDRIAL,DIMETH
YLADENOSINE
TRANSFERASE 2,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 LEU A 147
PHE A 135
GLU A 140
LEU A 177
ILE A 216
 None
 1.29A 2ydoA-6eroA:
undetectable		 2ydoA-6eroA:
23.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DR6_A_SRYA1956_1
(16S RRNA
30S RIBOSOMAL
PROTEIN S12)		 6ero DIMETHYLADENOSINE
TRANSFERASE 2,
MITOCHONDRIAL,DIMETH
YLADENOSINE
TRANSFERASE 2,
MITOCHONDRIAL
(Homo
sapiens) 		3 / 3 LYS A  93
PRO A  96
LYS A 103
 None
 1.46A 4dr6L-6eroA:
undetectable		 4dr6L-6eroA:
18.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DV7_A_SRYA1601_1
(16S RRNA
RIBOSOMAL PROTEIN
S12)		 6ero DIMETHYLADENOSINE
TRANSFERASE 2,
MITOCHONDRIAL,DIMETH
YLADENOSINE
TRANSFERASE 2,
MITOCHONDRIAL
(Homo
sapiens) 		3 / 3 LYS A  93
PRO A  96
LYS A 103
 None
 1.45A 4dv7L-6eroA:
undetectable		 4dv7L-6eroA:
18.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DV7_A_SRYA1601_1
(16S RRNA
RIBOSOMAL PROTEIN
S12)		 6ero DIMETHYLADENOSINE
TRANSFERASE 2,
MITOCHONDRIAL,DIMETH
YLADENOSINE
TRANSFERASE 2,
MITOCHONDRIAL
(Homo
sapiens) 		3 / 3 LYS A 103
PRO A 105
LYS A  93
 None
 1.46A 4dv7L-6eroA:
undetectable		 4dv7L-6eroA:
18.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_F_SAMF401_0
(METHYLTRANSFERASE
NSUN4)		 6ero DIMETHYLADENOSINE
TRANSFERASE 2,
MITOCHONDRIAL,DIMETH
YLADENOSINE
TRANSFERASE 2,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 PRO A 207
GLY A 208
LEU A 215
ASP A  17
LEU A  49
 None
 1.08A 4fp9F-6eroA:
6.3		 4fp9F-6eroA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K4Y_A_ACTA502_0
(RNA-DEPENDENT RNA
POLYMERASE)		 6ero DIMETHYLADENOSINE
TRANSFERASE 2,
MITOCHONDRIAL,DIMETH
YLADENOSINE
TRANSFERASE 2,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 5 LYS A 176
LEU A 177
GLU A 173
LEU A 144
 None
 1.06A 4k4yA-6eroA:
undetectable		 4k4yA-6eroA:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K4Y_E_ACTE503_0
(RNA-DEPENDENT RNA
POLYMERASE)		 6ero DIMETHYLADENOSINE
TRANSFERASE 2,
MITOCHONDRIAL,DIMETH
YLADENOSINE
TRANSFERASE 2,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 4 LYS A 176
LEU A 177
GLU A 173
LEU A 144
 None
 1.08A 4k4yE-6eroA:
undetectable		 4k4yE-6eroA:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K4Y_I_ACTI503_0
(RNA-DEPENDENT RNA
POLYMERASE)		 6ero DIMETHYLADENOSINE
TRANSFERASE 2,
MITOCHONDRIAL,DIMETH
YLADENOSINE
TRANSFERASE 2,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 5 LYS A 176
LEU A 177
GLU A 173
LEU A 144
 None
 1.08A 4k4yI-6eroA:
undetectable		 4k4yI-6eroA:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GWY_E_010E6_0
(N-[(5-METHYLISOXAZOL
-3-YL)CARBONYL]ALANY
L-L-VALYL-N~1~-((1R,
2Z)-4-(BENZYLOXY)-4-
OXO-1-{[(3R)-2-OXOPY
RROLIDIN-3-YL]METHYL
}BUT-2-ENYL)-L-LEUCI
NAMIDE
MAIN PROTEASE)		 6ero DIMETHYLADENOSINE
TRANSFERASE 2,
MITOCHONDRIAL,DIMETH
YLADENOSINE
TRANSFERASE 2,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 4 THR A  50
LEU A  76
HIS A  72
GLY A  77
 None
 1.37A 5gwyA-6eroA:
undetectable		 5gwyA-6eroA:
18.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_F_TA1F502_2
(TUBULIN BETA CHAIN)		 6ero DIMETHYLADENOSINE
TRANSFERASE 2,
MITOCHONDRIAL,DIMETH
YLADENOSINE
TRANSFERASE 2,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 5 LEU A 259
LEU A 290
THR A 251
PRO A 181
 None
 1.04A 6ew0F-6eroA:
undetectable		 6ew0F-6eroA:
13.38