SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6erq'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RB3_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 6erq DIMETHYLADENOSINE
TRANSFERASE 2,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 10 ALA F 185
LYS F 219
ILE F 178
ILE F 223
THR F 184
 None
 1.25A 1rb3A-6erqF:
undetectable		 1rb3A-6erqF:
18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O01_A_PQNA5001_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1)		 6erq DIMETHYLADENOSINE
TRANSFERASE 2,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 8 MET F 194
PHE F 228
ALA F  81
LEU F  84
 None
 1.09A 2o01A-6erqF:
undetectable		 2o01A-6erqF:
17.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K4Y_A_ACTA502_0
(RNA-DEPENDENT RNA
POLYMERASE)		 6erq DIMETHYLADENOSINE
TRANSFERASE 2,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 5 LYS F 236
LEU F 237
GLU F 233
LEU F 204
 None
 1.03A 4k4yA-6erqF:
undetectable		 4k4yA-6erqF:
23.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K4Y_E_ACTE503_0
(RNA-DEPENDENT RNA
POLYMERASE)		 6erq DIMETHYLADENOSINE
TRANSFERASE 2,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 4 LYS F 236
LEU F 237
GLU F 233
LEU F 204
 None
 1.04A 4k4yE-6erqF:
undetectable		 4k4yE-6erqF:
23.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K4Y_I_ACTI503_0
(RNA-DEPENDENT RNA
POLYMERASE)		 6erq DIMETHYLADENOSINE
TRANSFERASE 2,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 5 LYS F 236
LEU F 237
GLU F 233
LEU F 204
 None
 1.04A 4k4yI-6erqF:
undetectable		 4k4yI-6erqF:
23.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y8W_A_STRA604_1
(CYTOCHROME P450
21-HYDROXYLASE)		 6erq DIMETHYLADENOSINE
TRANSFERASE 2,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 SER F 169
LEU F 207
ARG F 157
ASP F 155
VAL F 191
 None
 1.10A 4y8wA-6erqF:
undetectable		 4y8wA-6erqF:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G5G_A_ACTA1231_0
(PUTATIVE XANTHINE
DEHYDROGENASE YAGR
MOLYBDENUM-BINDING
SU SUBUNIT
PUTATIVE XANTHINE
DEHYDROGENASE YAGT
IRON-SULFUR-BINDING
SUBUNIT)		 6erq DIMETHYLADENOSINE
TRANSFERASE 2,
MITOCHONDRIAL
(Homo
sapiens) 		3 / 3 ARG F 157
THR F 215
ASP F 210
 None
 0.93A 5g5gA-6erqF:
undetectable
5g5gB-6erqF:
undetectable		 5g5gA-6erqF:
21.24
5g5gB-6erqF:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GWY_E_010E6_0
(N-[(5-METHYLISOXAZOL
-3-YL)CARBONYL]ALANY
L-L-VALYL-N~1~-((1R,
2Z)-4-(BENZYLOXY)-4-
OXO-1-{[(3R)-2-OXOPY
RROLIDIN-3-YL]METHYL
}BUT-2-ENYL)-L-LEUCI
NAMIDE
MAIN PROTEASE)		 6erq DIMETHYLADENOSINE
TRANSFERASE 2,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 4 THR F 110
LEU F 136
HIS F 132
GLY F 137
 None
 1.30A 5gwyA-6erqF:
undetectable		 5gwyA-6erqF:
17.45