SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6es1'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRL_E_TFPE212_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 6es1 SYNAPTIC VESICLE
GLYCOPROTEIN 2C
(Homo
sapiens) 		4 / 7 PHE B 542
PHE B 507
PHE B 547
SER B 555
 None
 1.14A 1wrlE-6es1B:
undetectable		 1wrlE-6es1B:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSF_E_PZIE802_0
(GLUTAMATE RECEPTOR 2)		 6es1 SYNAPTIC VESICLE
GLYCOPROTEIN 2C
(Homo
sapiens) 		3 / 3 ASP B 546
ASN B 565
SER B 527
 None
 0.93A 3lsfB-6es1B:
undetectable
3lsfE-6es1B:
undetectable		 3lsfB-6es1B:
undetectable
3lsfE-6es1B:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_G_CLMG221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 6es1 SYNAPTIC VESICLE
GLYCOPROTEIN 2C
(Homo
sapiens) 		5 / 12 THR B 530
PHE B 507
SER B 527
PHE B 557
PHE B 522
 None
 1.45A 3u9fG-6es1B:
undetectable
3u9fH-6es1B:
undetectable		 3u9fG-6es1B:
undetectable
3u9fH-6es1B:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJJ_B_NCTB501_1
(CYTOCHROME P450 2A6)		 6es1 SYNAPTIC VESICLE
GLYCOPROTEIN 2C
(Homo
sapiens) 		4 / 7 PHE B 522
VAL B 505
PHE B 517
PHE B 532
 None
 0.98A 4ejjB-6es1B:
undetectable		 4ejjB-6es1B:
10.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJJ_B_NCTB501_1
(CYTOCHROME P450 2A6)		 6es1 SYNAPTIC VESICLE
GLYCOPROTEIN 2C
(Homo
sapiens) 		4 / 7 PHE B 542
VAL B 525
PHE B 537
PHE B 552
 None
 0.98A 4ejjB-6es1B:
undetectable		 4ejjB-6es1B:
10.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HUO_D_08HD501_0
(GAMMA-AMINOBUTYRIC
ACID RECEPTOR
SUBUNIT
ALPHA-1,GAMMA-AMINOB
UTYRIC ACID RECEPTOR
SUBUNIT ALPHA-1
GAMMA-AMINOBUTYRIC
ACID RECEPTOR
SUBUNIT GAMMA-2)		 6es1 SYNAPTIC VESICLE
GLYCOPROTEIN 2C
(Homo
sapiens) 		4 / 8 PHE B 532
PHE B 522
SER B 515
TYR B 497
 None
 1.11A 6huoC-6es1B:
undetectable
6huoD-6es1B:
undetectable		 6huoC-6es1B:
16.28
6huoD-6es1B:
20.00