SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6es4'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9H_A_RAPA108_1
(FKBP12.6)		 6es4 SYNCRIP, ISOFORM K
(Drosophila
melanogaster) 		5 / 12 GLU A 165
VAL A 210
ILE A 190
PHE A 184
ILE A 131
 EDO  A 309 ( 4.3A)
None
EDO  A 306 (-4.0A)
None
None
 1.15A 1c9hA-6es4A:
undetectable		 1c9hA-6es4A:
18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VAV_F_CSCF1383_2
(ACETYL-COA--DEACETYL
CEPHALOSPORIN C
ACETYLTRANSFERASE)		 6es4 SYNCRIP, ISOFORM K
(Drosophila
melanogaster) 		3 / 3 LEU A  96
MET A 100
MET A 197
 None
 0.87A 2vavF-6es4A:
undetectable		 2vavF-6es4A:
12.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DV1_A_SRYA1601_1
(16S RRNA
RIBOSOMAL PROTEIN
S12)		 6es4 SYNCRIP, ISOFORM K
(Drosophila
melanogaster) 		3 / 3 LYS A 234
LYS A 231
PRO A 232
 SO4  A 303 (-3.0A)
None
None
 1.05A 4dv1L-6es4A:
undetectable		 4dv1L-6es4A:
16.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K0B_B_SAMB504_0
(S-ADENOSYLMETHIONINE
SYNTHASE)		 6es4 SYNCRIP, ISOFORM K
(Drosophila
melanogaster) 		4 / 8 ASN A 204
ARG A 146
LEU A 180
ILE A 230
 None
 1.06A 4k0bA-6es4A:
undetectable		 4k0bA-6es4A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L7I_B_SAMB501_0
(S-ADENOSYLMETHIONINE
SYNTHASE)		 6es4 SYNCRIP, ISOFORM K
(Drosophila
melanogaster) 		4 / 8 ASN A 204
ARG A 146
LEU A 180
ILE A 230
 None
 1.09A 4l7iA-6es4A:
undetectable		 4l7iA-6es4A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QZU_C_RTLC201_0
(RETINOL-BINDING
PROTEIN 2)		 6es4 SYNCRIP, ISOFORM K
(Drosophila
melanogaster) 		5 / 12 PHE A 184
ALA A 221
LEU A 236
LEU A 195
LEU A 180
 None
CME  A 187 ( 3.7A)
None
None
None
 1.18A 4qzuC-6es4A:
undetectable		 4qzuC-6es4A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6I0Y_A_TRPA3001_0
(23S RIBOSOMAL RNA
TRYPTOPHANASE OPERON
LEADER PEPTIDE)		 6es4 SYNCRIP, ISOFORM K
(Drosophila
melanogaster) 		3 / 3 TRP A 191
ILE A 190
ASP A 192
 None
EDO  A 306 (-4.0A)
None
 0.86A 6i0y7-6es4A:
undetectable		 6i0y7-6es4A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMP_P_CHDP302_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 6es4 SYNCRIP, ISOFORM K
(Drosophila
melanogaster) 		4 / 7 ASP A 140
THR A 138
TYR A 148
TRP A 155
 None
None
EDO  A 306 (-4.5A)
None
 1.49A 6nmpN-6es4A:
undetectable
6nmpP-6es4A:
undetectable		 6nmpN-6es4A:
undetectable
6nmpP-6es4A:
undetectable