SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6esd'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZLQ_A_ACTA1503_0
(NICKEL-BINDING
PERIPLASMIC PROTEIN)		 6esd FLAVIN-DEPENDENT
L-TRYPTOPHAN OXIDASE
VIOA
(Chromobacterium
violaceum) 		4 / 4 LYS B 297
ARG B 296
ASP B 311
ASP B 144
 None
 0.70A 1zlqA-6esdB:
0.0		 1zlqA-6esdB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIM_A_CHDA525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 6esd FLAVIN-DEPENDENT
L-TRYPTOPHAN OXIDASE
VIOA
(Chromobacterium
violaceum) 		4 / 6 HIS B 379
ASP B 214
THR B 213
TRP B 257
 None
 1.49A 2eimA-6esdB:
undetectable
2eimC-6esdB:
undetectable		 2eimA-6esdB:
undetectable
2eimC-6esdB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B9Z_A_ACRA1818_1
(ALPHA-GLUCOSIDASE,
PUTATIVE, ADG31B)		 6esd FLAVIN-DEPENDENT
L-TRYPTOPHAN OXIDASE
VIOA
(Chromobacterium
violaceum) 		5 / 12 LEU B 187
ILE B 191
TYR B  65
LEU B 402
GLU B 399
 None
 1.33A 4b9zA-6esdB:
undetectable		 4b9zA-6esdB:
7.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B9Z_A_ACRA1818_1
(ALPHA-GLUCOSIDASE,
PUTATIVE, ADG31B)		 6esd FLAVIN-DEPENDENT
L-TRYPTOPHAN OXIDASE
VIOA
(Chromobacterium
violaceum) 		5 / 12 LEU B 187
ILE B 191
TYR B  65
LEU B 402
HIS B  79
 None
 1.49A 4b9zA-6esdB:
undetectable		 4b9zA-6esdB:
7.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EQ4_B_SALB601_1
(4-SUBSTITUTED
BENZOATES-GLUTAMATE
LIGASE GH3.12)		 6esd FLAVIN-DEPENDENT
L-TRYPTOPHAN OXIDASE
VIOA
(Chromobacterium
violaceum) 		4 / 8 LEU B 402
ILE B 191
VAL B 195
GLY B  16
 None
 0.90A 4eq4B-6esdB:
undetectable		 4eq4B-6esdB:
8.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G0U_F_ASWF101_1
(DNA TOPOISOMERASE
2-BETA)		 6esd FLAVIN-DEPENDENT
L-TRYPTOPHAN OXIDASE
VIOA
(Chromobacterium
violaceum) 		4 / 6 GLY B  61
ALA B 180
GLU B  59
GLN B  40
 FAD  B 501 (-4.1A)
None
None
FAD  B 501 (-4.9A)
 1.01A 4g0uA-6esdB:
2.4		 4g0uA-6esdB:
8.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DXB_A_ESTA1000_1
(ESTROGEN RECEPTOR)		 6esd FLAVIN-DEPENDENT
L-TRYPTOPHAN OXIDASE
VIOA
(Chromobacterium
violaceum) 		5 / 10 LEU B 377
ALA B 408
GLU B 407
LEU B 411
GLY B 383
 None
 1.41A 5dxbA-6esdB:
undetectable		 5dxbA-6esdB:
17.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KB5_A_ADNA401_1
(ADENOSINE KINASE)		 6esd FLAVIN-DEPENDENT
L-TRYPTOPHAN OXIDASE
VIOA
(Chromobacterium
violaceum) 		5 / 12 LEU B  24
GLY B  11
ALA B  20
LEU B  34
GLY B  44
 None
FAD  B 501 (-3.5A)
None
None
None
 0.94A 5kb5A-6esdB:
2.4		 5kb5A-6esdB:
12.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KXI_A_NCTA402_1
(NEURONAL
ACETYLCHOLINE
RECEPTOR SUBUNIT
ALPHA-4
NEURONAL
ACETYLCHOLINE
RECEPTOR SUBUNIT
BETA-2)		 6esd FLAVIN-DEPENDENT
L-TRYPTOPHAN OXIDASE
VIOA
(Chromobacterium
violaceum) 		4 / 8 TYR B 329
TRP B 318
THR B 310
LEU B 295
 None
 1.46A 5kxiA-6esdB:
undetectable
5kxiB-6esdB:
undetectable		 5kxiA-6esdB:
10.41
5kxiB-6esdB:
10.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KXI_D_NCTD402_1
(NEURONAL
ACETYLCHOLINE
RECEPTOR SUBUNIT
ALPHA-4
NEURONAL
ACETYLCHOLINE
RECEPTOR SUBUNIT
BETA-2)		 6esd FLAVIN-DEPENDENT
L-TRYPTOPHAN OXIDASE
VIOA
(Chromobacterium
violaceum) 		4 / 8 TYR B 329
TRP B 318
THR B 310
LEU B 295
 None
 1.42A 5kxiD-6esdB:
undetectable
5kxiE-6esdB:
undetectable		 5kxiD-6esdB:
10.41
5kxiE-6esdB:
10.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L8D_A_ACTA601_0
(NICKEL-BINDING
PERIPLASMIC PROTEIN)		 6esd FLAVIN-DEPENDENT
L-TRYPTOPHAN OXIDASE
VIOA
(Chromobacterium
violaceum) 		4 / 4 LYS B 297
ARG B 296
ASP B 311
ASP B 144
 None
 0.71A 5l8dA-6esdB:
0.0		 5l8dA-6esdB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MWU_A_ACTA601_0
(NICKEL-BINDING
PERIPLASMIC PROTEIN)		 6esd FLAVIN-DEPENDENT
L-TRYPTOPHAN OXIDASE
VIOA
(Chromobacterium
violaceum) 		4 / 4 LYS B 297
ARG B 296
ASP B 311
ASP B 144
 None
 0.71A 5mwuA-6esdB:
0.0		 5mwuA-6esdB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V4V_A_NCAA402_0
(NADPH DEHYDROGENASE
3)		 6esd FLAVIN-DEPENDENT
L-TRYPTOPHAN OXIDASE
VIOA
(Chromobacterium
violaceum) 		4 / 8 HIS B 373
TYR B 391
PHE B 253
PRO B 254
 None
 1.22A 5v4vA-6esdB:
undetectable		 5v4vA-6esdB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V4V_B_NCAB402_0
(NADPH DEHYDROGENASE
3)		 6esd FLAVIN-DEPENDENT
L-TRYPTOPHAN OXIDASE
VIOA
(Chromobacterium
violaceum) 		4 / 8 HIS B 373
TYR B 391
PHE B 253
PRO B 254
 None
 1.20A 5v4vB-6esdB:
undetectable		 5v4vB-6esdB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZBD_A_TRPA501_0
(FLAVIN-DEPENDENT
L-TRYPTOPHAN OXIDASE
VIOA)		 6esd FLAVIN-DEPENDENT
L-TRYPTOPHAN OXIDASE
VIOA
(Chromobacterium
violaceum) 		10 / 10 ARG B  64
TYR B 143
ALA B 145
HIS B 163
LEU B 267
TYR B 309
ASP B 311
VAL B 363
GLY B 396
TRP B 397
 CL  B 502 ( 3.6A)
None
None
CL  B 502 ( 4.9A)
FAD  B 501 (-3.8A)
None
None
None
FAD  B 501 ( 4.3A)
FAD  B 501 (-4.9A)
 0.42A 5zbdA-6esdB:
60.3		 5zbdA-6esdB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZBD_B_TRPB501_0
(FLAVIN-DEPENDENT
L-TRYPTOPHAN OXIDASE
VIOA)		 6esd FLAVIN-DEPENDENT
L-TRYPTOPHAN OXIDASE
VIOA
(Chromobacterium
violaceum) 		10 / 10 ARG B  64
TYR B 143
ALA B 145
HIS B 163
LEU B 267
TYR B 309
ASP B 311
VAL B 363
GLY B 396
TRP B 397
 CL  B 502 ( 3.6A)
None
None
CL  B 502 ( 4.9A)
FAD  B 501 (-3.8A)
None
None
None
FAD  B 501 ( 4.3A)
FAD  B 501 (-4.9A)
 0.45A 5zbdB-6esdB:
60.4		 5zbdB-6esdB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BXN_B_SAMB901_0
(DIPHTHAMIDE
BIOSYNTHESIS ENZYME
DPH2)		 6esd FLAVIN-DEPENDENT
L-TRYPTOPHAN OXIDASE
VIOA
(Chromobacterium
violaceum) 		5 / 12 LEU B 403
GLY B 401
SER B 378
CYH B 387
ILE B 238
 None
FAD  B 501 ( 4.6A)
None
None
None
 1.35A 6bxnB-6esdB:
2.5		 6bxnB-6esdB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CNJ_D_NCTD402_1
(NEURONAL
ACETYLCHOLINE
RECEPTOR SUBUNIT
ALPHA-4
NEURONAL
ACETYLCHOLINE
RECEPTOR SUBUNIT
BETA-2)		 6esd FLAVIN-DEPENDENT
L-TRYPTOPHAN OXIDASE
VIOA
(Chromobacterium
violaceum) 		4 / 8 TYR B 329
TRP B 318
THR B 310
LEU B 295
 None
 1.31A 6cnjD-6esdB:
undetectable
6cnjE-6esdB:
undetectable		 6cnjD-6esdB:
21.43
6cnjE-6esdB:
16.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G2P_A_TRPA502_0
(FLAVIN-DEPENDENT
L-TRYPTOPHAN OXIDASE
VIOA)		 6esd FLAVIN-DEPENDENT
L-TRYPTOPHAN OXIDASE
VIOA
(Chromobacterium
violaceum) 		6 / 7 ARG B  64
TYR B 143
HIS B 163
TYR B 309
VAL B 363
TRP B 397
 CL  B 502 ( 3.6A)
None
CL  B 502 ( 4.9A)
None
None
FAD  B 501 (-4.9A)
 0.44A 6g2pA-6esdB:
63.1		 6g2pA-6esdB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G2P_B_TRPB502_0
(FLAVIN-DEPENDENT
L-TRYPTOPHAN OXIDASE
VIOA)		 6esd FLAVIN-DEPENDENT
L-TRYPTOPHAN OXIDASE
VIOA
(Chromobacterium
violaceum) 		9 / 10 ARG B  64
TYR B 143
ALA B 145
HIS B 163
LEU B 267
TYR B 309
ASP B 311
VAL B 363
TRP B 397
 CL  B 502 ( 3.6A)
None
None
CL  B 502 ( 4.9A)
FAD  B 501 (-3.8A)
None
None
None
FAD  B 501 (-4.9A)
 0.27A 6g2pB-6esdB:
61.3		 6g2pB-6esdB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NM4_B_SAMB402_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
PRDM9)		 6esd FLAVIN-DEPENDENT
L-TRYPTOPHAN OXIDASE
VIOA
(Chromobacterium
violaceum) 		5 / 9 ILE B 238
ALA B 240
GLY B  16
LEU B  17
GLY B 400
 None
 1.28A 6nm4B-6esdB:
undetectable		 6nm4B-6esdB:
undetectable