SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6et7'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_A_ACTA3003_0
(BETA-CARBONIC
ANHYDRASE)		 6et7 DIGUANYLATE CYCLASE
(GGDEF)
DOMAIN-CONTAINING
PROTEIN
(Idiomarina
sp.
A28L) 		4 / 8 ASP A 163
VAL A 165
HIS A 283
GLY A 161
 None
 0.95A 1ekjA-6et7A:
undetectable
1ekjB-6et7A:
undetectable		 1ekjA-6et7A:
undetectable
1ekjB-6et7A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JFA_B_RALB600_2
(ESTROGEN RECEPTOR)		 6et7 DIGUANYLATE CYCLASE
(GGDEF)
DOMAIN-CONTAINING
PROTEIN
(Idiomarina
sp.
A28L) 		4 / 4 LEU A 152
THR A 151
ILE A 179
HIS A 145
 None
 1.34A 2jfaB-6et7A:
undetectable		 2jfaB-6et7A:
14.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD4_A_CHDA802_0
(FERROCHELATASE)		 6et7 DIGUANYLATE CYCLASE
(GGDEF)
DOMAIN-CONTAINING
PROTEIN
(Idiomarina
sp.
A28L) 		4 / 6 ARG A 299
ARG A 295
PRO A 217
VAL A 244
 None
CL  A 702 (-3.0A)
None
None
 1.49A 2qd4A-6et7A:
undetectable		 2qd4A-6et7A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QO4_A_CHDA130_0
(LIVER-BASIC FATTY
ACID BINDING PROTEIN)		 6et7 DIGUANYLATE CYCLASE
(GGDEF)
DOMAIN-CONTAINING
PROTEIN
(Idiomarina
sp.
A28L) 		5 / 12 TYR A 362
LEU A 499
ILE A 495
ALA A 503
THR A 333
 None
 1.41A 2qo4A-6et7A:
undetectable		 2qo4A-6et7A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NXU_A_RITA600_1
(CYTOCHROME P450 3A4)		 6et7 DIGUANYLATE CYCLASE
(GGDEF)
DOMAIN-CONTAINING
PROTEIN
(Idiomarina
sp.
A28L) 		5 / 12 SER A 592
ILE A 534
PHE A 535
ILE A 612
ALA A 613
 None
 1.08A 3nxuA-6et7A:
undetectable		 3nxuA-6et7A:
10.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NXU_B_RITB600_1
(CYTOCHROME P450 3A4)		 6et7 DIGUANYLATE CYCLASE
(GGDEF)
DOMAIN-CONTAINING
PROTEIN
(Idiomarina
sp.
A28L) 		5 / 12 SER A 592
ILE A 534
PHE A 535
ILE A 612
ALA A 613
 None
 1.08A 3nxuB-6et7A:
undetectable		 3nxuB-6et7A:
10.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CX7_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 6et7 DIGUANYLATE CYCLASE
(GGDEF)
DOMAIN-CONTAINING
PROTEIN
(Idiomarina
sp.
A28L) 		4 / 8 HIS A 193
GLU A 181
MET A 166
ILE A 179
 LBV  A 701 (-3.8A)
None
None
None
 1.35A 4cx7A-6et7A:
undetectable
4cx7B-6et7A:
undetectable		 4cx7A-6et7A:
12.57
4cx7B-6et7A:
12.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JX1_F_CAMF502_0
(CAMPHOR
5-MONOOXYGENASE)		 6et7 DIGUANYLATE CYCLASE
(GGDEF)
DOMAIN-CONTAINING
PROTEIN
(Idiomarina
sp.
A28L) 		4 / 4 TYR A 208
THR A 265
VAL A 298
ILE A 278
 None
 1.18A 4jx1F-6et7A:
undetectable		 4jx1F-6et7A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G44_A_YTZA1512_1
(NUCLEAR RECEPTOR
ROR-GAMMA)		 6et7 DIGUANYLATE CYCLASE
(GGDEF)
DOMAIN-CONTAINING
PROTEIN
(Idiomarina
sp.
A28L) 		5 / 9 LEU A 499
LEU A 434
ALA A 326
VAL A 323
ARG A 327
 None
 1.44A 5g44A-6et7A:
undetectable		 5g44A-6et7A:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3C_C_AC2C301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 6et7 DIGUANYLATE CYCLASE
(GGDEF)
DOMAIN-CONTAINING
PROTEIN
(Idiomarina
sp.
A28L) 		5 / 11 ALA A 631
VAL A 591
GLU A 593
ASP A 599
ILE A 611
 None
 0.78A 5i3cC-6et7A:
undetectable		 5i3cC-6et7A:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MVM_A_PFLA510_1
(PROTON-GATED ION
CHANNEL)		 6et7 DIGUANYLATE CYCLASE
(GGDEF)
DOMAIN-CONTAINING
PROTEIN
(Idiomarina
sp.
A28L) 		5 / 9 ILE A  44
ALA A  47
ILE A 229
ILE A  62
ALA A  71
 None
 1.13A 5mvmA-6et7A:
2.9
5mvmE-6et7A:
5.8		 5mvmA-6et7A:
21.35
5mvmE-6et7A:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O4Y_D_CCSD14_0
(PHE-MAA-ASN-PRO-HIS-
LEU-SER-TRP-SER-TRP-
9KK-9KK-ARG-CCS-GLY-
NH2
PROGRAMMED CELL
DEATH 1 LIGAND 1)		 6et7 DIGUANYLATE CYCLASE
(GGDEF)
DOMAIN-CONTAINING
PROTEIN
(Idiomarina
sp.
A28L) 		5 / 12 TRP A  96
GLY A 106
GLY A 243
VAL A 244
ARG A 294
 None
None
None
None
CL  A 702 (-4.5A)
 1.23A 5o4yD-6et7A:
undetectable
5o4yE-6et7A:
undetectable		 5o4yD-6et7A:
undetectable
5o4yE-6et7A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VC0_A_RITA602_1
(CYTOCHROME P450 3A4)		 6et7 DIGUANYLATE CYCLASE
(GGDEF)
DOMAIN-CONTAINING
PROTEIN
(Idiomarina
sp.
A28L) 		5 / 12 SER A 592
ILE A 534
PHE A 535
ILE A 612
ALA A 613
 None
 1.10A 5vc0A-6et7A:
undetectable		 5vc0A-6et7A:
10.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_G_CVIG301_0
(REGULATORY PROTEIN
TETR)		 6et7 DIGUANYLATE CYCLASE
(GGDEF)
DOMAIN-CONTAINING
PROTEIN
(Idiomarina
sp.
A28L) 		5 / 12 GLU A 541
LEU A 610
ILE A 612
VAL A 548
ASP A 542
 None
 1.09A 5vlmG-6et7A:
undetectable		 5vlmG-6et7A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DYO_A_LDPA901_0
(EBONY)		 6et7 DIGUANYLATE CYCLASE
(GGDEF)
DOMAIN-CONTAINING
PROTEIN
(Idiomarina
sp.
A28L) 		4 / 5 GLU A 388
VAL A 384
LEU A 363
HIS A 341
 None
 1.42A 6dyoA-6et7A:
undetectable		 6dyoA-6et7A:
25.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EMU_B_SAMB301_0
(TRNA
(GUANINE(9)-/ADENINE
(9)-N1)-METHYLTRANSF
ERASE)		 6et7 DIGUANYLATE CYCLASE
(GGDEF)
DOMAIN-CONTAINING
PROTEIN
(Idiomarina
sp.
A28L) 		5 / 12 ILE A 267
GLY A 268
ILE A 215
VAL A 244
ILE A 213
 None
 0.95A 6emuB-6et7A:
undetectable		 6emuB-6et7A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EMU_C_SAMC301_0
(TRNA
(GUANINE(9)-/ADENINE
(9)-N1)-METHYLTRANSF
ERASE)		 6et7 DIGUANYLATE CYCLASE
(GGDEF)
DOMAIN-CONTAINING
PROTEIN
(Idiomarina
sp.
A28L) 		5 / 12 ILE A 267
GLY A 268
ILE A 215
VAL A 244
ILE A 213
 None
 0.96A 6emuC-6et7A:
undetectable		 6emuC-6et7A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FBN_B_SAMB401_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 6et7 DIGUANYLATE CYCLASE
(GGDEF)
DOMAIN-CONTAINING
PROTEIN
(Idiomarina
sp.
A28L) 		4 / 7 ALA A 334
ASP A 350
ASP A 498
ILE A 495
 None
 0.96A 6fbnA-6et7A:
undetectable		 6fbnA-6et7A:
undetectable