SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6eti'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E71_M_ASCM995_0
(MYROSINASE MA1)
6eti ATP-BINDING CASSETTE
SUB-FAMILY G MEMBER
2

(Homo
sapiens)
4 / 7 ILE A 335
TYR A 282
PHE A 277
PHE A 293
None
1.26A 1e71M-6etiA:
undetectable
1e71M-6etiA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J8U_A_H4BA429_1
(PHENYLALANINE-4-HYDR
OXYLASE)
6eti ATP-BINDING CASSETTE
SUB-FAMILY G MEMBER
2

(Homo
sapiens)
4 / 7 LEU A 649
SER A 467
PHE A 470
LEU A 471
None
0.68A 1j8uA-6etiA:
undetectable
1j8uA-6etiA:
12.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JU6_A_LYAA317_1
(THYMIDYLATE SYNTHASE)
6eti ATP-BINDING CASSETTE
SUB-FAMILY G MEMBER
2

(Homo
sapiens)
5 / 11 ILE A 239
ASP A 254
LEU A  75
GLY A  74
ALA A 270
None
1.27A 1ju6A-6etiA:
undetectable
1ju6A-6etiA:
14.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JU6_C_LYAC315_1
(THYMIDYLATE SYNTHASE)
6eti ATP-BINDING CASSETTE
SUB-FAMILY G MEMBER
2

(Homo
sapiens)
5 / 10 ILE A 239
ASP A 254
LEU A  75
GLY A  74
ALA A 270
None
1.28A 1ju6C-6etiA:
undetectable
1ju6C-6etiA:
14.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JU6_D_LYAD315_1
(THYMIDYLATE SYNTHASE)
6eti ATP-BINDING CASSETTE
SUB-FAMILY G MEMBER
2

(Homo
sapiens)
5 / 11 ILE A 239
ASP A 254
LEU A  75
GLY A  74
ALA A 270
None
1.27A 1ju6D-6etiA:
undetectable
1ju6D-6etiA:
14.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQT_A_ACTA1871_0
(FPRA)
6eti ATP-BINDING CASSETTE
SUB-FAMILY G MEMBER
2

(Homo
sapiens)
4 / 7 PHE A 253
PRO A 245
ALA A  77
PHE A 240
None
1.06A 1lqtA-6etiA:
undetectable
1lqtA-6etiA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQU_A_ACTA1428_0
(FPRA)
6eti ATP-BINDING CASSETTE
SUB-FAMILY G MEMBER
2

(Homo
sapiens)
4 / 7 PHE A 253
PRO A 245
ALA A  77
PHE A 240
None
1.05A 1lquA-6etiA:
undetectable
1lquA-6etiA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OIP_A_VIVA1278_1
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)
6eti ATP-BINDING CASSETTE
SUB-FAMILY G MEMBER
2

(Homo
sapiens)
4 / 5 SER A 440
SER A 441
PHE A 489
VAL A 516
None
1.41A 1oipA-6etiA:
2.8
1oipA-6etiA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXQ_A_P1ZA2002_1
(SERUM ALBUMIN)
6eti ATP-BINDING CASSETTE
SUB-FAMILY G MEMBER
2

(Homo
sapiens)
5 / 12 LEU A  75
PHE A 253
LEU A 228
ILE A 249
ILE A 242
None
0.95A 2bxqA-6etiA:
undetectable
2bxqA-6etiA:
8.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NMZ_B_ROCB401_2
(PROTEASE)
6eti ATP-BINDING CASSETTE
SUB-FAMILY G MEMBER
2

(Homo
sapiens)
3 / 3 ARG A 147
VAL A 136
THR A 194
None
0.71A 2nmzA-6etiA:
undetectable
2nmzA-6etiA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QX6_B_ML1B233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])
6eti ATP-BINDING CASSETTE
SUB-FAMILY G MEMBER
2

(Homo
sapiens)
4 / 6 GLY A 428
GLY A 553
GLN A 617
PHE A 586
None
0.97A 2qx6A-6etiA:
undetectable
2qx6B-6etiA:
undetectable
2qx6A-6etiA:
16.59
2qx6B-6etiA:
16.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_A_RIMA199_1
(MATRIX PROTEIN 2)
6eti ATP-BINDING CASSETTE
SUB-FAMILY G MEMBER
2

(Homo
sapiens)
4 / 6 LEU A 228
LEU A 225
ILE A 196
ARG A 193
None
0.83A 2rlfA-6etiA:
undetectable
2rlfB-6etiA:
undetectable
2rlfA-6etiA:
20.51
2rlfB-6etiA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_C_RIMC399_1
(MATRIX PROTEIN 2)
6eti ATP-BINDING CASSETTE
SUB-FAMILY G MEMBER
2

(Homo
sapiens)
4 / 6 LEU A 228
LEU A 225
ILE A 196
ARG A 193
None
0.77A 2rlfC-6etiA:
undetectable
2rlfD-6etiA:
undetectable
2rlfC-6etiA:
20.51
2rlfD-6etiA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BCR_A_AZZA940_1
(GLYCOGEN
PHOSPHORYLASE,
MUSCLE FORM)
6eti ATP-BINDING CASSETTE
SUB-FAMILY G MEMBER
2

(Homo
sapiens)
4 / 5 PHE A 341
ALA A 273
GLY A 275
TYR A 276
None
1.21A 3bcrA-6etiA:
undetectable
3bcrA-6etiA:
7.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K4V_D_ROCD201_4
(HIV-1 PROTEASE)
6eti ATP-BINDING CASSETTE
SUB-FAMILY G MEMBER
2

(Homo
sapiens)
3 / 3 ARG A 147
VAL A 136
THR A 194
None
0.69A 3k4vD-6etiA:
undetectable
3k4vD-6etiA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SI7_A_ACTA5_0
(CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR)
6eti ATP-BINDING CASSETTE
SUB-FAMILY G MEMBER
2

(Homo
sapiens)
3 / 3 LYS A 369
SER A 468
GLN A 376
None
1.26A 3si7A-6etiA:
18.1
3si7A-6etiA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FOG_D_C2FD302_0
(THYMIDYLATE SYNTHASE)
6eti ATP-BINDING CASSETTE
SUB-FAMILY G MEMBER
2

(Homo
sapiens)
5 / 11 ILE A 239
ASP A 254
LEU A  75
GLY A  74
ALA A 270
None
1.25A 4fogD-6etiA:
undetectable
4fogD-6etiA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FQS_A_LYAA302_1
(THYMIDYLATE SYNTHASE)
6eti ATP-BINDING CASSETTE
SUB-FAMILY G MEMBER
2

(Homo
sapiens)
5 / 12 ILE A 239
ASP A 254
LEU A  75
GLY A  74
ALA A 270
None
1.23A 4fqsA-6etiA:
undetectable
4fqsA-6etiA:
13.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FQS_B_LYAB302_1
(THYMIDYLATE SYNTHASE)
6eti ATP-BINDING CASSETTE
SUB-FAMILY G MEMBER
2

(Homo
sapiens)
5 / 12 ILE A 239
ASP A 254
LEU A  75
GLY A  74
ALA A 270
None
1.24A 4fqsB-6etiA:
undetectable
4fqsB-6etiA:
13.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NC3_A_ERMA1202_2
(CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 2B AND E.
COLI SOLUBLE
CYTOCHROME B562)
6eti ATP-BINDING CASSETTE
SUB-FAMILY G MEMBER
2

(Homo
sapiens)
4 / 6 THR A 402
GLN A 582
LEU A 581
GLU A 585
None
1.08A 4nc3A-6etiA:
undetectable
4nc3A-6etiA:
13.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PCL_B_SAMB301_0
(O-METHYLTRANSFERASE
FAMILY PROTEIN)
6eti ATP-BINDING CASSETTE
SUB-FAMILY G MEMBER
2

(Homo
sapiens)
5 / 12 GLN A 437
LEU A 433
PHE A 489
ALA A 580
ASN A 629
None
1.35A 4pclB-6etiA:
2.2
4pclB-6etiA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_A_CUA602_0
(THIOCYANATE
DEHYDROGENASE)
6eti ATP-BINDING CASSETTE
SUB-FAMILY G MEMBER
2

(Homo
sapiens)
3 / 3 LYS A 346
HIS A 350
HIS A  40
None
1.27A 5oexA-6etiA:
undetectable
5oexA-6etiA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_B_CUB602_0
(THIOCYANATE
DEHYDROGENASE)
6eti ATP-BINDING CASSETTE
SUB-FAMILY G MEMBER
2

(Homo
sapiens)
3 / 3 LYS A 346
HIS A 350
HIS A  40
None
1.26A 5oexB-6etiA:
undetectable
5oexB-6etiA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_C_CUC603_0
(THIOCYANATE
DEHYDROGENASE)
6eti ATP-BINDING CASSETTE
SUB-FAMILY G MEMBER
2

(Homo
sapiens)
3 / 3 LYS A 346
HIS A 350
HIS A  40
None
1.25A 5oexC-6etiA:
undetectable
5oexC-6etiA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_D_CUD603_0
(THIOCYANATE
DEHYDROGENASE)
6eti ATP-BINDING CASSETTE
SUB-FAMILY G MEMBER
2

(Homo
sapiens)
3 / 3 LYS A 346
HIS A 350
HIS A  40
None
1.24A 5oexD-6etiA:
undetectable
5oexD-6etiA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TOA_A_ESTA601_1
(ESTROGEN RECEPTOR
BETA)
6eti ATP-BINDING CASSETTE
SUB-FAMILY G MEMBER
2

(Homo
sapiens)
5 / 12 LEU A 225
LEU A 226
ALA A 223
ILE A 242
LEU A 216
None
0.98A 5toaA-6etiA:
undetectable
5toaA-6etiA:
17.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X66_C_MTXC402_1
(THYMIDYLATE SYNTHASE)
6eti ATP-BINDING CASSETTE
SUB-FAMILY G MEMBER
2

(Homo
sapiens)
5 / 9 ILE A 239
ASP A 254
LEU A  75
GLY A  74
ALA A 270
None
1.33A 5x66C-6etiA:
undetectable
5x66C-6etiA:
15.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7P_B_CHDB401_0
(BILE SALT HYDROLASE)
6eti ATP-BINDING CASSETTE
SUB-FAMILY G MEMBER
2

(Homo
sapiens)
5 / 10 LEU A 252
ILE A 238
LEU A 209
LEU A 216
ALA A 221
None
1.21A 5y7pB-6etiA:
undetectable
5y7pB-6etiA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7P_D_CHDD401_0
(BILE SALT HYDROLASE)
6eti ATP-BINDING CASSETTE
SUB-FAMILY G MEMBER
2

(Homo
sapiens)
5 / 10 LEU A 252
ILE A 238
LEU A 209
LEU A 216
ALA A 221
None
1.19A 5y7pD-6etiA:
undetectable
5y7pD-6etiA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7P_H_CHDH401_0
(BILE SALT HYDROLASE)
6eti ATP-BINDING CASSETTE
SUB-FAMILY G MEMBER
2

(Homo
sapiens)
5 / 10 LEU A 252
ILE A 238
LEU A 209
LEU A 216
ALA A 221
None
1.18A 5y7pH-6etiA:
undetectable
5y7pH-6etiA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YW0_A_ACTA410_0
(UNCHARACTERIZED
PROTEIN KDOO)
6eti ATP-BINDING CASSETTE
SUB-FAMILY G MEMBER
2

(Homo
sapiens)
4 / 4 GLY A 197
LEU A 168
VAL A 164
GLU A 167
None
1.49A 5yw0A-6etiA:
undetectable
5yw0A-6etiA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BKL_C_EU7C101_0
(MATRIX PROTEIN 2)
6eti ATP-BINDING CASSETTE
SUB-FAMILY G MEMBER
2

(Homo
sapiens)
5 / 9 SER A 440
ALA A 444
SER A 443
ALA A 520
SER A 521
None
0.89A 6bklA-6etiA:
undetectable
6bklB-6etiA:
undetectable
6bklC-6etiA:
undetectable
6bklD-6etiA:
undetectable
6bklA-6etiA:
undetectable
6bklB-6etiA:
undetectable
6bklC-6etiA:
undetectable
6bklD-6etiA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BKL_G_EU7G101_0
(MATRIX PROTEIN 2)
6eti ATP-BINDING CASSETTE
SUB-FAMILY G MEMBER
2

(Homo
sapiens)
5 / 9 ALA A 444
SER A 443
ALA A 520
SER A 521
SER A 440
None
0.86A 6bklE-6etiA:
undetectable
6bklF-6etiA:
undetectable
6bklG-6etiA:
undetectable
6bklH-6etiA:
undetectable
6bklE-6etiA:
undetectable
6bklF-6etiA:
undetectable
6bklG-6etiA:
undetectable
6bklH-6etiA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BKL_G_EU7G101_0
(MATRIX PROTEIN 2)
6eti ATP-BINDING CASSETTE
SUB-FAMILY G MEMBER
2

(Homo
sapiens)
5 / 9 SER A 440
ALA A 444
SER A 443
ALA A 520
SER A 521
None
0.91A 6bklE-6etiA:
undetectable
6bklF-6etiA:
undetectable
6bklG-6etiA:
undetectable
6bklH-6etiA:
undetectable
6bklE-6etiA:
undetectable
6bklF-6etiA:
undetectable
6bklG-6etiA:
undetectable
6bklH-6etiA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BOC_A_EU7A102_0
(MATRIX PROTEIN 2)
6eti ATP-BINDING CASSETTE
SUB-FAMILY G MEMBER
2

(Homo
sapiens)
5 / 6 SER A 440
ALA A 444
SER A 443
ALA A 520
SER A 521
None
0.90A 6bocA-6etiA:
undetectable
6bocB-6etiA:
undetectable
6bocC-6etiA:
undetectable
6bocD-6etiA:
undetectable
6bocA-6etiA:
undetectable
6bocB-6etiA:
undetectable
6bocC-6etiA:
undetectable
6bocD-6etiA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BOC_A_EU7A102_0
(MATRIX PROTEIN 2)
6eti ATP-BINDING CASSETTE
SUB-FAMILY G MEMBER
2

(Homo
sapiens)
4 / 6 SER A 440
SER A 443
ALA A 520
SER A 521
None
0.93A 6bocA-6etiA:
undetectable
6bocB-6etiA:
undetectable
6bocC-6etiA:
undetectable
6bocD-6etiA:
undetectable
6bocA-6etiA:
undetectable
6bocB-6etiA:
undetectable
6bocC-6etiA:
undetectable
6bocD-6etiA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BOC_A_EU7A102_0
(MATRIX PROTEIN 2)
6eti ATP-BINDING CASSETTE
SUB-FAMILY G MEMBER
2

(Homo
sapiens)
4 / 6 SER A 521
SER A 440
ALA A 444
SER A 443
None
0.91A 6bocA-6etiA:
undetectable
6bocB-6etiA:
undetectable
6bocC-6etiA:
undetectable
6bocD-6etiA:
undetectable
6bocA-6etiA:
undetectable
6bocB-6etiA:
undetectable
6bocC-6etiA:
undetectable
6bocD-6etiA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HCO_A_FY5A1003_0
(ATP-BINDING CASSETTE
SUB-FAMILY G MEMBER
2)
6eti ATP-BINDING CASSETTE
SUB-FAMILY G MEMBER
2

(Homo
sapiens)
5 / 11 PHE A 439
THR A 542
ILE A 543
VAL A 546
MET A 549
BWQ  A1101 (-4.0A)
None
None
None
BWQ  A1101 (-4.1A)
0.74A 6hcoA-6etiA:
46.6
6hcoB-6etiA:
46.6
6hcoA-6etiA:
undetectable
6hcoB-6etiA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HCO_A_FY5A1003_0
(ATP-BINDING CASSETTE
SUB-FAMILY G MEMBER
2)
6eti ATP-BINDING CASSETTE
SUB-FAMILY G MEMBER
2

(Homo
sapiens)
5 / 11 THR A 435
PHE A 439
THR A 542
ILE A 543
VAL A 546
BWQ  A1101 (-4.3A)
BWQ  A1101 (-4.0A)
None
None
None
0.54A 6hcoA-6etiA:
46.6
6hcoB-6etiA:
46.6
6hcoA-6etiA:
undetectable
6hcoB-6etiA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6JI6_A_ACTA305_0
(GLUTATHIONE
S-TRANSFERASE
CLASS-MU 26 KDA
ISOZYME)
6eti ATP-BINDING CASSETTE
SUB-FAMILY G MEMBER
2

(Homo
sapiens)
4 / 5 GLY A 553
LEU A 554
TYR A 613
GLN A 617
None
0.92A 6ji6A-6etiA:
undetectable
6ji6A-6etiA:
undetectable