SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6eu2'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_A_GLYA1292_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 6eu2 DNA-DIRECTED RNA
POLYMERASE III
SUBUNIT RPC4
(Saccharomyces
cerevisiae) 		4 / 8 SER N 372
HIS N 366
LYS N 370
ARG N 364
 None
 1.02A 1eqbA-6eu2N:
undetectable
1eqbB-6eu2N:
undetectable		 1eqbA-6eu2N:
undetectable
1eqbB-6eu2N:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_B_GLYB2292_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 6eu2 DNA-DIRECTED RNA
POLYMERASE III
SUBUNIT RPC4
(Saccharomyces
cerevisiae) 		4 / 8 SER N 372
HIS N 366
LYS N 370
ARG N 364
 None
 1.01A 1eqbA-6eu2N:
undetectable
1eqbB-6eu2N:
undetectable		 1eqbA-6eu2N:
undetectable
1eqbB-6eu2N:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_C_GLYC3292_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 6eu2 DNA-DIRECTED RNA
POLYMERASE III
SUBUNIT RPC4
(Saccharomyces
cerevisiae) 		4 / 8 SER N 372
HIS N 366
LYS N 370
ARG N 364
 None
 1.02A 1eqbC-6eu2N:
undetectable
1eqbD-6eu2N:
undetectable		 1eqbC-6eu2N:
undetectable
1eqbD-6eu2N:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_D_GLYD4292_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 6eu2 DNA-DIRECTED RNA
POLYMERASE III
SUBUNIT RPC4
(Saccharomyces
cerevisiae) 		4 / 8 SER N 372
HIS N 366
LYS N 370
ARG N 364
 None
 1.02A 1eqbC-6eu2N:
undetectable
1eqbD-6eu2N:
undetectable		 1eqbC-6eu2N:
undetectable
1eqbD-6eu2N:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KB9_A_PCFA514_0
(CYTOCHROME B
CYTOCHROME C1, HEME
PROTEIN
UBIQUINOL-CYTOCHROME
C REDUCTASE COMPLEX
CORE PROTEIN I
UBIQUINOL-CYTOCHROME
C REDUCTASE
IRON-SULFUR SUBUNIT)		 6eu2 DNA-DIRECTED RNA
POLYMERASE III
SUBUNIT RPC5
DNA-DIRECTED RNA
POLYMERASE III
SUBUNIT RPC4
(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		4 / 8 SER M 108
HIS M 104
ILE N 395
PHE M  88
 None
 0.86A 1kb9A-6eu2M:
undetectable
1kb9C-6eu2M:
undetectable
1kb9D-6eu2M:
undetectable
1kb9E-6eu2M:
undetectable		 1kb9A-6eu2M:
undetectable
1kb9C-6eu2M:
undetectable
1kb9D-6eu2M:
undetectable
1kb9E-6eu2M:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MAA_B_DMEB996_1
(ACETYLCHOLINESTERASE)		 6eu2 DNA-DIRECTED RNA
POLYMERASE III
SUBUNIT RPC3
(Saccharomyces
cerevisiae) 		4 / 6 GLU O 649
ILE O 282
TYR O 199
GLY O 198
 None
 1.09A 1maaB-6eu2O:
undetectable
1maaD-6eu2O:
undetectable		 1maaB-6eu2O:
10.05
1maaD-6eu2O:
10.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AQJ_A_TRPA650_0
(TRYPTOPHAN
HALOGENASE, PRNA)		 6eu2 DNA-DIRECTED RNA
POLYMERASES I AND
III SUBUNIT RPAC2
(Saccharomyces
cerevisiae) 		5 / 11 ILE K  93
PRO K  94
ILE K  65
GLU K  68
ASN K  99
 None
 1.49A 2aqjA-6eu2K:
1.5		 2aqjA-6eu2K:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_C_SAMC301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 6eu2 DNA-DIRECTED RNA
POLYMERASE III
SUBUNIT RPC3
DNA-DIRECTED RNA
POLYMERASE III
SUBUNIT RPC6
(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		5 / 12 LEU P 269
LEU P 265
ASN P 295
ALA O 497
ALA O 504
 None
 1.16A 2bm9C-6eu2P:
undetectable		 2bm9C-6eu2P:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DQY_C_CHDC3_0
(LIVER
CARBOXYLESTERASE 1)		 6eu2 DNA-DIRECTED RNA
POLYMERASE III
SUBUNIT RPC3
(Saccharomyces
cerevisiae) 		4 / 6 LEU O 487
LEU O 296
PRO O 479
VAL O 478
 None
 1.19A 2dqyC-6eu2O:
undetectable		 2dqyC-6eu2O:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJF_B_ADNB2002_1
(235AA LONG
HYPOTHETICAL
BIOTIN--[ACETYL-COA-
CARBOXYLASE] LIGASE)		 6eu2 DNA-DIRECTED RNA
POLYMERASE III
SUBUNIT RPC5
(Saccharomyces
cerevisiae) 		4 / 6 ARG M 175
GLU M  81
PRO M 172
ALA M 160
 None
 1.39A 2ejfB-6eu2M:
undetectable		 2ejfB-6eu2M:
15.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F7A_A_BEZA1003_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 6eu2 DNA-DIRECTED RNA
POLYMERASE III
SUBUNIT RPC3
(Saccharomyces
cerevisiae) 		5 / 9 LEU O 540
LEU O 537
ILE O 541
PHE O 566
ILE O 511
 None
 1.30A 2f7aA-6eu2O:
undetectable		 2f7aA-6eu2O:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNI_A_MTKA501_1
(CYTOCHROME P450 2C8)		 6eu2 DNA-DIRECTED RNA
POLYMERASE III
SUBUNIT RPC3
DNA-DIRECTED RNA
POLYMERASE III
SUBUNIT RPC7
(Saccharomyces
cerevisiae) 		5 / 12 THR Q  72
SER O  97
VAL O  53
VAL O 104
VAL O  69
 None
 1.13A 2nniA-6eu2Q:
undetectable		 2nniA-6eu2Q:
11.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VMY_A_GLYA502_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 6eu2 DNA-DIRECTED RNA
POLYMERASE III
SUBUNIT RPC4
(Saccharomyces
cerevisiae) 		4 / 7 SER N 372
HIS N 366
LYS N 370
ARG N 364
 None
 1.02A 2vmyA-6eu2N:
undetectable
2vmyB-6eu2N:
undetectable		 2vmyA-6eu2N:
undetectable
2vmyB-6eu2N:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VMY_B_GLYB502_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 6eu2 DNA-DIRECTED RNA
POLYMERASE III
SUBUNIT RPC4
(Saccharomyces
cerevisiae) 		4 / 8 SER N 372
HIS N 366
LYS N 370
ARG N 364
 None
 0.96A 2vmyA-6eu2N:
undetectable
2vmyB-6eu2N:
undetectable		 2vmyA-6eu2N:
undetectable
2vmyB-6eu2N:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEK_A_DIFA1376_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 6eu2 DNA-DIRECTED RNA
POLYMERASE III
SUBUNIT RPC3
(Saccharomyces
cerevisiae) 		4 / 8 LEU O 627
LEU O 602
LYS O 605
ALA O 606
 None
 0.99A 2wekA-6eu2O:
undetectable		 2wekA-6eu2O:
14.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7H_C_SAMC530_1
(TYPE I RESTRICTION
ENZYME ECOKI M
PROTEIN)		 6eu2 DNA-DIRECTED RNA
POLYMERASE III
SUBUNIT RPC3
(Saccharomyces
cerevisiae) 		3 / 3 TYR O  49
GLU O 582
ASN O 575
 None
 1.00A 2y7hC-6eu2O:
2.3		 2y7hC-6eu2O:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_B_TOPB200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 6eu2 DNA-DIRECTED RNA
POLYMERASE III
SUBUNIT RPC3
(Saccharomyces
cerevisiae) 		5 / 12 ALA O 315
ASN O 454
LEU O 457
LEU O 468
VAL O 478
 None
 1.13A 3fl9B-6eu2O:
undetectable		 3fl9B-6eu2O:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_D_ACTD502_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 6eu2 DNA-DIRECTED RNA
POLYMERASE III
SUBUNIT RPC7
(Saccharomyces
cerevisiae) 		3 / 3 GLY Q  62
THR Q  64
ASN Q  60
 None
 0.67A 3v4tD-6eu2Q:
undetectable		 3v4tD-6eu2Q:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IOM_A_FOLA608_0
(FORMATE--TETRAHYDROF
OLATE LIGASE)		 6eu2 DNA-DIRECTED RNA
POLYMERASE III
SUBUNIT RPC3
(Saccharomyces
cerevisiae) 		4 / 7 ALA O 504
PRO O 502
GLU O 493
LEU O 540
 None
 0.97A 4iomA-6eu2O:
undetectable		 4iomA-6eu2O:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L4B_A_CAMA502_0
(CAMPHOR
5-MONOOXYGENASE)		 6eu2 DNA-DIRECTED RNA
POLYMERASE III
SUBUNIT RPC5
DNA-DIRECTED RNA
POLYMERASE III
SUBUNIT RPC4
(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		4 / 8 THR N 389
VAL N 412
VAL M 176
VAL M  87
 None
 0.93A 4l4bA-6eu2N:
undetectable		 4l4bA-6eu2N:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QZT_B_ACTB201_0
(RETINOL-BINDING
PROTEIN 2)		 6eu2 DNA-DIRECTED RNA
POLYMERASE III
SUBUNIT RPC3
(Saccharomyces
cerevisiae) 		4 / 5 TYR O  49
TYR O 132
LEU O 131
GLN O 652
 None
 1.41A 4qztB-6eu2O:
undetectable		 4qztB-6eu2O:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QZU_B_ACTB202_0
(RETINOL-BINDING
PROTEIN 2)		 6eu2 DNA-DIRECTED RNA
POLYMERASE III
SUBUNIT RPC3
(Saccharomyces
cerevisiae) 		4 / 7 TYR O  49
TYR O 132
LEU O 131
GLN O 652
 None
 1.41A 4qzuB-6eu2O:
undetectable		 4qzuB-6eu2O:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UW0_A_SAMA1506_0
(WBDD)		 6eu2 DNA-DIRECTED RNA
POLYMERASE III
SUBUNIT RPC6
(Saccharomyces
cerevisiae) 		5 / 12 ALA P 228
ILE P 221
LEU P 178
VAL P 182
ILE P 186
 None
 1.12A 4uw0A-6eu2P:
undetectable		 4uw0A-6eu2P:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_Z_BEZZ801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
BEZ-LEU-LEU)		 6eu2 DNA-DIRECTED RNA
POLYMERASE III
SUBUNIT RPC3
(Saccharomyces
cerevisiae) 		4 / 4 ILE O 164
GLY O 126
ILE O 282
LEU O 130
 None
 0.89A 5dzkl-6eu2O:
undetectable
5dzkz-6eu2O:
undetectable		 5dzkl-6eu2O:
undetectable
5dzkz-6eu2O:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HBS_A_RTLA201_1
(RETINOL-BINDING
PROTEIN 1)		 6eu2 DNA-DIRECTED RNA
POLYMERASE III
SUBUNIT RPC3
(Saccharomyces
cerevisiae) 		4 / 8 LEU O  79
LEU O  98
TYR O 121
GLN O 108
 None
 0.91A 5hbsA-6eu2O:
undetectable		 5hbsA-6eu2O:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ICX_F_SC2F1_1
(CETUXIMAB FAB LIGHT
CHAIN
MEDITOPE)		 6eu2 DNA-DIRECTED RNA
POLYMERASE III
SUBUNIT RPC3
(Saccharomyces
cerevisiae) 		3 / 3 VAL O 274
GLN O 193
CYH O 195
 None
 0.89A 5icxC-6eu2O:
undetectable
5icxF-6eu2O:
undetectable		 5icxC-6eu2O:
19.90
5icxF-6eu2O:
7.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF3_B_BO2B305_1
(PROTEASOME SUBUNIT
BETA TYPE-6)		 6eu2 DNA-DIRECTED RNA
POLYMERASE III
SUBUNIT RPC3
DNA-DIRECTED RNA
POLYMERASE III
SUBUNIT RPC7
(Saccharomyces
cerevisiae) 		5 / 12 THR O  94
THR O  93
SER Q  74
GLY Q  73
ALA O  61
 None
 1.35A 5lf3b-6eu2O:
undetectable		 5lf3b-6eu2O:
14.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF3_N_BO2N304_1
(PROTEASOME SUBUNIT
BETA TYPE-6)		 6eu2 DNA-DIRECTED RNA
POLYMERASE III
SUBUNIT RPC3
DNA-DIRECTED RNA
POLYMERASE III
SUBUNIT RPC7
(Saccharomyces
cerevisiae) 		5 / 12 THR O  94
THR O  93
SER Q  74
GLY Q  73
ALA O  61
 None
 1.35A 5lf3N-6eu2O:
undetectable		 5lf3N-6eu2O:
14.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MVS_A_ADNA401_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-79
SPECIFIC)		 6eu2 DNA-DIRECTED RNA
POLYMERASE III
SUBUNIT RPC6
DNA-DIRECTED RNA
POLYMERASE III
SUBUNIT RPC7
(Saccharomyces
cerevisiae) 		4 / 7 GLY Q  45
GLU P 308
LYS P 307
ASP P 306
 None
 0.97A 5mvsA-6eu2Q:
undetectable		 5mvsA-6eu2Q:
12.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIP_D_HFGD1003_0
(PROLYL-TRNA
SYNTHETASE, PUTATIVE)		 6eu2 DNA-DIRECTED RNA
POLYMERASE III
SUBUNIT RPC3
(Saccharomyces
cerevisiae) 		5 / 12 LEU O 487
GLU O 649
VAL O 650
GLU O 320
THR O 142
 None
 1.38A 5xipD-6eu2O:
undetectable		 5xipD-6eu2O:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YCN_A_8LXA501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 6eu2 DNA-DIRECTED RNA
POLYMERASE III
SUBUNIT RPC5
(Saccharomyces
cerevisiae) 		4 / 6 SER M  84
HIS M  86
HIS M 117
TYR M 112
 None
 1.01A 5ycnA-6eu2M:
undetectable		 5ycnA-6eu2M:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G9B_B_IXXB705_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN
ENVELOPE
GLYCOPROTEIN)		 6eu2 DNA-DIRECTED RNA
POLYMERASE III
SUBUNIT RPC5
(Saccharomyces
cerevisiae) 		4 / 5 ALA M  91
TYR M  90
GLN M 146
ILE M 123
 None
 1.32A 6g9bA-6eu2M:
undetectable
6g9bB-6eu2M:
undetectable		 6g9bA-6eu2M:
21.84
6g9bB-6eu2M:
15.85