SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6eu9'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S14_B_NOVB2300_1
(TOPOISOMERASE IV
SUBUNIT B)		 6eu9 RETINOIC ACID
RECEPTOR
(Platynereis
dumerilii) 		5 / 12 ASP A 313
GLU A 314
ASP A 450
ALA A 452
ILE A 321
 None
 1.19A 1s14B-6eu9A:
undetectable		 1s14B-6eu9A:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YVL_B_SAMB602_1
(HYPOTHETICAL PROTEIN)		 6eu9 RETINOIC ACID
RECEPTOR
(Platynereis
dumerilii) 		3 / 3 GLU A 326
ASP A 450
TYR A 490
 None
 0.83A 2yvlB-6eu9A:
undetectable		 2yvlB-6eu9A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_G_SVRG506_1
(PHOSPHOLIPASE A2)		 6eu9 RETINOIC ACID
RECEPTOR
(Platynereis
dumerilii) 		4 / 8 VAL A 367
VAL A 368
GLY A 371
LYS A 372
 None
 0.54A 3bjwA-6eu9A:
undetectable		 3bjwA-6eu9A:
17.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RD0_A_EDPA175_1
(FERRITIN LIGHT CHAIN)		 6eu9 RETINOIC ACID
RECEPTOR
(Platynereis
dumerilii) 		4 / 6 SER A 458
ALA A 455
ARG A 400
LEU A 512
 None
 1.02A 3rd0A-6eu9A:
2.0		 3rd0A-6eu9A:
14.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4DM8_A_REAA501_1
(RETINOIC ACID
RECEPTOR BETA)		 6eu9 RETINOIC ACID
RECEPTOR
(Platynereis
dumerilii) 		5 / 11 LEU A 394
ILE A 398
ARG A 404
PHE A 414
LEU A 433
 None
 0.72A 4dm8A-6eu9A:
31.7		 4dm8A-6eu9A:
36.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4DM8_A_REAA501_1
(RETINOIC ACID
RECEPTOR BETA)		 6eu9 RETINOIC ACID
RECEPTOR
(Platynereis
dumerilii) 		6 / 11 LEU A 394
ILE A 398
PHE A 414
SER A 415
LEU A 433
LEU A 526
 None
 0.89A 4dm8A-6eu9A:
31.7		 4dm8A-6eu9A:
36.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ECK_B_FOLB703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 6eu9 RETINOIC ACID
RECEPTOR
(Platynereis
dumerilii) 		5 / 12 ALA A 363
PHE A 414
SER A 413
LEU A 425
VAL A 356
 None
 1.10A 4eckB-6eu9A:
undetectable		 4eckB-6eu9A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LNW_A_T3A502_1
(THYROID HORMONE
RECEPTOR ALPHA)		 6eu9 RETINOIC ACID
RECEPTOR
(Platynereis
dumerilii) 		4 / 8 SER A 464
ASP A 466
GLN A 480
THR A 510
 None
 0.99A 4lnwA-6eu9A:
28.4		 4lnwA-6eu9A:
29.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OK1_A_198A1001_1
(ANDROGEN RECEPTOR)		 6eu9 RETINOIC ACID
RECEPTOR
(Platynereis
dumerilii) 		5 / 12 LEU A 484
VAL A 476
MET A 317
ILE A 321
VAL A 374
 None
 1.02A 4ok1A-6eu9A:
21.2		 4ok1A-6eu9A:
15.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TIW_A_OAQA302_0
(SULFOTRANSFERASE)		 6eu9 RETINOIC ACID
RECEPTOR
(Platynereis
dumerilii) 		5 / 12 ILE A 437
LEU A 420
ILE A 397
PHE A 430
LEU A 512
 None
 1.27A 5tiwA-6eu9A:
undetectable		 5tiwA-6eu9A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UAN_B_REAB503_1
(RETINOIC ACID
RECEPTOR BETA)		 6eu9 RETINOIC ACID
RECEPTOR
(Platynereis
dumerilii) 		6 / 12 LEU A 394
ILE A 398
PHE A 414
SER A 415
PHE A 430
LEU A 433
 None
 0.81A 5uanB-6eu9A:
32.0		 5uanB-6eu9A:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_A_CVIA301_0
(REGULATORY PROTEIN
TETR)		 6eu9 RETINOIC ACID
RECEPTOR
(Platynereis
dumerilii) 		5 / 12 ALA A 363
LEU A 394
ILE A 398
TYR A 454
PHE A 430
 None
 1.37A 5vlmA-6eu9A:
2.9		 5vlmA-6eu9A:
undetectable