SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6eux'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZQ_A_MTLA870_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 6eux POLYMERASE BASIC
PROTEIN 2
(Influenza
B
virus) 		4 / 8 GLN A 325
PHE A 327
ASN A 517
ASP A 518
 BYB  A 601 (-3.3A)
BYB  A 601 ( 4.4A)
None
None
 1.33A 1zzqA-6euxA:
undetectable		 1zzqA-6euxA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FAL_C_REAC501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 6eux POLYMERASE BASIC
PROTEIN 2
(Influenza
B
virus) 		5 / 10 ILE A 312
ALA A 315
ALA A 316
LEU A 505
ILE A 273
 None
 0.82A 3falC-6euxA:
undetectable		 3falC-6euxA:
17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FC6_A_REAA501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 6eux POLYMERASE BASIC
PROTEIN 2
(Influenza
B
virus) 		5 / 11 ILE A 312
ALA A 315
ALA A 316
LEU A 505
ILE A 273
 None
 0.87A 3fc6A-6euxA:
undetectable		 3fc6A-6euxA:
17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9V_B_DXCB323_0
(INVASIN IPAD)		 6eux POLYMERASE BASIC
PROTEIN 2
(Influenza
B
virus) 		4 / 7 ILE A 269
ILE A 273
LEU A 503
SER A 504
 None
 0.62A 3r9vA-6euxA:
undetectable
3r9vB-6euxA:
undetectable		 3r9vA-6euxA:
undetectable
3r9vB-6euxA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RQL_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 6eux POLYMERASE BASIC
PROTEIN 2
(Influenza
B
virus) 		4 / 8 PHE A 365
SER A 407
ARG A 334
TRP A 359
 None
None
BYB  A 601 ( 4.8A)
BYB  A 601 (-3.4A)
 1.37A 3rqlA-6euxA:
undetectable
3rqlB-6euxA:
undetectable		 3rqlA-6euxA:
11.42
3rqlB-6euxA:
11.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J4V_A_SVRA301_1
(NUCLEOCAPSID PROTEIN)		 6eux POLYMERASE BASIC
PROTEIN 2
(Influenza
B
virus) 		5 / 11 GLY A 349
ASN A 350
VAL A 416
MET A 412
ILE A 346
 None
 1.42A 4j4vA-6euxA:
undetectable		 4j4vA-6euxA:
15.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J4V_D_SVRD301_1
(NUCLEOCAPSID PROTEIN)		 6eux POLYMERASE BASIC
PROTEIN 2
(Influenza
B
virus) 		5 / 11 GLY A 349
ASN A 350
VAL A 416
MET A 412
ILE A 346
 None
 1.44A 4j4vD-6euxA:
undetectable
4j4vE-6euxA:
undetectable		 4j4vD-6euxA:
15.32
4j4vE-6euxA:
15.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PGF_A_ADNA502_2
(ADENOSYLHOMOCYSTEINA
SE)		 6eux POLYMERASE BASIC
PROTEIN 2
(Influenza
B
virus) 		4 / 6 THR A 482
GLU A 461
HIS A 366
LEU A 387
 None
 1.11A 4pgfA-6euxA:
undetectable		 4pgfA-6euxA:
10.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YVX_B_GMRB401_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3)		 6eux POLYMERASE BASIC
PROTEIN 2
(Influenza
B
virus) 		5 / 12 TYR A 474
LEU A 476
TYR A 453
SER A 444
ASN A 445
 None
 1.44A 4yvxB-6euxA:
undetectable		 4yvxB-6euxA:
13.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GWK_F_EVPF102_1
(DNA TOPOISOMERASE
2-ALPHA)		 6eux POLYMERASE BASIC
PROTEIN 2
(Influenza
B
virus) 		4 / 5 GLY A 370
ASP A 395
MET A 404
MET A 412
 None
 1.40A 5gwkA-6euxA:
undetectable		 5gwkA-6euxA:
6.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A5Y_D_9CRD501_0
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 6eux POLYMERASE BASIC
PROTEIN 2
(Influenza
B
virus) 		5 / 12 ILE A 312
ALA A 315
ALA A 316
LEU A 505
ILE A 273
 None
 0.82A 6a5yD-6euxA:
undetectable		 6a5yD-6euxA:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A5Z_D_9CRD501_0
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 6eux POLYMERASE BASIC
PROTEIN 2
(Influenza
B
virus) 		5 / 12 ILE A 312
ALA A 315
ALA A 316
LEU A 505
ILE A 273
 None
 0.83A 6a5zD-6euxA:
undetectable		 6a5zD-6euxA:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A5Z_L_9CRL501_0
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 6eux POLYMERASE BASIC
PROTEIN 2
(Influenza
B
virus) 		5 / 12 ILE A 312
ALA A 315
ALA A 316
LEU A 505
ILE A 273
 None
 0.84A 6a5zL-6euxA:
undetectable		 6a5zL-6euxA:
23.00