SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6evj'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERR_A_CCSA381_0
(ESTROGEN RECEPTOR)
6evj RNA-DIRECTED RNA
POLYMERASE CATALYTIC
SUBUNIT

(Influenza
A
virus)
4 / 5 HIS B 664
GLU B 519
ALA B 521
SER B 524
None
1.34A 1errA-6evjB:
undetectable
1errB-6evjB:
undetectable
1errA-6evjB:
undetectable
1errB-6evjB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_A_115A2_2
(HMG-COA REDUCTASE)
6evj RNA-DIRECTED RNA
POLYMERASE CATALYTIC
SUBUNIT

(Influenza
A
virus)
4 / 8 GLU B 175
LEU B 218
ALA B 221
LEU B 222
None
0.53A 1hwiB-6evjB:
1.7
1hwiB-6evjB:
10.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_D_115D3_1
(HMG-COA REDUCTASE)
6evj RNA-DIRECTED RNA
POLYMERASE CATALYTIC
SUBUNIT

(Influenza
A
virus)
4 / 8 GLU B 175
LEU B 218
ALA B 221
LEU B 222
None
0.49A 1hwiC-6evjB:
1.6
1hwiC-6evjB:
10.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P6K_A_MTLA870_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)
6evj RNA-DIRECTED RNA
POLYMERASE CATALYTIC
SUBUNIT

(Influenza
A
virus)
4 / 8 SER B 345
ARG B 316
ASN B 314
ASN B 346
None
1.30A 1p6kA-6evjB:
undetectable
1p6kA-6evjB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P6K_B_MTLB871_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)
6evj RNA-DIRECTED RNA
POLYMERASE CATALYTIC
SUBUNIT

(Influenza
A
virus)
4 / 8 SER B 345
ARG B 316
ASN B 314
ASN B 346
None
1.28A 1p6kB-6evjB:
undetectable
1p6kB-6evjB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RS6_B_MTLB871_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)
6evj RNA-DIRECTED RNA
POLYMERASE CATALYTIC
SUBUNIT

(Influenza
A
virus)
4 / 8 SER B 345
ARG B 316
ASN B 314
ASN B 346
None
1.32A 1rs6B-6evjB:
undetectable
1rs6B-6evjB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RS7_B_MTLB871_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)
6evj RNA-DIRECTED RNA
POLYMERASE CATALYTIC
SUBUNIT

(Influenza
A
virus)
4 / 8 SER B 345
ARG B 316
ASN B 314
ASN B 346
None
1.24A 1rs7B-6evjB:
undetectable
1rs7B-6evjB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SQ5_D_PAUD6004_0
(PANTOTHENATE KINASE)
6evj RNA-DIRECTED RNA
POLYMERASE CATALYTIC
SUBUNIT

(Influenza
A
virus)
5 / 10 VAL B 170
LEU B 122
GLY B 250
LEU B 167
ILE B 248
None
0.93A 1sq5D-6evjB:
undetectable
1sq5D-6evjB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T03_P_TFOP822_1
(POL POLYPROTEIN
SYNTHETIC
OLIGONUCLEOTIDE
PRIMER)
6evj RNA-DIRECTED RNA
POLYMERASE CATALYTIC
SUBUNIT

(Influenza
A
virus)
4 / 7 ASP B 305
ASP B 445
ASP B 446
LYS B 481
None
0.96A 1t03A-6evjB:
7.0
1t03A-6evjB:
8.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VID_A_SAMA301_1
(CATECHOL
O-METHYLTRANSFERASE)
6evj RNA-DIRECTED RNA
POLYMERASE CATALYTIC
SUBUNIT

(Influenza
A
virus)
4 / 5 SER B 443
GLU B 491
SER B 482
ASP B 445
None
1.39A 1vidA-6evjB:
undetectable
1vidA-6evjB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZLQ_A_ACTA1502_0
(NICKEL-BINDING
PERIPLASMIC PROTEIN)
6evj RNA-DIRECTED RNA
POLYMERASE CATALYTIC
SUBUNIT

(Influenza
A
virus)
4 / 5 PRO B  74
GLY B 474
ASN B 312
GLY B  81
None
1.15A 1zlqA-6evjB:
undetectable
1zlqA-6evjB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZQ_A_MTLA870_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)
6evj RNA-DIRECTED RNA
POLYMERASE CATALYTIC
SUBUNIT

(Influenza
A
virus)
4 / 8 SER B 345
ARG B 316
ASN B 314
ASN B 346
None
1.31A 1zzqA-6evjB:
undetectable
1zzqA-6evjB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZQ_B_MTLB871_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)
6evj RNA-DIRECTED RNA
POLYMERASE CATALYTIC
SUBUNIT

(Influenza
A
virus)
4 / 8 SER B 345
ARG B 316
ASN B 314
ASN B 346
None
1.26A 1zzqB-6evjB:
undetectable
1zzqB-6evjB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZU_B_MTLB871_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)
6evj RNA-DIRECTED RNA
POLYMERASE CATALYTIC
SUBUNIT

(Influenza
A
virus)
4 / 8 SER B 345
ARG B 316
ASN B 314
ASN B 346
None
1.27A 1zzuB-6evjB:
undetectable
1zzuB-6evjB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CL5_B_SAMB1217_1
(CATECHOL
O-METHYLTRANSFERASE)
6evj RNA-DIRECTED RNA
POLYMERASE CATALYTIC
SUBUNIT

(Influenza
A
virus)
4 / 6 SER B 443
GLU B 491
SER B 482
ASP B 445
None
1.39A 2cl5B-6evjB:
undetectable
2cl5B-6evjB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IGT_A_SAMA1001_1
(SAM DEPENDENT
METHYLTRANSFERASE)
6evj RNA-DIRECTED RNA
POLYMERASE CATALYTIC
SUBUNIT

(Influenza
A
virus)
3 / 3 ASP B  41
ASP B  48
ASP B 384
None
0.71A 2igtA-6evjB:
undetectable
2igtA-6evjB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JC9_A_ADNA1497_1
(CYTOSOLIC PURINE
5'-NUCLEOTIDASE)
6evj RNA-DIRECTED RNA
POLYMERASE CATALYTIC
SUBUNIT

(Influenza
A
virus)
4 / 7 ASP B 130
ILE B 147
ASN B 158
PHE B 150
None
1.28A 2jc9A-6evjB:
undetectable
2jc9A-6evjB:
9.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JC9_A_ADNA1497_1
(CYTOSOLIC PURINE
5'-NUCLEOTIDASE)
6evj RNA-DIRECTED RNA
POLYMERASE CATALYTIC
SUBUNIT

(Influenza
A
virus)
4 / 7 THR B 469
ILE B 475
ASN B 306
GLN B 442
None
0.96A 2jc9A-6evjB:
undetectable
2jc9A-6evjB:
9.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QAK_A_1UNA1001_2
(PROTEASE RETROPEPSIN)
6evj RNA-DIRECTED RNA
POLYMERASE CATALYTIC
SUBUNIT

(Influenza
A
virus)
3 / 3 ARG B 220
THR B 182
VAL B 181
None
1.00A 2qakA-6evjB:
undetectable
2qakA-6evjB:
15.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QMZ_A_LDPA501_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE)
6evj RNA-DIRECTED RNA
POLYMERASE CATALYTIC
SUBUNIT

(Influenza
A
virus)
4 / 7 GLU B 371
GLY B 352
ILE B 368
PHE B 381
None
1.02A 2qmzA-6evjB:
undetectable
2qmzB-6evjB:
undetectable
2qmzA-6evjB:
16.23
2qmzB-6evjB:
16.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XCT_G_CPFG1020_1
(DNA GYRASE SUBUNIT
B, DNA GYRASE
SUBUNIT A)
6evj RNA-DIRECTED RNA
POLYMERASE CATALYTIC
SUBUNIT

(Influenza
A
virus)
3 / 3 ARG B 249
GLY B 245
SER B 173
None
0.46A 2xctB-6evjB:
undetectable
2xctB-6evjB:
7.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7H_B_SAMB530_1
(TYPE I RESTRICTION
ENZYME ECOKI M
PROTEIN)
6evj RNA-DIRECTED RNA
POLYMERASE CATALYTIC
SUBUNIT

(Influenza
A
virus)
3 / 3 TYR B 555
GLU B 608
THR B 662
None
1.04A 2y7hB-6evjB:
undetectable
2y7hB-6evjB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZVJ_A_SAMA301_1
(CATECHOL
O-METHYLTRANSFERASE)
6evj RNA-DIRECTED RNA
POLYMERASE CATALYTIC
SUBUNIT

(Influenza
A
virus)
4 / 6 SER B 443
GLU B 491
SER B 482
ASP B 445
None
1.36A 2zvjA-6evjB:
undetectable
2zvjA-6evjB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BF1_D_PAUD248_0
(TYPE III
PANTOTHENATE KINASE)
6evj RNA-DIRECTED RNA
POLYMERASE CATALYTIC
SUBUNIT

(Influenza
A
virus)
5 / 11 LYS B 281
LEU B 282
VAL B 273
GLY B 270
THR B 493
None
1.20A 3bf1C-6evjB:
undetectable
3bf1D-6evjB:
undetectable
3bf1C-6evjB:
undetectable
3bf1D-6evjB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLD_A_GW6A1_1
(GLUCOCORTICOID
RECEPTOR)
6evj RNA-DIRECTED RNA
POLYMERASE CATALYTIC
SUBUNIT

(Influenza
A
virus)
5 / 12 LEU B  95
CYH B 263
CYH B 107
THR B 110
PHE B 333
None
1.24A 3cldA-6evjB:
undetectable
3cldA-6evjB:
14.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FRQ_B_ERYB195_1
(REPRESSOR PROTEIN
MPHR(A))
6evj RNA-DIRECTED RNA
POLYMERASE CATALYTIC
SUBUNIT

(Influenza
A
virus)
4 / 7 ASN B 225
TYR B 129
ARG B 126
ALA B 142
None
1.40A 3frqB-6evjB:
undetectable
3frqB-6evjB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_A_TFPA202_1
(PROTEIN S100-A4)
6evj RNA-DIRECTED RNA
POLYMERASE CATALYTIC
SUBUNIT

(Influenza
A
virus)
5 / 12 LEU B 102
PHE B 103
ILE B 262
PHE B 254
ASP B 112
None
1.08A 3ko0A-6evjB:
undetectable
3ko0B-6evjB:
undetectable
3ko0C-6evjB:
undetectable
3ko0D-6evjB:
undetectable
3ko0A-6evjB:
17.92
3ko0B-6evjB:
17.92
3ko0C-6evjB:
17.92
3ko0D-6evjB:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_B_TFPB202_2
(PROTEIN S100-A4)
6evj RNA-DIRECTED RNA
POLYMERASE CATALYTIC
SUBUNIT

(Influenza
A
virus)
4 / 6 LEU B 102
PHE B 103
ILE B 262
PHE B 254
None
0.89A 3ko0B-6evjB:
undetectable
3ko0B-6evjB:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_C_TFPC202_1
(PROTEIN S100-A4)
6evj RNA-DIRECTED RNA
POLYMERASE CATALYTIC
SUBUNIT

(Influenza
A
virus)
5 / 11 ASP B 112
LEU B 102
PHE B 103
ILE B 262
PHE B 254
None
1.08A 3ko0A-6evjB:
undetectable
3ko0B-6evjB:
undetectable
3ko0C-6evjB:
undetectable
3ko0D-6evjB:
undetectable
3ko0A-6evjB:
17.92
3ko0B-6evjB:
17.92
3ko0C-6evjB:
17.92
3ko0D-6evjB:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_D_TFPD202_1
(PROTEIN S100-A4)
6evj RNA-DIRECTED RNA
POLYMERASE CATALYTIC
SUBUNIT

(Influenza
A
virus)
5 / 11 LEU B 102
PHE B 103
ILE B 262
PHE B 254
ASP B 112
None
1.06A 3ko0C-6evjB:
undetectable
3ko0D-6evjB:
undetectable
3ko0E-6evjB:
undetectable
3ko0F-6evjB:
undetectable
3ko0C-6evjB:
17.92
3ko0D-6evjB:
17.92
3ko0E-6evjB:
17.92
3ko0F-6evjB:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_E_TFPE202_1
(PROTEIN S100-A4)
6evj RNA-DIRECTED RNA
POLYMERASE CATALYTIC
SUBUNIT

(Influenza
A
virus)
5 / 11 ASP B 112
LEU B 102
PHE B 103
ILE B 262
PHE B 254
None
1.04A 3ko0C-6evjB:
undetectable
3ko0D-6evjB:
undetectable
3ko0E-6evjB:
undetectable
3ko0F-6evjB:
undetectable
3ko0C-6evjB:
17.92
3ko0D-6evjB:
17.92
3ko0E-6evjB:
17.92
3ko0F-6evjB:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_F_TFPF202_1
(PROTEIN S100-A4)
6evj RNA-DIRECTED RNA
POLYMERASE CATALYTIC
SUBUNIT

(Influenza
A
virus)
5 / 11 LEU B 102
PHE B 103
ILE B 262
PHE B 254
ASP B 112
None
1.04A 3ko0E-6evjB:
undetectable
3ko0F-6evjB:
undetectable
3ko0G-6evjB:
undetectable
3ko0H-6evjB:
undetectable
3ko0E-6evjB:
17.92
3ko0F-6evjB:
17.92
3ko0G-6evjB:
17.92
3ko0H-6evjB:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_H_TFPH202_1
(PROTEIN S100-A4)
6evj RNA-DIRECTED RNA
POLYMERASE CATALYTIC
SUBUNIT

(Influenza
A
virus)
5 / 12 LEU B 102
PHE B 103
ILE B 262
PHE B 254
ASP B 112
None
1.14A 3ko0G-6evjB:
undetectable
3ko0H-6evjB:
undetectable
3ko0I-6evjB:
undetectable
3ko0J-6evjB:
undetectable
3ko0G-6evjB:
17.92
3ko0H-6evjB:
17.92
3ko0I-6evjB:
17.92
3ko0J-6evjB:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_I_TFPI202_1
(PROTEIN S100-A4)
6evj RNA-DIRECTED RNA
POLYMERASE CATALYTIC
SUBUNIT

(Influenza
A
virus)
5 / 12 ASP B 112
LEU B 102
PHE B 103
ILE B 262
PHE B 254
None
1.02A 3ko0G-6evjB:
undetectable
3ko0H-6evjB:
undetectable
3ko0I-6evjB:
undetectable
3ko0J-6evjB:
undetectable
3ko0G-6evjB:
17.92
3ko0H-6evjB:
17.92
3ko0I-6evjB:
17.92
3ko0J-6evjB:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_J_TFPJ202_1
(PROTEIN S100-A4)
6evj RNA-DIRECTED RNA
POLYMERASE CATALYTIC
SUBUNIT

(Influenza
A
virus)
5 / 11 ASP B 112
LEU B 102
PHE B 103
ILE B 262
PHE B 254
None
1.08A 3ko0A-6evjB:
undetectable
3ko0B-6evjB:
undetectable
3ko0I-6evjB:
undetectable
3ko0J-6evjB:
undetectable
3ko0A-6evjB:
17.92
3ko0B-6evjB:
17.92
3ko0I-6evjB:
17.92
3ko0J-6evjB:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_K_TFPK202_1
(PROTEIN S100-A4)
6evj RNA-DIRECTED RNA
POLYMERASE CATALYTIC
SUBUNIT

(Influenza
A
virus)
5 / 12 LEU B 102
PHE B 103
ILE B 262
PHE B 254
ASP B 112
None
1.05A 3ko0K-6evjB:
undetectable
3ko0L-6evjB:
undetectable
3ko0S-6evjB:
undetectable
3ko0T-6evjB:
undetectable
3ko0K-6evjB:
17.92
3ko0L-6evjB:
17.92
3ko0S-6evjB:
17.92
3ko0T-6evjB:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_L_TFPL202_1
(PROTEIN S100-A4)
6evj RNA-DIRECTED RNA
POLYMERASE CATALYTIC
SUBUNIT

(Influenza
A
virus)
5 / 12 LEU B 102
PHE B 103
ILE B 262
PHE B 254
ASP B 112
None
1.09A 3ko0K-6evjB:
undetectable
3ko0L-6evjB:
undetectable
3ko0M-6evjB:
undetectable
3ko0N-6evjB:
undetectable
3ko0K-6evjB:
17.92
3ko0L-6evjB:
17.92
3ko0M-6evjB:
17.92
3ko0N-6evjB:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_M_TFPM202_1
(PROTEIN S100-A4)
6evj RNA-DIRECTED RNA
POLYMERASE CATALYTIC
SUBUNIT

(Influenza
A
virus)
5 / 12 LEU B 102
PHE B 103
ILE B 262
PHE B 254
ASP B 112
None
1.01A 3ko0M-6evjB:
undetectable
3ko0N-6evjB:
undetectable
3ko0O-6evjB:
undetectable
3ko0P-6evjB:
undetectable
3ko0M-6evjB:
17.92
3ko0N-6evjB:
17.92
3ko0O-6evjB:
17.92
3ko0P-6evjB:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_N_TFPN202_1
(PROTEIN S100-A4)
6evj RNA-DIRECTED RNA
POLYMERASE CATALYTIC
SUBUNIT

(Influenza
A
virus)
5 / 11 ASP B 112
LEU B 102
PHE B 103
ILE B 262
PHE B 254
None
1.13A 3ko0K-6evjB:
undetectable
3ko0L-6evjB:
undetectable
3ko0M-6evjB:
undetectable
3ko0N-6evjB:
undetectable
3ko0K-6evjB:
17.92
3ko0L-6evjB:
17.92
3ko0M-6evjB:
17.92
3ko0N-6evjB:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_O_TFPO202_1
(PROTEIN S100-A4)
6evj RNA-DIRECTED RNA
POLYMERASE CATALYTIC
SUBUNIT

(Influenza
A
virus)
5 / 11 LEU B 102
PHE B 103
ILE B 262
PHE B 254
ASP B 112
None
1.02A 3ko0O-6evjB:
undetectable
3ko0P-6evjB:
undetectable
3ko0Q-6evjB:
undetectable
3ko0R-6evjB:
undetectable
3ko0O-6evjB:
17.92
3ko0P-6evjB:
17.92
3ko0Q-6evjB:
17.92
3ko0R-6evjB:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_P_TFPP202_1
(PROTEIN S100-A4)
6evj RNA-DIRECTED RNA
POLYMERASE CATALYTIC
SUBUNIT

(Influenza
A
virus)
5 / 12 ASP B 112
LEU B 102
PHE B 103
ILE B 262
PHE B 254
None
1.05A 3ko0M-6evjB:
undetectable
3ko0N-6evjB:
undetectable
3ko0O-6evjB:
undetectable
3ko0P-6evjB:
undetectable
3ko0M-6evjB:
17.92
3ko0N-6evjB:
17.92
3ko0O-6evjB:
17.92
3ko0P-6evjB:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_S_TFPS202_1
(PROTEIN S100-A4)
6evj RNA-DIRECTED RNA
POLYMERASE CATALYTIC
SUBUNIT

(Influenza
A
virus)
4 / 6 LEU B 102
PHE B 103
ILE B 262
PHE B 254
None
0.90A 3ko0S-6evjB:
undetectable
3ko0S-6evjB:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_T_TFPT202_1
(PROTEIN S100-A4)
6evj RNA-DIRECTED RNA
POLYMERASE CATALYTIC
SUBUNIT

(Influenza
A
virus)
5 / 11 ASP B 112
LEU B 102
PHE B 103
ILE B 262
PHE B 254
None
1.02A 3ko0Q-6evjB:
undetectable
3ko0R-6evjB:
undetectable
3ko0S-6evjB:
undetectable
3ko0T-6evjB:
undetectable
3ko0Q-6evjB:
17.92
3ko0R-6evjB:
17.92
3ko0S-6evjB:
17.92
3ko0T-6evjB:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KU9_B_SPMB700_1
(POLYAMINE OXIDASE)
6evj RNA-DIRECTED RNA
POLYMERASE CATALYTIC
SUBUNIT

(Influenza
A
virus)
4 / 7 GLU B 608
TYR B 555
PHE B 551
TYR B 599
None
1.31A 3ku9B-6evjB:
0.6
3ku9B-6evjB:
10.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M0W_B_P77B204_1
(PROTEIN S100-A4)
6evj RNA-DIRECTED RNA
POLYMERASE CATALYTIC
SUBUNIT

(Influenza
A
virus)
4 / 6 MET B 507
GLU B 508
PHE B 496
PHE B 495
None
1.32A 3m0wB-6evjB:
undetectable
3m0wJ-6evjB:
undetectable
3m0wB-6evjB:
15.65
3m0wJ-6evjB:
15.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N62_A_MTLA870_0
(NITRIC OXIDE
SYNTHASE)
6evj RNA-DIRECTED RNA
POLYMERASE CATALYTIC
SUBUNIT

(Influenza
A
virus)
4 / 8 SER B 345
ARG B 316
ASN B 314
ASN B 346
None
1.11A 3n62A-6evjB:
undetectable
3n62A-6evjB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N66_B_MTLB870_0
(NITRIC OXIDE
SYNTHASE)
6evj RNA-DIRECTED RNA
POLYMERASE CATALYTIC
SUBUNIT

(Influenza
A
virus)
4 / 8 SER B 345
ARG B 316
ASN B 314
ASN B 346
None
1.10A 3n66B-6evjB:
undetectable
3n66B-6evjB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NAI_B_URFB521_1
(RNA DEPENDENT RNA
POLYMERASE)
6evj RNA-DIRECTED RNA
POLYMERASE CATALYTIC
SUBUNIT

(Influenza
A
virus)
4 / 4 ARG B 239
ASP B 305
ASP B 445
ASP B 446
None
1.35A 3naiB-6evjB:
15.4
3naiB-6evjB:
9.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NAI_C_URFC521_1
(RNA DEPENDENT RNA
POLYMERASE)
6evj RNA-DIRECTED RNA
POLYMERASE CATALYTIC
SUBUNIT

(Influenza
A
virus)
4 / 5 ARG B 239
ASP B 305
ASP B 445
ASP B 446
None
1.36A 3naiC-6evjB:
15.2
3naiC-6evjB:
9.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O01_B_DXCB1_0
(CELL INVASION
PROTEIN SIPD)
6evj RNA-DIRECTED RNA
POLYMERASE CATALYTIC
SUBUNIT

(Influenza
A
virus)
5 / 9 ARG B 324
ILE B 325
ALA B 320
LEU B 415
VAL B  88
None
1.28A 3o01A-6evjB:
0.9
3o01B-6evjB:
1.0
3o01A-6evjB:
undetectable
3o01B-6evjB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P4W_C_DSFC320_1
(GLR4197 PROTEIN)
6evj RNA-DIRECTED RNA
POLYMERASE CATALYTIC
SUBUNIT

(Influenza
A
virus)
4 / 8 TYR B 555
ILE B 552
THR B 527
ILE B 530
None
0.83A 3p4wC-6evjB:
undetectable
3p4wC-6evjB:
13.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SG9_B_KANB305_1
(APH(2'')-ID)
6evj RNA-DIRECTED RNA
POLYMERASE CATALYTIC
SUBUNIT

(Influenza
A
virus)
4 / 8 ASP B 305
SER B 478
ASP B 446
GLU B 311
None
1.10A 3sg9B-6evjB:
0.7
3sg9B-6evjB:
12.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TVT_A_ASCA303_0
(THAUMATIN-1)
6evj RNA-DIRECTED RNA
POLYMERASE CATALYTIC
SUBUNIT

(Influenza
A
virus)
4 / 7 LEU B 298
ILE B 459
LYS B 456
VAL B 463
None
1.00A 4tvtA-6evjB:
undetectable
4tvtA-6evjB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XEY_A_1N1A601_2
(TYROSINE-PROTEIN
KINASE ABL1)
6evj RNA-DIRECTED RNA
POLYMERASE CATALYTIC
SUBUNIT

(Influenza
A
virus)
3 / 3 MET B 711
ASP B 165
PHE B 166
None
0.96A 4xeyA-6evjB:
undetectable
4xeyA-6evjB:
11.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XEY_B_1N1B601_2
(TYROSINE-PROTEIN
KINASE ABL1)
6evj RNA-DIRECTED RNA
POLYMERASE CATALYTIC
SUBUNIT

(Influenza
A
virus)
3 / 3 MET B 711
ASP B 165
PHE B 166
None
0.97A 4xeyB-6evjB:
undetectable
4xeyB-6evjB:
11.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D0Y_B_FOLB201_0
(CONSERVED
HYPOTHETICAL
MEMBRANE PROTEIN)
6evj RNA-DIRECTED RNA
POLYMERASE CATALYTIC
SUBUNIT

(Influenza
A
virus)
5 / 12 LEU B 441
GLN B 442
PHE B 466
THR B 469
HIS B  99
None
1.48A 5d0yB-6evjB:
undetectable
5d0yB-6evjB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LJC_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 1)
6evj RNA-DIRECTED RNA
POLYMERASE CATALYTIC
SUBUNIT

(Influenza
A
virus)
5 / 12 ALA B 320
LEU B 319
PRO B 341
ARG B 334
ILE B 325
None
0.96A 5ljcA-6evjB:
undetectable
5ljcA-6evjB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MUR_B_PFLB407_1
(PROTON-GATED ION
CHANNEL)
6evj RNA-DIRECTED RNA
POLYMERASE CATALYTIC
SUBUNIT

(Influenza
A
virus)
4 / 7 TYR B 555
ILE B 552
THR B 527
ILE B 530
None
0.87A 5murB-6evjB:
undetectable
5murB-6evjB:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MZR_E_PFLE409_1
(PROTON-GATED ION
CHANNEL)
6evj RNA-DIRECTED RNA
POLYMERASE CATALYTIC
SUBUNIT

(Influenza
A
virus)
4 / 8 TYR B 555
ILE B 552
THR B 527
ILE B 530
None
0.74A 5mzrE-6evjB:
undetectable
5mzrE-6evjB:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUN_B_MTLB805_0
(NITRIC OXIDE
SYNTHASE, BRAIN)
6evj RNA-DIRECTED RNA
POLYMERASE CATALYTIC
SUBUNIT

(Influenza
A
virus)
4 / 8 SER B 345
ARG B 316
ASN B 314
ASN B 346
None
1.18A 5vunB-6evjB:
undetectable
5vunB-6evjB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUO_B_MTLB805_0
(NITRIC OXIDE
SYNTHASE, BRAIN)
6evj RNA-DIRECTED RNA
POLYMERASE CATALYTIC
SUBUNIT

(Influenza
A
virus)
4 / 8 SER B 345
ARG B 316
ASN B 314
ASN B 346
None
1.19A 5vuoB-6evjB:
undetectable
5vuoB-6evjB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X66_F_MTXF402_1
(THYMIDYLATE SYNTHASE)
6evj RNA-DIRECTED RNA
POLYMERASE CATALYTIC
SUBUNIT

(Influenza
A
virus)
5 / 12 GLY B 245
THR B 400
MET B 343
ALA B 340
VAL B 339
None
1.14A 5x66F-6evjB:
undetectable
5x66F-6evjB:
17.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AN0_A_HISA520_0
(HISTIDINOL
DEHYDROGENASE)
6evj RNA-DIRECTED RNA
POLYMERASE CATALYTIC
SUBUNIT

(Influenza
A
virus)
4 / 6 LYS B 235
ARG B 233
GLU B 232
ALA B 231
None
1.14A 6an0A-6evjB:
undetectable
6an0A-6evjB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AUU_B_MTLB805_0
(NITRIC OXIDE
SYNTHASE, BRAIN)
6evj RNA-DIRECTED RNA
POLYMERASE CATALYTIC
SUBUNIT

(Influenza
A
virus)
4 / 8 SER B 345
ARG B 316
ASN B 314
ASN B 346
None
1.17A 6auuB-6evjB:
undetectable
6auuB-6evjB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EKZ_A_SNPA414_0
(AROMATIC
PEROXYGENASE)
6evj RNA-DIRECTED RNA
POLYMERASE CATALYTIC
SUBUNIT

(Influenza
A
virus)
4 / 5 PHE B 166
VAL B 181
MET B 246
VAL B 170
None
1.41A 6ekzA-6evjB:
undetectable
6ekzA-6evjB:
19.75