SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6ewi'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XNR_A_ACTA1001_0
(NUCLEAR
POLYADENYLATED
RNA-BINDING PROTEIN
3)		 6ewi CENTROSOMAL PROTEIN
120
(Oreochromis
niloticus) 		3 / 3 SER A 255
ARG A 254
GLN A 180
 None
 0.89A 2xnrA-6ewiA:
undetectable		 2xnrA-6ewiA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_D_TOPD200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 6ewi CENTROSOMAL PROTEIN
120
(Oreochromis
niloticus) 		5 / 9 ALA A 292
LEU A 338
ILE A 253
LEU A 227
PHE A 263
 None
 1.27A 3fl9D-6ewiA:
undetectable		 3fl9D-6ewiA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AYC_A_1YNA502_2
(PROTEIN CYP51)		 6ewi CENTROSOMAL PROTEIN
120
(Oreochromis
niloticus) 		4 / 7 VAL A 195
PRO A 330
PHE A 222
LEU A 311
 None
 1.13A 6aycA-6ewiA:
undetectable		 6aycA-6ewiA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MDQ_A_TESA604_0
(SERUM ALBUMIN)		 6ewi CENTROSOMAL PROTEIN
120
(Oreochromis
niloticus) 		4 / 8 GLY A 228
LEU A 227
ALA A 170
LYS A 168
 None
 0.81A 6mdqA-6ewiA:
undetectable		 6mdqA-6ewiA:
25.00