SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6ewj'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FXH_B_PACB1001_0
(PENICILLIN ACYLASE)		 6ewj PUTATIVE CAPSULAR
POLYSACCHARIDE
BIOSYNTHESIS PROTEIN
(Streptococcus
pneumoniae) 		4 / 7 PHE A 193
SER A 186
ALA A 188
ILE A 187
 None
 0.88A 1fxhA-6ewjA:
undetectable
1fxhB-6ewjA:
undetectable		 1fxhA-6ewjA:
undetectable
1fxhB-6ewjA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FXV_B_PNNB1001_0
(PENICILLIN ACYLASE)		 6ewj PUTATIVE CAPSULAR
POLYSACCHARIDE
BIOSYNTHESIS PROTEIN
(Streptococcus
pneumoniae) 		4 / 7 PHE A 190
SER A 192
PHE A 162
ALA A 188
 None
 1.17A 1fxvA-6ewjA:
undetectable
1fxvB-6ewjA:
undetectable		 1fxvA-6ewjA:
undetectable
1fxvB-6ewjA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_D_FUAD705_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 6ewj PUTATIVE CAPSULAR
POLYSACCHARIDE
BIOSYNTHESIS PROTEIN
(Streptococcus
pneumoniae) 		5 / 12 PHE A 162
PHE A 190
SER A 169
PHE A 193
PHE A 226
 None
 1.41A 1q23D-6ewjA:
undetectable
1q23E-6ewjA:
1.7		 1q23D-6ewjA:
16.06
1q23E-6ewjA:
16.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA501_1
(CYTOCHROME P450 2B4)		 6ewj PUTATIVE CAPSULAR
POLYSACCHARIDE
BIOSYNTHESIS PROTEIN
(Streptococcus
pneumoniae) 		4 / 7 SER A 230
LEU A  55
GLY A 206
THR A 203
 None
 1.11A 2bdmA-6ewjA:
undetectable		 2bdmA-6ewjA:
10.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2L8M_A_CAMA415_0
(CAMPHOR
5-MONOOXYGENASE)		 6ewj PUTATIVE CAPSULAR
POLYSACCHARIDE
BIOSYNTHESIS PROTEIN
(Streptococcus
pneumoniae) 		5 / 9 THR A 317
LEU A 377
THR A 394
ILE A 330
VAL A 398
 None
 1.34A 2l8mA-6ewjA:
undetectable		 2l8mA-6ewjA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VH3_A_DAHA2_1
(RANASMURFIN)		 6ewj PUTATIVE CAPSULAR
POLYSACCHARIDE
BIOSYNTHESIS PROTEIN
(Streptococcus
pneumoniae) 		5 / 9 ALA A  58
ALA A  60
PHE A 226
SER A 192
ALA A 209
 None
 1.30A 2vh3A-6ewjA:
undetectable		 2vh3A-6ewjA:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E00_A_9CRA7223_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 6ewj PUTATIVE CAPSULAR
POLYSACCHARIDE
BIOSYNTHESIS PROTEIN
(Streptococcus
pneumoniae) 		5 / 12 ILE A  65
ALA A  61
ALA A 209
ALA A  58
VAL A 166
 None
 1.03A 3e00A-6ewjA:
undetectable		 3e00A-6ewjA:
12.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NU9_A_478A401_2
(PROTEASE)		 6ewj PUTATIVE CAPSULAR
POLYSACCHARIDE
BIOSYNTHESIS PROTEIN
(Streptococcus
pneumoniae) 		5 / 10 GLY A  95
ALA A  96
VAL A 125
VAL A  79
VAL A  77
 None
 1.14A 3nu9B-6ewjA:
undetectable		 3nu9B-6ewjA:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FO4_A_MOAA502_1
(INOSINE
5'-MONOPHOSPHATE
DEHYDROGENASE)		 6ewj PUTATIVE CAPSULAR
POLYSACCHARIDE
BIOSYNTHESIS PROTEIN
(Streptococcus
pneumoniae) 		4 / 8 ASP A 170
SER A 171
THR A  52
GLY A 207
 None
 0.94A 4fo4A-6ewjA:
undetectable		 4fo4A-6ewjA:
13.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LVC_B_ADNB501_2
(S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(SAHASE))		 6ewj PUTATIVE CAPSULAR
POLYSACCHARIDE
BIOSYNTHESIS PROTEIN
(Streptococcus
pneumoniae) 		4 / 5 GLN A 271
THR A 203
THR A  52
LEU A 175
 None
 1.03A 4lvcB-6ewjA:
undetectable		 4lvcB-6ewjA:
10.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QB9_F_PARF500_1
(ENHANCED
INTRACELLULAR
SURVIVAL PROTEIN)		 6ewj PUTATIVE CAPSULAR
POLYSACCHARIDE
BIOSYNTHESIS PROTEIN
(Streptococcus
pneumoniae) 		5 / 11 PHE A 193
SER A 177
SER A 169
TYR A 138
GLU A 374
 None
 1.15A 4qb9F-6ewjA:
undetectable		 4qb9F-6ewjA:
10.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R87_I_SPMI202_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 6ewj PUTATIVE CAPSULAR
POLYSACCHARIDE
BIOSYNTHESIS PROTEIN
(Streptococcus
pneumoniae) 		4 / 7 ASN A 328
GLU A 325
GLU A 326
GLU A 372
 None
 1.19A 4r87I-6ewjA:
undetectable		 4r87I-6ewjA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4S0V_A_SUVA2001_2
(HUMAN OREXIN
RECEPTOR TYPE 2
FUSION PROTEIN TO P.
ABYSII GLYCOGEN
SYNTHASE)		 6ewj PUTATIVE CAPSULAR
POLYSACCHARIDE
BIOSYNTHESIS PROTEIN
(Streptococcus
pneumoniae) 		4 / 5 ILE A 126
PRO A 128
HIS A 173
VAL A  90
 None
 1.31A 4s0vA-6ewjA:
undetectable		 4s0vA-6ewjA:
10.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_A_377A401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 6ewj PUTATIVE CAPSULAR
POLYSACCHARIDE
BIOSYNTHESIS PROTEIN
(Streptococcus
pneumoniae) 		4 / 5 GLU A 130
GLU A 109
TYR A 112
TYR A 138
 None
 1.48A 4twdA-6ewjA:
undetectable
4twdE-6ewjA:
undetectable		 4twdA-6ewjA:
13.16
4twdE-6ewjA:
13.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_B_377B401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 6ewj PUTATIVE CAPSULAR
POLYSACCHARIDE
BIOSYNTHESIS PROTEIN
(Streptococcus
pneumoniae) 		4 / 5 TYR A 138
GLU A 130
GLU A 109
TYR A 112
 None
 1.47A 4twdA-6ewjA:
undetectable
4twdB-6ewjA:
undetectable		 4twdA-6ewjA:
13.16
4twdB-6ewjA:
13.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5R_A_IPHA904_0
(PROTEIN ARGONAUTE-2)		 6ewj PUTATIVE CAPSULAR
POLYSACCHARIDE
BIOSYNTHESIS PROTEIN
(Streptococcus
pneumoniae) 		4 / 4 PHE A 190
VAL A 166
ALA A 188
PHE A 142
 None
 1.43A 4w5rA-6ewjA:
undetectable		 4w5rA-6ewjA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5T_A_IPHA904_0
(PROTEIN ARGONAUTE-2)		 6ewj PUTATIVE CAPSULAR
POLYSACCHARIDE
BIOSYNTHESIS PROTEIN
(Streptococcus
pneumoniae) 		4 / 4 PHE A 190
VAL A 166
ALA A 188
PHE A 142
 None
 1.47A 4w5tA-6ewjA:
undetectable		 4w5tA-6ewjA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M54_B_TA1B502_1
(TUBULIN BETA-2B
CHAIN)		 6ewj PUTATIVE CAPSULAR
POLYSACCHARIDE
BIOSYNTHESIS PROTEIN
(Streptococcus
pneumoniae) 		5 / 12 ASP A  12
GLU A  17
THR A  47
ARG A 274
LEU A 272
 None
 1.50A 5m54B-6ewjA:
undetectable		 5m54B-6ewjA:
12.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M8R_B_MMSB514_1
(5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE)		 6ewj PUTATIVE CAPSULAR
POLYSACCHARIDE
BIOSYNTHESIS PROTEIN
(Streptococcus
pneumoniae) 		4 / 8 HIS A 344
SER A 310
HIS A 173
HIS A 313
 None
 1.01A 5m8rB-6ewjA:
undetectable		 5m8rB-6ewjA:
10.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M8R_D_MMSD509_1
(5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE)		 6ewj PUTATIVE CAPSULAR
POLYSACCHARIDE
BIOSYNTHESIS PROTEIN
(Streptococcus
pneumoniae) 		4 / 8 HIS A 344
SER A 310
HIS A 173
HIS A 313
 None
 1.00A 5m8rD-6ewjA:
undetectable		 5m8rD-6ewjA:
10.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6APH_A_ADNA501_2
(ADENOSYLHOMOCYSTEINA
SE)		 6ewj PUTATIVE CAPSULAR
POLYSACCHARIDE
BIOSYNTHESIS PROTEIN
(Streptococcus
pneumoniae) 		4 / 5 GLN A 271
THR A 203
THR A  52
LEU A 175
 None
 1.10A 6aphA-6ewjA:
undetectable		 6aphA-6ewjA:
11.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F3M_A_ADNA502_2
(-)		 6ewj PUTATIVE CAPSULAR
POLYSACCHARIDE
BIOSYNTHESIS PROTEIN
(Streptococcus
pneumoniae) 		4 / 4 GLN A 271
THR A 203
THR A  52
LEU A 175
 None
 1.14A 6f3mA-6ewjA:
undetectable		 6f3mA-6ewjA:
10.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F3M_C_ADNC502_2
(-)		 6ewj PUTATIVE CAPSULAR
POLYSACCHARIDE
BIOSYNTHESIS PROTEIN
(Streptococcus
pneumoniae) 		4 / 4 GLN A 271
THR A 203
THR A  52
LEU A 175
 None
 1.15A 6f3mC-6ewjA:
undetectable		 6f3mC-6ewjA:
10.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GBN_B_ADNB501_2
(-)		 6ewj PUTATIVE CAPSULAR
POLYSACCHARIDE
BIOSYNTHESIS PROTEIN
(Streptococcus
pneumoniae) 		4 / 5 GLN A 271
THR A 203
THR A  52
LEU A 175
 None
 1.07A 6gbnB-6ewjA:
3.7		 6gbnB-6ewjA:
10.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HCX_A_ZMRA519_1
(NEURAMINIDASE)		 6ewj PUTATIVE CAPSULAR
POLYSACCHARIDE
BIOSYNTHESIS PROTEIN
(Streptococcus
pneumoniae) 		3 / 3 TRP A 158
ILE A 217
GLU A 220
 None
 0.73A 6hcxA-6ewjA:
undetectable		 6hcxA-6ewjA:
22.09