SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6ewp'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IEP_A_STIA201_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL)		 6ewp CENTROSOMAL PROTEIN
OF 120 KDA
(Mus
musculus) 		4 / 6 VAL A 500
ILE A 596
MET A 504
ARG A 480
 None
 1.09A 1iepA-6ewpA:
undetectable		 1iepA-6ewpA:
11.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AJV_L_COCL501_1
(ANTIBODY 7A1 FAB')		 6ewp CENTROSOMAL PROTEIN
OF 120 KDA
(Mus
musculus) 		4 / 7 TYR A 483
TYR A 601
TYR A 580
PHE A 459
 None
 1.18A 2ajvH-6ewpA:
2.0
2ajvL-6ewpA:
undetectable		 2ajvH-6ewpA:
16.59
2ajvL-6ewpA:
18.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EIG_A_MTXA200_2
(DIHYDROFOLATE
REDUCTASE)		 6ewp CENTROSOMAL PROTEIN
OF 120 KDA
(Mus
musculus) 		4 / 5 ASP A 598
ILE A 596
VAL A 475
THR A 494
 None
 1.11A 3eigA-6ewpA:
undetectable		 3eigA-6ewpA:
17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ETE_B_H3PB552_1
(GLUTAMATE
DEHYDROGENASE)		 6ewp CENTROSOMAL PROTEIN
OF 120 KDA
(Mus
musculus) 		3 / 3 TYR A 512
TYR A 481
ILE A 492
 None
 0.77A 3eteA-6ewpA:
undetectable
3eteB-6ewpA:
undetectable		 3eteA-6ewpA:
10.08
3eteB-6ewpA:
10.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MS9_B_STIB1_2
(TYROSINE-PROTEIN
KINASE ABL1)		 6ewp CENTROSOMAL PROTEIN
OF 120 KDA
(Mus
musculus) 		4 / 7 VAL A 500
ILE A 596
MET A 504
ARG A 480
 None
 1.30A 3ms9B-6ewpA:
undetectable		 3ms9B-6ewpA:
11.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3Q_B_9PLB501_1
(CYTOCHROME P450 2A6)		 6ewp CENTROSOMAL PROTEIN
OF 120 KDA
(Mus
musculus) 		5 / 10 PHE A 486
PHE A 517
PHE A 459
ALA A 514
ILE A 492
 None
 1.30A 3t3qB-6ewpA:
undetectable		 3t3qB-6ewpA:
11.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3Q_C_9PLC501_1
(CYTOCHROME P450 2A6)		 6ewp CENTROSOMAL PROTEIN
OF 120 KDA
(Mus
musculus) 		5 / 10 PHE A 486
PHE A 517
PHE A 459
ALA A 514
ILE A 492
 None
 1.31A 3t3qC-6ewpA:
undetectable		 3t3qC-6ewpA:
11.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ERG_B_SAMB401_0
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
CATALYTIC SUBUNIT
TRM61)		 6ewp CENTROSOMAL PROTEIN
OF 120 KDA
(Mus
musculus) 		5 / 12 SER A 592
ARG A 595
VAL A 475
CYH A 477
LEU A 537
 None
 1.20A 5ergB-6ewpA:
2.0		 5ergB-6ewpA:
undetectable