SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6ewx'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BFP_D_H4BD1290_1
(PTERIDINE REDUCTASE
1)		 6ewx PEAK1-RELATED
KINASE-ACTIVATING
PSEUDOKINASE 1
(Rattus
norvegicus) 		4 / 8 PHE A1179
LEU A1110
LEU A1120
LEU A1125
 None
 1.02A 2bfpD-6ewxA:
undetectable		 2bfpD-6ewxA:
14.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NK2_X_LDPX433_1
(6-HYDROXY-L-NICOTINE
OXIDASE)		 6ewx PEAK1-RELATED
KINASE-ACTIVATING
PSEUDOKINASE 1
(Rattus
norvegicus) 		4 / 7 ASN A1019
LEU A1099
LEU A1345
PHE A1018
 None
 0.94A 3nk2X-6ewxA:
undetectable		 3nk2X-6ewxA:
12.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TYE_B_YTZB902_1
(DIHYDROPTEROATE
SYNTHASE)		 6ewx PEAK1-RELATED
KINASE-ACTIVATING
PSEUDOKINASE 1
(Rattus
norvegicus) 		3 / 3 PHE A 957
LYS A 988
SER A 987
 None
 1.34A 3tyeB-6ewxA:
undetectable		 3tyeB-6ewxA:
17.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XI3_B_29SB601_1
(ESTROGEN RECEPTOR)		 6ewx PEAK1-RELATED
KINASE-ACTIVATING
PSEUDOKINASE 1
(Rattus
norvegicus) 		5 / 12 LEU A1226
LEU A1126
ILE A1020
GLY A1106
LEU A1107
 None
 1.01A 4xi3B-6ewxA:
undetectable		 4xi3B-6ewxA:
16.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NWU_A_ACAA18_2
(WTFP-TAG,GP41)		 6ewx PEAK1-RELATED
KINASE-ACTIVATING
PSEUDOKINASE 1
(Rattus
norvegicus) 		3 / 3 LEU A1291
LEU A1345
TRP A1344
 None
 0.87A 5nwuA-6ewxA:
undetectable		 5nwuA-6ewxA:
16.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TOA_B_ESTB601_1
(ESTROGEN RECEPTOR
BETA)		 6ewx PEAK1-RELATED
KINASE-ACTIVATING
PSEUDOKINASE 1
(Rattus
norvegicus) 		5 / 12 LEU A1100
LEU A1099
ILE A1176
LEU A1174
HIS A1117
 None
 1.18A 5toaB-6ewxA:
undetectable		 5toaB-6ewxA:
15.66