SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6ewz'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2OAX_D_SNLD4001_2 (MINERALOCORTICOID RECEPTOR)	6ewz	GTP PYROPHOSPHOKINASE (Staphylococcus aureus)	4 / 5	LEU A 154 LEU A 128 CYH A 115 THR A 179	None	1.19A	2oaxD-6ewzA: undetectable	2oaxD-6ewzA: 16.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4GKH_F_KANF301_1 (AMINOGLYCOSIDE 3'-PHOSPHOTRANSFERAS E APHA1-IAB)	6ewz	GTP PYROPHOSPHOKINASE (Staphylococcus aureus)	4 / 8	ASP A 119 ASP A 141 ARG A 139 GLU A 218	None	1.09A	4gkhF-6ewzA: undetectable	4gkhF-6ewzA: 11.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4PST_A_FOLA201_1 (DIHYDROFOLATE REDUCTASE)	6ewz	GTP PYROPHOSPHOKINASE (Staphylococcus aureus)	3 / 3	ILE A 121 ASP A 141 ARG A 178	None None GTP A 301 ( 4.7A)	0.81A	4pstA-6ewzA: undetectable	4pstA-6ewzA: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5E4D_B_BEZB201_0 (HYDROXYNITRILE LYASE)	6ewz	GTP PYROPHOSPHOKINASE (Staphylococcus aureus)	5 / 11	VAL A 113 VAL A 114 TYR A 151 ILE A 143 ILE A 121	None None GTP A 301 (-3.6A) None None	1.06A	5e4dB-6ewzA: undetectable	5e4dB-6ewzA: undetectable

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["2OAX_D_SNLD4001_2","MINERALOCORTICOID RECEPTOR","6ewz","GTP PYROPHOSPHOKINASE","Staphylococcus aureus",4,"LEU A 154;LEU A 128;CYH A 115;THR A 179","None","1.19A","2oaxD-6ewzA:undetectable","2oaxD-6ewzA:16.73"],["4GKH_F_KANF301_1","AMINOGLYCOSIDE 3'-PHOSPHOTRANSFERASE APHA1-IAB","6ewz","GTP PYROPHOSPHOKINASE","Staphylococcus aureus",4,"ASP A 119;ASP A 141;ARG A 139;GLU A 218","None","1.09A","4gkhF-6ewzA:undetectable","4gkhF-6ewzA:11.81"],["4PST_A_FOLA201_1","DIHYDROFOLATE REDUCTASE","6ewz","GTP PYROPHOSPHOKINASE","Staphylococcus aureus",3,"ILE A 121;ASP A 141;ARG A 178","None;None;GTP A 301 ( 4.7A)","0.81A","4pstA-6ewzA:undetectable","4pstA-6ewzA:undetectable"],["5E4D_B_BEZB201_0","HYDROXYNITRILE LYASE","6ewz","GTP PYROPHOSPHOKINASE","Staphylococcus aureus",5,"VAL A 113;VAL A 114;TYR A 151;ILE A 143;ILE A 121","None;None;GTP A 301 (-3.6A);None;None","1.06A","5e4dB-6ewzA:undetectable","5e4dB-6ewzA:undetectable"]]