SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6exc'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BDW_A_DVAA6_0
(GRAMICIDIN A)		 6exc ICMP (DOTM)
(Legionella
pneumophila) 		3 / 3 ALA A 282
VAL A 284
TRP A 212
 None
 0.75A 1bdwA-6excA:
undetectable
1bdwB-6excA:
undetectable		 1bdwA-6excA:
undetectable
1bdwB-6excA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HK3_A_T44A3003_1
(SERUM ALBUMIN)		 6exc ICMP (DOTM)
(Legionella
pneumophila) 		3 / 4 LYS A 177
ALA A 193
MET A 375
 None
 0.86A 1hk3A-6excA:
2.0		 1hk3A-6excA:
7.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQT_A_ACTA1866_0
(FPRA)		 6exc ICMP (DOTM)
(Legionella
pneumophila) 		4 / 4 ARG A 202
LEU A 174
ASN A 173
VAL A 203
 None
 1.45A 1lqtA-6excA:
undetectable		 1lqtA-6excA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQT_B_ACTB1875_0
(FPRA)		 6exc ICMP (DOTM)
(Legionella
pneumophila) 		4 / 4 ARG A 202
LEU A 174
ASN A 173
VAL A 203
 None
 1.46A 1lqtB-6excA:
undetectable		 1lqtB-6excA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQU_A_ACTA1423_0
(FPRA)		 6exc ICMP (DOTM)
(Legionella
pneumophila) 		4 / 4 ARG A 202
LEU A 174
ASN A 173
VAL A 203
 None
 1.45A 1lquA-6excA:
undetectable		 1lquA-6excA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQU_B_ACTB1432_0
(FPRA)		 6exc ICMP (DOTM)
(Legionella
pneumophila) 		4 / 4 ARG A 202
LEU A 174
ASN A 173
VAL A 203
 None
 1.48A 1lquB-6excA:
undetectable		 1lquB-6excA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VAV_F_CSCF1383_2
(ACETYL-COA--DEACETYL
CEPHALOSPORIN C
ACETYLTRANSFERASE)		 6exc ICMP (DOTM)
(Legionella
pneumophila) 		3 / 3 LEU A 285
MET A 319
MET A 230
 None
 0.99A 2vavF-6excA:
undetectable		 2vavF-6excA:
10.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JUS_B_ECNB602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 6exc ICMP (DOTM)
(Legionella
pneumophila) 		5 / 9 TYR A 283
LEU A 285
THR A 286
ALA A 341
ILE A 354
 None
 1.42A 3jusB-6excA:
undetectable		 3jusB-6excA:
11.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DM8_A_REAA501_1
(RETINOIC ACID
RECEPTOR BETA)		 6exc ICMP (DOTM)
(Legionella
pneumophila) 		5 / 11 LEU A 247
LEU A 244
ILE A 243
ARG A 237
LEU A 316
 None
 1.11A 4dm8A-6excA:
undetectable		 4dm8A-6excA:
16.02