SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6exn'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D8C_A_SORA4000_0
(MALATE SYNTHASE G)		 6exn PRE-MRNA-SPLICING
FACTOR CWC2
(Saccharomyces
cerevisiae) 		3 / 3 GLN M  12
HIS M  91
PRO M  85
 None
ZN  M1000 (-2.9A)
None
 0.95A 1d8cA-6exnM:
undetectable		 1d8cA-6exnM:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7B_B_HLTB4001_1
(SERUM ALBUMIN)		 6exn PRE-MRNA-SPLICING
FACTOR CWC2
(Saccharomyces
cerevisiae) 		4 / 4 ARG M 131
LYS M 132
ASP M 119
GLY M 128
 None
None
None
G  6  39 ( 3.3A)
 1.46A 1e7bB-6exnM:
undetectable		 1e7bB-6exnM:
7.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJ2_A_SAMA2200_0
(PROTEIN (METHIONINE
REPRESSOR))		 6exn PRE-MRNA-SPLICING
FACTOR CWC2
(Saccharomyces
cerevisiae) 		5 / 12 ALA M  77
PHE M  75
GLY M  79
ARG M 114
GLU M 193
 None
A  6  35 ( 3.7A)
None
None
None
 0.99A 1mj2A-6exnM:
undetectable
1mj2B-6exnM:
undetectable		 1mj2A-6exnM:
undetectable
1mj2B-6exnM:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJ2_C_SAMC2199_0
(PROTEIN (METHIONINE
REPRESSOR))		 6exn PRE-MRNA-SPLICING
FACTOR CWC2
(Saccharomyces
cerevisiae) 		5 / 12 ALA M  77
PHE M  75
GLY M  79
ARG M 114
GLU M 193
 None
A  6  35 ( 3.7A)
None
None
None
 0.98A 1mj2C-6exnM:
undetectable
1mj2D-6exnM:
undetectable		 1mj2C-6exnM:
undetectable
1mj2D-6exnM:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJO_C_SAMC200_0
(METHIONINE REPRESSOR)		 6exn PRE-MRNA-SPLICING
FACTOR CWC2
(Saccharomyces
cerevisiae) 		5 / 12 ALA M  77
PHE M  75
GLY M  79
ARG M 114
GLU M 193
 None
A  6  35 ( 3.7A)
None
None
None
 0.99A 1mjoC-6exnM:
undetectable
1mjoD-6exnM:
undetectable		 1mjoC-6exnM:
undetectable
1mjoD-6exnM:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_D_SAMD200_0
(METHIONINE REPRESSOR)		 6exn PRE-MRNA-SPLICING
FACTOR CWC2
(Saccharomyces
cerevisiae) 		5 / 12 ALA M  77
PHE M  75
GLY M  79
ARG M 114
GLU M 193
 None
A  6  35 ( 3.7A)
None
None
None
 0.95A 1mjqC-6exnM:
undetectable
1mjqD-6exnM:
undetectable		 1mjqC-6exnM:
undetectable
1mjqD-6exnM:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1U18_B_HSMB402_1
(NITROPHORIN 1)		 6exn PRE-MRNA-SPLICING
FACTOR CWC2
(Saccharomyces
cerevisiae) 		4 / 5 ASP M 209
THR M 203
LEU M 204
LEU M 205
 None
 1.20A 1u18B-6exnM:
undetectable		 1u18B-6exnM:
16.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_C_ACHC1210_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 6exn PRE-MRNA-SPLICING
FACTOR CLF1
(Saccharomyces
cerevisiae) 		4 / 8 TYR S 137
VAL S 166
TYR S 156
CYH S 160
 None
 1.27A 2xz5A-6exnS:
undetectable
2xz5C-6exnS:
undetectable		 2xz5A-6exnS:
undetectable
2xz5C-6exnS:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_D_ACHD1210_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 6exn PRE-MRNA-SPLICING
FACTOR CLF1
(Saccharomyces
cerevisiae) 		4 / 8 TYR S 137
VAL S 166
TYR S 156
CYH S 160
 None
 1.27A 2xz5C-6exnS:
undetectable
2xz5D-6exnS:
undetectable		 2xz5C-6exnS:
undetectable
2xz5D-6exnS:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DZG_B_NCAB302_0
(ADP-RIBOSYL CYCLASE
1)		 6exn PRE-MRNA-SPLICING
FACTOR CLF1
(Saccharomyces
cerevisiae) 		4 / 7 LEU S  92
GLU S  89
SER S  96
THR S 128
 None
 1.25A 3dzgB-6exnS:
undetectable		 3dzgB-6exnS:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K37_A_BCZA468_1
(NEURAMINIDASE)		 6exn PRE-MRNA-SPLICING
FACTOR CLF1
(Saccharomyces
cerevisiae) 		3 / 3 ASP S 174
ARG S 178
ARG S 207
 None
 0.98A 3k37A-6exnS:
undetectable		 3k37A-6exnS:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KU9_B_SPMB700_1
(POLYAMINE OXIDASE)		 6exn PRE-MRNA-SPLICING
FACTOR CLF1
(Saccharomyces
cerevisiae) 		4 / 7 GLU S  53
TYR S  46
PHE S  74
TYR S  54
 G  6  86 ( 4.3A)
None
None
G  6  86 ( 4.5A)
 1.35A 3ku9B-6exnS:
undetectable		 3ku9B-6exnS:
10.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ROP_A_NCAA302_0
(ADP-RIBOSYL CYCLASE
1)		 6exn PRE-MRNA-SPLICING
FACTOR CLF1
(Saccharomyces
cerevisiae) 		4 / 6 LEU S  92
GLU S  89
SER S  96
THR S 128
 None
 1.24A 3ropA-6exnS:
undetectable		 3ropA-6exnS:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IJI_H_BEZH501_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN YIBF)		 6exn PRE-MRNA-PROCESSING
PROTEIN 45
(Saccharomyces
cerevisiae) 		4 / 7 ASN K  87
ALA K  89
SER K  90
TYR K  93
 None
C  5 111 ( 3.3A)
None
U  5 110 ( 4.6A)
 1.15A 4ijiH-6exnK:
undetectable		 4ijiH-6exnK:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L3G_F_ACTF401_0
(METHYLAMINE
DEHYDROGENASE HEAVY
CHAIN)		 6exn PRE-MRNA-SPLICING
FACTOR CLF1
(Saccharomyces
cerevisiae) 		3 / 3 ARG S  44
LEU S  40
GLU S  41
 None
 0.67A 4l3gF-6exnS:
undetectable		 4l3gF-6exnS:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PFJ_B_ADNB502_1
(ADENOSYLHOMOCYSTEINA
SE)		 6exn PRE-MRNA-SPLICING
FACTOR CWC2
(Saccharomyces
cerevisiae) 		5 / 12 HIS M  92
ASP M  95
GLU M  97
LEU M  90
GLY M  64
 None
 1.24A 4pfjB-6exnM:
undetectable		 4pfjB-6exnM:
10.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PGF_B_ADNB502_1
(ADENOSYLHOMOCYSTEINA
SE)		 6exn PRE-MRNA-SPLICING
FACTOR CWC2
(Saccharomyces
cerevisiae) 		5 / 12 HIS M  92
ASP M  95
GLU M  97
LEU M  90
GLY M  64
 None
 1.21A 4pgfB-6exnM:
undetectable		 4pgfB-6exnM:
10.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EMU_B_SAMB301_0
(TRNA
(GUANINE(9)-/ADENINE
(9)-N1)-METHYLTRANSF
ERASE)		 6exn PRE-MRNA-SPLICING
FACTOR CWC2
(Saccharomyces
cerevisiae) 		5 / 12 LEU M 204
GLY M 220
ILE M 156
ASP M 143
ILE M 142
 None
 1.07A 6emuB-6exnM:
undetectable		 6emuB-6exnM:
undetectable