SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6exs'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LIN_A_TFPA155_1
(CALMODULIN)		 6exs PEPTIDE ABC
TRANSPORTER PERMEASE
(Staphylococcus
hominis) 		4 / 7 GLN A 344
MET A  43
PHE A 257
MET A  51
 C3H  A 514 (-2.8A)
None
None
None
 1.28A 1linA-6exsA:
undetectable		 1linA-6exsA:
17.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NW5_A_SAMA401_0
(MODIFICATION
METHYLASE RSRI)		 6exs PEPTIDE ABC
TRANSPORTER PERMEASE
(Staphylococcus
hominis) 		5 / 12 ASP A  90
GLY A 134
SER A 133
ALA A  89
ALA A  98
 None
OLC  A 502 ( 4.5A)
None
None
None
 1.31A 1nw5A-6exsA:
undetectable		 1nw5A-6exsA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SN0_B_T44B602_1
(TRANSTHYRETIN)		 6exs PEPTIDE ABC
TRANSPORTER PERMEASE
(Staphylococcus
hominis) 		4 / 7 LEU A 299
ALA A 295
LYS A 431
ALA A 428
 None
 1.03A 1sn0B-6exsA:
undetectable
1sn0D-6exsA:
undetectable		 1sn0B-6exsA:
18.80
1sn0D-6exsA:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SN0_B_T44B602_1
(TRANSTHYRETIN)		 6exs PEPTIDE ABC
TRANSPORTER PERMEASE
(Staphylococcus
hominis) 		4 / 7 LYS A 431
ALA A 428
LEU A 299
ALA A 295
 None
 1.02A 1sn0B-6exsA:
undetectable
1sn0D-6exsA:
undetectable		 1sn0B-6exsA:
18.80
1sn0D-6exsA:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VE3_A_SAMA302_0
(HYPOTHETICAL PROTEIN
PH0226)		 6exs PEPTIDE ABC
TRANSPORTER PERMEASE
(Staphylococcus
hominis) 		5 / 12 GLY A 132
ILE A  88
ALA A  86
ILE A  78
SER A  81
 None
None
None
None
OLC  A 502 (-4.5A)
 1.01A 1ve3A-6exsA:
undetectable		 1ve3A-6exsA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_J_BEZJ5041_0
(CES1 PROTEIN)		 6exs PEPTIDE ABC
TRANSPORTER PERMEASE
(Staphylococcus
hominis) 		4 / 4 GLY A 196
SER A  39
ILE A 106
HIS A 110
 None
 1.15A 1yajJ-6exsA:
undetectable		 1yajJ-6exsA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OPX_A_DXCA1003_0
(ALDEHYDE
DEHYDROGENASE A)		 6exs PEPTIDE ABC
TRANSPORTER PERMEASE
(Staphylococcus
hominis) 		4 / 5 ILE A  62
LEU A  60
ALA A  67
PHE A 190
 None
 0.99A 2opxA-6exsA:
undetectable		 2opxA-6exsA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZIF_A_SAMA298_0
(PUTATIVE
MODIFICATION
METHYLASE)		 6exs PEPTIDE ABC
TRANSPORTER PERMEASE
(Staphylococcus
hominis) 		5 / 12 ALA A 452
SER A  69
PHE A 257
THR A 263
VAL A 269
 None
 1.23A 2zifA-6exsA:
undetectable		 2zifA-6exsA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AI9_X_SAMX501_0
(UPF0217 PROTEIN
MJ1640)		 6exs PEPTIDE ABC
TRANSPORTER PERMEASE
(Staphylococcus
hominis) 		5 / 9 LEU A 105
ILE A 108
GLY A 109
LEU A 101
GLU A  36
 None
None
None
OLC  A 512 ( 4.0A)
None
 1.04A 3ai9X-6exsA:
undetectable		 3ai9X-6exsA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_B_PM6B301_1
(THIOPURINE
S-METHYLTRANSFERASE)		 6exs PEPTIDE ABC
TRANSPORTER PERMEASE
(Staphylococcus
hominis) 		4 / 8 ARG A 337
GLY A 339
LEU A 322
ARG A 184
 None
 1.15A 3bgdB-6exsA:
undetectable		 3bgdB-6exsA:
15.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ETE_B_H3PB552_1
(GLUTAMATE
DEHYDROGENASE)		 6exs PEPTIDE ABC
TRANSPORTER PERMEASE
(Staphylococcus
hominis) 		3 / 3 TYR A 397
TYR A 320
ILE A 390
 OLC  A 505 ( 3.7A)
None
None
 0.84A 3eteA-6exsA:
undetectable
3eteB-6exsA:
undetectable		 3eteA-6exsA:
10.71
3eteB-6exsA:
10.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IB2_A_IBPA3960_1
(LACTOTRANSFERRIN)		 6exs PEPTIDE ABC
TRANSPORTER PERMEASE
(Staphylococcus
hominis) 		4 / 4 GLY A 313
VAL A 316
GLY A 457
THR A 458
 C3H  A 514 (-3.3A)
None
None
None
 0.90A 3ib2A-6exsA:
undetectable		 3ib2A-6exsA:
10.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JZ0_B_CLYB900_1
(LINCOSAMIDE
NUCLEOTIDYLTRANSFERA
SE)		 6exs PEPTIDE ABC
TRANSPORTER PERMEASE
(Staphylococcus
hominis) 		4 / 8 GLU A  36
GLU A  33
SER A  81
ILE A 131
 None
None
OLC  A 502 (-4.5A)
None
 1.08A 3jz0B-6exsA:
2.6		 3jz0B-6exsA:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PRS_A_RITA1001_1
(ENDOTHIAPEPSIN)		 6exs PEPTIDE ABC
TRANSPORTER PERMEASE
(Staphylococcus
hominis) 		5 / 10 ILE A 243
ILE A  88
THR A  93
ILE A 106
ILE A  78
 None
None
OLC  A 512 (-4.7A)
None
None
 1.19A 3prsA-6exsA:
undetectable		 3prsA-6exsA:
14.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AX8_A_SAMA1474_0
(WBDD)		 6exs PEPTIDE ABC
TRANSPORTER PERMEASE
(Staphylococcus
hominis) 		5 / 12 GLY A 102
ALA A  98
ASN A 139
ILE A 106
ILE A 129
 None
 0.96A 4ax8A-6exsA:
undetectable		 4ax8A-6exsA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AZT_A_SAMA1472_0
(METHYLTRANSFERASE
WBDD)		 6exs PEPTIDE ABC
TRANSPORTER PERMEASE
(Staphylococcus
hominis) 		5 / 12 GLY A 102
ALA A  98
ASN A 139
ILE A 106
ILE A 129
 None
 0.96A 4aztA-6exsA:
undetectable		 4aztA-6exsA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FFW_B_715B801_1
(DIPEPTIDYL PEPTIDASE
4)		 6exs PEPTIDE ABC
TRANSPORTER PERMEASE
(Staphylococcus
hominis) 		5 / 12 GLU A  36
GLY A 102
TYR A  79
TYR A  40
VAL A 166
 None
 1.21A 4ffwB-6exsA:
undetectable		 4ffwB-6exsA:
8.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J4V_C_SVRC301_1
(NUCLEOCAPSID PROTEIN)		 6exs PEPTIDE ABC
TRANSPORTER PERMEASE
(Staphylococcus
hominis) 		4 / 8 GLY A 313
ASN A 318
PHE A 472
ILE A 390
 C3H  A 514 (-3.3A)
None
None
None
 0.91A 4j4vC-6exsA:
undetectable		 4j4vC-6exsA:
15.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PFJ_A_ADNA502_2
(ADENOSYLHOMOCYSTEINA
SE)		 6exs PEPTIDE ABC
TRANSPORTER PERMEASE
(Staphylococcus
hominis) 		4 / 7 THR A 380
LEU A 459
ASN A 456
SER A 386
 None
 1.06A 4pfjA-6exsA:
undetectable		 4pfjA-6exsA:
10.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R29_D_SAMD301_0
(UNCHARACTERIZED
PROTEIN)		 6exs PEPTIDE ABC
TRANSPORTER PERMEASE
(Staphylococcus
hominis) 		5 / 12 SER A 165
ILE A 107
ALA A 198
MET A 197
GLY A 196
 None
 0.97A 4r29D-6exsA:
undetectable		 4r29D-6exsA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XE5_A_OBNA1104_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 6exs PEPTIDE ABC
TRANSPORTER PERMEASE
(Staphylococcus
hominis) 		5 / 12 GLN A 344
GLU A 340
GLY A  42
GLU A  36
ILE A 129
 C3H  A 514 (-2.8A)
None
None
None
None
 1.27A 4xe5A-6exsA:
undetectable		 4xe5A-6exsA:
5.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_P_BEZP801_1
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 6exs PEPTIDE ABC
TRANSPORTER PERMEASE
(Staphylococcus
hominis) 		4 / 6 PHE A 190
ALA A 193
MET A  46
LEU A 191
 None
 1.06A 5dzkB-6exsA:
undetectable
5dzkP-6exsA:
undetectable		 5dzkB-6exsA:
undetectable
5dzkP-6exsA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_U_BEZU801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 6exs PEPTIDE ABC
TRANSPORTER PERMEASE
(Staphylococcus
hominis) 		4 / 6 PHE A 190
ALA A 193
MET A  46
LEU A 191
 None
 1.14A 5dzkg-6exsA:
undetectable
5dzku-6exsA:
undetectable		 5dzkg-6exsA:
undetectable
5dzku-6exsA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E4D_B_BEZB202_0
(HYDROXYNITRILE LYASE)		 6exs PEPTIDE ABC
TRANSPORTER PERMEASE
(Staphylococcus
hominis) 		4 / 7 THR A 263
LEU A 255
VAL A 245
THR A 249
 None
OLC  A 513 (-4.2A)
None
None
 0.92A 5e4dA-6exsA:
undetectable
5e4dB-6exsA:
undetectable		 5e4dA-6exsA:
undetectable
5e4dB-6exsA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IWU_A_ERYA404_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 6exs PEPTIDE ABC
TRANSPORTER PERMEASE
(Staphylococcus
hominis) 		4 / 6 GLY A 396
ASP A 326
ARG A 324
TYR A 320
 OLC  A 505 (-3.4A)
None
None
None
 1.08A 5iwuA-6exsA:
undetectable		 5iwuA-6exsA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O4Y_A_CCSA14_0
(PHE-MAA-ASN-PRO-HIS-
LEU-SER-TRP-SER-TRP-
9KK-9KK-ARG-CCS-GLY-
NH2)		 6exs PEPTIDE ABC
TRANSPORTER PERMEASE
(Staphylococcus
hominis) 		4 / 6 PHE A 207
TRP A 203
ARG A  24
GLY A  27
 OLC  A 508 ( 4.8A)
None
None
None
 0.91A 5o4yA-6exsA:
undetectable		 5o4yA-6exsA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O4Y_F_CCSF14_0
(PHE-MAA-ASN-PRO-HIS-
LEU-SER-TRP-SER-TRP-
9KK-9KK-ARG-CCS-GLY-
NH2)		 6exs PEPTIDE ABC
TRANSPORTER PERMEASE
(Staphylococcus
hominis) 		4 / 6 PHE A 207
TRP A 203
ARG A  24
GLY A  25
 OLC  A 508 ( 4.8A)
None
None
None
 1.05A 5o4yF-6exsA:
undetectable		 5o4yF-6exsA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O4Y_F_CCSF14_0
(PHE-MAA-ASN-PRO-HIS-
LEU-SER-TRP-SER-TRP-
9KK-9KK-ARG-CCS-GLY-
NH2)		 6exs PEPTIDE ABC
TRANSPORTER PERMEASE
(Staphylococcus
hominis) 		4 / 6 PHE A 207
TRP A 203
ARG A  24
GLY A  27
 OLC  A 508 ( 4.8A)
None
None
None
 1.08A 5o4yF-6exsA:
undetectable		 5o4yF-6exsA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GS4_A_F9EA601_0
(DIPEPTIDE AND
TRIPEPTIDE PERMEASE
A)		 6exs PEPTIDE ABC
TRANSPORTER PERMEASE
(Staphylococcus
hominis) 		5 / 10 TYR A  41
ASN A 167
ASN A 347
PRO A 348
GLU A 418
 C3H  A 514 (-4.0A)
C3H  A 514 (-3.6A)
C3H  A 514 (-4.0A)
C3H  A 514 (-4.1A)
None
 0.61A 6gs4A-6exsA:
37.1		 6gs4A-6exsA:
undetectable
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6GZ9_A_TXCA501_0
(PEPTIDE ABC
TRANSPORTER PERMEASE)		 6exs PEPTIDE ABC
TRANSPORTER PERMEASE
(Staphylococcus
hominis) 		10 / 10 TYR A  41
TYR A  79
TYR A 163
VAL A 166
ASN A 167
ALA A 170
GLN A 310
ASN A 347
PRO A 348
ASN A 426
 C3H  A 514 (-4.0A)
None
None
None
C3H  A 514 (-3.6A)
C3H  A 514 ( 3.7A)
C3H  A 514 (-3.5A)
C3H  A 514 (-4.0A)
C3H  A 514 (-4.1A)
None
 0.56A 6gz9A-6exsA:
60.6		 6gz9A-6exsA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H7U_A_FVTA501_0
(PEPTIDE ABC
TRANSPORTER PERMEASE)		 6exs PEPTIDE ABC
TRANSPORTER PERMEASE
(Staphylococcus
hominis) 		6 / 6 VAL A 166
ASN A 167
ASN A 347
PRO A 348
ILE A 351
GLU A 418
 None
C3H  A 514 (-3.6A)
C3H  A 514 (-4.0A)
C3H  A 514 (-4.1A)
None
None
 0.53A 6h7uA-6exsA:
61.8		 6h7uA-6exsA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HZP_A_FVTA501_0
(PEPTIDE ABC
TRANSPORTER PERMEASE)		 6exs PEPTIDE ABC
TRANSPORTER PERMEASE
(Staphylococcus
hominis) 		8 / 8 TYR A  41
VAL A 166
ASN A 167
GLN A 310
ASN A 347
PRO A 348
ILE A 351
GLU A 418
 C3H  A 514 (-4.0A)
None
C3H  A 514 (-3.6A)
C3H  A 514 (-3.5A)
C3H  A 514 (-4.0A)
C3H  A 514 (-4.1A)
None
None
 0.24A 6hzpA-6exsA:
62.6		 6hzpA-6exsA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6QYA_B_FOZB401_0
(THYMIDYLATE SYNTHASE)		 6exs PEPTIDE ABC
TRANSPORTER PERMEASE
(Staphylococcus
hominis) 		5 / 12 HIS A  56
LEU A  60
GLY A  59
ILE A  62
ALA A  67
 None
 1.30A 6qyaB-6exsA:
undetectable		 6qyaB-6exsA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6QYA_D_FOZD401_0
(THYMIDYLATE SYNTHASE)		 6exs PEPTIDE ABC
TRANSPORTER PERMEASE
(Staphylococcus
hominis) 		5 / 12 HIS A  56
LEU A  60
GLY A  59
ILE A  62
ALA A  67
 None
 1.29A 6qyaD-6exsA:
undetectable		 6qyaD-6exsA:
undetectable