SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6ey0'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IG3_A_VIBA502_1
(THIAMIN
PYROPHOSPHOKINASE)		 6ey0 LLAMA NANOBODY NB01
(Lama
glama) 		4 / 8 LEU E 100
SER E  33
SER E  31
ASP E 101
 None
 0.97A 1ig3A-6ey0E:
undetectable
1ig3B-6ey0E:
undetectable		 1ig3A-6ey0E:
13.69
1ig3B-6ey0E:
13.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q2H_B_ACTB501_0
(SECRETION CHAPERONE,
PHAGE-DISPLAY
DERIVED PEPTIDE)		 6ey0 T9SS COMPONENT
CYTOPLASMIC MEMBRANE
PROTEIN PORM
LLAMA NANOBODY NB01
(Porphyromonas
gingivalis;
Lama
glama) 		3 / 3 ARG E 100
SER A  90
TYR E  58
 None
 0.88A 2q2hA-6ey0E:
undetectable
2q2hB-6ey0E:
undetectable		 2q2hA-6ey0E:
undetectable
2q2hB-6ey0E:
undetectable
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QXV_B_MTXB2000_1
(ANTI-METHOTREXATE
CDR1-4 GRAFT VHH)		 6ey0 LLAMA NANOBODY NB01
(Lama
glama) 		5 / 12 MET E  34
ARG E  71
VAL E  78
ALA E  94
TYR E 102
 None
 0.78A 3qxvB-6ey0E:
21.3		 3qxvB-6ey0E:
56.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QXV_D_MTXD2000_1
(ANTI-METHOTREXATE
CDR1-4 GRAFT VHH)		 6ey0 LLAMA NANOBODY NB01
(Lama
glama) 		5 / 12 MET E  34
ARG E  71
VAL E  78
ALA E  94
TYR E 102
 None
 0.87A 3qxvD-6ey0E:
21.3		 3qxvD-6ey0E:
56.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QXV_E_MTXE2000_1
(ANTI-METHOTREXATE
CDR1-4 GRAFT VHH)		 6ey0 LLAMA NANOBODY NB01
(Lama
glama) 		5 / 12 MET E  34
ARG E  71
VAL E  78
ALA E  94
TYR E 102
 None
 0.80A 3qxvE-6ey0E:
18.0		 3qxvE-6ey0E:
56.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OBW_B_SAMB601_0
(2-METHOXY-6-POLYPREN
YL-1,4-BENZOQUINOL
METHYLASE,
MITOCHONDRIAL)		 6ey0 T9SS COMPONENT
CYTOPLASMIC MEMBRANE
PROTEIN PORM
LLAMA NANOBODY NB01
(Porphyromonas
gingivalis;
Lama
glama) 		5 / 12 GLY E  98
ASP A  96
ILE E  51
ASN E  55
GLY E  35
 None
 0.91A 4obwB-6ey0E:
undetectable		 4obwB-6ey0E:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OBW_C_SAMC601_0
(2-METHOXY-6-POLYPREN
YL-1,4-BENZOQUINOL
METHYLASE,
MITOCHONDRIAL)		 6ey0 T9SS COMPONENT
CYTOPLASMIC MEMBRANE
PROTEIN PORM
LLAMA NANOBODY NB01
(Porphyromonas
gingivalis;
Lama
glama) 		5 / 12 GLY E  98
ASP A  96
ILE E  51
ASN E  55
GLY E  35
 None
 0.92A 4obwC-6ey0E:
undetectable		 4obwC-6ey0E:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UY8_7_TRP71002_0
(TRYPTOPHANASE)		 6ey0 T9SS COMPONENT
CYTOPLASMIC MEMBRANE
PROTEIN PORM
(Porphyromonas
gingivalis) 		4 / 4 ILE A 116
ASN A 114
ILE A 193
VAL A 190
 None
 1.30A 4uy87-6ey0A:
undetectable		 4uy87-6ey0A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECO_D_LEUD602_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 6ey0 LLAMA NANOBODY NB01
(Lama
glama) 		4 / 7 ALA E  88
THR E  87
VAL E 109
GLU E  85
 None
 0.82A 5ecoD-6ey0E:
undetectable		 5ecoD-6ey0E:
undetectable