SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6ey5'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BRF_A_SORA2_0
(LIN-12 AND GLP-1
PHENOTYPE PROTEIN 1,
ISOFORM A)		 6ey5 T9SS COMPONENT
CYTOPLASMIC MEMBRANE
PROTEIN PORM
(Porphyromonas
gingivalis) 		3 / 3 LYS A 426
LYS A 489
VAL A 515
 None
 1.10A 3brfA-6ey5A:
undetectable		 3brfA-6ey5A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KW2_A_ADNA300_1
(PROBABLE R-RNA
METHYLTRANSFERASE)		 6ey5 T9SS COMPONENT
CYTOPLASMIC MEMBRANE
PROTEIN PORM
(Porphyromonas
gingivalis) 		5 / 11 ALA A 375
ILE A 352
LEU A 328
THR A 356
ALA A 366
 None
 1.14A 3kw2A-6ey5A:
undetectable		 3kw2A-6ey5A:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TWP_D_SALD404_1
(ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE)		 6ey5 T9SS COMPONENT
CYTOPLASMIC MEMBRANE
PROTEIN PORM
(Porphyromonas
gingivalis) 		4 / 5 ASN A 334
ALA A 366
PRO A 368
ALA A 375
 None
 1.41A 3twpD-6ey5A:
undetectable		 3twpD-6ey5A:
12.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ENH_A_FVXA602_1
(CHOLESTEROL
24-HYDROXYLASE)		 6ey5 T9SS COMPONENT
CYTOPLASMIC MEMBRANE
PROTEIN PORM
(Porphyromonas
gingivalis) 		5 / 12 LEU A 357
ILE A 336
THR A 393
ALA A 391
ALA A 350
 None
 0.77A 4enhA-6ey5A:
undetectable		 4enhA-6ey5A:
11.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O2B_B_LOCB503_2
(TUBULIN BETA-2B
CHAIN)		 6ey5 T9SS COMPONENT
CYTOPLASMIC MEMBRANE
PROTEIN PORM
(Porphyromonas
gingivalis) 		5 / 12 ALA A 330
LEU A 328
ASN A 354
ILE A 365
ILE A 336
 None
 1.05A 4o2bB-6ey5A:
undetectable		 4o2bB-6ey5A:
10.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PEV_C_ADNC501_1
(MEMBRANE LIPOPROTEIN
FAMILY PROTEIN)		 6ey5 T9SS COMPONENT
CYTOPLASMIC MEMBRANE
PROTEIN PORM
(Porphyromonas
gingivalis) 		5 / 12 VAL A 450
LEU A 455
PHE A 491
PHE A 453
GLY A 434
 None
 1.46A 4pevC-6ey5A:
undetectable		 4pevC-6ey5A:
12.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WW7_A_ACTA305_0
(EKC/KEOPS COMPLEX
SUBUNIT BUD32)		 6ey5 T9SS COMPONENT
CYTOPLASMIC MEMBRANE
PROTEIN PORM
(Porphyromonas
gingivalis) 		4 / 6 LEU A 395
GLU A 374
ASN A 353
ILE A 352
 None
 0.97A 4ww7A-6ey5A:
undetectable		 4ww7A-6ey5A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZSF_A_6T0A910_0
(TOLL-LIKE RECEPTOR 7)		 6ey5 T9SS COMPONENT
CYTOPLASMIC MEMBRANE
PROTEIN PORM
(Porphyromonas
gingivalis) 		4 / 7 THR A 244
ASP A 243
ILE A 388
THR A 387
 None
 0.99A 5zsfA-6ey5A:
undetectable
5zsfB-6ey5A:
undetectable		 5zsfA-6ey5A:
22.22
5zsfB-6ey5A:
22.22