SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6ez4'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FKF_A_FK5A108_1
(FK506 BINDING
PROTEIN)		 6ez4 RNA POLYMERASE
II-ASSOCIATED
PROTEIN 3
(Homo
sapiens) 		5 / 11 VAL A 595
ILE A 594
TYR A 578
ILE A 573
PHE A 556
 None
 1.36A 1fkfA-6ez4A:
undetectable		 1fkfA-6ez4A:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FKJ_A_FK5A108_1
(FK506 BINDING
PROTEIN)		 6ez4 RNA POLYMERASE
II-ASSOCIATED
PROTEIN 3
(Homo
sapiens) 		5 / 11 VAL A 595
ILE A 594
TYR A 578
ILE A 573
PHE A 556
 None
 1.33A 1fkjA-6ez4A:
undetectable		 1fkjA-6ez4A:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q6I_A_FK5A301_1
(FKBP-TYPE
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKPA)		 6ez4 RNA POLYMERASE
II-ASSOCIATED
PROTEIN 3
(Homo
sapiens) 		5 / 9 VAL A 595
ILE A 594
TYR A 578
ILE A 573
PHE A 556
 None
 1.46A 1q6iA-6ez4A:
undetectable		 1q6iA-6ez4A:
12.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q6I_B_FK5B401_1
(FKBP-TYPE
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKPA)		 6ez4 RNA POLYMERASE
II-ASSOCIATED
PROTEIN 3
(Homo
sapiens) 		5 / 10 VAL A 595
ILE A 594
TYR A 578
ILE A 573
PHE A 556
 None
 1.47A 1q6iB-6ez4A:
undetectable		 1q6iB-6ez4A:
12.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FKE_A_FK5A108_1
(FK506 BINDING
PROTEIN)		 6ez4 RNA POLYMERASE
II-ASSOCIATED
PROTEIN 3
(Homo
sapiens) 		5 / 11 VAL A 595
ILE A 594
TYR A 578
ILE A 573
PHE A 556
 None
 1.37A 2fkeA-6ez4A:
undetectable		 2fkeA-6ez4A:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IHZ_A_FK5A501_1
(70 KDA
PEPTIDYLPROLYL
ISOMERASE, PUTATIVE)		 6ez4 RNA POLYMERASE
II-ASSOCIATED
PROTEIN 3
(Homo
sapiens) 		5 / 10 VAL A 595
ILE A 594
TYR A 578
ILE A 573
PHE A 556
 None
 1.36A 3ihzA-6ez4A:
undetectable		 3ihzA-6ez4A:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O5R_A_FK5A1001_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP5)		 6ez4 RNA POLYMERASE
II-ASSOCIATED
PROTEIN 3
(Homo
sapiens) 		5 / 11 VAL A 595
ILE A 594
TYR A 578
ILE A 573
PHE A 556
 None
 1.39A 3o5rA-6ez4A:
undetectable		 3o5rA-6ez4A:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UF8_A_FK5A114_1
(UBIQUITIN-LIKE
PROTEIN SMT3,
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE)		 6ez4 RNA POLYMERASE
II-ASSOCIATED
PROTEIN 3
(Homo
sapiens) 		5 / 10 VAL A 595
ILE A 594
TYR A 578
ILE A 573
PHE A 556
 None
 1.44A 3uf8A-6ez4A:
undetectable		 3uf8A-6ez4A:
16.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UQA_A_FK5A114_1
(UBIQUITIN-LIKE
PROTEIN SMT3,
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE)		 6ez4 RNA POLYMERASE
II-ASSOCIATED
PROTEIN 3
(Homo
sapiens) 		5 / 10 VAL A 595
ILE A 594
TYR A 578
ILE A 573
PHE A 556
 None
 1.41A 3uqaA-6ez4A:
undetectable		 3uqaA-6ez4A:
16.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VAW_A_FK5A114_1
(UBIQUITIN-LIKE
PROTEIN
SMT3,PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE)		 6ez4 RNA POLYMERASE
II-ASSOCIATED
PROTEIN 3
(Homo
sapiens) 		5 / 11 VAL A 595
ILE A 594
TYR A 578
ILE A 573
PHE A 556
 None
 1.36A 3vawA-6ez4A:
undetectable		 3vawA-6ez4A:
16.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DZ2_A_FK5A200_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE)		 6ez4 RNA POLYMERASE
II-ASSOCIATED
PROTEIN 3
(Homo
sapiens) 		5 / 11 VAL A 595
ILE A 594
TYR A 578
ILE A 573
PHE A 556
 None
 1.41A 4dz2A-6ez4A:
undetectable
4dz2B-6ez4A:
undetectable		 4dz2A-6ez4A:
14.78
4dz2B-6ez4A:
14.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DZ2_B_FK5B200_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE)		 6ez4 RNA POLYMERASE
II-ASSOCIATED
PROTEIN 3
(Homo
sapiens) 		5 / 11 VAL A 595
ILE A 594
TYR A 578
ILE A 573
PHE A 556
 None
 1.40A 4dz2A-6ez4A:
undetectable
4dz2B-6ez4A:
undetectable		 4dz2A-6ez4A:
14.78
4dz2B-6ez4A:
14.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DZ3_A_FK5A201_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE)		 6ez4 RNA POLYMERASE
II-ASSOCIATED
PROTEIN 3
(Homo
sapiens) 		5 / 10 VAL A 595
ILE A 594
TYR A 578
ILE A 573
PHE A 556
 None
 1.40A 4dz3A-6ez4A:
undetectable		 4dz3A-6ez4A:
14.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DZ3_B_FK5B201_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE)		 6ez4 RNA POLYMERASE
II-ASSOCIATED
PROTEIN 3
(Homo
sapiens) 		5 / 10 VAL A 595
ILE A 594
TYR A 578
ILE A 573
PHE A 556
 None
 1.41A 4dz3B-6ez4A:
undetectable		 4dz3B-6ez4A:
14.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LAX_A_FK5A301_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP4)		 6ez4 RNA POLYMERASE
II-ASSOCIATED
PROTEIN 3
(Homo
sapiens) 		5 / 10 VAL A 595
ILE A 594
TYR A 578
ILE A 573
PHE A 556
 None
 1.37A 4laxA-6ez4A:
undetectable		 4laxA-6ez4A:
13.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UAN_B_REAB503_1
(RETINOIC ACID
RECEPTOR BETA)		 6ez4 RNA POLYMERASE
II-ASSOCIATED
PROTEIN 3
(Homo
sapiens) 		5 / 12 ALA A 639
LEU A 618
LEU A 615
ILE A 614
ILE A 611
 None
 0.94A 5uanB-6ez4A:
undetectable		 5uanB-6ez4A:
12.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MKE_C_FK5C201_1
(PEPTIDYLPROLYL
ISOMERASE)		 6ez4 RNA POLYMERASE
II-ASSOCIATED
PROTEIN 3
(Homo
sapiens) 		5 / 10 VAL A 595
ILE A 594
TYR A 578
ILE A 573
PHE A 556
 None
 1.43A 6mkeC-6ez4A:
undetectable		 6mkeC-6ez4A:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MKE_D_FK5D201_1
(PEPTIDYLPROLYL
ISOMERASE)		 6ez4 RNA POLYMERASE
II-ASSOCIATED
PROTEIN 3
(Homo
sapiens) 		5 / 10 VAL A 595
ILE A 594
TYR A 578
ILE A 573
PHE A 556
 None
 1.44A 6mkeD-6ez4A:
undetectable		 6mkeD-6ez4A:
23.40