SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6ez8'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AO8_A_MTXA170_1
(DIHYDROFOLATE
REDUCTASE)		 6ez8 HUNTINGTIN
(Homo
sapiens) 		5 / 12 LEU A2221
ALA A2281
LEU A2253
THR A2566
ALA A2222
 None
 1.01A 1ao8A-6ez8A:
undetectable		 1ao8A-6ez8A:
13.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C3S_A_SHHA952_1
(HDLP (HISTONE
DEACETYLASE-LIKE
PROTEIN))		 6ez8 FACTOR VIII INTRON
22 PROTEIN
HUNTINGTIN
(Homo
sapiens) 		5 / 11 PRO B 282
HIS A2909
PHE A2965
ASP B 196
LEU B 201
 None
 1.43A 1c3sA-6ez8B:
undetectable		 1c3sA-6ez8B:
11.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DTL_A_BEPA204_1
(CARDIAC TROPONIN C)		 6ez8 HUNTINGTIN
(Homo
sapiens) 		5 / 11 ILE A 106
LEU A 121
LEU A 166
LEU A 192
LEU A 189
 None
 1.01A 1dtlA-6ez8A:
undetectable		 1dtlA-6ez8A:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_G_ACTG3009_0
(BETA-CARBONIC
ANHYDRASE)		 6ez8 HUNTINGTIN
(Homo
sapiens) 		4 / 5 GLY A2916
LEU A2919
THR A2920
VAL A2550
 None
 0.67A 1ekjF-6ez8A:
undetectable
1ekjG-6ez8A:
undetectable		 1ekjF-6ez8A:
undetectable
1ekjG-6ez8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1G50_A_ESTA600_1
(ESTROGEN RECEPTOR)		 6ez8 FACTOR VIII INTRON
22 PROTEIN
HUNTINGTIN
(Homo
sapiens) 		5 / 11 LEU B  98
ALA B  94
LEU B 125
HIS A2771
LEU B  71
 None
 1.12A 1g50A-6ez8B:
undetectable		 1g50A-6ez8B:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HK3_A_T44A3002_1
(SERUM ALBUMIN)		 6ez8 HUNTINGTIN
(Homo
sapiens) 		4 / 8 GLN A1272
LEU A 985
LEU A1101
SER A1096
 None
 0.93A 1hk3A-6ez8A:
undetectable		 1hk3A-6ez8A:
6.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQT_B_ACTB1873_0
(FPRA)		 6ez8 HUNTINGTIN
(Homo
sapiens) 		3 / 3 ASP A 671
ASP A 673
LYS A 732
 None
 1.15A 1lqtB-6ez8A:
undetectable		 1lqtB-6ez8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NW3_A_ACTA600_0
(HISTONE
METHYLTRANSFERASE
DOT1L)		 6ez8 HUNTINGTIN
(Homo
sapiens) 		4 / 5 LEU A 391
VAL A 351
TYR A 354
THR A 390
 None
 1.49A 1nw3A-6ez8A:
undetectable		 1nw3A-6ez8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_I_FUAI707_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 6ez8 HUNTINGTIN
(Homo
sapiens) 		3 / 3 VAL A2314
ALA A2313
HIS A 892
 None
 0.75A 1q23G-6ez8A:
undetectable		 1q23G-6ez8A:
11.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_L_FUAL710_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 6ez8 HUNTINGTIN
(Homo
sapiens) 		3 / 3 VAL A2314
ALA A2313
HIS A 892
 None
 0.71A 1q23J-6ez8A:
undetectable		 1q23J-6ez8A:
11.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TDN_A_LEUA487_0
(L-AMINO ACID OXIDASE)		 6ez8 HUNTINGTIN
(Homo
sapiens) 		4 / 7 ARG A2011
HIS A1940
TYR A1988
ILE A1950
 None
 1.42A 1tdnA-6ez8A:
undetectable		 1tdnA-6ez8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TKQ_B_DVAB6_0
(GRAMICIDIN A)		 6ez8 HUNTINGTIN
(Homo
sapiens) 		3 / 3 ALA A1827
VAL A1829
TRP A1832
 None
 0.87A 1tkqB-6ez8A:
undetectable		 1tkqB-6ez8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XIU_B_9CRB202_1
(RXR-LIKE PROTEIN)		 6ez8 HUNTINGTIN
(Homo
sapiens) 		5 / 12 ILE A1791
ALA A1794
ALA A1795
LEU A1741
HIS A1781
 None
 1.04A 1xiuB-6ez8A:
undetectable		 1xiuB-6ez8A:
10.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA3_A_STRA1001_1
(MINERALOCORTICOID
RECEPTOR)		 6ez8 HUNTINGTIN
(Homo
sapiens) 		5 / 12 LEU A1627
ASN A1631
LEU A1633
LEU A1611
THR A1774
 None
 1.28A 1ya3A-6ez8A:
undetectable		 1ya3A-6ez8A:
11.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA3_C_STRC3001_1
(MINERALOCORTICOID
RECEPTOR)		 6ez8 HUNTINGTIN
(Homo
sapiens) 		5 / 12 LEU A1627
LEU A1630
ASN A1631
LEU A1633
THR A1774
 None
 0.97A 1ya3C-6ez8A:
undetectable		 1ya3C-6ez8A:
11.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZLQ_A_ACTA1507_0
(NICKEL-BINDING
PERIPLASMIC PROTEIN)		 6ez8 HUNTINGTIN
(Homo
sapiens) 		3 / 3 GLN A 668
HIS A 679
ARG A 682
 None
 1.09A 1zlqA-6ez8A:
undetectable		 1zlqA-6ez8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AA5_B_STRB302_1
(MINERALOCORTICOID
RECEPTOR)		 6ez8 HUNTINGTIN
(Homo
sapiens) 		5 / 12 LEU A1627
ASN A1631
LEU A1633
LEU A1611
THR A1774
 None
 1.36A 2aa5B-6ez8A:
undetectable		 2aa5B-6ez8A:
11.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AA5_B_STRB302_1
(MINERALOCORTICOID
RECEPTOR)		 6ez8 HUNTINGTIN
(Homo
sapiens) 		5 / 12 LEU A2141
LEU A2147
SER A2158
MET A2131
THR A2168
 None
 1.31A 2aa5B-6ez8A:
undetectable		 2aa5B-6ez8A:
11.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AZY_A_CHDA237_0
(PHOSPHOLIPASE A2,
MAJOR ISOENZYME)		 6ez8 HUNTINGTIN
(Homo
sapiens) 		5 / 11 ARG A1000
ILE A 909
HIS A1007
GLY A1040
LEU A1025
 None
 1.04A 2azyA-6ez8A:
undetectable		 2azyA-6ez8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXE_B_1FLB2003_1
(SERUM ALBUMIN)		 6ez8 HUNTINGTIN
(Homo
sapiens) 		5 / 10 LEU A2253
LEU A2303
LEU A2395
ILE A2391
ALA A2281
 None
 1.12A 2bxeB-6ez8A:
undetectable		 2bxeB-6ez8A:
6.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXQ_A_P1ZA2002_1
(SERUM ALBUMIN)		 6ez8 HUNTINGTIN
(Homo
sapiens) 		5 / 12 LEU A1614
LEU A1630
LEU A1581
ILE A1575
ILE A1606
 None
 1.04A 2bxqA-6ez8A:
undetectable		 2bxqA-6ez8A:
6.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DR2_A_TRPA479_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 6ez8 HUNTINGTIN
FACTOR VIII INTRON
22 PROTEIN
(Homo
sapiens;
Homo
sapiens) 		5 / 11 GLY B 163
GLU A2863
GLN B 166
CYH B 190
GLN B 191
 None
 1.47A 2dr2A-6ez8B:
undetectable		 2dr2A-6ez8B:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F8D_A_BEZA1001_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 6ez8 HUNTINGTIN
(Homo
sapiens) 		4 / 6 VAL A 746
SER A 728
ARG A 682
HIS A 679
 None
 1.03A 2f8dA-6ez8A:
undetectable		 2f8dA-6ez8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OAX_B_SNLB2001_1
(MINERALOCORTICOID
RECEPTOR)		 6ez8 HUNTINGTIN
(Homo
sapiens) 		5 / 12 LEU A1627
ASN A1631
LEU A1633
LEU A1611
THR A1774
 None
 1.33A 2oaxB-6ez8A:
undetectable		 2oaxB-6ez8A:
11.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OAX_D_SNLD4001_2
(MINERALOCORTICOID
RECEPTOR)		 6ez8 FACTOR VIII INTRON
22 PROTEIN
(Homo
sapiens) 		4 / 5 LEU B 314
LEU B 320
MET B 344
THR B 294
 None
 1.39A 2oaxD-6ez8B:
undetectable		 2oaxD-6ez8B:
15.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEK_A_DIFA1376_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 6ez8 HUNTINGTIN
(Homo
sapiens) 		4 / 8 LEU A 843
LEU A 879
LYS A 882
ALA A 883
 None
 0.80A 2wekA-6ez8A:
undetectable		 2wekA-6ez8A:
8.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y69_C_CHDC1265_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 6ez8 HUNTINGTIN
(Homo
sapiens) 		4 / 5 PHE A3094
PHE A3056
LEU A3052
PHE A3039
 None
 1.20A 2y69C-6ez8A:
undetectable
2y69J-6ez8A:
undetectable		 2y69C-6ez8A:
undetectable
2y69J-6ez8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y69_P_CHDP1265_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 6ez8 HUNTINGTIN
(Homo
sapiens) 		4 / 5 PHE A3094
PHE A3056
LEU A3052
PHE A3039
 None
 1.32A 2y69P-6ez8A:
undetectable
2y69W-6ez8A:
undetectable		 2y69P-6ez8A:
undetectable
2y69W-6ez8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A9E_B_REAB1_1
(RETINOIC ACID
RECEPTOR ALPHA)		 6ez8 HUNTINGTIN
(Homo
sapiens) 		5 / 11 PHE A1653
LEU A1676
ILE A1672
PHE A1739
VAL A1645
 None
 1.34A 3a9eB-6ez8A:
undetectable		 3a9eB-6ez8A:
13.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABM_C_CHDC271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 6ez8 HUNTINGTIN
(Homo
sapiens) 		4 / 5 PHE A3094
PHE A3056
LEU A3052
PHE A3039
 None
 1.20A 3abmC-6ez8A:
undetectable
3abmJ-6ez8A:
undetectable		 3abmC-6ez8A:
undetectable
3abmJ-6ez8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABM_P_CHDP1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 6ez8 HUNTINGTIN
(Homo
sapiens) 		4 / 5 PHE A3094
PHE A3056
LEU A3052
PHE A3039
 None
 1.27A 3abmP-6ez8A:
undetectable
3abmW-6ez8A:
undetectable		 3abmP-6ez8A:
undetectable
3abmW-6ez8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG3_C_CHDC271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 6ez8 HUNTINGTIN
(Homo
sapiens) 		4 / 5 PHE A3094
PHE A3056
LEU A3052
PHE A3039
 None
 1.28A 3ag3C-6ez8A:
undetectable
3ag3J-6ez8A:
undetectable		 3ag3C-6ez8A:
undetectable
3ag3J-6ez8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3APW_B_DP0B190_1
(ALPHA-1-ACID
GLYCOPROTEIN 2)		 6ez8 HUNTINGTIN
(Homo
sapiens) 		5 / 12 VAL A 746
ILE A 749
PHE A 380
LEU A 376
SER A 725
 None
 1.36A 3apwB-6ez8A:
undetectable		 3apwB-6ez8A:
13.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AY0_A_ADNA401_1
(UNCHARACTERIZED
PROTEIN MJ0883)		 6ez8 HUNTINGTIN
(Homo
sapiens) 		5 / 10 PHE A1496
ASN A1492
VAL A1471
LEU A1448
PHE A1467
 None
 1.40A 3ay0A-6ez8A:
undetectable		 3ay0A-6ez8A:
8.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CS8_A_BRLA503_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 6ez8 HUNTINGTIN
(Homo
sapiens) 		5 / 12 ILE A2851
LEU A2810
MET A2858
LEU A2895
LEU A2881
 None
 1.31A 3cs8A-6ez8A:
undetectable		 3cs8A-6ez8A:
11.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CYX_A_ROCA201_2
(HIV-1 PROTEASE)		 6ez8 HUNTINGTIN
(Homo
sapiens) 		3 / 3 ARG A 929
VAL A 919
THR A 862
 None
 0.79A 3cyxA-6ez8A:
undetectable		 3cyxA-6ez8A:
15.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_A_CHDA200_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 6ez8 HUNTINGTIN
(Homo
sapiens) 		4 / 5 PRO A2238
THR A2175
VAL A2176
GLY A2174
 None
 0.99A 3elzA-6ez8A:
undetectable		 3elzA-6ez8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWX_A_EPAA1_2
(PROTEIN (PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
(PPAR-DELTA)))		 6ez8 HUNTINGTIN
(Homo
sapiens) 		5 / 12 THR A2252
LEU A2303
HIS A2183
LEU A2201
TYR A2197
 None
 1.33A 3gwxA-6ez8A:
undetectable		 3gwxA-6ez8A:
10.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWX_B_EPAB3_1
(PROTEIN (PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
(PPAR-DELTA)))		 6ez8 HUNTINGTIN
(Homo
sapiens) 		5 / 12 THR A2252
LEU A2303
HIS A2183
LEU A2201
TYR A2197
 None
 1.38A 3gwxB-6ez8A:
undetectable		 3gwxB-6ez8A:
10.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP2_A_PNNA5001_0
(TRANSCRIPTIONAL
REGULATOR TCAR)		 6ez8 HUNTINGTIN
(Homo
sapiens) 		4 / 8 THR A2062
LEU A2020
SER A2023
ASN A2033
 None
 1.02A 3kp2A-6ez8A:
undetectable
3kp2B-6ez8A:
undetectable		 3kp2A-6ez8A:
undetectable
3kp2B-6ez8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LM8_B_VIBB223_1
(THIAMINE
PYROPHOSPHOKINASE)		 6ez8 HUNTINGTIN
(Homo
sapiens) 		4 / 7 TYR A1351
LEU A1350
LEU A1830
CYH A1354
 None
 0.77A 3lm8B-6ez8A:
undetectable
3lm8D-6ez8A:
undetectable		 3lm8B-6ez8A:
11.52
3lm8D-6ez8A:
11.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LM8_C_VIBC223_1
(THIAMINE
PYROPHOSPHOKINASE)		 6ez8 HUNTINGTIN
(Homo
sapiens) 		4 / 8 TYR A1351
LEU A1350
LEU A1830
CYH A1354
 None
 0.78A 3lm8A-6ez8A:
undetectable
3lm8C-6ez8A:
undetectable		 3lm8A-6ez8A:
11.52
3lm8C-6ez8A:
11.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LM8_D_VIBD223_1
(THIAMINE
PYROPHOSPHOKINASE)		 6ez8 HUNTINGTIN
(Homo
sapiens) 		4 / 8 TYR A1351
LEU A1350
LEU A1830
CYH A1354
 None
 0.76A 3lm8B-6ez8A:
undetectable
3lm8D-6ez8A:
undetectable		 3lm8B-6ez8A:
11.52
3lm8D-6ez8A:
11.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LS4_H_TCIH220_2
(HEAVY CHAIN OF
ANTIBODY FAB
FRAGMENT
LIGHT CHAIN OF
ANTIBODY FAB
FRAGMENT)		 6ez8 FACTOR VIII INTRON
22 PROTEIN
HUNTINGTIN
(Homo
sapiens) 		4 / 5 GLN A2272
ILE B 364
LEU A2269
PHE A2383
 None
 1.15A 3ls4L-6ez8A:
undetectable		 3ls4L-6ez8A:
11.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MBG_A_ACTA207_0
(FAD-LINKED
SULFHYDRYL OXIDASE
ALR)		 6ez8 FACTOR VIII INTRON
22 PROTEIN
(Homo
sapiens) 		4 / 7 GLU B 147
LEU B 125
THR B  91
ALA B  94
 None
 1.29A 3mbgA-6ez8B:
1.0
3mbgB-6ez8B:
undetectable		 3mbgA-6ez8B:
undetectable
3mbgB-6ez8B:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8Y_B_SALB900_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 6ez8 HUNTINGTIN
(Homo
sapiens) 		4 / 5 VAL A2470
LEU A2471
ILE A2502
ALA A2501
 None
 1.00A 3n8yB-6ez8A:
undetectable		 3n8yB-6ez8A:
10.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NBQ_A_URFA400_1
(URIDINE
PHOSPHORYLASE 1)		 6ez8 HUNTINGTIN
(Homo
sapiens) 		5 / 9 GLY A 122
GLU A 126
LEU A 121
LEU A 120
ILE A 106
 None
 1.45A 3nbqA-6ez8A:
undetectable		 3nbqA-6ez8A:
7.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NBQ_A_URFA400_1
(URIDINE
PHOSPHORYLASE 1)		 6ez8 HUNTINGTIN
(Homo
sapiens) 		5 / 9 GLY A1628
GLU A1582
LEU A1630
LEU A1627
ILE A1621
 None
 1.38A 3nbqA-6ez8A:
undetectable		 3nbqA-6ez8A:
7.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O02_B_JN3B1_1
(CELL INVASION
PROTEIN SIPD)		 6ez8 HUNTINGTIN
(Homo
sapiens) 		5 / 10 ILE A2446
ASN A2495
ALA A2498
LEU A2467
VAL A2470
 None
 1.21A 3o02A-6ez8A:
undetectable
3o02B-6ez8A:
undetectable		 3o02A-6ez8A:
13.53
3o02B-6ez8A:
13.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OKX_B_SAMB201_1
(YAEB-LIKE PROTEIN
RPA0152)		 6ez8 HUNTINGTIN
(Homo
sapiens) 		5 / 12 LEU A 807
ARG A 808
GLY A 769
THR A 770
LEU A 841
 None
 1.31A 3okxB-6ez8A:
undetectable		 3okxB-6ez8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU7_C_SAMC300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 6ez8 HUNTINGTIN
(Homo
sapiens) 		5 / 12 LEU A1828
TYR A 957
GLY A1773
LEU A1747
HIS A1765
 None
 1.34A 3ou7C-6ez8A:
undetectable		 3ou7C-6ez8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PGH_B_FLPB701_1
(CYCLOOXYGENASE-2)		 6ez8 HUNTINGTIN
(Homo
sapiens) 		5 / 11 LEU A1088
LEU A1070
TRP A1041
GLY A1061
ALA A1063
 None
 1.16A 3pghB-6ez8A:
undetectable		 3pghB-6ez8A:
8.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PO7_A_ZONA601_1
(AMINE OXIDASE
[FLAVIN-CONTAINING]
B)		 6ez8 HUNTINGTIN
(Homo
sapiens) 		4 / 8 TYR A1844
LEU A1837
TYR A1901
PHE A1898
 None
 1.32A 3po7A-6ez8A:
undetectable		 3po7A-6ez8A:
8.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q95_B_ESLB700_1
(ESTROGEN RECEPTOR)		 6ez8 FACTOR VIII INTRON
22 PROTEIN
HUNTINGTIN
(Homo
sapiens) 		5 / 12 LEU B  98
ALA B  94
LEU B 125
HIS A2771
LEU B  71
 None
 1.09A 3q95B-6ez8B:
undetectable		 3q95B-6ez8B:
15.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QX3_D_EVPD1_1
(DNA TOPOISOMERASE
2-BETA)		 6ez8 HUNTINGTIN
(Homo
sapiens) 		4 / 5 GLY A2964
ARG A2962
GLN A3006
MET A3076
 None
 1.20A 3qx3B-6ez8A:
undetectable		 3qx3B-6ez8A:
5.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3S_C_9PLC1_1
(CYTOCHROME P450 2A13)		 6ez8 FACTOR VIII INTRON
22 PROTEIN
HUNTINGTIN
(Homo
sapiens) 		4 / 7 PHE A2965
ALA B 202
THR B 205
LEU B 288
 None
 1.07A 3t3sC-6ez8A:
undetectable		 3t3sC-6ez8A:
8.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3Z_A_9PLA501_1
(CYTOCHROME P450 2E1)		 6ez8 HUNTINGTIN
(Homo
sapiens) 		4 / 6 PHE A1634
LEU A1614
ALA A1607
LEU A1648
 None
 0.99A 3t3zA-6ez8A:
undetectable		 3t3zA-6ez8A:
9.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TBG_A_RTZA1_1
(CYTOCHROME P450 2D6)		 6ez8 HUNTINGTIN
(Homo
sapiens) 		5 / 12 LEU A1429
LEU A1445
GLY A1469
LEU A1472
PHE A1475
 None
 1.30A 3tbgA-6ez8A:
undetectable		 3tbgA-6ez8A:
8.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VW1_D_CVID301_1
(PUTATIVE REGULATORY
PROTEIN)		 6ez8 HUNTINGTIN
(Homo
sapiens) 		3 / 3 TYR A2447
MET A2358
LEU A2322
 None
 0.88A 3vw1D-6ez8A:
undetectable		 3vw1D-6ez8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W68_A_VIVA301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 6ez8 HUNTINGTIN
(Homo
sapiens) 		5 / 12 PHE A 873
ILE A 846
VAL A 849
LEU A 850
VAL A 907
 None
 1.08A 3w68A-6ez8A:
undetectable		 3w68A-6ez8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W68_B_VIVB301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 6ez8 FACTOR VIII INTRON
22 PROTEIN
(Homo
sapiens) 		5 / 12 SER B 324
VAL B 274
LEU B 318
PHE B 319
VAL B 271
 None
 1.07A 3w68B-6ez8B:
undetectable		 3w68B-6ez8B:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AZT_A_SAMA1472_1
(METHYLTRANSFERASE
WBDD)		 6ez8 HUNTINGTIN
(Homo
sapiens) 		3 / 3 GLN A2555
ASP A2574
GLN A2525
 None
 0.91A 4aztA-6ez8A:
undetectable		 4aztA-6ez8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F4D_A_CHDA505_0
(FERROCHELATASE,
MITOCHONDRIAL)		 6ez8 HUNTINGTIN
(Homo
sapiens) 		4 / 7 ILE A1751
ARG A 780
VAL A1662
MET A1659
 None
 1.32A 4f4dA-6ez8A:
undetectable		 4f4dA-6ez8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F4D_B_CHDB503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 6ez8 HUNTINGTIN
(Homo
sapiens) 		4 / 8 ILE A1751
ARG A 780
VAL A1662
MET A1659
 None
 1.32A 4f4dB-6ez8A:
undetectable		 4f4dB-6ez8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FN9_A_STRA301_1
(STEROID RECEPTOR 2)		 6ez8 FACTOR VIII INTRON
22 PROTEIN
(Homo
sapiens) 		6 / 12 LEU B 181
LEU B 184
ALA B 188
GLN B 191
ALA B 202
CYH B 269
 None
 1.32A 4fn9A-6ez8B:
undetectable		 4fn9A-6ez8B:
18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KHP_A_PARA1606_1
(16S RIBOSOMAL RNA
30S RIBOSOMAL
PROTEIN S9
30S RIBOSOMAL
PROTEIN S10)		 6ez8 HUNTINGTIN
(Homo
sapiens) 		3 / 3 TYR A2784
ARG A2528
SER A2614
 None
 0.90A 4khpI-6ez8A:
undetectable
4khpJ-6ez8A:
undetectable		 4khpI-6ez8A:
16.39
4khpJ-6ez8A:
12.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N09_B_ADNB401_2
(ADENOSINE KINASE)		 6ez8 HUNTINGTIN
(Homo
sapiens) 		4 / 5 LEU A1267
SER A1271
LEU A1141
LEU A1293
 None
 1.23A 4n09B-6ez8A:
undetectable		 4n09B-6ez8A:
8.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N09_D_ADND401_2
(ADENOSINE KINASE)		 6ez8 HUNTINGTIN
(Homo
sapiens) 		4 / 5 LEU A1267
SER A1271
LEU A1141
LEU A1293
 None
 1.24A 4n09D-6ez8A:
undetectable		 4n09D-6ez8A:
8.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKV_C_AERC601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 6ez8 HUNTINGTIN
(Homo
sapiens) 		4 / 6 TYR A2675
LEU A2720
VAL A2748
ALA A2747
 None
 0.80A 4nkvC-6ez8A:
undetectable		 4nkvC-6ez8A:
7.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_A_STRA601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 6ez8 HUNTINGTIN
(Homo
sapiens) 		5 / 12 LEU A1633
PHE A1634
ILE A1575
ALA A1607
ILE A1675
 None
 0.88A 4nkxA-6ez8A:
undetectable		 4nkxA-6ez8A:
7.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PBH_A_BEZA401_0
(TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT, PUTATIVE)		 6ez8 HUNTINGTIN
(Homo
sapiens) 		5 / 12 ILE A2679
ALA A2690
LEU A2723
ASP A2731
LEU A2734
 None
 1.47A 4pbhA-6ez8A:
undetectable		 4pbhA-6ez8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QYN_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 2)		 6ez8 HUNTINGTIN
(Homo
sapiens) 		5 / 12 ALA A2913
THR A2924
THR A2920
LEU A2595
LEU A2895
 None
 1.28A 4qynA-6ez8A:
undetectable		 4qynA-6ez8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_F_377F402_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 6ez8 FACTOR VIII INTRON
22 PROTEIN
(Homo
sapiens) 		4 / 8 ALA B  93
ALA B  89
ALA B 127
ALA B 124
 None
 0.72A 4twdF-6ez8B:
undetectable
4twdG-6ez8B:
undetectable
4twdH-6ez8B:
undetectable
4twdI-6ez8B:
undetectable
4twdJ-6ez8B:
undetectable		 4twdF-6ez8B:
12.84
4twdG-6ez8B:
12.84
4twdH-6ez8B:
12.84
4twdI-6ez8B:
12.84
4twdJ-6ez8B:
12.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_F_377F402_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 6ez8 FACTOR VIII INTRON
22 PROTEIN
(Homo
sapiens) 		4 / 8 ALA B 127
ALA B 124
ALA B  93
ALA B  89
 None
 0.77A 4twdF-6ez8B:
undetectable
4twdG-6ez8B:
undetectable
4twdH-6ez8B:
undetectable
4twdI-6ez8B:
undetectable
4twdJ-6ez8B:
undetectable		 4twdF-6ez8B:
12.84
4twdG-6ez8B:
12.84
4twdH-6ez8B:
12.84
4twdI-6ez8B:
12.84
4twdJ-6ez8B:
12.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_F_377F402_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 6ez8 FACTOR VIII INTRON
22 PROTEIN
(Homo
sapiens) 		5 / 8 ALA B 128
ALA B 124
ALA B  93
ALA B  89
ALA B  87
 None
 1.32A 4twdF-6ez8B:
undetectable
4twdG-6ez8B:
undetectable
4twdH-6ez8B:
undetectable
4twdI-6ez8B:
undetectable
4twdJ-6ez8B:
undetectable		 4twdF-6ez8B:
12.84
4twdG-6ez8B:
12.84
4twdH-6ez8B:
12.84
4twdI-6ez8B:
12.84
4twdJ-6ez8B:
12.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DB5_A_CYSA503_0
(CYSTEINE DESULFURASE)		 6ez8 HUNTINGTIN
FACTOR VIII INTRON
22 PROTEIN
(Homo
sapiens;
Homo
sapiens) 		4 / 8 HIS A2906
ARG A2960
HIS A2909
THR B 198
 None
 1.23A 5db5A-6ez8A:
undetectable
5db5B-6ez8A:
undetectable		 5db5A-6ez8A:
undetectable
5db5B-6ez8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GSN_A_MMZA503_1
(FLAVIN-CONTAINING
MONOOXYGENASE)		 6ez8 HUNTINGTIN
(Homo
sapiens) 		3 / 3 ASN A1886
SER A 835
SER A 836
 None
 0.79A 5gsnA-6ez8A:
undetectable		 5gsnA-6ez8A:
8.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HS6_A_J3ZA302_1
(17-BETA-HYDROXYSTERO
ID DEHYDROGENASE 14)		 6ez8 HUNTINGTIN
(Homo
sapiens) 		4 / 8 LEU A 958
LEU A1828
MET A1821
THR A1824
 None
 1.14A 5hs6A-6ez8A:
undetectable		 5hs6A-6ez8A:
12.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGI_A_ZITA402_2
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		 6ez8 HUNTINGTIN
(Homo
sapiens) 		4 / 6 HIS A2308
GLU A2357
ALA A2396
LEU A2452
 None
 1.05A 5igiA-6ez8A:
undetectable		 5igiA-6ez8A:
10.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JS5_A_ASCA202_0
(CYTOCHROME C')		 6ez8 HUNTINGTIN
(Homo
sapiens) 		3 / 3 CYH A1591
LYS A1593
HIS A1592
 None
 0.97A 5js5A-6ez8A:
undetectable		 5js5A-6ez8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_A_RCXA601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 6ez8 HUNTINGTIN
(Homo
sapiens) 		5 / 12 VAL A2782
ALA A2745
GLY A2777
ALA A2778
LEU A2767
 None
 1.09A 5kirA-6ez8A:
undetectable		 5kirA-6ez8A:
7.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_B_RCXB601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 6ez8 HUNTINGTIN
(Homo
sapiens) 		5 / 12 VAL A2782
ALA A2745
GLY A2777
ALA A2778
LEU A2767
 None
 1.06A 5kirB-6ez8A:
undetectable		 5kirB-6ez8A:
7.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LJB_A_RTLA201_1
(RETINOL-BINDING
PROTEIN 1)		 6ez8 HUNTINGTIN
(Homo
sapiens) 		4 / 8 LEU A1293
LEU A1142
ILE A1087
GLN A1083
 None
 0.98A 5ljbA-6ez8A:
undetectable		 5ljbA-6ez8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0S_A_SAMA501_1
(PEPTIDE
N-METHYLTRANSFERASE)		 6ez8 HUNTINGTIN
(Homo
sapiens) 		4 / 4 SER A 346
ALA A 347
GLN A 389
THR A 390
 None
 1.42A 5n0sA-6ez8A:
undetectable		 5n0sA-6ez8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0W_A_SAMA501_1
(PEPTIDE
N-METHYLTRANSFERASE)		 6ez8 HUNTINGTIN
(Homo
sapiens) 		4 / 4 SER A 346
ALA A 347
GLN A 389
THR A 390
 None
 1.44A 5n0wA-6ez8A:
undetectable		 5n0wA-6ez8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NWW_A_ACAA18_1
(SCRFP-TAG,GP41)		 6ez8 HUNTINGTIN
(Homo
sapiens) 		5 / 12 GLN A2669
LEU A2671
LEU A2672
GLU A2673
LEU A2674
 None
 0.91A 5nwwA-6ez8A:
undetectable		 5nwwA-6ez8A:
9.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OS7_A_ACTA402_0
(CASEIN KINASE II
SUBUNIT ALPHA)		 6ez8 HUNTINGTIN
(Homo
sapiens) 		3 / 3 HIS A1928
SER A1925
LYS A1968
 None
 1.48A 5os7A-6ez8A:
undetectable		 5os7A-6ez8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TE8_B_08JB602_1
(CYTOCHROME P450 3A4)		 6ez8 FACTOR VIII INTRON
22 PROTEIN
(Homo
sapiens) 		5 / 8 SER B 324
LEU B 340
ALA B 336
ILE B 364
LEU B 360
 None
 1.48A 5te8B-6ez8B:
undetectable		 5te8B-6ez8B:
10.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TOA_A_ESTA601_1
(ESTROGEN RECEPTOR
BETA)		 6ez8 HUNTINGTIN
(Homo
sapiens) 		6 / 12 LEU A1776
LEU A1747
LEU A1748
ILE A1835
LEU A1814
LEU A1740
 None
 1.47A 5toaA-6ez8A:
undetectable		 5toaA-6ez8A:
7.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5U4S_B_BEZB301_0
(PUTATIVE SHORT CHAIN
DEHYDROGENASE)		 6ez8 HUNTINGTIN
FACTOR VIII INTRON
22 PROTEIN
(Homo
sapiens;
Homo
sapiens) 		4 / 8 SER B 324
LEU B 321
LEU B 320
PRO A1996
 None
 0.79A 5u4sB-6ez8B:
undetectable		 5u4sB-6ez8B:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WAU_C_CHDC306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 6ez8 HUNTINGTIN
(Homo
sapiens) 		4 / 5 PHE A3094
PHE A3056
LEU A3052
PHE A3039
 None
 1.22A 5wauC-6ez8A:
undetectable
5wauJ-6ez8A:
undetectable		 5wauC-6ez8A:
undetectable
5wauJ-6ez8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WAU_C_CHDC308_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 6ez8 HUNTINGTIN
(Homo
sapiens) 		4 / 5 PHE A3094
PHE A3056
LEU A3052
PHE A3039
 None
 1.23A 5wauc-6ez8A:
undetectable
5wauj-6ez8A:
undetectable		 5wauc-6ez8A:
undetectable
5wauj-6ez8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDQ_C_CHDC308_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 6ez8 HUNTINGTIN
(Homo
sapiens) 		4 / 5 PHE A3094
PHE A3056
LEU A3052
PHE A3039
 None
 1.28A 5xdqC-6ez8A:
undetectable
5xdqJ-6ez8A:
undetectable		 5xdqC-6ez8A:
undetectable
5xdqJ-6ez8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDQ_P_CHDP306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 6ez8 HUNTINGTIN
(Homo
sapiens) 		4 / 5 PHE A3094
PHE A3056
LEU A3052
PHE A3039
 None
 1.28A 5xdqP-6ez8A:
undetectable
5xdqW-6ez8A:
undetectable		 5xdqP-6ez8A:
undetectable
5xdqW-6ez8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y2T_B_8LXB501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 6ez8 HUNTINGTIN
(Homo
sapiens) 		4 / 8 HIS A 722
PHE A 727
SER A 779
LEU A 800
 None
 1.07A 5y2tB-6ez8A:
undetectable		 5y2tB-6ez8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YOD_F_BEZF201_0
(NS3 PROTEASE)		 6ez8 HUNTINGTIN
FACTOR VIII INTRON
22 PROTEIN
(Homo
sapiens;
Homo
sapiens) 		4 / 5 HIS B  82
ALA A1073
SER A1231
TYR A1232
 None
 1.43A 5yodF-6ez8B:
undetectable		 5yodF-6ez8B:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A5Z_L_9CRL501_0
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 6ez8 HUNTINGTIN
(Homo
sapiens) 		5 / 12 ILE A1791
ALA A1794
PHE A1736
ILE A1680
HIS A1781
 None
 0.96A 6a5zL-6ez8A:
undetectable		 6a5zL-6ez8A:
15.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A60_D_9CRD501_0
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 6ez8 HUNTINGTIN
(Homo
sapiens) 		5 / 12 ILE A1791
ALA A1794
ALA A1795
LEU A1741
HIS A1781
 None
 1.04A 6a60D-6ez8A:
undetectable		 6a60D-6ez8A:
15.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A60_D_9CRD501_0
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 6ez8 HUNTINGTIN
(Homo
sapiens) 		5 / 12 ILE A1791
ALA A1794
PHE A1736
ILE A1680
HIS A1781
 None
 0.99A 6a60D-6ez8A:
undetectable		 6a60D-6ez8A:
15.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AYC_A_1YNA502_1
(PROTEIN CYP51)		 6ez8 HUNTINGTIN
(Homo
sapiens) 		5 / 12 PHE A1799
ALA A1795
TYR A1351
ALA A1357
THR A1363
 None
 1.30A 6aycA-6ez8A:
undetectable		 6aycA-6ez8A:
15.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B54_A_OAQA302_0
(SULFOTRANSFERASE)		 6ez8 HUNTINGTIN
(Homo
sapiens) 		5 / 12 MET A 155
ILE A 151
LEU A 192
LEU A 147
LEU A 129
 None
 1.25A 6b54A-6ez8A:
undetectable		 6b54A-6ez8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BRD_A_RFPA502_1
(RIFAMPIN
MONOOXYGENASE)		 6ez8 HUNTINGTIN
(Homo
sapiens) 		5 / 12 VAL A 318
LEU A 684
PHE A 688
THR A 370
GLY A 371
 None
 1.37A 6brdA-6ez8A:
undetectable		 6brdA-6ez8A:
8.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_A_EY4A502_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 6ez8 HUNTINGTIN
(Homo
sapiens) 		4 / 7 ALA A2251
THR A2252
GLN A2177
VAL A2176
 None
 0.91A 6cduA-6ez8A:
undetectable
6cduE-6ez8A:
undetectable		 6cduA-6ez8A:
undetectable
6cduE-6ez8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_B_EY4B500_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 6ez8 HUNTINGTIN
(Homo
sapiens) 		4 / 6 GLN A2177
VAL A2176
ALA A2251
THR A2252
 None
 0.81A 6cduB-6ez8A:
undetectable
6cduC-6ez8A:
undetectable		 6cduB-6ez8A:
undetectable
6cduC-6ez8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_D_EY4D500_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 6ez8 HUNTINGTIN
(Homo
sapiens) 		4 / 7 GLN A2177
VAL A2176
ALA A2251
THR A2252
 None
 0.80A 6cduC-6ez8A:
undetectable
6cduD-6ez8A:
undetectable		 6cduC-6ez8A:
undetectable
6cduD-6ez8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_H_EY4H500_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 6ez8 HUNTINGTIN
(Homo
sapiens) 		4 / 7 GLN A2177
VAL A2176
ALA A2251
THR A2252
 None
 0.86A 6cduH-6ez8A:
undetectable
6cduI-6ez8A:
undetectable		 6cduH-6ez8A:
undetectable
6cduI-6ez8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6I_A_8PRA509_1
(ENVELOPE
GLYCOPROTEIN,GP,GP1
ENVELOPE
GLYCOPROTEIN)		 6ez8 HUNTINGTIN
(Homo
sapiens) 		5 / 12 VAL A1425
LEU A1460
ALA A1428
LEU A1448
LEU A1451
 None
 0.78A 6f6iA-6ez8A:
undetectable
6f6iB-6ez8A:
undetectable		 6f6iA-6ez8A:
11.25
6f6iB-6ez8A:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGC_A_D95A816_0
(GEPHYRIN)		 6ez8 HUNTINGTIN
(Homo
sapiens) 		5 / 11 PHE A1584
ILE A1585
LEU A1588
LEU A1571
ILE A1609
 None
 1.48A 6fgcA-6ez8A:
undetectable		 6fgcA-6ez8A:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FTP_B_DM2B501_1
(ALPHA-1-ANTICHYMOTRY
PSIN)		 6ez8 FACTOR VIII INTRON
22 PROTEIN
(Homo
sapiens) 		5 / 9 GLN B 323
LEU B 314
PHE B 319
GLU B 316
LEU B 320
 None
 1.41A 6ftpA-6ez8B:
undetectable
6ftpB-6ez8B:
undetectable		 6ftpA-6ez8B:
19.05
6ftpB-6ez8B:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GMD_B_ACTB402_0
(CASEIN KINASE II
SUBUNIT ALPHA)		 6ez8 HUNTINGTIN
(Homo
sapiens) 		3 / 3 HIS A1928
SER A1925
LYS A1968
 None
 1.48A 6gmdB-6ez8A:
undetectable		 6gmdB-6ez8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD4_B_STIB602_1
(TYROSINE-PROTEIN
KINASE ABL1)		 6ez8 HUNTINGTIN
(Homo
sapiens) 		4 / 6 LEU A2878
VAL A2776
MET A2854
GLY A2856
 None
 0.89A 6hd4B-6ez8A:
undetectable		 6hd4B-6ez8A:
12.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN5_D_LLLD301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 6ez8 HUNTINGTIN
FACTOR VIII INTRON
22 PROTEIN
(Homo
sapiens;
Homo
sapiens) 		4 / 6 ARG A1998
GLU B 331
ASP B 333
GLU B 335
 None
 1.43A 6mn5D-6ez8A:
undetectable		 6mn5D-6ez8A:
15.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6QXS_B_FOZB403_0
(THYMIDYLATE SYNTHASE)		 6ez8 HUNTINGTIN
(Homo
sapiens) 		5 / 12 LEU A1270
ILE A1289
LEU A1223
GLY A1224
ASN A1146
 None
 1.10A 6qxsB-6ez8A:
undetectable		 6qxsB-6ez8A:
undetectable