SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6ezm'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FBY_A_9CRA500_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 6ezm IMIDAZOLEGLYCEROL-PH
OSPHATE DEHYDRATASE
(Saccharomyces
cerevisiae) 		5 / 12 ALA U 131
PHE U 193
LEU U 196
ALA U 195
HIS U 162
 None
None
None
None
MN  U 301 (-3.2A)
 1.08A 1fbyA-6ezmU:
undetectable		 1fbyA-6ezmU:
16.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FBY_B_9CRB1500_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 6ezm IMIDAZOLEGLYCEROL-PH
OSPHATE DEHYDRATASE
(Saccharomyces
cerevisiae) 		5 / 12 ALA U 131
PHE U 193
LEU U 196
ALA U 195
HIS U 162
 None
None
None
None
MN  U 301 (-3.2A)
 1.06A 1fbyB-6ezmU:
undetectable		 1fbyB-6ezmU:
16.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OE2_A_CUA502_0
(DISSIMILATORY
COPPER-CONTAINING
NITRITE REDUCTASE)		 6ezm IMIDAZOLEGLYCEROL-PH
OSPHATE DEHYDRATASE
(Saccharomyces
cerevisiae) 		3 / 3 GLU U  94
HIS U  90
HIS U 162
 MN  U 301 ( 2.4A)
MN  U 301 ( 3.2A)
MN  U 301 (-3.2A)
 0.55A 1oe2A-6ezmU:
undetectable		 1oe2A-6ezmU:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OE2_A_CUA502_0
(DISSIMILATORY
COPPER-CONTAINING
NITRITE REDUCTASE)		 6ezm IMIDAZOLEGLYCEROL-PH
OSPHATE DEHYDRATASE
(Saccharomyces
cerevisiae) 		3 / 3 GLU U 190
HIS U 186
HIS U  64
 MN  U 302 ( 2.4A)
MN  U 302 ( 3.5A)
MN  U 302 ( 3.4A)
 0.35A 1oe2A-6ezmU:
undetectable		 1oe2A-6ezmU:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UKB_A_BEZA1300_0
(2-HYDROXY-6-OXO-7-ME
THYLOCTA-2,4-DIENOAT
E HYDROLASE)		 6ezm IMIDAZOLEGLYCEROL-PH
OSPHATE DEHYDRATASE
(Saccharomyces
cerevisiae) 		5 / 11 GLY U 101
ALA U 103
PHE U 104
LEU U  23
VAL U  79
 None
 0.88A 1ukbA-6ezmU:
undetectable		 1ukbA-6ezmU:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OTH_A_NIMA300_1
(PHOSPHOLIPASE A2
VRV-PL-VIIIA)		 6ezm IMIDAZOLEGLYCEROL-PH
OSPHATE DEHYDRATASE
(Saccharomyces
cerevisiae) 		4 / 5 LEU U 100
ALA U 170
ILE U  98
SER U 166
 None
 1.09A 2othA-6ezmU:
undetectable		 2othA-6ezmU:
17.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_C_KLNC1498_1
(CYTOCHROME P450 3A4)		 6ezm IMIDAZOLEGLYCEROL-PH
OSPHATE DEHYDRATASE
(Saccharomyces
cerevisiae) 		5 / 12 PHE U  61
SER U  73
LEU U 175
LEU U 164
ILE U 200
 None
 1.23A 2v0mC-6ezmU:
undetectable		 2v0mC-6ezmU:
11.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_D_TOPD200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 6ezm IMIDAZOLEGLYCEROL-PH
OSPHATE DEHYDRATASE
(Saccharomyces
cerevisiae) 		5 / 9 ALA U 103
LEU U  23
ILE U 200
LEU U 196
PHE U 167
 None
 1.47A 3fl9D-6ezmU:
undetectable		 3fl9D-6ezmU:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_A_LYAA514_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		 6ezm IMIDAZOLEGLYCEROL-PH
OSPHATE DEHYDRATASE
(Saccharomyces
cerevisiae) 		5 / 12 ALA U 170
ILE U 200
SER U  73
LEU U 196
LEU U 175
 None
 1.13A 3k2hA-6ezmU:
undetectable		 3k2hA-6ezmU:
10.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UM5_A_CP6A609_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 6ezm IMIDAZOLEGLYCEROL-PH
OSPHATE DEHYDRATASE
(Saccharomyces
cerevisiae) 		5 / 10 ILE U  19
VAL U  55
SER U  73
ILE U 200
ILE U  21
 None
 1.14A 3um5A-6ezmU:
undetectable		 3um5A-6ezmU:
7.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UM5_B_CP6B709_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 6ezm IMIDAZOLEGLYCEROL-PH
OSPHATE DEHYDRATASE
(Saccharomyces
cerevisiae) 		5 / 10 ILE U  19
VAL U  55
SER U  73
ILE U 200
ILE U  21
 None
 1.17A 3um5B-6ezmU:
undetectable		 3um5B-6ezmU:
7.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ECK_A_FOLA703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 6ezm IMIDAZOLEGLYCEROL-PH
OSPHATE DEHYDRATASE
(Saccharomyces
cerevisiae) 		5 / 12 ALA U 103
LEU U  77
PHE U 167
PHE U 193
VAL U 177
 None
 1.25A 4eckA-6ezmU:
undetectable		 4eckA-6ezmU:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I1N_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 6ezm IMIDAZOLEGLYCEROL-PH
OSPHATE DEHYDRATASE
(Saccharomyces
cerevisiae) 		5 / 11 ILE U 173
ALA U 170
LEU U 100
PHE U 104
LEU U  23
 None
 1.39A 4i1nA-6ezmU:
undetectable		 4i1nA-6ezmU:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IQQ_B_D16B402_1
(THYMIDYLATE SYNTHASE)		 6ezm IMIDAZOLEGLYCEROL-PH
OSPHATE DEHYDRATASE
(Saccharomyces
cerevisiae) 		4 / 7 ILE U 200
LEU U 100
GLY U 101
PHE U 104
 None
 0.78A 4iqqB-6ezmU:
undetectable		 4iqqB-6ezmU:
16.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IQQ_C_D16C402_1
(THYMIDYLATE SYNTHASE)		 6ezm IMIDAZOLEGLYCEROL-PH
OSPHATE DEHYDRATASE
(Saccharomyces
cerevisiae) 		4 / 7 ILE U 200
LEU U 100
GLY U 101
PHE U 104
 None
 0.71A 4iqqC-6ezmU:
undetectable		 4iqqC-6ezmU:
16.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R3A_A_RBFA402_1
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 6ezm IMIDAZOLEGLYCEROL-PH
OSPHATE DEHYDRATASE
(Saccharomyces
cerevisiae) 		5 / 12 GLN U  51
ALA U 197
ILE U 200
ILE U  53
LEU U  77
 None
 1.19A 4r3aA-6ezmU:
undetectable		 4r3aA-6ezmU:
14.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WOZ_F_MN9F401_0
(N-ACETYLNEURAMINATE
LYASE)		 6ezm IMIDAZOLEGLYCEROL-PH
OSPHATE DEHYDRATASE
(Saccharomyces
cerevisiae) 		4 / 5 LEU U  62
ASP U  63
LEU U 155
THR U  92
 None
 1.27A 4wozF-6ezmU:
undetectable
4wozH-6ezmU:
undetectable		 4wozF-6ezmU:
undetectable
4wozH-6ezmU:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D75_A_FK5A301_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP3)		 6ezm IMIDAZOLEGLYCEROL-PH
OSPHATE DEHYDRATASE
(Saccharomyces
cerevisiae) 		5 / 11 LEU U 196
ILE U  66
ALA U 103
ILE U  19
PHE U 163
 None
 1.22A 5d75A-6ezmU:
undetectable		 5d75A-6ezmU:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GPG_A_RAPA301_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP3)		 6ezm IMIDAZOLEGLYCEROL-PH
OSPHATE DEHYDRATASE
(Saccharomyces
cerevisiae) 		5 / 11 LEU U 196
ILE U  66
ALA U 103
ILE U  19
PHE U 163
 None
 1.18A 5gpgA-6ezmU:
undetectable		 5gpgA-6ezmU:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEN_B_VDYB201_1
(CDL2.2)		 6ezm IMIDAZOLEGLYCEROL-PH
OSPHATE DEHYDRATASE
(Saccharomyces
cerevisiae) 		5 / 10 LEU U  69
VAL U 177
ILE U 173
LEU U 175
LEU U  23
 None
 1.18A 5ienB-6ezmU:
undetectable		 5ienB-6ezmU:
18.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NOO_B_D16B402_1
(THYMIDYLATE SYNTHASE)		 6ezm IMIDAZOLEGLYCEROL-PH
OSPHATE DEHYDRATASE
(Saccharomyces
cerevisiae) 		4 / 7 ILE U 200
LEU U 100
GLY U 101
PHE U 104
 None
 0.84A 5nooB-6ezmU:
undetectable		 5nooB-6ezmU:
16.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6QYA_B_FOZB401_0
(THYMIDYLATE SYNTHASE)		 6ezm IMIDAZOLEGLYCEROL-PH
OSPHATE DEHYDRATASE
(Saccharomyces
cerevisiae) 		5 / 12 LEU U 155
HIS U 162
LEU U 100
GLY U  97
ILE U  66
 None
MN  U 301 (-3.2A)
None
None
None
 1.31A 6qyaB-6ezmU:
undetectable		 6qyaB-6ezmU:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6QYA_D_FOZD401_0
(THYMIDYLATE SYNTHASE)		 6ezm IMIDAZOLEGLYCEROL-PH
OSPHATE DEHYDRATASE
(Saccharomyces
cerevisiae) 		5 / 12 LEU U 155
HIS U 162
LEU U 100
GLY U  97
ILE U  66
 None
MN  U 301 (-3.2A)
None
None
None
 1.31A 6qyaD-6ezmU:
undetectable		 6qyaD-6ezmU:
undetectable