SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6ezy'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

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	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1U18_A_HSMA401_1 (NITROPHORIN 1)	6ezy	- (-)	4 / 4	ASP A 165 LEU A 99 LEU A 163 LEU A 156	ASP A 165 ( 0.5A) LEU A 99 ( 0.5A) LEU A 163 ( 0.6A) LEU A 156 ( 0.6A)	1.36A	1u18A-6ezyA: undetectable	1u18A-6ezyA: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3CLD_B_GW6B2_2 (GLUCOCORTICOID RECEPTOR)	6ezy	- (-)	4 / 8	LEU A 110 ALA A 140 LEU A 143 MET A 184	LEU A 110 ( 0.6A) ALA A 140 ( 0.0A) LEU A 143 ( 0.5A) MET A 184 ( 0.0A)	0.82A	3cldB-6ezyA: undetectable	3cldB-6ezyA: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3OU7_A_SAMA300_0 (SAM-DEPENDENT METHYLTRANSFERASE)	6ezy	- (-)	5 / 12	TYR A 77 GLY A 24 GLY A 81 ASP A 83 LEU A 84	TYR A 77 ( 1.3A) GLY A 24 ( 0.0A) GLY A 81 ( 0.0A) ASP A 83 ( 0.6A) LEU A 84 ( 0.5A)	1.13A	3ou7A-6ezyA: undetectable	3ou7A-6ezyA: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3VLN_A_ASCA904_0 (GLUTATHIONE S-TRANSFERASE OMEGA-1)	6ezy	- (-)	4 / 6	ARG A 15 PRO A 54 GLU A 65 SER A 66	ARG A 15 ( 0.6A) PRO A 54 ( 1.1A) GLU A 65 ( 0.6A) SER A 66 ( 0.0A)	0.95A	3vlnA-6ezyA: 20.5	3vlnA-6ezyA: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4KLR_A_CHDA505_0 (FERROCHELATASE, MITOCHONDRIAL)	6ezy	- (-)	4 / 5	LEU A 110 PRO A 109 LEU A 113 ILE A 179	LEU A 110 ( 0.6A) PRO A 109 ( 1.1A) LEU A 113 ( 0.6A) ILE A 179 ( 0.7A)	0.84A	4klrA-6ezyA: undetectable	4klrA-6ezyA: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4XIW_G_AZMG402_1 (CARBONIC ANHYDRASE, ALPHA TYPE)	6ezy	- (-)	5 / 12	VAL A 56 LEU A 3 VAL A 5 LEU A 20 THR A 19	VAL A 56 ( 0.6A) LEU A 3 ( 0.6A) VAL A 5 ( 0.6A) LEU A 20 ( 0.6A) THR A 19 ( 0.8A)	0.90A	4xiwG-6ezyA: undetectable	4xiwG-6ezyA: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5L6E_B_ACTB401_0 (N6-ADENOSINE-METHYLT RANSFERASE 70 KDA SUBUNIT N6-ADENOSINE-METHYLT RANSFERASE SUBUNIT METTL14)	6ezy	- (-)	4 / 6	GLU A 96 ARG A 92 LEU A 163 ARG A 67	GLU A 96 ( 0.6A) ARG A 92 ( 0.6A) LEU A 163 ( 0.6A) ARG A 67 ( 0.6A)	0.87A	5l6eA-6ezyA: undetectable 5l6eB-6ezyA: undetectable	5l6eA-6ezyA: undetectable 5l6eB-6ezyA: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5QGG_A_ACTA301_0 (PEROXISOMAL COENZYME A DIPHOSPHATASE NUDT7)	6ezy	- (-)	4 / 4	VAL A 57 VAL A 56 TYR A 6 GLN A 48	VAL A 57 ( 0.6A) VAL A 56 ( 0.6A) TYR A 6 ( 1.3A) GLN A 48 ( 0.6A)	1.11A	5qggA-6ezyA: undetectable	5qggA-6ezyA: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5QGO_A_ACTA302_0 (PEROXISOMAL COENZYME A DIPHOSPHATASE NUDT7)	6ezy	- (-)	4 / 4	VAL A 57 VAL A 56 TYR A 6 GLN A 48	VAL A 57 ( 0.6A) VAL A 56 ( 0.6A) TYR A 6 ( 1.3A) GLN A 48 ( 0.6A)	1.14A	5qgoA-6ezyA: undetectable	5qgoA-6ezyA: undetectable

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1U18_A_HSMA401_1","NITROPHORIN 1","6ezy","-","-",4,"ASP A 165;LEU A  99;LEU A 163;LEU A 156","ASP A 165 ( 0.5A);LEU A  99 ( 0.5A);LEU A 163 ( 0.6A);LEU A 156 ( 0.6A)","1.36A","1u18A-6ezyA:undetectable","1u18A-6ezyA:undetectable"],["3CLD_B_GW6B2_2","GLUCOCORTICOID RECEPTOR","6ezy","-","-",4,"LEU A 110;ALA A 140;LEU A 143;MET A 184","LEU A 110 ( 0.6A);ALA A 140 ( 0.0A);LEU A 143 ( 0.5A);MET A 184 ( 0.0A)","0.82A","3cldB-6ezyA:undetectable","3cldB-6ezyA:undetectable"],["3OU7_A_SAMA300_0","SAM-DEPENDENT METHYLTRANSFERASE","6ezy","-","-",5,"TYR A  77;GLY A  24;GLY A  81;ASP A  83;LEU A  84","TYR A  77 ( 1.3A);GLY A  24 ( 0.0A);GLY A  81 ( 0.0A);ASP A  83 ( 0.6A);LEU A  84 ( 0.5A)","1.13A","3ou7A-6ezyA:undetectable","3ou7A-6ezyA:undetectable"],["3VLN_A_ASCA904_0","GLUTATHIONE S-TRANSFERASE OMEGA-1","6ezy","-","-",4,"ARG A  15;PRO A  54;GLU A  65;SER A  66","ARG A  15 ( 0.6A);PRO A  54 ( 1.1A);GLU A  65 ( 0.6A);SER A  66 ( 0.0A)","0.95A","3vlnA-6ezyA:20.5","3vlnA-6ezyA:undetectable"],["4KLR_A_CHDA505_0","FERROCHELATASE, MITOCHONDRIAL","6ezy","-","-",4,"LEU A 110;PRO A 109;LEU A 113;ILE A 179","LEU A 110 ( 0.6A);PRO A 109 ( 1.1A);LEU A 113 ( 0.6A);ILE A 179 ( 0.7A)","0.84A","4klrA-6ezyA:undetectable","4klrA-6ezyA:undetectable"],["4XIW_G_AZMG402_1","CARBONIC ANHYDRASE, ALPHA TYPE","6ezy","-","-",5,"VAL A  56;LEU A   3;VAL A   5;LEU A  20;THR A  19","VAL A  56 ( 0.6A);LEU A   3 ( 0.6A);VAL A   5 ( 0.6A);LEU A  20 ( 0.6A);THR A  19 ( 0.8A)","0.90A","4xiwG-6ezyA:undetectable","4xiwG-6ezyA:undetectable"],["5L6E_B_ACTB401_0","N6-ADENOSINE-METHYLTRANSFERASE 70 KDA SUBUNIT;N6-ADENOSINE-METHYLTRANSFERASE SUBUNIT METTL14","6ezy","-","-",4,"GLU A  96;ARG A  92;LEU A 163;ARG A  67","GLU A  96 ( 0.6A);ARG A  92 ( 0.6A);LEU A 163 ( 0.6A);ARG A  67 ( 0.6A)","0.87A","5l6eA-6ezyA:undetectable;5l6eB-6ezyA:undetectable","5l6eA-6ezyA:undetectable;5l6eB-6ezyA:undetectable"],["5QGG_A_ACTA301_0","PEROXISOMAL COENZYME A DIPHOSPHATASE NUDT7","6ezy","-","-",4,"VAL A  57;VAL A  56;TYR A   6;GLN A  48","VAL A  57 ( 0.6A);VAL A  56 ( 0.6A);TYR A   6 ( 1.3A);GLN A  48 ( 0.6A)","1.11A","5qggA-6ezyA:undetectable","5qggA-6ezyA:undetectable"],["5QGO_A_ACTA302_0","PEROXISOMAL COENZYME A DIPHOSPHATASE NUDT7","6ezy","-","-",4,"VAL A  57;VAL A  56;TYR A   6;GLN A  48","VAL A  57 ( 0.6A);VAL A  56 ( 0.6A);TYR A   6 ( 1.3A);GLN A  48 ( 0.6A)","1.14A","5qgoA-6ezyA:undetectable","5qgoA-6ezyA:undetectable"]]