SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6f0k'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DZ6_A_CAMA502_0
(CYTOCHROME P450-CAM)		 6f0k ACTF
(Rhodothermus
marinus) 		4 / 5 PHE F 158
TYR F 127
LEU F  67
ASP F 216
 None
 1.37A 1dz6A-6f0kF:
undetectable		 1dz6A-6f0kF:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EA1_A_TPFA470_1
(CYTOCHROME P450
51-LIKE RV0764C)		 6f0k FE-S-CLUSTER-CONTAIN
ING HYDROGENASE
(Rhodothermus
marinus) 		4 / 8 TYR B 475
ARG B 217
PHE B 105
THR B 259
 None
 1.26A 1ea1A-6f0kB:
undetectable		 1ea1A-6f0kB:
11.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GMK_A_DVAA8_0
(GRAMICIDIN A)		 6f0k POLYSULPHIDE
REDUCTASE NRFD
(Rhodothermus
marinus) 		3 / 4 VAL C  73
TRP C  84
TRP C 419
 None
 1.29A 1gmkA-6f0kC:
undetectable
1gmkB-6f0kC:
undetectable		 1gmkA-6f0kC:
undetectable
1gmkB-6f0kC:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GMK_D_DVAD8_0
(GRAMICIDIN A)		 6f0k ACTF
(Rhodothermus
marinus) 		3 / 3 TRP F 361
VAL F 315
TRP F 313
 None
 1.44A 1gmkC-6f0kF:
undetectable
1gmkD-6f0kF:
undetectable		 1gmkC-6f0kF:
undetectable
1gmkD-6f0kF:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HXB_A_ROCA100_2
(HIV-1 PROTEASE)		 6f0k FE-S-CLUSTER-CONTAIN
ING HYDROGENASE
(Rhodothermus
marinus) 		3 / 3 ARG B 954
THR B 947
VAL B 950
 None
 0.89A 1hxbA-6f0kB:
0.9		 1hxbA-6f0kB:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICV_B_NIOB702_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 6f0k ACTF
POLYSULPHIDE
REDUCTASE NRFD
(Rhodothermus
marinus) 		4 / 5 PHE C 342
GLY C 261
THR F 228
PHE C 267
 None
 1.19A 1icvA-6f0kC:
undetectable
1icvB-6f0kC:
undetectable		 1icvA-6f0kC:
21.56
1icvB-6f0kC:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KF6_N_ACTN803_0
(FUMARATE REDUCTASE
FLAVOPROTEIN
FUMARATE REDUCTASE
IRON-SULFUR PROTEIN)		 6f0k FE-S-CLUSTER-CONTAIN
ING HYDROGENASE
(Rhodothermus
marinus) 		4 / 6 ARG B 575
GLY B 359
ASP B 252
TRP B 711
 None
 1.05A 1kf6M-6f0kB:
undetectable
1kf6N-6f0kB:
undetectable		 1kf6M-6f0kB:
undetectable
1kf6N-6f0kB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_A_NOVA400_2
(DNA GYRASE SUBUNIT B)		 6f0k FE-S-CLUSTER-CONTAIN
ING HYDROGENASE
(Rhodothermus
marinus) 		3 / 3 ASN B 605
PHE B 574
VAL B 701
 None
 0.82A 1kijA-6f0kB:
undetectable		 1kijA-6f0kB:
12.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MEH_A_MOAA600_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE)		 6f0k CYTOCHROME C FAMILY
PROTEIN
FE-S-CLUSTER-CONTAIN
ING HYDROGENASE
(Rhodothermus
marinus) 		5 / 10 SER A 127
ASN A 131
ILE A 200
GLY A 199
GLU B 963
 HEC  A 302 (-2.5A)
HEC  A 302 (-2.7A)
HEC  A 302 (-3.4A)
None
None
 1.29A 1mehA-6f0kA:
undetectable		 1mehA-6f0kA:
9.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MOG_A_RBFA200_1
(DODECIN)		 6f0k ACTF
(Rhodothermus
marinus) 		3 / 3 PHE F 230
TRP F 225
GLU F 300
 None
 0.93A 1mogA-6f0kF:
undetectable		 1mogA-6f0kF:
24.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBH_D_SAMD3293_0
(GLYCINE
N-METHYLTRANSFERASE)		 6f0k ACTF
(Rhodothermus
marinus) 		5 / 12 TRP F 169
ILE F 168
ALA F 236
SER F 238
TYR F 165
 None
 1.40A 1nbhD-6f0kF:
undetectable		 1nbhD-6f0kF:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P6K_A_MTLA870_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 6f0k FE-S-CLUSTER-CONTAIN
ING HYDROGENASE
POLYSULPHIDE
REDUCTASE NRFD
QUINOL:CYTOCHROME C
OXIDOREDUCTASE
MONOHEME CYTOCHROME
SUBUNIT
(Rhodothermus
marinus;
Rhodothermus
marinus;
Rhodothermus
marinus) 		4 / 8 ARG C 142
PHE B 939
ASN E  37
ASP E  41
 None
None
HEC  A 301 (-2.9A)
None
 1.15A 1p6kA-6f0kC:
0.3		 1p6kA-6f0kC:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P6K_B_MTLB871_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 6f0k FE-S-CLUSTER-CONTAIN
ING HYDROGENASE
POLYSULPHIDE
REDUCTASE NRFD
QUINOL:CYTOCHROME C
OXIDOREDUCTASE
MONOHEME CYTOCHROME
SUBUNIT
(Rhodothermus
marinus;
Rhodothermus
marinus;
Rhodothermus
marinus) 		4 / 8 ARG C 142
PHE B 939
ASN E  37
ASP E  41
 None
None
HEC  A 301 (-2.9A)
None
 1.14A 1p6kB-6f0kC:
undetectable		 1p6kB-6f0kC:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q6I_A_FK5A301_1
(FKBP-TYPE
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKPA)		 6f0k ACTH
QUINOL:CYTOCHROME C
OXIDOREDUCTASE
MONOHEME CYTOCHROME
SUBUNIT
(Rhodothermus
marinus) 		5 / 9 TYR H 159
LEU E 102
ILE E 172
TYR E 113
ILE E 112
 None
None
None
HEC  E 400 ( 4.6A)
None
 1.37A 1q6iA-6f0kH:
undetectable		 1q6iA-6f0kH:
15.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q6I_B_FK5B401_1
(FKBP-TYPE
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKPA)		 6f0k ACTH
QUINOL:CYTOCHROME C
OXIDOREDUCTASE
MONOHEME CYTOCHROME
SUBUNIT
(Rhodothermus
marinus) 		5 / 10 TYR H 159
LEU E 102
ILE E 172
TYR E 113
ILE E 112
 None
None
None
HEC  E 400 ( 4.6A)
None
 1.41A 1q6iB-6f0kH:
undetectable		 1q6iB-6f0kH:
15.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RS6_A_MTLA870_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 6f0k FE-S-CLUSTER-CONTAIN
ING HYDROGENASE
POLYSULPHIDE
REDUCTASE NRFD
QUINOL:CYTOCHROME C
OXIDOREDUCTASE
MONOHEME CYTOCHROME
SUBUNIT
(Rhodothermus
marinus;
Rhodothermus
marinus;
Rhodothermus
marinus) 		4 / 8 ARG C 142
PHE B 939
ASN E  37
ASP E  41
 None
None
HEC  A 301 (-2.9A)
None
 1.15A 1rs6A-6f0kC:
undetectable		 1rs6A-6f0kC:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RS6_B_MTLB871_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 6f0k FE-S-CLUSTER-CONTAIN
ING HYDROGENASE
POLYSULPHIDE
REDUCTASE NRFD
QUINOL:CYTOCHROME C
OXIDOREDUCTASE
MONOHEME CYTOCHROME
SUBUNIT
(Rhodothermus
marinus;
Rhodothermus
marinus;
Rhodothermus
marinus) 		4 / 8 ARG C 142
PHE B 939
ASN E  37
ASP E  41
 None
None
HEC  A 301 (-2.9A)
None
 1.15A 1rs6B-6f0kC:
undetectable		 1rs6B-6f0kC:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RS7_A_ACTA860_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 6f0k FE-S-CLUSTER-CONTAIN
ING HYDROGENASE
(Rhodothermus
marinus) 		4 / 5 GLY B 309
ILE B 311
VAL B 573
SER B 291
 None
 1.09A 1rs7A-6f0kB:
undetectable		 1rs7A-6f0kB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RS7_B_ACTB861_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 6f0k FE-S-CLUSTER-CONTAIN
ING HYDROGENASE
(Rhodothermus
marinus) 		4 / 6 GLY B 309
ILE B 311
GLN B 362
VAL B 573
 None
 0.89A 1rs7B-6f0kB:
undetectable		 1rs7B-6f0kB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TKQ_B_DVAB8_0
(GRAMICIDIN A)		 6f0k ACTF
(Rhodothermus
marinus) 		4 / 5 VAL F  45
GLY F  44
VAL F 388
TRP F 382
 None
 1.03A 1tkqB-6f0kF:
undetectable		 1tkqB-6f0kF:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TKQ_B_DVAB8_0
(GRAMICIDIN A)		 6f0k ACTF
(Rhodothermus
marinus) 		4 / 5 VAL F 390
GLY F 391
VAL F 389
TRP F 107
 None
 0.94A 1tkqB-6f0kF:
undetectable		 1tkqB-6f0kF:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WSV_A_THHA3001_1
(AMINOMETHYLTRANSFERA
SE)		 6f0k POLYSULPHIDE
REDUCTASE NRFD
ACTD
ACTF
(Rhodothermus
marinus;
Rhodothermus
marinus;
Rhodothermus
marinus) 		3 / 3 ASP C 253
GLU D 122
TYR F 284
 None
 0.79A 1wsvA-6f0kC:
undetectable		 1wsvA-6f0kC:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WU8_C_ADNC502_1
(HYPOTHETICAL PROTEIN
PH0463)		 6f0k FE-S-CLUSTER-CONTAIN
ING HYDROGENASE
POLYSULPHIDE
REDUCTASE NRFD
(Rhodothermus
marinus) 		4 / 7 ASN B 905
ASN C  76
HIS C 139
VAL C  87
 None
 1.22A 1wu8A-6f0kB:
undetectable
1wu8C-6f0kB:
undetectable		 1wu8A-6f0kB:
15.94
1wu8C-6f0kB:
15.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XDK_F_9CRF1600_2
(RETINOIC ACID
RECEPTOR, BETA)		 6f0k FE-S-CLUSTER-CONTAIN
ING HYDROGENASE
(Rhodothermus
marinus) 		3 / 3 LEU B 357
PHE B 255
ARG B 285
 None
 0.69A 1xdkF-6f0kB:
undetectable		 1xdkF-6f0kB:
15.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XWF_B_ADNB433_2
(ADENOSYLHOMOCYSTEINA
SE)		 6f0k POLYSULPHIDE
REDUCTASE NRFD
(Rhodothermus
marinus) 		3 / 3 THR C 315
GLU C 394
HIS C 247
 None
 0.90A 1xwfB-6f0kC:
undetectable		 1xwfB-6f0kC:
10.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XWF_D_ADND433_2
(ADENOSYLHOMOCYSTEINA
SE)		 6f0k POLYSULPHIDE
REDUCTASE NRFD
(Rhodothermus
marinus) 		3 / 3 THR C 315
GLU C 394
HIS C 247
 None
 0.91A 1xwfD-6f0kC:
undetectable		 1xwfD-6f0kC:
10.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZQ_A_MTLA870_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 6f0k FE-S-CLUSTER-CONTAIN
ING HYDROGENASE
POLYSULPHIDE
REDUCTASE NRFD
QUINOL:CYTOCHROME C
OXIDOREDUCTASE
MONOHEME CYTOCHROME
SUBUNIT
(Rhodothermus
marinus;
Rhodothermus
marinus;
Rhodothermus
marinus) 		4 / 8 ARG C 142
PHE B 939
ASN E  37
ASP E  41
 None
None
HEC  A 301 (-2.9A)
None
 1.16A 1zzqA-6f0kC:
undetectable		 1zzqA-6f0kC:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZQ_B_ACTB861_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 6f0k FE-S-CLUSTER-CONTAIN
ING HYDROGENASE
(Rhodothermus
marinus) 		4 / 5 GLY B 309
GLN B 362
VAL B 573
SER B 291
 None
 0.98A 1zzqB-6f0kB:
undetectable		 1zzqB-6f0kB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZQ_B_MTLB871_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 6f0k FE-S-CLUSTER-CONTAIN
ING HYDROGENASE
POLYSULPHIDE
REDUCTASE NRFD
QUINOL:CYTOCHROME C
OXIDOREDUCTASE
MONOHEME CYTOCHROME
SUBUNIT
(Rhodothermus
marinus;
Rhodothermus
marinus;
Rhodothermus
marinus) 		4 / 8 ARG C 142
PHE B 939
ASN E  37
ASP E  41
 None
None
HEC  A 301 (-2.9A)
None
 1.15A 1zzqB-6f0kC:
undetectable		 1zzqB-6f0kC:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZU_A_ACTA860_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 6f0k FE-S-CLUSTER-CONTAIN
ING HYDROGENASE
(Rhodothermus
marinus) 		4 / 5 GLY B 309
GLN B 362
VAL B 573
SER B 291
 None
 0.98A 1zzuA-6f0kB:
undetectable		 1zzuA-6f0kB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZU_B_MTLB871_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 6f0k FE-S-CLUSTER-CONTAIN
ING HYDROGENASE
POLYSULPHIDE
REDUCTASE NRFD
QUINOL:CYTOCHROME C
OXIDOREDUCTASE
MONOHEME CYTOCHROME
SUBUNIT
(Rhodothermus
marinus;
Rhodothermus
marinus;
Rhodothermus
marinus) 		4 / 8 ARG C 142
PHE B 939
ASN E  37
ASP E  41
 None
None
HEC  A 301 (-2.9A)
None
 1.13A 1zzuB-6f0kC:
undetectable		 1zzuB-6f0kC:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3C_B_PNXB2434_1
(CHITINASE)		 6f0k POLYSULPHIDE
REDUCTASE NRFD
(Rhodothermus
marinus) 		4 / 6 TYR C 354
GLY C 274
PHE C 277
SER C 278
 None
 1.37A 2a3cB-6f0kC:
undetectable		 2a3cB-6f0kC:
12.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B17_A_DIFA701_1
(PHOSPHOLIPASE A2
VRV-PL-VIIIA)		 6f0k ACTD
POLYSULPHIDE
REDUCTASE NRFD
(Rhodothermus
marinus) 		5 / 10 LEU D 142
ALA C 215
ILE C 189
GLY C 220
ASP D  52
 None
 1.32A 2b17A-6f0kD:
undetectable		 2b17A-6f0kD:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXC_B_P1ZB2001_1
(SERUM ALBUMIN)		 6f0k FE-S-CLUSTER-CONTAIN
ING HYDROGENASE
(Rhodothermus
marinus) 		5 / 9 GLU B 203
LEU B 418
LEU B 197
ALA B 511
ALA B 501
 None
 1.50A 2bxcB-6f0kB:
undetectable		 2bxcB-6f0kB:
9.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HRC_A_CHDA703_0
(FERROCHELATASE)		 6f0k FE-S-CLUSTER-CONTAIN
ING HYDROGENASE
(Rhodothermus
marinus) 		4 / 4 LEU B 497
PRO B 496
LEU B 500
ARG B 201
 None
 1.22A 2hrcA-6f0kB:
undetectable		 2hrcA-6f0kB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IT4_A_PPFA500_1
(CARBONIC ANHYDRASE 1)		 6f0k ACTF
(Rhodothermus
marinus) 		4 / 8 HIS F 355
ALA F 352
LEU F  76
THR F  75
 None
 0.75A 2it4A-6f0kF:
undetectable		 2it4A-6f0kF:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O01_A_PQNA5001_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1)		 6f0k ACTF
(Rhodothermus
marinus) 		4 / 8 TRP F 169
PHE F 234
ALA F  77
LEU F  78
 None
 1.02A 2o01A-6f0kF:
undetectable		 2o01A-6f0kF:
6.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OD9_A_NCAA3721_0
(NAD-DEPENDENT
DEACETYLASE HST2)		 6f0k ACTF
(Rhodothermus
marinus) 		3 / 3 PHE F 245
PHE F 393
PHE F 394
 None
 0.82A 2od9A-6f0kF:
undetectable		 2od9A-6f0kF:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PIV_A_T3A933_1
(ANDROGEN RECEPTOR)		 6f0k ACTH
QUINOL:CYTOCHROME C
OXIDOREDUCTASE
MONOHEME CYTOCHROME
SUBUNIT
(Rhodothermus
marinus) 		5 / 9 PRO E  95
ILE E  94
GLY E 106
GLU E 101
TYR H 159
 None
 1.50A 2pivA-6f0kE:
undetectable		 2pivA-6f0kE:
15.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PNC_B_CLUB809_1
(COPPER AMINE
OXIDASE, LIVER
ISOZYME)		 6f0k FE-S-CLUSTER-CONTAIN
ING HYDROGENASE
(Rhodothermus
marinus) 		4 / 6 ALA B 702
TYR B 424
ASP B 582
TYR B 216
 None
 1.46A 2pncB-6f0kB:
undetectable		 2pncB-6f0kB:
9.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q64_B_1UNB1001_2
(PROTEASE RETROPEPSIN)		 6f0k FE-S-CLUSTER-CONTAIN
ING HYDROGENASE
(Rhodothermus
marinus) 		3 / 3 ARG B 954
THR B 947
VAL B 950
 None
 0.83A 2q64A-6f0kB:
undetectable		 2q64A-6f0kB:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QAK_A_1UNA1001_2
(PROTEASE RETROPEPSIN)		 6f0k FE-S-CLUSTER-CONTAIN
ING HYDROGENASE
(Rhodothermus
marinus) 		3 / 3 ARG B 954
THR B 947
VAL B 950
 None
 0.70A 2qakA-6f0kB:
0.9		 2qakA-6f0kB:
24.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QBL_A_CAMA517_0
(CYTOCHROME P450-CAM)		 6f0k ACTF
(Rhodothermus
marinus) 		5 / 7 PHE F 158
TYR F 127
LEU F  67
THR F  71
ASP F 216
 None
 1.45A 2qblA-6f0kF:
undetectable		 2qblA-6f0kF:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD3_B_CHDB504_0
(FERROCHELATASE)		 6f0k POLYSULPHIDE
REDUCTASE NRFD
(Rhodothermus
marinus) 		4 / 6 MET C 357
ILE C 398
ARG C 395
PRO C 365
 None
 1.39A 2qd3B-6f0kC:
undetectable		 2qd3B-6f0kC:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQG_A_NCAA3721_0
(NAD-DEPENDENT
DEACETYLASE HST2)		 6f0k ACTF
(Rhodothermus
marinus) 		3 / 3 PHE F 245
PHE F 393
PHE F 394
 None
 0.82A 2qqgA-6f0kF:
undetectable		 2qqgA-6f0kF:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W98_A_P1ZA1351_1
(PROSTAGLANDIN
REDUCTASE 2)		 6f0k ACTD
POLYSULPHIDE
REDUCTASE NRFD
(Rhodothermus
marinus) 		5 / 10 ILE D 125
PHE D  78
LEU C 235
VAL C 231
LEU C 234
 None
 1.39A 2w98A-6f0kD:
undetectable		 2w98A-6f0kD:
12.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W98_B_P1ZB1357_1
(PROSTAGLANDIN
REDUCTASE 2)		 6f0k FE-S-CLUSTER-CONTAIN
ING HYDROGENASE
(Rhodothermus
marinus) 		4 / 6 TYR B 725
LEU B 644
ASN B 605
ASP B 577
 None
 1.45A 2w98A-6f0kB:
undetectable
2w98B-6f0kB:
undetectable		 2w98A-6f0kB:
11.61
2w98B-6f0kB:
11.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W98_B_P1ZB1357_1
(PROSTAGLANDIN
REDUCTASE 2)		 6f0k FE-S-CLUSTER-CONTAIN
ING HYDROGENASE
(Rhodothermus
marinus) 		4 / 6 TYR B 725
LEU B 644
ASN B 605
ASP B 596
 None
 1.43A 2w98A-6f0kB:
undetectable
2w98B-6f0kB:
undetectable		 2w98A-6f0kB:
11.61
2w98B-6f0kB:
11.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W9G_A_TOPA1159_1
(DIHYDROFOLATE
REDUCTASE)		 6f0k FE-S-CLUSTER-CONTAIN
ING HYDROGENASE
(Rhodothermus
marinus) 		5 / 10 ALA B 607
LEU B 644
LEU B 635
VAL B 572
PHE B 574
 None
 1.16A 2w9gA-6f0kB:
undetectable		 2w9gA-6f0kB:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W9S_C_TOPC1160_1
(DIHYDROFOLATE
REDUCTASE TYPE 1
FROM TN4003)		 6f0k ACTF
POLYSULPHIDE
REDUCTASE NRFD
(Rhodothermus
marinus) 		5 / 10 ALA C 273
SER F 288
ILE F 285
PHE F 281
THR C 315
 None
 1.19A 2w9sC-6f0kC:
undetectable		 2w9sC-6f0kC:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XCT_H_CPFH1020_1
(DNA GYRASE SUBUNIT
B, DNA GYRASE
SUBUNIT A)		 6f0k FE-S-CLUSTER-CONTAIN
ING HYDROGENASE
(Rhodothermus
marinus) 		3 / 3 ARG B 110
GLU B 141
SER B 545
 None
 0.81A 2xctD-6f0kB:
2.3		 2xctD-6f0kB:
9.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XDC_A_DVAA8_0
(GRAMICIDIN A)		 6f0k ACTF
(Rhodothermus
marinus) 		3 / 3 VAL F 319
TRP F 313
TRP F 361
 None
 1.36A 2xdcA-6f0kF:
undetectable
2xdcB-6f0kF:
undetectable		 2xdcA-6f0kF:
undetectable
2xdcB-6f0kF:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XDC_B_DVAB8_0
(GRAMICIDIN A)		 6f0k ACTF
(Rhodothermus
marinus) 		3 / 3 TRP F 361
VAL F 319
TRP F 313
 None
 1.34A 2xdcA-6f0kF:
undetectable
2xdcB-6f0kF:
undetectable		 2xdcA-6f0kF:
undetectable
2xdcB-6f0kF:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y5M_A_DVAA8_0
(VAL-GRAMICIDIN A)		 6f0k ACTF
(Rhodothermus
marinus) 		3 / 3 VAL F 319
TRP F 313
TRP F 361
 None
 1.34A 2y5mA-6f0kF:
undetectable
2y5mB-6f0kF:
undetectable		 2y5mA-6f0kF:
undetectable
2y5mB-6f0kF:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y6N_A_DVAA8_0
(VAL-GRAMICIDIN A)		 6f0k ACTF
(Rhodothermus
marinus) 		3 / 3 VAL F 319
TRP F 313
TRP F 361
 None
 1.35A 2y6nA-6f0kF:
undetectable
2y6nB-6f0kF:
undetectable		 2y6nA-6f0kF:
undetectable
2y6nB-6f0kF:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y6N_B_DVAB8_0
(VAL-GRAMICIDIN A)		 6f0k ACTF
(Rhodothermus
marinus) 		3 / 3 TRP F 361
VAL F 319
TRP F 313
 None
 1.35A 2y6nA-6f0kF:
undetectable
2y6nB-6f0kF:
undetectable		 2y6nA-6f0kF:
undetectable
2y6nB-6f0kF:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YVL_C_SAMC604_0
(HYPOTHETICAL PROTEIN)		 6f0k ACTF
(Rhodothermus
marinus) 		5 / 12 GLY F 237
SER F 238
ALA F 242
LEU F 243
ALA F 286
 None
 1.25A 2yvlC-6f0kF:
undetectable		 2yvlC-6f0kF:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AOB_C_RFPC2002_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 6f0k FE-S-CLUSTER-CONTAIN
ING HYDROGENASE
(Rhodothermus
marinus) 		5 / 12 ALA B 468
THR B 101
PHE B 105
PHE B 585
GLY B 472
 None
 1.32A 3aobC-6f0kB:
undetectable		 3aobC-6f0kB:
8.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DH0_A_SAMA220_0
(SAM DEPENDENT
METHYLTRANSFERASE)		 6f0k ACTF
(Rhodothermus
marinus) 		5 / 12 LEU F  48
VAL F 390
GLY F 387
GLY F  44
LEU F  76
 None
 1.30A 3dh0A-6f0kF:
undetectable		 3dh0A-6f0kF:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_B_TRPB1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 6f0k POLYSULPHIDE
REDUCTASE NRFD
(Rhodothermus
marinus) 		4 / 8 GLY C  23
ASP C  28
VAL C 299
VAL C  20
 None
 0.80A 3fi0B-6f0kC:
undetectable		 3fi0B-6f0kC:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FRE_X_TOPX300_1
(DIHYDROFOLATE
REDUCTASE)		 6f0k ACTF
POLYSULPHIDE
REDUCTASE NRFD
(Rhodothermus
marinus) 		5 / 9 ALA C 273
SER F 288
ILE F 285
PHE F 281
THR C 315
 None
 1.22A 3freX-6f0kC:
undetectable		 3freX-6f0kC:
18.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GCL_A_AINA609_1
(LACTOPEROXIDASE)		 6f0k FE-S-CLUSTER-CONTAIN
ING HYDROGENASE
(Rhodothermus
marinus) 		4 / 6 ARG B 278
GLU B 280
PHE B 750
PRO B 754
 None
 1.29A 3gclA-6f0kB:
undetectable		 3gclA-6f0kB:
9.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GV1_B_BEZB303_0
(DISULFIDE
INTERCHANGE PROTEIN)		 6f0k FE-S-CLUSTER-CONTAIN
ING HYDROGENASE
(Rhodothermus
marinus) 		4 / 4 LEU B 635
ALA B 607
VAL B 646
PRO B 645
 None
 1.20A 3gv1B-6f0kB:
undetectable		 3gv1B-6f0kB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H52_C_486C4_2
(GLUCOCORTICOID
RECEPTOR)		 6f0k FE-S-CLUSTER-CONTAIN
ING HYDROGENASE
(Rhodothermus
marinus) 		3 / 3 MET B 800
CYH B 980
PRO B 862
 SF4  B1103 ( 4.7A)
SF4  B1104 (-2.2A)
None
 1.14A 3h52C-6f0kB:
undetectable		 3h52C-6f0kB:
13.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCO_B_CHDB1_0
(FERROCHELATASE,
MITOCHONDRIAL)		 6f0k FE-S-CLUSTER-CONTAIN
ING HYDROGENASE
(Rhodothermus
marinus) 		4 / 4 LEU B 497
PRO B 496
LEU B 500
ARG B 201
 None
 1.32A 3hcoB-6f0kB:
undetectable		 3hcoB-6f0kB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEE_B_30BB500_2
(GENOME POLYPROTEIN)		 6f0k ACTD
(Rhodothermus
marinus) 		3 / 3 PHE D 110
TYR D 101
LEU D 113
 None
HEC  A 301 (-4.3A)
None
 0.67A 3keeB-6f0kD:
undetectable		 3keeB-6f0kD:
16.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_A_TFPA201_1
(PROTEIN S100-A4)		 6f0k FE-S-CLUSTER-CONTAIN
ING HYDROGENASE
(Rhodothermus
marinus) 		5 / 9 GLY B 298
ILE B 842
CYH B 813
GLY B 257
PHE B 263
 None
SF4  B1104 (-4.6A)
SF4  B1104 (-2.2A)
None
None
 1.17A 3ko0A-6f0kB:
undetectable
3ko0C-6f0kB:
undetectable		 3ko0A-6f0kB:
20.79
3ko0C-6f0kB:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_R_TFPR201_1
(PROTEIN S100-A4)		 6f0k FE-S-CLUSTER-CONTAIN
ING HYDROGENASE
(Rhodothermus
marinus) 		5 / 10 GLY B 298
ILE B 842
CYH B 813
GLY B 257
PHE B 263
 None
SF4  B1104 (-4.6A)
SF4  B1104 (-2.2A)
None
None
 1.23A 3ko0R-6f0kB:
undetectable
3ko0T-6f0kB:
undetectable		 3ko0R-6f0kB:
20.79
3ko0T-6f0kB:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N58_C_ADNC500_1
(ADENOSYLHOMOCYSTEINA
SE)		 6f0k FE-S-CLUSTER-CONTAIN
ING HYDROGENASE
(Rhodothermus
marinus) 		5 / 12 ASP B 152
THR B 668
ASP B 450
LEU B 158
GLY B 446
 None
 1.24A 3n58C-6f0kB:
2.8		 3n58C-6f0kB:
10.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N61_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE)		 6f0k POLYSULPHIDE
REDUCTASE NRFD
(Rhodothermus
marinus) 		4 / 7 TRP C 262
PHE C 254
SER C 402
VAL C 397
 None
 1.14A 3n61A-6f0kC:
0.2
3n61B-6f0kC:
0.1		 3n61A-6f0kC:
12.81
3n61B-6f0kC:
12.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NS1_C_PM6C1_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 6f0k FE-S-CLUSTER-CONTAIN
ING HYDROGENASE
(Rhodothermus
marinus) 		4 / 6 GLU B 329
ARG B 333
ALA B 330
ALA B 313
 None
 1.22A 3ns1C-6f0kB:
undetectable		 3ns1C-6f0kB:
7.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NVK_I_SAMI228_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)		 6f0k FE-S-CLUSTER-CONTAIN
ING HYDROGENASE
(Rhodothermus
marinus) 		5 / 12 GLY B 540
ALA B 100
ASP B 471
ASP B 539
VAL B 536
 None
 1.00A 3nvkI-6f0kB:
undetectable		 3nvkI-6f0kB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NVK_J_SAMJ228_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE
NOP5/NOP56 RELATED
PROTEIN)		 6f0k FE-S-CLUSTER-CONTAIN
ING HYDROGENASE
(Rhodothermus
marinus) 		5 / 12 GLY B 540
ALA B 100
ASP B 471
ASP B 539
VAL B 536
 None
 0.93A 3nvkF-6f0kB:
undetectable
3nvkJ-6f0kB:
undetectable		 3nvkF-6f0kB:
undetectable
3nvkJ-6f0kB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QL6_A_NIMA614_1
(LACTOPEROXIDASE)		 6f0k CYTOCHROME C FAMILY
PROTEIN
QUINOL:CYTOCHROME C
OXIDOREDUCTASE
MONOHEME CYTOCHROME
SUBUNIT
(Rhodothermus
marinus) 		4 / 7 GLN A 173
ARG E 105
GLU A  69
PRO E 173
 None
 1.31A 3ql6A-6f0kA:
undetectable		 3ql6A-6f0kA:
8.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RUK_D_AERD601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 6f0k POLYSULPHIDE
REDUCTASE NRFD
(Rhodothermus
marinus) 		5 / 11 TYR C 340
ASN C 344
ILE C 343
GLY C 348
ALA C 351
 None
 1.05A 3rukD-6f0kC:
undetectable		 3rukD-6f0kC:
10.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TM4_A_SAMA401_1
(TRNA (GUANINE
N2-)-METHYLTRANSFERA
SE TRM14)		 6f0k FE-S-CLUSTER-CONTAIN
ING HYDROGENASE
(Rhodothermus
marinus) 		4 / 5 HIS B 652
SER B 610
THR B 613
ASP B 604
 None
 1.41A 3tm4A-6f0kB:
undetectable		 3tm4A-6f0kB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TX2_A_BEZA251_0
(PROBABLE
6-PHOSPHOGLUCONOLACT
ONASE)		 6f0k FE-S-CLUSTER-CONTAIN
ING HYDROGENASE
(Rhodothermus
marinus) 		4 / 7 ARG B 275
ALA B 271
MET B 299
ALA B 806
 None
 1.46A 3tx2A-6f0kB:
undetectable		 3tx2A-6f0kB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WIP_G_ACHG301_0
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 6f0k POLYSULPHIDE
REDUCTASE NRFD
(Rhodothermus
marinus) 		4 / 8 THR C  37
ARG C 441
LEU C 440
MET C 445
 None
 1.30A 3wipG-6f0kC:
undetectable
3wipH-6f0kC:
undetectable		 3wipG-6f0kC:
undetectable
3wipH-6f0kC:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A7T_A_5FWA1002_1
(SUPEROXIDE DISMUTASE
[CU-ZN])		 6f0k FE-S-CLUSTER-CONTAIN
ING HYDROGENASE
POLYSULPHIDE
REDUCTASE NRFD
(Rhodothermus
marinus) 		3 / 3 ASN B 905
TRP C  82
ASP C 406
 None
 0.85A 4a7tA-6f0kB:
undetectable
4a7tF-6f0kB:
undetectable		 4a7tA-6f0kB:
20.65
4a7tF-6f0kB:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_H_ZPCH1318_2
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 6f0k FE-S-CLUSTER-CONTAIN
ING HYDROGENASE
(Rhodothermus
marinus) 		4 / 7 ILE B  91
TYR B  99
HIS B 538
VAL B 481
 None
 1.05A 4a97H-6f0kB:
undetectable		 4a97H-6f0kB:
14.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AQL_A_TXCA1452_2
(GUANINE DEAMINASE)		 6f0k ACTF
(Rhodothermus
marinus) 		4 / 5 HIS F 224
LEU F 126
LEU F 367
ASP F 125
 None
 1.13A 4aqlA-6f0kF:
undetectable		 4aqlA-6f0kF:
9.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D33_A_ACTA860_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 6f0k FE-S-CLUSTER-CONTAIN
ING HYDROGENASE
(Rhodothermus
marinus) 		4 / 5 GLY B 309
ILE B 311
VAL B 573
SER B 291
 None
 0.87A 4d33A-6f0kB:
undetectable		 4d33A-6f0kB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D33_B_ACTB860_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 6f0k FE-S-CLUSTER-CONTAIN
ING HYDROGENASE
(Rhodothermus
marinus) 		4 / 5 GLY B 309
ILE B 311
VAL B 573
SER B 291
 None
 0.88A 4d33B-6f0kB:
undetectable		 4d33B-6f0kB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D39_B_ACTB860_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 6f0k FE-S-CLUSTER-CONTAIN
ING HYDROGENASE
(Rhodothermus
marinus) 		5 / 6 GLY B 309
ILE B 311
GLN B 362
VAL B 573
SER B 291
 None
 0.97A 4d39B-6f0kB:
undetectable		 4d39B-6f0kB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DF3_A_SAMA301_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)		 6f0k FE-S-CLUSTER-CONTAIN
ING HYDROGENASE
(Rhodothermus
marinus) 		5 / 12 GLY B 540
ALA B 100
ASP B 471
ASP B 539
VAL B 536
 None
 1.02A 4df3A-6f0kB:
2.0		 4df3A-6f0kB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DF3_B_SAMB301_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)		 6f0k FE-S-CLUSTER-CONTAIN
ING HYDROGENASE
(Rhodothermus
marinus) 		5 / 12 GLY B 540
ALA B 100
ASP B 471
ASP B 539
VAL B 536
 None
 1.05A 4df3B-6f0kB:
undetectable		 4df3B-6f0kB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EAH_A_ACTA1002_0
(ACTIN, ALPHA
SKELETAL MUSCLE
FORMIN-LIKE PROTEIN
3)		 6f0k FE-S-CLUSTER-CONTAIN
ING HYDROGENASE
ACTH
(Rhodothermus
marinus;
Rhodothermus
marinus) 		4 / 5 ARG B 968
THR H 144
GLN B 959
GLU B 963
 None
 1.34A 4eahA-6f0kB:
undetectable
4eahE-6f0kB:
undetectable
4eahG-6f0kB:
undetectable		 4eahA-6f0kB:
undetectable
4eahE-6f0kB:
undetectable
4eahG-6f0kB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EAH_F_ACTF401_0
(ACTIN, ALPHA
SKELETAL MUSCLE
FORMIN-LIKE PROTEIN
3)		 6f0k FE-S-CLUSTER-CONTAIN
ING HYDROGENASE
ACTH
(Rhodothermus
marinus;
Rhodothermus
marinus) 		4 / 4 ARG B 968
THR H 144
GLN B 959
GLU B 963
 None
 1.33A 4eahB-6f0kB:
0.3
4eahC-6f0kB:
0.9
4eahF-6f0kB:
0.0		 4eahB-6f0kB:
undetectable
4eahC-6f0kB:
undetectable
4eahF-6f0kB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FFW_A_715A801_1
(DIPEPTIDYL PEPTIDASE
4)		 6f0k ACTD
FE-S-CLUSTER-CONTAIN
ING HYDROGENASE
(Rhodothermus
marinus) 		5 / 12 GLU B 874
GLY D 107
VAL B 911
ASN B 890
HIS B 867
 None
None
None
SF4  B1102 (-3.7A)
None
 1.45A 4ffwA-6f0kB:
undetectable		 4ffwA-6f0kB:
7.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FOG_A_C2FA302_0
(THYMIDYLATE SYNTHASE)		 6f0k FE-S-CLUSTER-CONTAIN
ING HYDROGENASE
(Rhodothermus
marinus) 		5 / 11 HIS B 464
SER B 144
ASP B 582
GLY B 583
PHE B 585
 None
 1.34A 4fogA-6f0kB:
undetectable		 4fogA-6f0kB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FOX_C_D16C301_1
(THYMIDYLATE SYNTHASE)		 6f0k FE-S-CLUSTER-CONTAIN
ING HYDROGENASE
(Rhodothermus
marinus) 		5 / 11 HIS B 464
SER B 144
ASP B 582
GLY B 583
PHE B 585
 None
 1.44A 4foxC-6f0kB:
undetectable		 4foxC-6f0kB:
18.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FOX_H_D16H301_1
(THYMIDYLATE SYNTHASE)		 6f0k FE-S-CLUSTER-CONTAIN
ING HYDROGENASE
(Rhodothermus
marinus) 		5 / 11 HIS B 464
SER B 144
ASP B 582
GLY B 583
PHE B 585
 None
 1.41A 4foxH-6f0kB:
undetectable		 4foxH-6f0kB:
18.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G19_D_ACTD302_0
(GLUTATHIONE
TRANSFERASE GTE1)		 6f0k CYTOCHROME C FAMILY
PROTEIN
FE-S-CLUSTER-CONTAIN
ING HYDROGENASE
QUINOL:CYTOCHROME C
OXIDOREDUCTASE
MONOHEME CYTOCHROME
SUBUNIT
(Rhodothermus
marinus;
Rhodothermus
marinus;
Rhodothermus
marinus) 		3 / 3 TYR A  40
PHE E  42
ARG B  76
 None
 1.02A 4g19D-6f0kA:
undetectable		 4g19D-6f0kA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IFX_A_ACTA404_0
(THIAMINE
BIOSYNTHESIS
LIPOPROTEIN APBE)		 6f0k ACTF
(Rhodothermus
marinus) 		4 / 5 SER F 199
LYS F 197
ARG F 196
LEU F  89
 None
 1.34A 4ifxA-6f0kF:
undetectable		 4ifxA-6f0kF:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IG1_A_ACTA504_0
(FAD:PROTEIN FMN
TRANSFERASE)		 6f0k ACTF
(Rhodothermus
marinus) 		4 / 5 SER F 199
LYS F 197
ARG F 196
LEU F  89
 None
 1.30A 4ig1A-6f0kF:
undetectable		 4ig1A-6f0kF:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IV0_B_SAMB302_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 6f0k POLYSULPHIDE
REDUCTASE NRFD
(Rhodothermus
marinus) 		5 / 12 ILE C  95
GLY C  96
ILE C 102
MET C 124
ILE C 105
 None
 1.11A 4iv0B-6f0kC:
undetectable		 4iv0B-6f0kC:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KCN_A_ACTA803_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 6f0k FE-S-CLUSTER-CONTAIN
ING HYDROGENASE
(Rhodothermus
marinus) 		5 / 6 GLY B 309
ILE B 311
GLN B 362
VAL B 573
SER B 291
 None
 1.16A 4kcnA-6f0kB:
undetectable		 4kcnA-6f0kB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYK_B_IMNB300_1
(LACTOYLGLUTATHIONE
LYASE)		 6f0k ACTD
ACTF
(Rhodothermus
marinus) 		5 / 12 PHE D  78
GLY F 272
LYS F 273
LEU F 333
PHE F 329
 None
 1.08A 4kykA-6f0kD:
undetectable
4kykB-6f0kD:
undetectable		 4kykA-6f0kD:
18.48
4kykB-6f0kD:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LBG_A_ADNA402_1
(PROBABLE SUGAR
KINASE PROTEIN)		 6f0k POLYSULPHIDE
REDUCTASE NRFD
(Rhodothermus
marinus) 		5 / 10 ALA C 290
ILE C 300
ALA C 121
ALA C 120
ILE C 117
 None
 1.06A 4lbgA-6f0kC:
undetectable		 4lbgA-6f0kC:
14.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LBG_B_ADNB402_1
(PROBABLE SUGAR
KINASE PROTEIN)		 6f0k POLYSULPHIDE
REDUCTASE NRFD
(Rhodothermus
marinus) 		5 / 9 ALA C 290
ILE C 300
ALA C 121
ALA C 120
ILE C 117
 None
 1.03A 4lbgB-6f0kC:
undetectable		 4lbgB-6f0kC:
14.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWZ_A_SAMA301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 6f0k POLYSULPHIDE
REDUCTASE NRFD
(Rhodothermus
marinus) 		5 / 12 ILE C  95
GLY C  96
ILE C 102
MET C 124
ILE C 105
 None
 1.11A 4mwzA-6f0kC:
undetectable		 4mwzA-6f0kC:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NC3_A_ERMA1202_2
(CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 2B AND E.
COLI SOLUBLE
CYTOCHROME B562)		 6f0k FE-S-CLUSTER-CONTAIN
ING HYDROGENASE
(Rhodothermus
marinus) 		4 / 6 THR B 215
LEU B 204
LEU B 497
GLU B 498
 None
 1.18A 4nc3A-6f0kB:
undetectable		 4nc3A-6f0kB:
12.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OBW_C_SAMC601_0
(2-METHOXY-6-POLYPREN
YL-1,4-BENZOQUINOL
METHYLASE,
MITOCHONDRIAL)		 6f0k FE-S-CLUSTER-CONTAIN
ING HYDROGENASE
ACTD
(Rhodothermus
marinus;
Rhodothermus
marinus) 		5 / 12 ASN B 870
ASN B 780
GLY D  97
SER B 875
ASN D 104
 None
 1.25A 4obwC-6f0kB:
undetectable		 4obwC-6f0kB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OR0_B_NPSB603_1
(SERUM ALBUMIN)		 6f0k FE-S-CLUSTER-CONTAIN
ING HYDROGENASE
(Rhodothermus
marinus) 		5 / 11 ARG B 303
VAL B 288
SER B 250
LEU B 286
LEU B 256
 None
 1.28A 4or0B-6f0kB:
undetectable		 4or0B-6f0kB:
10.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PB1_A_RBVA501_1
(NUPC FAMILY PROTEIN)		 6f0k ACTD
(Rhodothermus
marinus) 		5 / 12 GLY D  97
GLN D  93
ALA D  98
PHE D 111
SER D 116
 None
 1.36A 4pb1A-6f0kD:
undetectable		 4pb1A-6f0kD:
12.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PST_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 6f0k POLYSULPHIDE
REDUCTASE NRFD
(Rhodothermus
marinus) 		3 / 3 ILE C  86
ASP C 169
ARG C 395
 None
 0.85A 4pstA-6f0kC:
undetectable		 4pstA-6f0kC:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QZU_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 2)		 6f0k POLYSULPHIDE
REDUCTASE NRFD
ACTD
ACTF
(Rhodothermus
marinus;
Rhodothermus
marinus;
Rhodothermus
marinus) 		5 / 12 ALA D  74
THR D 124
THR D  82
LEU C 234
LEU F 333
 None
 1.37A 4qzuA-6f0kD:
undetectable		 4qzuA-6f0kD:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RTP_A_SAMA301_0
(DNA ADENINE
METHYLASE)		 6f0k FE-S-CLUSTER-CONTAIN
ING HYDROGENASE
(Rhodothermus
marinus) 		5 / 12 GLY B 126
ALA B 136
SER B 133
SER B 116
TYR B  99
 None
 1.24A 4rtpA-6f0kB:
undetectable		 4rtpA-6f0kB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RV6_A_RPBA1103_1
(POLY [ADP-RIBOSE]
POLYMERASE 1)		 6f0k ACTH
QUINOL:CYTOCHROME C
OXIDOREDUCTASE
MONOHEME CYTOCHROME
SUBUNIT
(Rhodothermus
marinus) 		5 / 11 GLU E  76
GLY H 147
TYR E  81
ALA H 160
SER H 146
 None
 1.45A 4rv6A-6f0kE:
undetectable		 4rv6A-6f0kE:
13.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RV6_B_RPBB1103_1
(POLY [ADP-RIBOSE]
POLYMERASE 1)		 6f0k ACTH
QUINOL:CYTOCHROME C
OXIDOREDUCTASE
MONOHEME CYTOCHROME
SUBUNIT
(Rhodothermus
marinus) 		5 / 11 GLU E  76
GLY H 147
TYR E  81
ALA H 160
SER H 146
 None
 1.44A 4rv6B-6f0kE:
undetectable		 4rv6B-6f0kE:
13.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TVT_A_ASCA303_0
(THAUMATIN-1)		 6f0k POLYSULPHIDE
REDUCTASE NRFD
ACTD
(Rhodothermus
marinus;
Rhodothermus
marinus) 		4 / 7 LEU C 242
GLU D 122
SER C 245
VAL C 250
 None
 1.08A 4tvtA-6f0kC:
undetectable		 4tvtA-6f0kC:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNW_A_RTZA602_1
(CYTOCHROME P450 2D6)		 6f0k FE-S-CLUSTER-CONTAIN
ING HYDROGENASE
(Rhodothermus
marinus) 		5 / 12 LEU B 304
GLY B 309
SER B 656
VAL B 573
THR B 658
 None
 1.22A 4wnwA-6f0kB:
undetectable		 4wnwA-6f0kB:
11.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XDT_A_ACTA406_0
(FAD:PROTEIN FMN
TRANSFERASE)		 6f0k ACTF
(Rhodothermus
marinus) 		4 / 5 SER F 199
LYS F 197
ARG F 196
LEU F  89
 None
 1.25A 4xdtA-6f0kF:
undetectable		 4xdtA-6f0kF:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4E_A_IPHA904_0
(PROTEIN ARGONAUTE-2)		 6f0k FE-S-CLUSTER-CONTAIN
ING HYDROGENASE
(Rhodothermus
marinus) 		4 / 7 ARG B 575
ILE B 598
PRO B 258
ASP B 260
 None
 1.05A 4z4eA-6f0kB:
undetectable		 4z4eA-6f0kB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZDY_A_1YNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 6f0k ACTF
POLYSULPHIDE
REDUCTASE NRFD
(Rhodothermus
marinus) 		5 / 12 GLY C 237
ILE F 354
GLY F 348
LEU F 332
PHE F 329
 None
 1.24A 4zdyA-6f0kC:
undetectable		 4zdyA-6f0kC:
10.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C0O_E_SAME301_0
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
TRMI)		 6f0k QUINOL:CYTOCHROME C
OXIDOREDUCTASE
MONOHEME CYTOCHROME
SUBUNIT
(Rhodothermus
marinus) 		5 / 12 ALA E 138
PRO E 137
GLY E 126
ALA E 115
HIS E 118
 HEC  E 400 (-3.3A)
HEC  E 400 ( 4.9A)
None
None
HEC  E 400 (-3.2A)
 1.20A 5c0oE-6f0kE:
undetectable		 5c0oE-6f0kE:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_R_BEZR801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 6f0k ACTF
(Rhodothermus
marinus) 		4 / 7 PHE F  83
ALA F 242
PRO F 102
LEU F  81
 None
 0.99A 5dzkD-6f0kF:
undetectable
5dzkR-6f0kF:
undetectable		 5dzkD-6f0kF:
undetectable
5dzkR-6f0kF:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E26_D_PAUD601_0
(PANTOTHENATE KINASE
2, MITOCHONDRIAL)		 6f0k POLYSULPHIDE
REDUCTASE NRFD
(Rhodothermus
marinus) 		4 / 8 VAL C 319
ALA C 273
ARG C 395
GLY C  94
 None
 0.79A 5e26C-6f0kC:
undetectable
5e26D-6f0kC:
undetectable		 5e26C-6f0kC:
undetectable
5e26D-6f0kC:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ERG_B_SAMB401_0
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
CATALYTIC SUBUNIT
TRM61)		 6f0k POLYSULPHIDE
REDUCTASE NRFD
ACTF
(Rhodothermus
marinus;
Rhodothermus
marinus) 		5 / 12 GLY F  79
SER F  80
PHE F  83
VAL C 314
LEU F  89
 None
 1.15A 5ergB-6f0kF:
undetectable		 5ergB-6f0kF:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESK_A_1YNA701_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 6f0k FE-S-CLUSTER-CONTAIN
ING HYDROGENASE
(Rhodothermus
marinus) 		4 / 4 ALA B 231
PRO B 392
LEU B 389
HIS B 387
 None
 1.32A 5eskA-6f0kB:
undetectable		 5eskA-6f0kB:
9.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW8_G_FK5G201_1
(FK506-BINDING
PROTEIN 1)		 6f0k FE-S-CLUSTER-CONTAIN
ING HYDROGENASE
(Rhodothermus
marinus) 		3 / 3 ILE B  92
PRO B  93
ILE B  95
 None
 0.32A 5hw8F-6f0kB:
undetectable		 5hw8F-6f0kB:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKQ_A_JMSA602_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 6f0k POLYSULPHIDE
REDUCTASE NRFD
(Rhodothermus
marinus) 		3 / 3 VAL C 319
SER C 278
MET C 308
 None
 0.86A 5ikqA-6f0kC:
0.0		 5ikqA-6f0kC:
8.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5INZ_D_DVAD2_0
(THETA DEFENSIN-2,
D-PEPTIDE
THETA DEFENSIN-2,
L-PEPTIDE)		 6f0k FE-S-CLUSTER-CONTAIN
ING HYDROGENASE
(Rhodothermus
marinus) 		4 / 4 GLY B 899
CYH B 897
ARG B 901
GLY B 941
 F3S  B1101 (-3.6A)
F3S  B1101 (-2.2A)
None
None
 1.41A 5inzA-6f0kB:
undetectable
5inzC-6f0kB:
undetectable
5inzD-6f0kB:
undetectable		 5inzA-6f0kB:
undetectable
5inzC-6f0kB:
undetectable
5inzD-6f0kB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J6H_A_NCAA402_0
(H-2 CLASS I
HISTOCOMPATIBILITY
ANTIGEN, Q10 ALPHA
CHAIN)		 6f0k FE-S-CLUSTER-CONTAIN
ING HYDROGENASE
ACTH
(Rhodothermus
marinus;
Rhodothermus
marinus) 		3 / 3 PRO B  96
ARG H 149
GLU B 115
 None
 0.99A 5j6hA-6f0kB:
undetectable		 5j6hA-6f0kB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JLC_A_1YNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 6f0k ACTF
POLYSULPHIDE
REDUCTASE NRFD
(Rhodothermus
marinus) 		5 / 12 ALA C 330
PHE F 281
TYR F 284
THR C 315
PHE C 267
 None
 1.13A 5jlcA-6f0kC:
1.1		 5jlcA-6f0kC:
9.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KPR_A_PAUA404_0
(PANTOTHENATE KINASE
3)		 6f0k POLYSULPHIDE
REDUCTASE NRFD
(Rhodothermus
marinus) 		4 / 5 GLU C 394
GLY C  94
SER C 278
GLY C 279
 None
 1.09A 5kprA-6f0kC:
undetectable		 5kprA-6f0kC:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LI8_A_KKKA502_1
(PUTATIVE CYTOCHROME
P450 126)		 6f0k ACTD
CYTOCHROME C FAMILY
PROTEIN
POLYSULPHIDE
REDUCTASE NRFD
(Rhodothermus
marinus) 		5 / 12 THR A   9
PRO D 145
VAL C 182
ALA D 134
SER A  16
 None
 1.41A 5li8A-6f0kA:
undetectable		 5li8A-6f0kA:
11.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N4T_A_BEZA507_0
(BETA-LACTAMASE VIM-2)		 6f0k FE-S-CLUSTER-CONTAIN
ING HYDROGENASE
(Rhodothermus
marinus) 		3 / 3 THR B 947
HIS B 867
ASN B 890
 None
None
SF4  B1102 (-3.7A)
 1.00A 5n4tA-6f0kB:
undetectable		 5n4tA-6f0kB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NWV_A_ACAA18_2
(SCRFP-TAG,GP41)		 6f0k ACTF
(Rhodothermus
marinus) 		4 / 7 GLN F  61
LEU F 367
TRP F 361
TRP F 304
 None
 1.10A 5nwvA-6f0kF:
undetectable		 5nwvA-6f0kF:
16.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OG9_A_TESA504_1
(-)		 6f0k POLYSULPHIDE
REDUCTASE NRFD
(Rhodothermus
marinus) 		4 / 8 ILE C 117
VAL C 299
ILE C 448
THR C  37
 None
 0.79A 5og9A-6f0kC:
1.8		 5og9A-6f0kC:
11.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TIW_B_OAQB302_0
(SULFOTRANSFERASE)		 6f0k POLYSULPHIDE
REDUCTASE NRFD
(Rhodothermus
marinus) 		5 / 12 ILE C 398
ILE C 266
PHE C 271
SER C 251
THR C 325
 None
 1.24A 5tiwB-6f0kC:
undetectable		 5tiwB-6f0kC:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UAN_B_REAB503_1
(RETINOIC ACID
RECEPTOR BETA)		 6f0k POLYSULPHIDE
REDUCTASE NRFD
(Rhodothermus
marinus) 		5 / 12 ILE C 105
ILE C 102
SER C 116
PHE C 280
VAL C 314
 None
 1.41A 5uanB-6f0kC:
undetectable		 5uanB-6f0kC:
10.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UH6_C_RFPC1201_1
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA)		 6f0k ACTF
(Rhodothermus
marinus) 		5 / 12 LEU F 179
GLN F 195
HIS F  88
ARG F 196
ARG F  91
 None
 1.50A 5uh6C-6f0kF:
undetectable		 5uh6C-6f0kF:
5.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UHC_C_RFPC1201_1
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA)		 6f0k ACTF
(Rhodothermus
marinus) 		5 / 12 LEU F 179
GLN F 195
HIS F  88
ARG F 196
ARG F  91
 None
 1.48A 5uhcC-6f0kF:
0.0		 5uhcC-6f0kF:
5.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UHD_C_RFPC1201_2
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA)		 6f0k FE-S-CLUSTER-CONTAIN
ING HYDROGENASE
(Rhodothermus
marinus) 		4 / 4 ARG B 110
PHE B 263
ASP B 260
LEU B 386
 None
 1.34A 5uhdC-6f0kB:
0.0		 5uhdC-6f0kB:
6.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UHG_C_RFPC1201_1
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA)		 6f0k ACTF
(Rhodothermus
marinus) 		5 / 12 LEU F 179
GLN F 195
HIS F  88
ARG F 196
ARG F  91
 None
 1.30A 5uhgC-6f0kF:
0.0		 5uhgC-6f0kF:
5.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_A_ACRA607_0
(ALPHA-AMYLASE)		 6f0k FE-S-CLUSTER-CONTAIN
ING HYDROGENASE
(Rhodothermus
marinus) 		4 / 4 ARG B 795
SER B 791
ASP B 792
ASN B 796
 None
None
HEC  A 302 ( 4.6A)
None
 1.15A 6ag0A-6f0kB:
undetectable		 6ag0A-6f0kB:
26.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AV6_D_H4BD502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 6f0k POLYSULPHIDE
REDUCTASE NRFD
(Rhodothermus
marinus) 		4 / 7 TRP C 262
PHE C 254
SER C 402
VAL C 397
 None
 1.20A 6av6C-6f0kC:
undetectable
6av6D-6f0kC:
undetectable		 6av6C-6f0kC:
24.74
6av6D-6f0kC:
24.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AZ3_1_PAR11802_1
(RRNA ALPHA
RIBOSOMAL PROTEIN
UL4
RIBOSOMAL PROTEIN
UL15
RIBOSOMAL PROTEIN
EL15)		 6f0k ACTF
POLYSULPHIDE
REDUCTASE NRFD
(Rhodothermus
marinus) 		3 / 3 ARG C 110
LYS F 338
ARG C 112
 None
 1.31A 6az3C-6f0kC:
undetectable
6az3L-6f0kC:
undetectable
6az3M-6f0kC:
undetectable		 6az3C-6f0kC:
22.62
6az3L-6f0kC:
15.66
6az3M-6f0kC:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B58_A_ACTA607_0
(FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT)		 6f0k FE-S-CLUSTER-CONTAIN
ING HYDROGENASE
QUINOL:CYTOCHROME C
OXIDOREDUCTASE
MONOHEME CYTOCHROME
SUBUNIT
(Rhodothermus
marinus;
Rhodothermus
marinus) 		4 / 4 GLY B 126
ARG E  71
ASN B 127
LEU B 112
 None
 1.33A 6b58A-6f0kB:
undetectable		 6b58A-6f0kB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6E5Z_A_CCSA106_0
(PROTEIN/NUCLEIC ACID
DEGLYCASE DJ-1)		 6f0k POLYSULPHIDE
REDUCTASE NRFD
(Rhodothermus
marinus) 		6 / 10 GLY C 279
ILE C  95
ALA C  98
THR C 125
HIS C  97
GLY C  94
 None
 1.25A 6e5zA-6f0kC:
undetectable		 6e5zA-6f0kC:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6J_D_ACTD404_0
(L-LYSINE
3-HYDROXYLASE)		 6f0k FE-S-CLUSTER-CONTAIN
ING HYDROGENASE
(Rhodothermus
marinus) 		4 / 6 GLU B 491
TRP B 166
HIS B 494
ALA B 493
 None
 1.25A 6f6jC-6f0kB:
undetectable
6f6jD-6f0kB:
undetectable		 6f6jC-6f0kB:
undetectable
6f6jD-6f0kB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G31_J_ZOLJ401_0
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE)		 6f0k ACTF
(Rhodothermus
marinus) 		4 / 6 LEU F 410
ASP F 407
GLN F 183
GLN F  87
 None
 1.38A 6g31J-6f0kF:
4.4		 6g31J-6f0kF:
24.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNF_C_QPSC602_2
(-)		 6f0k CYTOCHROME C FAMILY
PROTEIN
FE-S-CLUSTER-CONTAIN
ING HYDROGENASE
(Rhodothermus
marinus) 		5 / 12 VAL A 133
ASP A 119
ARG B 958
GLU B 955
PRO A 203
 HEC  A 303 (-4.1A)
None
HEC  A 302 (-3.7A)
None
HEC  A 302 (-4.1A)
 1.16A 6gnfC-6f0kA:
undetectable		 6gnfC-6f0kA:
10.54