SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6f1y'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T46_A_STIA3_2
(HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG)		 6f1y CYTOPLASMIC DYNEIN 1
LIGHT INTERMEDIATE
CHAIN 2
(Homo
sapiens) 		4 / 7 VAL j  59
TYR j 265
CYH j 262
CYH j 231
 None
 0.93A 1t46A-6f1yj:
undetectable		 1t46A-6f1yj:
12.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VPT_A_SAMA400_0
(VP39)		 6f1y CYTOPLASMIC DYNEIN 1
LIGHT INTERMEDIATE
CHAIN 2
(Homo
sapiens) 		5 / 12 GLN j 150
ILE j 134
VAL j 136
ALA j 137
LEU j  70
 None
 0.70A 1vptA-6f1yj:
undetectable		 1vptA-6f1yj:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BRF_A_SORA2_0
(LIN-12 AND GLP-1
PHENOTYPE PROTEIN 1,
ISOFORM A)		 6f1y CYTOPLASMIC DYNEIN 1
LIGHT INTERMEDIATE
CHAIN 2
(Homo
sapiens) 		3 / 3 LYS j  55
LYS j 285
VAL j 288
 None
 0.88A 3brfA-6f1yj:
undetectable		 3brfA-6f1yj:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K36_A_SAMA504_0
(ANAEROBIC
SULFATASE-MATURATING
ENZYME)		 6f1y CYTOPLASMIC DYNEIN 1
LIGHT INTERMEDIATE
CHAIN 2
(Homo
sapiens) 		5 / 12 ASN j 105
LEU j 132
VAL j  59
ILE j 134
LEU j  70
 None
 1.05A 4k36A-6f1yj:
undetectable		 4k36A-6f1yj:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K36_B_SAMB504_0
(ANAEROBIC
SULFATASE-MATURATING
ENZYME)		 6f1y CYTOPLASMIC DYNEIN 1
LIGHT INTERMEDIATE
CHAIN 2
(Homo
sapiens) 		5 / 12 ASN j 105
LEU j 132
VAL j  59
ILE j 134
LEU j  70
 None
 1.10A 4k36B-6f1yj:
1.7		 4k36B-6f1yj:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZC_B_ACTB401_0
(PROTON-GATED ION
CHANNEL)		 6f1y CYTOPLASMIC DYNEIN 1
HEAVY CHAIN 1,DYNEIN
HEAVY CHAIN
(Homo
sapiens) 		4 / 6 ILE f 877
ARG f 914
ILE f 910
GLU f 865
 None
 1.43A 4zzcB-6f1yf:
2.7
4zzcC-6f1yf:
2.8		 4zzcB-6f1yf:
undetectable
4zzcC-6f1yf:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DNU_A_BEZA319_0
(SHKAI2IB)		 6f1y CYTOPLASMIC DYNEIN 1
HEAVY CHAIN 1,DYNEIN
HEAVY CHAIN
(Homo
sapiens) 		4 / 5 GLN f 813
ILE f 816
ILE f 820
TYR f 788
 None
 1.16A 5dnuA-6f1yf:
undetectable		 5dnuA-6f1yf:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DNV_A_BEZA304_0
(SHKAI2IB)		 6f1y CYTOPLASMIC DYNEIN 1
HEAVY CHAIN 1,DYNEIN
HEAVY CHAIN
(Homo
sapiens) 		4 / 5 GLN f 813
ILE f 816
ILE f 820
TYR f 788
 None
 1.13A 5dnvA-6f1yf:
undetectable		 5dnvA-6f1yf:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DXE_A_ESTA1000_1
(ESTROGEN RECEPTOR)		 6f1y CYTOPLASMIC DYNEIN 1
LIGHT INTERMEDIATE
CHAIN 2
(Homo
sapiens) 		4 / 8 LEU j 109
GLU j  62
HIS j 159
LEU j 156
 None
 1.15A 5dxeA-6f1yj:
undetectable		 5dxeA-6f1yj:
16.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECK_D_ILED601_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 6f1y CYTOPLASMIC DYNEIN 1
HEAVY CHAIN 1,DYNEIN
HEAVY CHAIN
(Homo
sapiens) 		4 / 6 ALA f 921
THR f 923
VAL f 925
VAL f1044
 None
 0.99A 5eckD-6f1yf:
undetectable		 5eckD-6f1yf:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6J_A_ACTA404_0
(L-LYSINE
3-HYDROXYLASE)		 6f1y CYTOPLASMIC DYNEIN 1
LIGHT INTERMEDIATE
CHAIN 2
(Homo
sapiens) 		4 / 6 ILE j 134
TYR j 284
LEU j 280
VAL j 230
 None
 0.98A 6f6jA-6f1yj:
undetectable		 6f6jA-6f1yj:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_E_AM2E301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 6f1y CYTOPLASMIC DYNEIN 1
LIGHT INTERMEDIATE
CHAIN 2
(Homo
sapiens) 		4 / 7 THR j 232
HIS j 115
GLU j  62
ASP j  63
 None
 1.26A 6mn4E-6f1yj:
undetectable		 6mn4E-6f1yj:
undetectable